Denali Therapeutics Inc.

NasdaqGS:DNLI Voorraadrapport

Marktkapitalisatie: US$3.1b

Denali Therapeutics Beheer

Beheer criteriumcontroles 4/4

De CEO Denali Therapeutics is Ryan Watts, benoemd in Aug2015, heeft een ambtstermijn van 10.75 jaar. De totale jaarlijkse vergoeding van { bedraagt $ 4.75M, bestaande uit 15.1% salaris en 84.9% bonussen, inclusief aandelen en opties van het bedrijf. bezit rechtstreeks 1.43% van de aandelen van het bedrijf, ter waarde $ 43.89M. De gemiddelde ambtstermijn van het managementteam en de raad van bestuur bedraagt respectievelijk 7.3 jaar en 7.1 jaar.

Belangrijke informatie

Ryan Watts

Algemeen directeur

US$4.8m

Totale compensatie

Percentage CEO-salaris15.11%
Dienstverband CEO10.8yrs
Eigendom CEO1.4%
Management gemiddelde ambtstermijn7.3yrs
Gemiddelde ambtstermijn bestuur7.1yrs

Recente managementupdates

Recent updates

Seeking Alpha • 18h

Denali Therapeutics: 'Strong Buy' On AVLAYAH Approval And End Of 2026 FTD-GRN Data

Summary Denali Therapeutics maintains a "Strong Buy" rating following an FDA Accelerated Approval of AVLAYAH for Hunter syndrome and robust pipeline momentum. The company's DNL593 for FTD-GRN is differentiated by restoring both extracellular and lysosomal PGRN; phase 1/2 data readout is expected by the end of 2026. AVLAYAH’s full approval depends on confirmatory COMPASS study results; commercial performance remains unproven post-April 2026 launch. The company holds $1.05B in cash but may need additional funding within 12 months, with a $400M ATM facility available for potential dilution. Read the full article on Seeking Alpha
Analyseartikel • May 08

We're Not Very Worried About Denali Therapeutics' (NASDAQ:DNLI) Cash Burn Rate

There's no doubt that money can be made by owning shares of unprofitable businesses. For example, although Amazon.com...
Seeking Alpha • Mar 20

Denali Therapeutics: Vast Pipeline, First Approval Up Ahead

Summary Denali Therapeutics' stock has significantly dropped from $100 to $15 since 2021, but the company is now heavily derisked with promising product candidates nearing key milestones. Lead asset DNL310 shows strong biomarker data for Hunter syndrome, with plans for a BLA submission and accelerated approval by Q2 2025. The Biogen partnership for Parkinson’s Disease asset DNL151 includes substantial milestone payments and profit-sharing, highlighting its potential impact. Despite past failures, Denali's extensive pipeline and solid financial runway make it a compelling buy at current low stock prices. Read the full article on Seeking Alpha
Seeking Alpha • Jan 09

Denali: Despite ALS Primary Endpoint Failure, Possible Path Forward Remains

Summary Denali Therapeutics Inc.'s DNL343 failed to meet the primary endpoint in the phase 2/3 HEALY ALS trial, but potential biomarker analyses in 2025 may offer a path forward. Despite the trial setback in ALS, Denali's stock remains stable due to continued pre-specified analyses expected in late 2025. BLA filing of tividenofusp alfa for the treatment of patients with MPS II remains on track under the Accelerated Approval Pathway Program in early 2025. Financially, Denali has $1.28 billion in cash but may need additional funding in 2025, posing a risk of shareholder dilution. Read the full article on Seeking Alpha
Analyseartikel • Dec 09

We're Hopeful That Denali Therapeutics (NASDAQ:DNLI) Will Use Its Cash Wisely

There's no doubt that money can be made by owning shares of unprofitable businesses. For example, biotech and mining...
Seeking Alpha • Aug 20

Denali Therapeutics: A Promising Biotech With Revolutionary BBB-Crossing Technology

Summary Denali Therapeutics' proprietary Transport Vehicle technology enables drug delivery across the blood-brain barrier, targeting neurodegenerative diseases. DNL310, targeting MPS II, and DNL343 for ALS are key drug candidates with potential, though competition is significant. The company’s $500 million capital raise supports its aggressive R&D investment, providing a runway for developing its pipeline. Despite its promising platform, DNLI still has a relatively high cash burn and regulatory hurdles before achieving drug approval. Due to Denali's high-risk, long-term biotech development, I deem DNLI a DCA "buy" for investors who understand the inherent risks. Read the full article on Seeking Alpha
Analyseartikel • Jul 26

Companies Like Denali Therapeutics (NASDAQ:DNLI) Are In A Position To Invest In Growth

Just because a business does not make any money, does not mean that the stock will go down. For example, biotech and...
Analyseartikel • May 23

Revenues Not Telling The Story For Denali Therapeutics Inc. (NASDAQ:DNLI) After Shares Rise 25%

Denali Therapeutics Inc. ( NASDAQ:DNLI ) shareholders would be excited to see that the share price has had a great...
Seeking Alpha • May 13

Denali Therapeutics: MPS Treatment Program Continues With End Of 2024 Data

Summary Denali Therapeutics Inc.'s DNL-310 is currently being explored in an ongoing phase 2/3 COMPASS study for treatment of patients with MPS II; Enrollment completion expected in 2024. Denali is in talks with CDER division of FDA to seek for Accelerated Approval pathway for DNL-310 for the treatment of patients with MPS II. Biomarker and safety data from a phase 1/2 study, using DNL-126 for the treatment of patients with MPS IIIA, expected end of 2024. Another promising program from the pipeline is the development of DNL-343, which is being advanced in the phase 2/3 HEALEY ALS Platform trial for treatment of patients with amyotrophic lateral sclerosis. Read the full article on Seeking Alpha
Analyseartikel • Apr 17

An Intrinsic Calculation For Denali Therapeutics Inc. (NASDAQ:DNLI) Suggests It's 44% Undervalued

Key Insights Using the 2 Stage Free Cash Flow to Equity, Denali Therapeutics fair value estimate is US$30.71 Denali...
Analyseartikel • Mar 21

Denali Therapeutics Inc.'s (NASDAQ:DNLI) Price Is Right But Growth Is Lacking After Shares Rocket 25%

Those holding Denali Therapeutics Inc. ( NASDAQ:DNLI ) shares would be relieved that the share price has rebounded 25...
Seeking Alpha • Mar 07

Denali: Leveraging Transport Vehicle Technology For Neurological Gains

Summary Denali's stock performance has been flat despite the biotech sector's 20% rise; recently raised $500 million in a PIPE. ALS trial failure with partner Sanofi pressured stock; Denali's focus is on transport vehicle (TV) technology and BBB crossing. Denali boasts a strong financial position with $1.53 billion in cash, extending operational runway significantly. Recommends "buy" based on Denali's innovative TV technology, financial health, and potential in neurological disorders despite biotech risks. Read the full article on Seeking Alpha
Analyseartikel • Feb 21

Companies Like Denali Therapeutics (NASDAQ:DNLI) Are In A Position To Invest In Growth

There's no doubt that money can be made by owning shares of unprofitable businesses. For example, although...
Analyseartikel • Jan 26

Improved Revenues Required Before Denali Therapeutics Inc. (NASDAQ:DNLI) Shares Find Their Feet

Denali Therapeutics Inc.'s ( NASDAQ:DNLI ) price-to-sales (or "P/S") ratio of 7x might make it look like a buy right...
Analyseartikel • Nov 20

We're Not Very Worried About Denali Therapeutics' (NASDAQ:DNLI) Cash Burn Rate

Just because a business does not make any money, does not mean that the stock will go down. For example, biotech and...
Analyseartikel • Oct 09

Investor Optimism Abounds Denali Therapeutics Inc. (NASDAQ:DNLI) But Growth Is Lacking

With a median price-to-sales (or "P/S") ratio of close to 10.4x in the Biotechs industry in the United States, you...
Analyseartikel • Aug 22

Companies Like Denali Therapeutics (NASDAQ:DNLI) Are In A Position To Invest In Growth

There's no doubt that money can be made by owning shares of unprofitable businesses. For example, biotech and mining...

Analyse CEO-vergoeding

Hoe is Ryan Watts's beloning veranderd ten opzichte van Denali Therapeutics's winst?
DatumTotale vergoedingSalarisBedrijfswinsten
Mar 31 2026n/an/a

-US$508m

Dec 31 2025US$5mUS$718k

-US$513m

Sep 30 2025n/an/a

-US$499m

Jun 30 2025n/an/a

-US$479m

Mar 31 2025n/an/a

-US$454m

Dec 31 2024US$7mUS$690k

-US$423m

Sep 30 2024n/an/a

-US$427m

Jun 30 2024n/an/a

-US$420m

Mar 31 2024n/an/a

-US$137m

Dec 31 2023US$8mUS$670k

-US$145m

Sep 30 2023n/an/a

-US$124m

Jun 30 2023n/an/a

-US$128m

Mar 31 2023n/an/a

-US$371m

Dec 31 2022US$9mUS$645k

-US$326m

Sep 30 2022n/an/a

-US$303m

Jun 30 2022n/an/a

-US$284m

Mar 31 2022n/an/a

-US$286m

Dec 31 2021US$13mUS$610k

-US$291m

Sep 30 2021n/an/a

US$30m

Jun 30 2021n/an/a

US$56m

Mar 31 2021n/an/a

US$58m

Dec 31 2020US$9mUS$589k

US$71m

Sep 30 2020n/an/a

-US$228m

Jun 30 2020n/an/a

-US$216m

Mar 31 2020n/an/a

-US$215m

Dec 31 2019US$5mUS$567k

-US$198m

Compensatie versus markt: De totale vergoeding ($USD 4.75M ) Ryan } ligt onder het gemiddelde voor bedrijven van vergelijkbare omvang in de US markt ($USD 7.00M ).

Compensatie versus inkomsten: De vergoeding van Ryan is het afgelopen jaar in lijn geweest met de bedrijfsprestaties.

CEO

Ryan Watts (49 yo)

10.8yrs
Tenure
US$4,751,515
Compensatie

Dr. Ryan J. Watts, Ph D., serves as Director at PEEL Therapeutics, Inc. since February 2023. He is the Co-Founder of Denali Therapeutics Inc. and has been its President and Chief Executive Officer since Au...

Leiderschapsteam

NaamPositieTenureCompensatieEigendom
Ryan Watts
Co-Founder10.8yrsUS$4.75m1.43%
$ 43.9m
Alexander Schuth
Co-Founder11.2yrsUS$4.26m0.42%
$ 12.9m
Dana Andersen
Chief Technical and Manufacturing Officer7.8yrsgeen gegevensgeen gegevens
Joe Lewcock
Chief Scientific Officer5.8yrsgeen gegevensgeen gegevens
Chris Walsh
General Counsel7.3yrsgeen gegevensgeen gegevens
Cindy Dunkle
Chief People Officerno datageen gegevensgeen gegevens
Katie Peng
Chief Commercial Officer4.7yrsgeen gegevensgeen gegevens
Peter Chin
Acting Chief Medical Officer & Head of Developmentless than a yeargeen gegevens0.13%
$ 4.0m
7.3yrs
Gemiddelde duur
53yo
Gemiddelde leeftijd

Ervaren management: Het managementteam van DNLI is doorgewinterd en ervaren (gemiddelde ambtstermijn van 7.3 jaar).

Bestuursleden

NaamPositieTenureCompensatieEigendom
Ryan Watts
Co-Founder11.2yrsUS$4.75m1.43%
$ 43.9m
Jay Flatley
Independent Director11.1yrsUS$316.38k0.22%
$ 6.7m
Julian Baker
Independent Chairpersonless than a yearUS$474.35k0.21%
$ 6.3m
Eric Reiman
Member of Scientific Advisory Boardno datageen gegevensgeen gegevens
David Schenkein
Independent Director11.1yrsUS$311.38k0.042%
$ 1.3m
David Holtzman
Member of Scientific Advisory Board5.5yrsgeen gegevensgeen gegevens
Peter Klein
Independent Director8.2yrsUS$318.88k0.014%
$ 416.5k
Jennifer Cook
Independent Director7.5yrsUS$301.38k0.013%
$ 388.5k
Steve Krognes
Independent Director4yrsUS$297.15k0.51%
$ 15.7m
Stacie Weninger
Member of Scientific Advisory Board5.3yrsgeen gegevensgeen gegevens
Henrik Zetterberg
Member of Scientific Advisory Board7.1yrsgeen gegevensgeen gegevens
Nancy Thornberry
Independent Director5.3yrsUS$306.38k0.012%
$ 362.0k
7.1yrs
Gemiddelde duur
61yo
Gemiddelde leeftijd

Ervaren bestuur: De raad van bestuur van DNLI wordt beschouwd als ervaren (gemiddelde ambtstermijn 7.1 jaar).

Bedrijfsanalyse en status van financiële gegevens

GegevensLaatst bijgewerkt (UTC-tijd)
Bedrijfsanalyse2026/05/27 02:51
Aandelenkoers aan het einde van de dag2026/05/27 00:00
Inkomsten2026/03/31
Jaarlijkse inkomsten2025/12/31

Gegevensbronnen

De gegevens die gebruikt zijn in onze bedrijfsanalyse zijn afkomstig van S&P Global Market Intelligence LLC. De volgende gegevens worden gebruikt in ons analysemodel om dit rapport te genereren. De gegevens zijn genormaliseerd, waardoor er een vertraging kan optreden voordat de bron beschikbaar is.

PakketGegevensTijdframeVoorbeeld Amerikaanse bron *
Financiële gegevens bedrijf10 jaar
  • Resultatenrekening
  • Kasstroomoverzicht
  • Balans
Consensus schattingen analisten+3 jaar
  • Financiële prognoses
  • Koersdoelen analisten
Marktprijzen30 jaar
  • Aandelenprijzen
  • Dividenden, splitsingen en acties
Eigendom10 jaar
  • Top aandeelhouders
  • Handel met voorkennis
Beheer10 jaar
  • Leiderschapsteam
  • Raad van bestuur
Belangrijkste ontwikkelingen10 jaar
  • Bedrijfsaankondigingen

* Voorbeeld voor effecten uit de VS, voor niet-Amerikaanse effecten worden gelijkwaardige formulieren en bronnen gebruikt.

Tenzij anders vermeld zijn alle financiële gegevens gebaseerd op een jaarperiode, maar worden ze elk kwartaal bijgewerkt. Dit staat bekend als Trailing Twelve Month (TTM) of Last Twelve Month (LTM) gegevens. Meer informatie.

Analysemodel en Snowflake

Details van het analysemodel dat is gebruikt om dit rapport te genereren zijn beschikbaar op onze Github-pagina. We hebben ook handleidingen over hoe je onze rapporten kunt gebruiken en tutorials op YouTube.

Leer meer over het team van wereldklasse dat het Simply Wall St-analysemodel heeft ontworpen en gebouwd.

Industrie en sector

Onze industrie- en sectormetrics worden elke 6 uur berekend door Simply Wall St, details van ons proces zijn beschikbaar op Github.

Bronnen van analisten

Denali Therapeutics Inc. wordt gevolgd door 31 analisten. 19 van deze analisten hebben de schattingen van de omzet of winst ingediend die zijn gebruikt als input voor ons rapport. Inzendingen van analisten worden de hele dag door bijgewerkt.

AnalistInstelling
null nullBaird
Joel BeattyBaird
Charles MooreBaird