Stock Analysis

Assessing Xeris Biopharma Holdings (XERS) Valuation Following Upgrades and Fresh Earnings Revisions

If you’ve been tracking Xeris Biopharma Holdings (XERS), you probably noticed the recent jump in excitement around the stock. A fresh wave of analyst upgrades and positive earnings estimate revisions have set the tone, reinforcing what momentum watchers have suspected: investors are taking another look at Xeris as near-term prospects brighten up. These triggers have moved sentiment quickly, and for anyone considering adding XERS to their portfolio, it feels like a moment when signals are converging. Looking at the stock’s run over the past year, it’s not just a short-term blip. Xeris has seen price growth that easily outpaces both its industry and the general market, especially visible in its past quarter and yearly performance. That kind of sustained upward movement, paired with optimism about profit potential, is the kind of momentum that can draw in more attention and potentially recalibrate market expectations. So, after this period of sharp gains and bullish upgrades, the real question is whether Xeris is undervalued or if the market is already pricing in the next chapter of growth.
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Most Popular Narrative: 16.8% Undervalued

The current valuation narrative points to Xeris Biopharma Holdings trading below its estimated fair value. This outlook suggests market expectations could align more closely with new guidance and profitability forecasts.

Continued investment in expanding the commercial footprint, enhancing patient support, and deepening engagement with healthcare professionals positions Xeris to capture a larger share of the growing at-home and patient-centric treatment market. This supports both revenue growth and improved SG&A leverage.

Want to discover the hidden drivers behind this bold valuation call? What are analysts counting on to justify a much higher target? The narrative hinges on a set of assumptions and projections that could surprise even the most seasoned biotech investors. Prepare for some eye-opening metrics fueling this fair value estimate.

Result: Fair Value of $9.00 (UNDERVALUED)

Have a read of the narrative in full and understand what's behind the forecasts.

However, heavy reliance on a few key products and rising expenses could quickly dampen optimism if market or pipeline expectations are not met.

Find out about the key risks to this Xeris Biopharma Holdings narrative.

Another View: A Market-Based Comparison

Taking a different angle, a look at Xeris Biopharma Holdings's value compared to the industry average raises eyebrows, as the stock actually appears more expensive using this approach. Could the strong growth narrative be running ahead of fundamentals?

See what the numbers say about this price — find out in our valuation breakdown.

NasdaqGS:XERS PS Ratio as at Sep 2025
NasdaqGS:XERS PS Ratio as at Sep 2025

Stay updated when valuation signals shift by adding Xeris Biopharma Holdings to your watchlist or portfolio. Alternatively, explore our screener to discover other companies that fit your criteria.

Build Your Own Xeris Biopharma Holdings Narrative

If these perspectives do not match your own, or if you prefer to analyze information independently, you’re welcome to build your own in just a few minutes – Do it your way.

A great starting point for your Xeris Biopharma Holdings research is our analysis highlighting 3 key rewards and 2 important warning signs that could impact your investment decision.

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This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

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About NasdaqGS:XERS

Xeris Biopharma Holdings

A commercial-stage biopharmaceutical company, engages in developing and commercializing therapies for chronic endocrine and neurological diseases in Illinois.

Good value with reasonable growth potential.

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