Is Castle Biosciences (CSTL) Overvalued After Its Recent 3‑Month Rally? A Fresh Look at the Numbers

Castle Biosciences (CSTL) has quietly turned into one of this year’s surprising healthcare winners, with the stock up about 68% over the past 3 months and roughly 36% year to date.

See our latest analysis for Castle Biosciences.

That move has come as investors have warmed to Castle’s mix of steady revenue growth and narrowing losses, with a 30 day share price return of just over 10% building on a powerful 90 day rally and stronger multi year total shareholder returns.

If Castle’s run has you rethinking your healthcare exposure, this could be a good moment to explore other potential winners across healthcare stocks and see what else fits your strategy.

With shares now trading slightly above Wall Street’s average target yet still showing a hefty implied intrinsic discount, the key question is whether Castle remains mispriced or if the market is already discounting years of future growth.

Most Popular Narrative Narrative: 7.4% Overvalued

With Castle Biosciences closing at $38.25 against a narrative fair value near the mid 30s, the story leans toward a richer pricing backdrop.

The ongoing shift toward precision and individualized medicine across healthcare systems, combined with Castle's robust real-world evidence (e.g., NCI SEER study showing 32% reduction in melanoma mortality), sets the stage for broader clinical adoption and increased commercial and payer demand, likely boosting test volumes and supporting higher revenues.

Read the complete narrative.

Want to see why modest top line growth assumptions still support an aggressive future earnings multiple and richer margins than today, even without near term profitability? The full narrative unpacks how projected revenue mix, margin expansion and share count changes interact to justify that valuation target.

Result: Fair Value of $35.63 (OVERVALUED)

Have a read of the narrative in full and understand what's behind the forecasts.

However, lingering reimbursement uncertainty and rising competitive pressure could still derail adoption, compress margins, and challenge the growth expectations embedded in this narrative.

Find out about the key risks to this Castle Biosciences narrative.

Another Way of Looking at Value

While the consensus narrative pegs Castle as about 7.4% overvalued versus its fair value, our DCF model paints a very different picture, suggesting the shares trade almost 40% below intrinsic value. When one framework sees upside and the other signals caution, which story do you trust with your money?

Look into how the SWS DCF model arrives at its fair value.

Simply Wall St performs a discounted cash flow (DCF) on every stock in the world every day (check out Castle Biosciences for example). We show the entire calculation in full. You can track the result in your watchlist or portfolio and be alerted when this changes, or use our stock screener to discover 900 undervalued stocks based on their cash flows. If you save a screener we even alert you when new companies match - so you never miss a potential opportunity.

Build Your Own Castle Biosciences Narrative

If you see the story differently, or want to dig into the numbers yourself, you can build a fresh perspective in minutes: Do it your way.

A great starting point for your Castle Biosciences research is our analysis highlighting 1 key reward and 1 important warning sign that could impact your investment decision.

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This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

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