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Praxis Precision Medicines, Inc.NasdaqGS:PRAX Stock Report

Market Cap US$8.9b
Share Price
US$335.61
US$449.13
25.3% undervalued intrinsic discount
1Y790.7%
7D-3.2%
Portfolio Value
View

Praxis Precision Medicines, Inc.

NasdaqGS:PRAX Stock Report

Market Cap: US$8.9b

Praxis Precision Medicines (PRAX) Stock Overview

A clinical-stage biopharmaceutical company, engages in the development of therapies for central nervous system (CNS) disorders characterized by neuronal excitation-inhibition imbalance in the United States. More details

PRAX fundamental analysis
Snowflake Score
Valuation3/6
Future Growth5/6
Past Performance0/6
Financial Health5/6
Dividends0/6

PRAX Community Fair Values

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Praxis Precision Medicines, Inc. Competitors

Price History & Performance

Summary of share price highs, lows and changes for Praxis Precision Medicines
Historical stock prices
Current Share PriceUS$335.61
52 Week HighUS$358.76
52 Week LowUS$35.21
Beta2.78
1 Month Change-2.03%
3 Month Change1.21%
1 Year Change790.68%
3 Year Change2,010.76%
5 Year Change21.40%
Change since IPO-19.52%

Recent News & Updates

Recent updates

Seeking Alpha Apr 06

Praxis: Strong Buy As Relutrigine Submission Accepted Plus Expansion Potential

Summary Praxis Precision Medicines, Inc. remains a Strong Buy, driven by two NDA submissions and pipeline expansion opportunities targeting essential tremor and developmental and epileptic encephalopathies. The company's relutrigine achieved a 46% placebo-adjusted reduction in motor seizure frequency for SCN2A/SCN8A DEE and is under FDA priority review with a PDUFA date of September 27, 2026. Pipeline expansion includes relutrigine's potential sNDA for broad DEE and elsunersen for early-onset SCN2A DEE, with key data readouts expected in 2026–2027. With $926.1M cash at 2025 year-end and a $621.2M January 2026 raise, PRAX is funded into 2028, supporting robust R&D and regulatory milestones. Read the full article on Seeking Alpha
Analysis Article Jul 18

We're Hopeful That Praxis Precision Medicines (NASDAQ:PRAX) Will Use Its Cash Wisely

Just because a business does not make any money, does not mean that the stock will go down. For example, although...
Seeking Alpha Mar 04

Praxis: A High-Risk, High-Reward Epilepsy Play Post Ulixacaltamide (Rating Upgrade)

Summary Ulixacaltamide’s Phase 3 study was recommended to stop for futility, significantly lowering its chances of success in essential tremor. Investor focus shifts to the epilepsy pipeline, led by vormatrigine (focal epilepsy) and relutrigine (SCN2A/SCN8A-DEEs). Vormatrigine must differentiate from Xcopri and XEN1101 in a highly competitive focal epilepsy market. Relutrigine showed promising seizure reduction in rare pediatric epilepsies but needs confirmation in larger pivotal trials. Praxis has $400M+ cash, funding operations into 2028, with key epilepsy trial readouts expected in 2H 2025. Read the full article on Seeking Alpha
Seeking Alpha Dec 26

Praxis Precision Medicines: Multiple Potential Drivers

Summary Praxis Precision Medicines, Inc., a promising clinical stage biopharma concern, has seen significant stock gains in the second half of 2024. Analyst firms are quite bullish on the stock, with eight firms recently issuing Buy ratings and price targets ranging from $114 to $305 per share. The company has several potential drivers with its late-stage pipeline candidates and possesses a decent balance sheet. While the stock should only be considered by aggressive investors given its recent rally, I have taken a small position in PRAX stock via covered call orders. An analysis around Praxis Precision Medicines follows in the paragraphs below. Read the full article on Seeking Alpha
Seeking Alpha Oct 13

Praxis Precision Medicines: Great Price Movement, But Still Not Convinced

Summary Praxis Precision Medicines has shown impressive growth, but past trial failures and current risks warrant caution before investing. The lead candidate, Ulixacaltamide, is in a phase 3 trial for essential tremor, with results expected by the end of 2024. PRAX-628 shows promise for epilepsy, but the small patient cohort and competitive landscape raise concerns. Despite significant stock gains, I remain unconvinced and seek more data before making an investment decision. Read the full article on Seeking Alpha
Seeking Alpha Mar 26

Praxis: 2nd Half 2024 ET Readout Could Lead To U.S. Regulatory Filing

Summary Praxis Precision Medicines, Inc. results from the phase 3 Essential3 program, using ulixacaltamide for the treatment of patients with essential tremor, expected in the 2nd half of 2024. Company believes that the essential tremor U.S. market opportunity could be $4 billion. Positive data achieved in phase 2 study, using PRAX-628 for focal epilepsy; Phase 2b study targeting this very same patient population to be initiated 2nd half of 2024. With cash on hand, plus underwritten public offering that brought in $161.7 million in cash, Praxis Precision Medicines believes it can fund its operations into 2026. Read the full article on Seeking Alpha

Shareholder Returns

PRAXUS BiotechsUS Market
7D-3.2%-4.9%-1.0%
1Y790.7%28.1%23.3%

Return vs Industry: PRAX exceeded the US Biotechs industry which returned 28.1% over the past year.

Return vs Market: PRAX exceeded the US Market which returned 23.3% over the past year.

Price Volatility

Is PRAX's price volatile compared to industry and market?
PRAX volatility
PRAX Average Weekly Movement8.3%
Biotechs Industry Average Movement10.9%
Market Average Movement7.2%
10% most volatile stocks in US Market16.2%
10% least volatile stocks in US Market3.2%

Stable Share Price: PRAX has not had significant price volatility in the past 3 months compared to the US market.

Volatility Over Time: PRAX's weekly volatility has decreased from 28% to 8% over the past year.

About the Company

FoundedEmployeesCEOWebsite
2015168Marcio De'Souzapraxismedicines.com

Praxis Precision Medicines, Inc., a clinical-stage biopharmaceutical company, engages in the development of therapies for central nervous system (CNS) disorders characterized by neuronal excitation-inhibition imbalance in the United States. The company’s platforms include Cerebrum, a small molecule platform for CNS small molecule therapies to develop orally available precision therapies; and Solidus to discover and develop antisense oligonucleotide. It also develops ulixacaltamide, a small molecule inhibitor of T-type calcium channels that in NDA for the treatment of essential tremor; relutrigine, a small molecule, which is in NDA for the treatment of SCN2A- and SCN8A-developmental and epileptic encephalopathies (DEE), as well as in Phase 3 trial for broad DEEs; vormatrigine, a small molecule targeting the hyperexcitable state of sodium-channels in the brain that is in Phase 3 trial for the treatment of adjunctive focal epilepsy, as well as in Phase 2 trial for monotherapy focal epilepsy; and Elsunersen, a clinical-stage ASO designed to selectively decrease SCN2A gene expression, which is in Phase 3 trial for the treatment of SCN2A-DEE.

Praxis Precision Medicines, Inc. Fundamentals Summary

How do Praxis Precision Medicines's earnings and revenue compare to its market cap?
PRAX fundamental statistics
Market capUS$8.94b
Earnings (TTM)-US$326.53m
Revenue (TTM)n/a
0.0x
P/S Ratio
-28.7x
P/E Ratio

Earnings & Revenue

Key profitability statistics from the latest earnings report (TTM)
PRAX income statement (TTM)
RevenueUS$0
Cost of RevenueUS$284.30m
Gross Profit-US$284.30m
Other ExpensesUS$42.24m
Earnings-US$326.53m

Last Reported Earnings

Mar 31, 2026

Next Earnings Date

n/a

Earnings per share (EPS)-11.71
Gross Margin0.00%
Net Profit Margin0.00%
Debt/Equity Ratio0%

How did PRAX perform over the long term?

See historical performance and comparison

Company Analysis and Financial Data Status

DataLast Updated (UTC time)
Company Analysis2026/05/20 02:04
End of Day Share Price 2026/05/20 00:00
Earnings2026/03/31
Annual Earnings2025/12/31

Data Sources

The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.

PackageDataTimeframeExample US Source *
Company Financials10 years
  • Income statement
  • Cash flow statement
  • Balance sheet
Analyst Consensus Estimates+3 years
  • Forecast financials
  • Analyst price targets
Market Prices30 years
  • Stock prices
  • Dividends, Splits and Actions
Ownership10 years
  • Top shareholders
  • Insider trading
Management10 years
  • Leadership team
  • Board of directors
Key Developments10 years
  • Company announcements

* Example for US securities, for non-US equivalent regulatory forms and sources are used.

Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more.

Analysis Model and Snowflake

Details of the analysis model used to generate this report is available on our Github page, we also have guides on how to use our reports and tutorials on Youtube.

Learn about the world class team who designed and built the Simply Wall St analysis model.

Industry and Sector Metrics

Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on Github.

Analyst Sources

Praxis Precision Medicines, Inc. is covered by 27 analysts. 17 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.

AnalystInstitution
Brian SkorneyBaird
Joel BeattyBaird
null nullBaird