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Lyell Immunopharma, Inc.NasdaqGS:LYEL Stock Report

Market Cap US$486.5m
Share Price
US$19.33
US$37.17
48.0% undervalued intrinsic discount
1Y134.3%
7D1.7%
Portfolio Value
View

Lyell Immunopharma, Inc.

NasdaqGS:LYEL Stock Report

Market Cap: US$486.5m

Lyell Immunopharma (LYEL) Stock Overview

A clinical-stage cell therapy company, develops chimeric antigen receptor (CAR) T-cell product candidates for patients with hematologic malignancies and solid tumors. More details

LYEL fundamental analysis
Snowflake Score
Valuation2/6
Future Growth2/6
Past Performance0/6
Financial Health6/6
Dividends0/6

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Lyell Immunopharma, Inc. Competitors

Price History & Performance

Summary of share price highs, lows and changes for Lyell Immunopharma
Historical stock prices
Current Share PriceUS$20.06
52 Week HighUS$45.00
52 Week LowUS$7.65
Beta-0.058
1 Month Change-7.90%
3 Month Change-11.67%
1 Year Change134.35%
3 Year Change-60.20%
5 Year Changen/a
Change since IPO-94.06%

Recent News & Updates

Seeking Alpha Apr 16

A First Look At Lyell Immunopharma

Summary Lyell Immunopharma offers potential upside with lead CAR T candidate ronde-cel for 3L+ relapsed-refractory large B-cell lymphoma, showing strong efficacy and safety. Ronde-cel's registrational trial targets impressive potential results, with pivotal data expected mid-2027 and BLA submission in 2H27. LYL273, recently in-licensed for metastatic colorectal cancer, demonstrated a 67% ORR and 8-month mPFS at dose level 2; pivotal trial initiation is planned for 1H27. Despite a $300 million premium to cash and a history of clinical failures, LYEL is a high-risk, high-reward play best suited for aggressive, risk-tolerant investors. Read the full article on Seeking Alpha

Recent updates

Seeking Alpha Apr 16

A First Look At Lyell Immunopharma

Summary Lyell Immunopharma offers potential upside with lead CAR T candidate ronde-cel for 3L+ relapsed-refractory large B-cell lymphoma, showing strong efficacy and safety. Ronde-cel's registrational trial targets impressive potential results, with pivotal data expected mid-2027 and BLA submission in 2H27. LYL273, recently in-licensed for metastatic colorectal cancer, demonstrated a 67% ORR and 8-month mPFS at dose level 2; pivotal trial initiation is planned for 1H27. Despite a $300 million premium to cash and a history of clinical failures, LYEL is a high-risk, high-reward play best suited for aggressive, risk-tolerant investors. Read the full article on Seeking Alpha
Seeking Alpha Oct 25

Lyell Immunopharma: Oversold And Poised For A Turning Point To Growth

Summary Lyell Immunopharma, Inc.'s financials show reduced losses and efficient cash management, with a strong cash position supporting operations through 2027 despite a challenging biotech environment. The company's innovative CAR T-cell therapies, particularly LYL119 and IMPT-314, target critical oncology challenges with promising early clinical results expected by late 2025. Lyell's acquisition of ImmPACT Bio expands its pipeline into hematologic cancers, enhancing its portfolio with dual-targeting CAR T-cell therapies and broadening therapeutic options. Despite market skepticism and high-risk nature, Lyell's undervalued assets and strategic focus on T-cell reprogramming and operational efficiency position it for long-term success. Read the full article on Seeking Alpha
Seeking Alpha Apr 16

Lyell Immunopharma: Testing The T-Cell Thesis With 2 Upcoming Data Catalysts

Summary Lyell Immunopharma, Inc.'s stock price has risen over 20% YTD and over 45% in the past 12 months. The company focuses on T-cell therapies for solid tumors and has two clinical-stage assets. Lyell has upcoming data catalysts, with Phase 1 results expected in the first half of 2024 and the second half of this year. The two programs in question involve a CAR-T cell therapy targeting breast and lung cancer and a TIL therapy targeting melanoma, lung, and colorectal cancer. Lyell has funding to last until 2027 and a review of its approach to designing cell therapies gives me some optimism upcoming data readouts can be positive - there is substantial risk to this thesis; however, that must be acknowledged. Read the full article on Seeking Alpha
Analysis Article Feb 23

Companies Like Lyell Immunopharma (NASDAQ:LYEL) Are In A Position To Invest In Growth

We can readily understand why investors are attracted to unprofitable companies. For example, although Amazon.com made...
Analysis Article Nov 09

Companies Like Lyell Immunopharma (NASDAQ:LYEL) Are In A Position To Invest In Growth

We can readily understand why investors are attracted to unprofitable companies. For example, although Amazon.com made...
Analysis Article Aug 29

Analysts' Revenue Estimates For Lyell Immunopharma, Inc. (NASDAQ:LYEL) Are Surging Higher

Lyell Immunopharma, Inc. ( NASDAQ:LYEL ) shareholders will have a reason to smile today, with the analysts making...
Analysis Article Aug 11

We Think Lyell Immunopharma (NASDAQ:LYEL) Can Afford To Drive Business Growth

Even when a business is losing money, it's possible for shareholders to make money if they buy a good business at the...
Analysis Article Dec 15

Lyell Immunopharma (NASDAQ:LYEL) Is In A Good Position To Deliver On Growth Plans

Even when a business is losing money, it's possible for shareholders to make money if they buy a good business at the...
Seeking Alpha Oct 06

Lyell Immunopharma gets FDA nod to start phase 1 trial of its cancer therapy LYL845

Lyell Immunopharma (NASDAQ:LYEL) on Thursday said the U.S. FDA had cleared its investigational new drug application to start a phase 1 trial for its experimental cancer therapy LYL845. LYEL stock +4.1% to $8.42 after hours. LYL485 is a tumor infiltrating lymphocyte enhanced with LYEL's reprogramming technology. The early-stage trial will evaluate LYL485 as a treatment for melanoma, the most serious type of skin cancer, LYEL said in a statement. The trial will also have expansion cohorts for patients with non-small cell lung cancer and colorectal cancer. Initial data presentation from the trial is expected in 2024.
Analysis Article Sep 12

Companies Like Lyell Immunopharma (NASDAQ:LYEL) Are In A Position To Invest In Growth

We can readily understand why investors are attracted to unprofitable companies. For example, biotech and mining...
Analysis Article Aug 08

News Flash: Analysts Just Made A Huge Upgrade To Their Lyell Immunopharma, Inc. (NASDAQ:LYEL) Forecasts

Lyell Immunopharma, Inc. ( NASDAQ:LYEL ) shareholders will have a reason to smile today, with the analysts making...

Shareholder Returns

LYELUS BiotechsUS Market
7D1.7%1.2%2.1%
1Y134.3%41.9%30.6%

Return vs Industry: LYEL exceeded the US Biotechs industry which returned 41.9% over the past year.

Return vs Market: LYEL exceeded the US Market which returned 31% over the past year.

Price Volatility

Is LYEL's price volatile compared to industry and market?
LYEL volatility
LYEL Average Weekly Movement10.4%
Biotechs Industry Average Movement10.6%
Market Average Movement7.2%
10% most volatile stocks in US Market16.1%
10% least volatile stocks in US Market3.2%

Stable Share Price: LYEL has not had significant price volatility in the past 3 months compared to the US market.

Volatility Over Time: LYEL's weekly volatility (10%) has been stable over the past year.

About the Company

FoundedEmployeesCEOWebsite
2018300Lynn Seelywww.lyell.com

Lyell Immunopharma, Inc., a clinical-stage cell therapy company, develops chimeric antigen receptor (CAR) T-cell product candidates for patients with hematologic malignancies and solid tumors. The company’s lead product candidate include rondecabtagene autoleucel, an autologous dual-targeting CD19/CD20 CAR T-cell therapy in development, which is in pivotal PiNACLE trial in the 3L+ setting and in a Phase 1/2 clinical trial in the 2L setting, as well as a second pivotal trial, PiNACLE-H2H, which is a Phase 3 head-to-head CAR T cell therapy randomized controlled trial of ronde-cel for LBCL in the 2L setting for the treatment of large B-cell lymphoma; and LYL273, a GCC-targeted CAR T-cell product candidate enhanced with CD19 CAR expression and controlled cytokine release designed to improve CAR T-cell expansion, immune cell infiltration, and cancer cell killing in the hostile solid tumor microenvironment, which is in Phase 1 clinical trial for the treatment of refractory metastatic colorectal cancer. The company develops therapies using various approaches, such as c-Jun overexpression and NR4A3 gene knockout, to endow functional resistance to exhaustion; Epi-R to generate population of stem-like T cells with reduced exhaustion and improved proliferation and antitumor activity; and CD62L positive enrichment to generate CAR T cells with enhanced antitumor activity.

Lyell Immunopharma, Inc. Fundamentals Summary

How do Lyell Immunopharma's earnings and revenue compare to its market cap?
LYEL fundamental statistics
Market capUS$486.48m
Earnings (TTM)-US$246.41m
Revenue (TTM)US$31.00k
Over9,999x
P/S Ratio
-1.9x
P/E Ratio

Earnings & Revenue

Key profitability statistics from the latest earnings report (TTM)
LYEL income statement (TTM)
RevenueUS$31.00k
Cost of RevenueUS$0
Gross ProfitUS$31.00k
Other ExpensesUS$246.44m
Earnings-US$246.41m

Last Reported Earnings

Mar 31, 2026

Next Earnings Date

n/a

Earnings per share (EPS)-10.56
Gross Margin100.00%
Net Profit Margin-794,858.06%
Debt/Equity Ratio0%

How did LYEL perform over the long term?

See historical performance and comparison

Company Analysis and Financial Data Status

DataLast Updated (UTC time)
Company Analysis2026/05/07 06:23
End of Day Share Price 2026/05/07 00:00
Earnings2026/03/31
Annual Earnings2025/12/31

Data Sources

The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.

PackageDataTimeframeExample US Source *
Company Financials10 years
  • Income statement
  • Cash flow statement
  • Balance sheet
Analyst Consensus Estimates+3 years
  • Forecast financials
  • Analyst price targets
Market Prices30 years
  • Stock prices
  • Dividends, Splits and Actions
Ownership10 years
  • Top shareholders
  • Insider trading
Management10 years
  • Leadership team
  • Board of directors
Key Developments10 years
  • Company announcements

* Example for US securities, for non-US equivalent regulatory forms and sources are used.

Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more.

Analysis Model and Snowflake

Details of the analysis model used to generate this report is available on our Github page, we also have guides on how to use our reports and tutorials on Youtube.

Learn about the world class team who designed and built the Simply Wall St analysis model.

Industry and Sector Metrics

Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on Github.

Analyst Sources

Lyell Immunopharma, Inc. is covered by 7 analysts. 6 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.

AnalystInstitution
Jack AllenBaird
Jason ZemanskyBofA Global Research
Reni BenjaminCitizens JMP Securities, LLC