Lyell Immunopharma (LYEL) Stock Overview
A clinical-stage cell therapy company, develops chimeric antigen receptor (CAR) T-cell product candidates for patients with hematologic malignancies and solid tumors. More details
| Snowflake Score | |
|---|---|
| Valuation | 2/6 |
| Future Growth | 2/6 |
| Past Performance | 0/6 |
| Financial Health | 6/6 |
| Dividends | 0/6 |
LYEL Community Fair Values
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Read full narrativeLyell Immunopharma, Inc. Competitors
Price History & Performance
| Historical stock prices | |
|---|---|
| Current Share Price | US$20.06 |
| 52 Week High | US$45.00 |
| 52 Week Low | US$7.65 |
| Beta | -0.058 |
| 1 Month Change | -7.90% |
| 3 Month Change | -11.67% |
| 1 Year Change | 134.35% |
| 3 Year Change | -60.20% |
| 5 Year Change | n/a |
| Change since IPO | -94.06% |
Recent News & Updates
Recent updates
Shareholder Returns
| LYEL | US Biotechs | US Market | |
|---|---|---|---|
| 7D | 1.7% | 1.2% | 2.1% |
| 1Y | 134.3% | 41.9% | 30.6% |
Return vs Industry: LYEL exceeded the US Biotechs industry which returned 41.9% over the past year.
Return vs Market: LYEL exceeded the US Market which returned 31% over the past year.
Price Volatility
| LYEL volatility | |
|---|---|
| LYEL Average Weekly Movement | 10.4% |
| Biotechs Industry Average Movement | 10.6% |
| Market Average Movement | 7.2% |
| 10% most volatile stocks in US Market | 16.1% |
| 10% least volatile stocks in US Market | 3.2% |
Stable Share Price: LYEL has not had significant price volatility in the past 3 months compared to the US market.
Volatility Over Time: LYEL's weekly volatility (10%) has been stable over the past year.
About the Company
| Founded | Employees | CEO | Website |
|---|---|---|---|
| 2018 | 300 | Lynn Seely | www.lyell.com |
Lyell Immunopharma, Inc., a clinical-stage cell therapy company, develops chimeric antigen receptor (CAR) T-cell product candidates for patients with hematologic malignancies and solid tumors. The company’s lead product candidate include rondecabtagene autoleucel, an autologous dual-targeting CD19/CD20 CAR T-cell therapy in development, which is in pivotal PiNACLE trial in the 3L+ setting and in a Phase 1/2 clinical trial in the 2L setting, as well as a second pivotal trial, PiNACLE-H2H, which is a Phase 3 head-to-head CAR T cell therapy randomized controlled trial of ronde-cel for LBCL in the 2L setting for the treatment of large B-cell lymphoma; and LYL273, a GCC-targeted CAR T-cell product candidate enhanced with CD19 CAR expression and controlled cytokine release designed to improve CAR T-cell expansion, immune cell infiltration, and cancer cell killing in the hostile solid tumor microenvironment, which is in Phase 1 clinical trial for the treatment of refractory metastatic colorectal cancer. The company develops therapies using various approaches, such as c-Jun overexpression and NR4A3 gene knockout, to endow functional resistance to exhaustion; Epi-R to generate population of stem-like T cells with reduced exhaustion and improved proliferation and antitumor activity; and CD62L positive enrichment to generate CAR T cells with enhanced antitumor activity.
Lyell Immunopharma, Inc. Fundamentals Summary
| LYEL fundamental statistics | |
|---|---|
| Market cap | US$486.48m |
| Earnings (TTM) | -US$246.41m |
| Revenue (TTM) | US$31.00k |
Is LYEL overvalued?
See Fair Value and valuation analysisEarnings & Revenue
| LYEL income statement (TTM) | |
|---|---|
| Revenue | US$31.00k |
| Cost of Revenue | US$0 |
| Gross Profit | US$31.00k |
| Other Expenses | US$246.44m |
| Earnings | -US$246.41m |
Last Reported Earnings
Mar 31, 2026
Next Earnings Date
n/a
| Earnings per share (EPS) | -10.56 |
| Gross Margin | 100.00% |
| Net Profit Margin | -794,858.06% |
| Debt/Equity Ratio | 0% |
How did LYEL perform over the long term?
See historical performance and comparisonCompany Analysis and Financial Data Status
| Data | Last Updated (UTC time) |
|---|---|
| Company Analysis | 2026/05/07 06:23 |
| End of Day Share Price | 2026/05/07 00:00 |
| Earnings | 2026/03/31 |
| Annual Earnings | 2025/12/31 |
Data Sources
The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.
| Package | Data | Timeframe | Example US Source * |
|---|---|---|---|
| Company Financials | 10 years |
| |
| Analyst Consensus Estimates | +3 years |
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| Market Prices | 30 years |
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| Ownership | 10 years |
| |
| Management | 10 years |
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| Key Developments | 10 years |
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* Example for US securities, for non-US equivalent regulatory forms and sources are used.
Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more.
Analysis Model and Snowflake
Details of the analysis model used to generate this report is available on our Github page, we also have guides on how to use our reports and tutorials on Youtube.
Learn about the world class team who designed and built the Simply Wall St analysis model.
Industry and Sector Metrics
Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on Github.
Analyst Sources
Lyell Immunopharma, Inc. is covered by 7 analysts. 6 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.
| Analyst | Institution |
|---|---|
| Jack Allen | Baird |
| Jason Zemansky | BofA Global Research |
| Reni Benjamin | Citizens JMP Securities, LLC |