Lyell Immunopharma, Inc.

NasdaqGS:LYEL Stock Report

Market Cap: US$376.4m

Lyell Immunopharma Past Earnings Performance

Past criteria checks 0/6

Lyell Immunopharma's earnings have been declining at an average annual rate of -7.2%, while the Biotechs industry saw earnings growing at 33.8% annually. Revenues have been declining at an average rate of 33.4% per year.

Key information

-7.16%

Earnings growth rate

57.61%

EPS growth rate

Biotechs Industry Growth17.04%
Revenue growth rate-33.42%
Return on equity-90.04%
Net Margin-794,858.06%
Last Earnings Update31 Mar 2026

Recent past performance updates

Recent updates

Seeking Alpha Apr 16

A First Look At Lyell Immunopharma

Summary Lyell Immunopharma offers potential upside with lead CAR T candidate ronde-cel for 3L+ relapsed-refractory large B-cell lymphoma, showing strong efficacy and safety. Ronde-cel's registrational trial targets impressive potential results, with pivotal data expected mid-2027 and BLA submission in 2H27. LYL273, recently in-licensed for metastatic colorectal cancer, demonstrated a 67% ORR and 8-month mPFS at dose level 2; pivotal trial initiation is planned for 1H27. Despite a $300 million premium to cash and a history of clinical failures, LYEL is a high-risk, high-reward play best suited for aggressive, risk-tolerant investors. Read the full article on Seeking Alpha
Seeking Alpha Oct 25

Lyell Immunopharma: Oversold And Poised For A Turning Point To Growth

Summary Lyell Immunopharma, Inc.'s financials show reduced losses and efficient cash management, with a strong cash position supporting operations through 2027 despite a challenging biotech environment. The company's innovative CAR T-cell therapies, particularly LYL119 and IMPT-314, target critical oncology challenges with promising early clinical results expected by late 2025. Lyell's acquisition of ImmPACT Bio expands its pipeline into hematologic cancers, enhancing its portfolio with dual-targeting CAR T-cell therapies and broadening therapeutic options. Despite market skepticism and high-risk nature, Lyell's undervalued assets and strategic focus on T-cell reprogramming and operational efficiency position it for long-term success. Read the full article on Seeking Alpha
Seeking Alpha Apr 16

Lyell Immunopharma: Testing The T-Cell Thesis With 2 Upcoming Data Catalysts

Summary Lyell Immunopharma, Inc.'s stock price has risen over 20% YTD and over 45% in the past 12 months. The company focuses on T-cell therapies for solid tumors and has two clinical-stage assets. Lyell has upcoming data catalysts, with Phase 1 results expected in the first half of 2024 and the second half of this year. The two programs in question involve a CAR-T cell therapy targeting breast and lung cancer and a TIL therapy targeting melanoma, lung, and colorectal cancer. Lyell has funding to last until 2027 and a review of its approach to designing cell therapies gives me some optimism upcoming data readouts can be positive - there is substantial risk to this thesis; however, that must be acknowledged. Read the full article on Seeking Alpha
Analysis Article Feb 23

Companies Like Lyell Immunopharma (NASDAQ:LYEL) Are In A Position To Invest In Growth

We can readily understand why investors are attracted to unprofitable companies. For example, although Amazon.com made...
Analysis Article Nov 09

Companies Like Lyell Immunopharma (NASDAQ:LYEL) Are In A Position To Invest In Growth

We can readily understand why investors are attracted to unprofitable companies. For example, although Amazon.com made...
Analysis Article Aug 29

Analysts' Revenue Estimates For Lyell Immunopharma, Inc. (NASDAQ:LYEL) Are Surging Higher

Lyell Immunopharma, Inc. ( NASDAQ:LYEL ) shareholders will have a reason to smile today, with the analysts making...
Analysis Article Aug 11

We Think Lyell Immunopharma (NASDAQ:LYEL) Can Afford To Drive Business Growth

Even when a business is losing money, it's possible for shareholders to make money if they buy a good business at the...
Analysis Article Dec 15

Lyell Immunopharma (NASDAQ:LYEL) Is In A Good Position To Deliver On Growth Plans

Even when a business is losing money, it's possible for shareholders to make money if they buy a good business at the...
Seeking Alpha Oct 06

Lyell Immunopharma gets FDA nod to start phase 1 trial of its cancer therapy LYL845

Lyell Immunopharma (NASDAQ:LYEL) on Thursday said the U.S. FDA had cleared its investigational new drug application to start a phase 1 trial for its experimental cancer therapy LYL845. LYEL stock +4.1% to $8.42 after hours. LYL485 is a tumor infiltrating lymphocyte enhanced with LYEL's reprogramming technology. The early-stage trial will evaluate LYL485 as a treatment for melanoma, the most serious type of skin cancer, LYEL said in a statement. The trial will also have expansion cohorts for patients with non-small cell lung cancer and colorectal cancer. Initial data presentation from the trial is expected in 2024.
Analysis Article Sep 12

Companies Like Lyell Immunopharma (NASDAQ:LYEL) Are In A Position To Invest In Growth

We can readily understand why investors are attracted to unprofitable companies. For example, biotech and mining...
Analysis Article Aug 08

News Flash: Analysts Just Made A Huge Upgrade To Their Lyell Immunopharma, Inc. (NASDAQ:LYEL) Forecasts

Lyell Immunopharma, Inc. ( NASDAQ:LYEL ) shareholders will have a reason to smile today, with the analysts making...

Revenue & Expenses Breakdown

How Lyell Immunopharma makes and spends money. Based on latest reported earnings, on an LTM basis.


Earnings and Revenue History

NasdaqGS:LYEL Revenue, expenses and earnings (USD Millions)
DateRevenueEarningsG+A ExpensesR&D Expenses
31 Mar 260-24641152
31 Dec 250-27445159
30 Sep 250-32649155
30 Jun 250-33150166
31 Mar 250-33553172
31 Dec 240-34352172
30 Sep 240-20451170
30 Jun 240-21054174
31 Mar 240-22861181
31 Dec 230-23567183
30 Sep 2349-19080174
30 Jun 2348-20991172
31 Mar 2384-182102168
31 Dec 2285-183117159
30 Sep 2239-258123140
30 Jun 2242-237118130
31 Mar 229-263107133
31 Dec 2111-25089139
30 Sep 2110-20572154
30 Jun 218-19259153
31 Mar 219-23052201
31 Dec 208-20847182
31 Dec 191-1313964

Quality Earnings: LYEL is currently unprofitable.

Growing Profit Margin: LYEL is currently unprofitable.


Free Cash Flow vs Earnings Analysis


Past Earnings Growth Analysis

Earnings Trend: LYEL is unprofitable, and losses have increased over the past 5 years at a rate of 7.2% per year.

Accelerating Growth: Unable to compare LYEL's earnings growth over the past year to its 5-year average as it is currently unprofitable

Earnings vs Industry: LYEL is unprofitable, making it difficult to compare its past year earnings growth to the Biotechs industry (43%).


Return on Equity

High ROE: LYEL has a negative Return on Equity (-90.04%), as it is currently unprofitable.


Return on Assets


Return on Capital Employed


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Company Analysis and Financial Data Status

DataLast Updated (UTC time)
Company Analysis2026/05/20 05:40
End of Day Share Price 2026/05/20 00:00
Earnings2026/03/31
Annual Earnings2025/12/31

Data Sources

The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.

PackageDataTimeframeExample US Source *
Company Financials10 years
  • Income statement
  • Cash flow statement
  • Balance sheet
Analyst Consensus Estimates+3 years
  • Forecast financials
  • Analyst price targets
Market Prices30 years
  • Stock prices
  • Dividends, Splits and Actions
Ownership10 years
  • Top shareholders
  • Insider trading
Management10 years
  • Leadership team
  • Board of directors
Key Developments10 years
  • Company announcements

* Example for US securities, for non-US equivalent regulatory forms and sources are used.

Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more.

Analysis Model and Snowflake

Details of the analysis model used to generate this report is available on our Github page, we also have guides on how to use our reports and tutorials on Youtube.

Learn about the world class team who designed and built the Simply Wall St analysis model.

Industry and Sector Metrics

Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on Github.

Analyst Sources

Lyell Immunopharma, Inc. is covered by 7 analysts. 6 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.

AnalystInstitution
Jack AllenBaird
Jason ZemanskyBofA Global Research
Reni BenjaminCitizens JMP Securities, LLC