September 2025's Top Penny Stocks To Consider

As the U.S. stock market experiences fluctuations following recent comments from Federal Reserve Chair Jerome Powell, investors are navigating a landscape marked by both record highs and cautious optimism. For those willing to explore beyond the well-known giants, penny stocks—typically representing smaller or newer companies—continue to hold intrigue with their potential for growth and affordability. In this article, we examine three penny stocks that stand out for their financial strength and resilience in today's evolving market conditions.

Top 10 Penny Stocks In The United States

Click here to see the full list of 370 stocks from our US Penny Stocks screener.

Let's explore several standout options from the results in the screener.

Vanda Pharmaceuticals (VNDA)

Simply Wall St Financial Health Rating: ★★★★★★

Overview: Vanda Pharmaceuticals Inc. is a biopharmaceutical company that develops and commercializes therapies for high unmet medical needs globally, with a market cap of $265.31 million.

Operations: The company's revenue is generated from its Biotechnology (Startups) segment, totaling $203.47 million.

Market Cap: $265.31M

Vanda Pharmaceuticals, with a market cap of US$265.31 million, operates in the biopharmaceutical sector and reported revenues of US$203.47 million from its biotechnology segment. Despite being debt-free and having substantial short-term assets (US$394.9M) that cover both short-term (US$121.5M) and long-term liabilities (US$16.9M), the company remains unprofitable, with increasing losses over the past five years at a significant rate of 73.8% annually. Recent events include participation in major healthcare conferences and ongoing regulatory challenges regarding generic versions of its drug Hetlioz®.

• Click to explore a detailed breakdown of our findings in Vanda Pharmaceuticals' financial health report.
• Review our growth performance report to gain insights into Vanda Pharmaceuticals' future.

Metagenomi (MGX)

Simply Wall St Financial Health Rating: ★★★★★★

Overview: Metagenomi, Inc. is a genetic medicines company in the United States that develops therapeutics using a metagenomics-derived genome editing toolbox, with a market cap of $76.94 million.

Operations: The company's revenue is primarily generated from its efforts in advancing next-generation gene-editing technologies and therapies, amounting to $33.77 million.

Market Cap: $76.94M

Metagenomi, Inc., with a market cap of US$76.94 million, is currently pre-revenue and unprofitable, experiencing increased losses over the past five years at an annual rate of 27.4%. Despite being debt-free and having short-term assets (US$211.7M) that exceed both short-term (US$33.3M) and long-term liabilities (US$43.2M), the company's earnings are forecast to decline by 16.7% annually over the next three years. Recent changes include significant index exclusions and a new board appointment with Laurence Reid, PhD, bringing extensive biotech experience to its leadership amid ongoing volatility challenges in share price stability.

• Unlock comprehensive insights into our analysis of Metagenomi stock in this financial health report.
• Learn about Metagenomi's future growth trajectory here.

Riskified (RSKD)

Simply Wall St Financial Health Rating: ★★★★★★

Overview: Riskified Ltd. develops an e-commerce risk intelligence platform to help online merchants build trusted consumer relationships across various global regions, with a market cap of approximately $748.11 million.

Operations: The company's revenue is primarily generated from its Security Software & Services segment, totaling $335.83 million.

Market Cap: $748.11M

Riskified Ltd., with a market cap of US$748.11 million, is trading significantly below its estimated fair value and remains debt-free. Despite being unprofitable, it has managed to reduce losses by 21% annually over the past five years and maintains a positive cash flow runway exceeding three years. Recent earnings show increased sales but also higher net losses compared to the previous year. The company has initiated a share buyback program worth up to US$75 million and raised its revenue guidance for 2025. A new partnership with HUMAN Security aims to enhance fraud prevention in AI-driven ecommerce transactions, addressing emerging risks in this space.

• Navigate through the intricacies of Riskified with our comprehensive balance sheet health report here.
• Gain insights into Riskified's future direction by reviewing our growth report.

Summing It All Up

• Dive into all 370 of the US Penny Stocks we have identified here.
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This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

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