U.S. Pharmaceuticals & Biotech Leverage Leaders

Intellia Therapeutics

Market Cap: US$2.2b

Operates as a clinical-stage genome editing company focused on developing potentially curative therapeutics using CRISPR/Cas9-based technologies.

Dianthus Therapeutics

Market Cap: US$4.5b

A clinical-stage biotechnology company, engages in the development of therapies for patients with severe autoimmune diseases.

Vaxcyte

Market Cap: US$7.4b

A clinical-stage vaccine innovation company, develops conjugate and novel protein vaccines to prevent or treat bacterial infectious diseases.

Exelixis

Market Cap: US$13.0b

An oncology company, focuses on the discovery, development, and commercialization of new medicines for difficult-to-treat cancers in the United States.

ACADIA Pharmaceuticals

Market Cap: US$3.7b

A biopharmaceutical company, focuses on the development and commercialization of medicines for neurological and rare disease in North America.

Biogen

Market Cap: US$29.0b

Biogen Inc. discovers, develops, manufactures, and delivers therapies in the United States, Europe, Germany, Asia, and internationally.

Corcept Therapeutics

Market Cap: US$8.6b

A biopharmaceutical company, engages in the discovery and development of medications to treat severe endocrinologic, oncologic, metabolic, and neurologic disorders in the United States.

Stevanato Group

Market Cap: US$4.8b

Engages in the design, production, and distribution of products and processes to provide solutions for biopharma and healthcare industries in Europe, the Middle East, Africa, North America, South America, and the Asia Pacific.

Trevi Therapeutics

Market Cap: US$2.4b

A clinical-stage biopharmaceutical company, develops and commercializes investigational therapy for the treatment of chronic cough in patients with idiopathic pulmonary fibrosis (IPF) and non-IPF interstitial lung disease, and refractory chronic cough.

Regeneron Pharmaceuticals

Market Cap: US$62.1b

Regeneron Pharmaceuticals, Inc. discovers, invents, develops, manufactures, and commercializes medicines to treat various diseases worldwide.

United Therapeutics

Market Cap: US$22.8b

Engages in the development and commercialization of products to address the unmet medical needs of patients with chronic and life-threatening diseases in the United States and internationally.

IDEAYA Biosciences

Market Cap: US$2.7b

A precision medicine oncology company, develops targeted therapeutics for patient populations selected using molecular diagnostics in the United States.

Catalyst Pharmaceuticals

Market Cap: US$3.8b

A commercial-stage biopharmaceutical company, focuses on developing and commercializing medicines for patients living with rare diseases in the United States.

Structure Therapeutics

Market Cap: US$3.2b

A clinical stage global biopharmaceutical company, develops and delivers novel oral small molecule therapeutics to treat various chronic diseases with unmet medical needs in the United States.

Kiniksa Pharmaceuticals International

Market Cap: US$4.2b

A biopharmaceutical company, develops and commercializes medical therapies in the United States, the United Kingdom, and internationally.

Hisamitsu Pharmaceutical

Market Cap: US$8.2b

Manufactures and sells pharmaceuticals in Japan.

Supernus Pharmaceuticals

Market Cap: US$2.6b

A biopharmaceutical company, engages in the development and commercialization of products for the treatment of central nervous system (CNS) diseases in the United States.

GRAIL

Market Cap: US$2.7b

A commercial-stage healthcare company, provides multi-cancer early detection testing and services in the United States and internationally.

Agilent Technologies

Market Cap: US$35.9b

Provides application focused solutions to the life sciences, diagnostics, and applied chemical markets worldwide.

Enliven Therapeutics

Market Cap: US$2.7b

A clinical-stage biopharmaceutical company, focuses on the discovery and development of small molecule inhibitors to help patients with cancer.

Incyte

Market Cap: US$19.6b

A biopharmaceutical company, engages in the discovery, development, and commercialization of therapeutics in the United States, Europe, Canada, and Japan.

Spyre Therapeutics

Market Cap: US$7.7b

A clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD) and rheumatic diseases.

Neurocrine Biosciences

Market Cap: US$15.9b

Neurocrine Biosciences, Inc. discovers, develops, and commercialize pharmaceuticals for neurological, psychiatric, endocrine, and immunological disorders in the United States and internationally.

Bio-Techne

Market Cap: US$9.1b

Develops, manufactures, and sells life science reagents, instruments, and services for the research, diagnostics, and bioprocessing markets worldwide.

Apogee Therapeutics

Market Cap: US$6.8b

A clinical stage biotechnology company, develops novel biologics for the treatment of atopic dermatitis, asthma, eosinophilic esophagitis, chronic obstructive pulmonary disease, and other inflammatory and immunology indications in the United States.

Krystal Biotech

Market Cap: US$10.3b

A commercial-stage biotechnology company, discovers, develops, manufactures, and commercializes genetic medicines to treat diseases with high unmet medical needs in the United States.

Vericel

Market Cap: US$2.0b

A commercial-stage biopharmaceutical company, engages in the research, development, manufacture, and distribution of cellular therapies and specialty biologic products for sports medicine and severe burn care markets in North America.

MBX Biosciences

Market Cap: US$2.0b

A clinical-stage biopharmaceutical company, focuses on the discovery and development of precision peptide therapies for the treatment of endocrine and metabolic disorders.

Roivant Sciences

Market Cap: US$22.6b

A clinical-stage biopharmaceutical company, focuses on the discovery, development, and commercialization of medicines and technologies.

Celldex Therapeutics

Market Cap: US$2.5b

A biopharmaceutical company, engages in developing therapeutic antibodies for patients with severe inflammatory, allergic, autoimmune, and other diseases.

Tango Therapeutics

Market Cap: US$4.0b

A precision oncology company, focuses on the discovery and development of drugs in defined patient populations with unmet medical need.

Viking Therapeutics

Market Cap: US$3.5b

A clinical-stage biopharmaceutical company, focuses on the development of novel therapies for metabolic and endocrine disorders.

Nektar Therapeutics

Market Cap: US$2.1b

A biopharmaceutical company, focuses on discovering and developing medicines in the field of immunotherapy in the United States and internationally.

Oruka Therapeutics

Market Cap: US$4.4b

A clinical-stage biopharmaceutical company, focuses on developing novel monoclonal antibody therapeutics for psoriasis (PsO), and other inflammatory and immunology (I&I) indications.

Immunome

Market Cap: US$2.1b

A biotechnology company, engages in the discovery, design, development, manufacturing, and commercialization of antibody-drug conjugates and other oncology therapeutics in the United States.

Kailera Therapeutics

Market Cap: US$2.6b

Operates as a clinical-stage biopharmaceutical company developing therapies for obesity and related conditions.