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Key Takeaways Unicycive has successfully completed clinical development of its lead asset, Oxylanthanum Carbonate (OLC). OLC has been designed to improve on current phosphate binders by offering better efficacy, fewer pills, and improved tolerability over alternative treatments for hyperphosphatemia chronic kidney disease patients on dialysis.Read more

A Global Powerhouse in the Making Sector: Global Industrials / Energy Transition Current Price: €43.62 | Target Price: €74.50 The Institutionalization of a Global Champion I maintain my BUY rating on Metlen Energy & Metals (MTLN) , raising the 12-month price target to €74.50. The investment thesis has evolved from a "Greek recovery play" to a "Global Industrial Leader" narrative.Read more

It is almost impossible to obtain a drug label from the FDA for pediatric use - this topical non-steroidal drug ZORYVE is very safe and highly effective for both pediatric and adult patients. The drug is potent in the skin, it is not well absorbed and is quickly metabolized which limits systemic exposure and minimizes side effect risks.Read more

West Red Lake Gold Mines – $4,000 Gold Scenario Assumptions Production: 100,000 oz/year AISC: $1,200/oz Gold Price: $4,000/oz Valuation Multiple: 10× FCF Shares Outstanding (assumed): 100M Step 1: Revenue Revenue = 100,000 oz × $4,000 = $400,000,000 Step 2: Costs Costs = 100,000 oz × $1,200 = $120,000,000 Step 3: Free Cash Flow (FCF) FCF = $400,000,000 – $120,000,000 = $280,000,000 Step 4: Market Cap (10× FCF) Market Cap = $280,000,000 × 10 = $2,800,000,000 Step 5: Stock Price Stock Price = $2,800,000,000 ÷ 100,000,000 = $28/share ✅ Conclusion: At $4,000/oz gold, 100k oz/year production, and $1,200/oz AISC, West Red Lake could trade around $28/share (based on 100M shares). ⚠️ With the actual 2025 share count (~343M basic / ~517M fully diluted) , the per-share price would be much lower.Read more

Operational Depth and Strategic Pivot Analysis 1. Business Model Mechanics: Inflation-Resilient Cash Flow Freehold Royalties' business model differs from traditional Exploration and Production (E&P) companies with a fundamental structural advantage: The company does not bear any of the costs of drilling, completion, operation, or environmental rehabilitation on its land.Read more

Intuitive Surgical (ISRG) is a pioneer in robotic-assisted surgery, revolutionizing the medical field with its da Vinci surgical system. Founded in 1995, the company has continuously innovated, making minimally invasive surgery more precise and efficient.Read more

Endeavour Silver (EDR.TO) Valuation Scenario Assumptions Production Estimate: 9 million oz annually starting in 2025 Price of Silver: $100 per oz All-in Sustaining Costs (AISC): $20 per oz (post-Terronera) Valuation Multiple: 10× free cash flow (FCF) Revenue & Cost Calculation 1. Annual Revenue Revenue = Production × Price per oz Revenue = 9,000,000 × 100 = $900,000,000 USD 2.Read more

98% of pancreatic cancer patients in Phase II study generated powerful immune responses to the KRAS antigens. Median T-cell immune response above threshold was 44-fold.Read more

Business Overview Key Metrics Total: 8/17 +1 ✅ Projected Operating Margin: 19.87% +0 ⚠️ Projected 5-Year Revenue CAGR: 5.14% +2 ✅✅ Last 5-Year ROIC: 55.60% +1 ✅ Estimated Cost of Capital: 7.78% (less than ROIC) +1 ✅ Last 5-Year Shares Outstanding CAGR: -3.09% -1 ❌ Projected 5-Year EPS CAGR: 9.50% (given the easiness of "manipulation" of EPS growth below 10% represents a slight negative) +1 ✅ Projected 5-Year Dividend CAGR: 12.72% +1 ✅ Estimated Debt Rating: A3 +2 ✅✅ Morningstar Moat: Wide +0 ⚠️ Morningstar Uncertainty: Medium Domino's Pizza is a great brand, enjoying a wide moat that results in an operating margin of around ~ 20%. Given the maturity of the business, its revenue growth is below 10% but still modestly above the economy growth rate.Read more