Xenon Pharmaceuticals Past Earnings Performance
Past criteria checks 0/6
Xenon Pharmaceuticals's earnings have been declining at an average annual rate of -33.6%, while the Biotechs industry saw earnings growing at 33.7% annually. Revenues have been declining at an average rate of 50.1% per year.
Key information
-33.60%
Earnings growth rate
-23.50%
EPS growth rate
| Biotechs Industry Growth | 17.04% |
| Revenue growth rate | -50.06% |
| Return on equity | -32.94% |
| Net Margin | n/a |
| Last Earnings Update | 30 Jun 2026 |
Recent past performance updates
Recent updates
Seeking Alpha • 6h
Xenon: The Psychiatry Pause Matters More Than You Think (Rating Downgrade)
Summary Xenon Pharmaceuticals is downgraded to Hold after pausing azetukalner trials in MDD and bipolar depression due to neuropsychiatric adverse events. Azetukalner's safety concerns materially impact its psychiatric disorder prospects and introduce regulatory and commercial uncertainties, especially regarding dosing and market positioning. Epilepsy remains XENE's core opportunity, with FOS peak sales estimates of $1–1.5 billion, but safety events may affect FDA review and product labeling. At a ~$4 billion market cap and $1.2 billion cash, XENE is now priced without psychiatric optionality, and further clarity on safety and labeling is needed. Read the full article on Seeking Alpha
Narrative Update • Aug 09
XENE: Upcoming NDA Filing And Kv7 Data Readouts Will Shape Risk Balance
Analysts lifted their fair value estimate for Xenon Pharmaceuticals to $69 from $63, citing updated models that reflect recent Street research and revised long term assumptions on revenue potential, margins, and future P/E expectations. Analyst Commentary Recent Street research around Xenon Pharmaceuticals highlights both interest in the epilepsy opportunity and a set of clear caution flags that investors should factor into expectations for execution and valuation risk.
Narrative Update • Jul 10
XENE: Epilepsy Trial Progress Will Define Edge Versus Slower Kv7 Rival
Analysts have lifted their fair value estimate for Xenon Pharmaceuticals from about $55.40 to about $80.56, reflecting updated models that incorporate revised assumptions for long term revenue potential, profit margins, and future P/E multiples in light of recent Street research and competitive positioning versus Biohaven. Analyst Commentary Recent Street research around Xenon Pharmaceuticals highlights a mix of optimism on the epilepsy opportunity and caution around execution and competitive risk, particularly in comparison with Biohaven.Narrative Update • Jun 26
XENE: Phase 3 Success And Mixed Street Views Will Shape Next Chapter
The updated analyst price target for Xenon Pharmaceuticals has moved from $58.58 to $63.00, as analysts factor in refreshed models and recent Street research that includes higher targets from firms such as JPMorgan and Wells Fargo, alongside a modest trim from Needham. Analyst Commentary Recent Street research on Xenon Pharmaceuticals shows a mixed tone, with some large firms, including JPMorgan, lifting price targets while other bearish analysts trim expectations.New Narrative • Mar 27
Epilepsy And Depression Pipeline Will Define Fair Long Term Outlook
Catalysts About Xenon Pharmaceuticals Xenon Pharmaceuticals is a neuroscience focused biopharma company developing ion channel based therapies for epilepsy, depression, bipolar disorder and pain. What are the underlying business or industry changes driving this perspective?
New Narrative • Mar 09
Late Stage Neuroscience Pipeline Will Transform Ion Channel Franchise Over The Coming Years
Catalysts About Xenon Pharmaceuticals Xenon Pharmaceuticals is a neuroscience focused biopharma company developing ion channel targeted medicines for epilepsy, neuropsychiatric conditions and pain. What are the underlying business or industry changes driving this perspective?Analysis Article • Oct 01
Xenon Pharmaceuticals (NASDAQ:XENE) Is In A Good Position To Deliver On Growth Plans
There's no doubt that money can be made by owning shares of unprofitable businesses. For example, although Amazon.com...Seeking Alpha • Apr 18
Xenon- A Later Stage Story
Summary Xenon's lead asset, azetukalner, shows promise in treating focal onset seizures with positive phase IIb results and upcoming phase III data expected by end of 2025. Azetukalner's unique Kv7 potassium channel mechanism and rapid onset of action could address unmet needs in treatment-resistant epilepsy and potentially depression. Financially stable, Xenon is well-funded into 2027, with potential $1Bn market opportunity if azetukalner succeeds in focal onset seizures and expands into other indications. Despite broader biotech market challenges, Xenon's strong efficacy and safety data position it well, with significant interest from major pharma in neurology and neuropsychiatry. Read the full article on Seeking AlphaSeeking Alpha • Jan 16
Xenon Pharmaceuticals: 2025 Could Be Pivotal For Azetukalner's Epilepsy Potential
Summary Xenon Pharmaceuticals' Azetukalner has good Phase 2 data for MDD using Kv7 potassium channels. This also gives it a good safety profile. The company has robust financials with a runway that should last into 2027 or more. So, I think it should have enough resources to take its late-stage pipeline to approval. Epilepsy and MDD have an attractive TAM of several billions of dollars in the US and abroad. XENE could tap into these niche markets over time. I also believe its late-stage IP is diversified with ion channel modulators for pain and other neurological conditions. So it’s not overly exposed to Azetukalner. I concede that XENE has a premium valuation, but I think 2025 will provide significant clinical data that could justify a “Buy” rating at these levels. Read the full article on Seeking AlphaSeeking Alpha • Aug 09
Xenon Pharmaceuticals: Good Data In Epilepsy, But Doubts Remain
Summary Xenon Pharmaceuticals is a Canadian biopharma company targeting neurological diseases with a focus on ion channel-blocking technology. The clinical stage asset, azetukalner, is in late stage development for epilepsy and Major Depressive Disorder, showing promising results in reducing seizure frequency. Despite a history of failures and low trading volume, Xenon has a strong cash position and upcoming catalysts in phase 3 trials for their lead asset. Read the full article on Seeking AlphaSeeking Alpha • Feb 08
Xenon Pharmaceuticals: Analysts Still Positive Despite Recent Trial 'Setbacks'
Summary Today, we focused on Xenon Pharmaceuticals Inc., a clinical-stage biopharmaceutical company focused on developing therapeutics for neurological disorders. The company has experienced "setbacks" in recent trials, but its primary drug candidate, XEN1101, shows significant potential for treating epilepsy. Xenon has initiated Phase 3 clinical trials for XEN1101 and has received myriad positive ratings from analysts, but the stock may be vulnerable to profit-taking. An analysis around Xenon Pharmaceuticals follows in the paragraphs below. Read the full article on Seeking AlphaSeeking Alpha • Oct 19
Xenon started at outperform at Raymond James on experimental epilepsy drug
Raymond James has initiated Xenon Pharmaceuticals (NASDAQ:XENE) with an outperform rating citing the blockbuster potential of XEN1101, currently in phase 2 for epilepsy. The firm has a $52 price target (~46% upside based on Tuesday's close). Analyst Danielle Brill is confident that XEN1101 will be successful given its strong phase 2 results. She predicted a greater than $1B peak sales opportunity. Xenon (XENE) plans to initiate two identical phase 3 clinical trials. She noted that the the candidate, which is also under development for major depressive disorder, could further benefit from proof-of-concept data in that indication expected in 2023. Brill added that the company's pipeline also presents growth opportunities with XEN496 in KCNQ2 developmental and epileptic encephalopathy (KCNQ2-DEE), and NBI-921352 for SCN8A developmental and epileptic encephalopathy (SCN8A-DEE). XEN1101 is also under investigation for primary generic clonic tonic seizures (PGTCS). In August, BofA started Xenon (XENE) with a buy rating also citing the blockbuster potential of XEN1101 for epilepsy.Seeking Alpha • Sep 06
Putting Xenon Pharmaceuticals Back In The Spotlight
Summary Today, we are revisiting Xenon Pharmaceuticals for the first time in 2022. The company is well-funded and advancing several compounds in its pipeline, one of which might have blockbuster potential. An investment analysis follows in the paragraphs below. "Potential has a shelf life." - Margaret Atwood We last looked in on Xenon Pharmaceuticals (XENE) nearly nine months ago. In the summary of that article, the conclusion was that the company had some promising attributes and was worthy of a small 'watch item' via covered call positions. That turned out to be a profitable trade. Time for another potential round trip? We update the investment thesis on Xenon below. Seeking Alpha Company Overview: Xenon Pharmaceuticals is a clinical-stage biotech company focused on developing therapeutics to treat patients with neurological disorders. The company is based just outside of Vancouver, Canada. The stock trades just under $40.00 a share and sports an approximate market cap just north of $2.4 billion. August Company Presentation The company has several compounds in development as can be seen by the pipeline chart above. August Company Presentation The most important asset in development is a candidate called for the moment XEN1011. This is a next generation Kv7 potassium channel opener with potential applications in treating the focal onset seizures which occurs in epileptics as well as other potential neurological disorders. August Company Presentation A Phase 2b trial produced encouraging results in the fourth quarter of last year. The company then disclosed new, compelling efficacy data from that study 'X-TOLE' in June of this year. A Phase 2 study 'X-TOLE2' should initiate by the end of this year, followed shortly by a Phase 3 trial X-TOLE3. If successful, the company plans to submit a market application around this compound to treat epilepsy. August Company Presentation The compound is also in development for other neurological disorders. The company currently has a Phase 2 'X-NOVA' study underway examining XEN1101 in major depressive disorder or MDD. This trial in parallel with an investigator-led Phase 2 MDD study led by Xenon's collaborators at Mount Sinai. Topline results should be out in 2023. August Company Presentation XEN1101 is also now targeting primary generalized tonic clonic seizures or PGTCS. Management plans to initiate a Phase 3 clinical trial, called X-ACKT, to support potential regulatory submissions in PGTCS. This study should kick soon after initiation of the X-TOLE2 trial. August Company Presentation Another compound 'XEN496' is being developed to treat rare KCNQ2-DEE pediatric epilepsy. A Phase 3 study called EPIK, is ongoing to evaluate the efficacy, safety, and tolerability of XEN496 administered as adjunctive treatment in approximately 40 pediatric patients aged one month to less than six years with KCNQ2-DEE. This trial should complete sometime in 2023. August Company Presentation Finally the company has licensed a selective Nav1.6 sodium channel inhibitor 'XEN901', now known as NBI-921352, to Neurocrine Biosciences (NBIX). That compound is in Phase 2 development for a couple of indications. As the result of this licensing agreement, Xenon has the potential to receive certain clinical, regulatory, and commercial milestone payments, as well as future sales royalties on any eventual commercialization. Analyst Commentary & Balance Sheet: Since second quarter results were posted on August 9th, five analyst firms including Needham and Wedbush have reissued Buy ratings on XENE. Price targets proffered ranged from $46 to $52 a share. On August 29th, Bank of America initiated the shares as a new Buy with a $45 a share price target. Here is the commentary from the bank's analyst at the time of that call.Seeking Alpha • Aug 29
Xenon initiated with Buy at BofA citing potential of anti-seizure drug
Bank of America launched its coverage on clinical-stage biotech Xenon Pharmaceuticals Inc. (NASDAQ:XENE) with a Buy rating on Monday, arguing that the company’s mid-stage epilepsy candidate XEN1101 is poised to become a blockbuster drug. XEN1101 belongs to a class of drugs known as Kv7 potassium channel openers, and the drug is expected to undergo its Phase 3 program in H2 2022, XENE said this month. The analysts led by Jason M. Gerberry point to the blockbuster potential of XEN1101 ahead of important catalysts for its safety data, second confirmatory, and label expansion studies. The ease of use, novel mechanism of action, and strong efficacy differentiate XEN1101 from other anti-seizure medications, the team with a $48 per share target on XENE argued. Wall Street stands firmly behind the prospects of Xenon (XENE) with eleven Buy ratings and no Hold or Sell ratings.Revenue & Expenses Breakdown
Revenue & Expenses Breakdown
How Xenon Pharmaceuticals makes and spends money. Based on latest reported earnings, on an LTM basis.
Earnings and Revenue History
| Date | Revenue | Earnings | G+A Expenses | R&D Expenses |
|---|---|---|---|---|
| 30 Jun 26 | 0 | -409 | 89 | 0 |
| 31 Mar 26 | 0 | -383 | 84 | 0 |
| 31 Dec 25 | 8 | -346 | 80 | 0 |
| 30 Sep 25 | 8 | -306 | 76 | 0 |
| 30 Jun 25 | 8 | -278 | 73 | 0 |
| 31 Mar 25 | 8 | -251 | 73 | 0 |
| 31 Dec 24 | 0 | -234 | 69 | 0 |
| 30 Sep 24 | 0 | -213 | 64 | 0 |
| 30 Jun 24 | 0 | -199 | 60 | 0 |
| 31 Mar 24 | 0 | -189 | 52 | 0 |
| 31 Dec 23 | 0 | -182 | 47 | 0 |
| 30 Sep 23 | 0 | -175 | 42 | 0 |
| 30 Jun 23 | 0 | -164 | 38 | 0 |
| 31 Mar 23 | 1 | -147 | 36 | 0 |
| 31 Dec 22 | 9 | -125 | 33 | 0 |
| 30 Sep 22 | 13 | -113 | 31 | 0 |
| 30 Jun 22 | 21 | -91 | 27 | 0 |
| 31 Mar 22 | 23 | -83 | 25 | 0 |
| 31 Dec 21 | 18 | -77 | 22 | 0 |
| 30 Sep 21 | 20 | -66 | 18 | 0 |
| 30 Jun 21 | 18 | -59 | 17 | 0 |
| 31 Mar 21 | 29 | -37 | 14 | 0 |
| 31 Dec 20 | 32 | -29 | 13 | 0 |
| 30 Sep 20 | 30 | -28 | 13 | 0 |
| 30 Jun 20 | 27 | -28 | 13 | 0 |
| 31 Mar 20 | 14 | -38 | 12 | 0 |
| 31 Dec 19 | 7 | -42 | 11 | 0 |
| 30 Sep 19 | 4 | -39 | 10 | 0 |
| 30 Jun 19 | 0 | -44 | 9 | 0 |
| 31 Mar 19 | 0 | -42 | 9 | 0 |
| 31 Dec 18 | 0 | -34 | 8 | 0 |
| 30 Sep 18 | 0 | -34 | 8 | 0 |
| 30 Jun 18 | 0 | -27 | 8 | 0 |
| 31 Mar 18 | 0 | -27 | 7 | 0 |
| 31 Dec 17 | 0 | -31 | 7 | 0 |
| 30 Sep 17 | 1 | -29 | 7 | 4 |
| 30 Jun 17 | 1 | -29 | 7 | 10 |
| 31 Mar 17 | 1 | -27 | 7 | 15 |
| 31 Dec 16 | 2 | -23 | 7 | 19 |
| 30 Sep 16 | 5 | -21 | 7 | 18 |
| 30 Jun 16 | 9 | -17 | 6 | 16 |
| 31 Mar 16 | 12 | -10 | 5 | 14 |
| 31 Dec 15 | 16 | -16 | 10 | 12 |
| 30 Sep 15 | 17 | -2 | 10 | 11 |
Quality Earnings: XENE is currently unprofitable.
Growing Profit Margin: XENE is currently unprofitable.
Free Cash Flow vs Earnings Analysis
Past Earnings Growth Analysis
Earnings Trend: XENE is unprofitable, and losses have increased over the past 5 years at a rate of 33.6% per year.
Accelerating Growth: Unable to compare XENE's earnings growth over the past year to its 5-year average as it is currently unprofitable
Earnings vs Industry: XENE is unprofitable, making it difficult to compare its past year earnings growth to the Biotechs industry (64.6%).
Return on Equity
High ROE: XENE has a negative Return on Equity (-32.94%), as it is currently unprofitable.
Return on Assets
Return on Capital Employed
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Company Analysis and Financial Data Status
| Data | Last Updated (UTC time) |
|---|---|
| Company Analysis | 2026/09/18 23:04 |
| End of Day Share Price | 2026/09/18 00:00 |
| Earnings | 2026/06/30 |
| Annual Earnings | 2025/12/31 |
Data Sources
The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.
| Package | Data | Timeframe | Example US Source * |
|---|---|---|---|
| Company Financials | 10 years |
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| Analyst Consensus Estimates | +3 years |
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| Market Prices | 30 years |
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| Ownership | 10 years |
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| Management | 10 years |
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| Key Developments | 10 years |
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* Example for US securities, for non-US equivalent regulatory forms and sources are used.
Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more.
Analysis Model and Snowflake
Details of the analysis model used to generate this report is available on our Github page, we also have guides on how to use our reports and tutorials on Youtube.
Learn about the who designed and built the Simply Wall St analysis model.
Industry and Sector Metrics
Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on Github.
Analyst Sources
Xenon Pharmaceuticals Inc. is covered by 25 analysts. 16 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.
| Analyst | Institution |
|---|---|
| Brian Skorney | Baird |
| Jason Matthew Gerberry | BofA Global Research |
| John Newman | Canaccord Genuity |