Sutro Biopharma, Inc.

NasdaqGM:STRO Stock Report

Market Cap: US$624.4m

Sutro Biopharma Future Growth

Future criteria checks 0/6

Sutro Biopharma's revenue is forecast to decline at 22.2% per annum while its annual earnings are expected to grow at 0.5% per year. EPS is expected to grow by 24.8% per annum.

Key information

0.5%

Earnings growth rate

24.83%

EPS growth rate

Biotechs earnings growth23.4%
Revenue growth rate-22.2%
Future return on equityn/a
Analyst coverage

Good

Last updated01 May 2026

Recent future growth updates

Analysis Article Aug 16

Analysts Are Upgrading Sutro Biopharma, Inc. (NASDAQ:STRO) After Its Latest Results

Sutro Biopharma, Inc. ( NASDAQ:STRO ) defied analyst predictions to release its quarterly results, which were ahead of...

Recent updates

Seeking Alpha May 01

Sutro Biopharma: Recycling Past Data Ahead Of The Readout, Sell

Summary Sutro Biopharma underwent major restructuring, including management changes, layoffs, and a 1-for-10 reverse split to maintain NASDAQ compliance. STRO's lead program, STRO-004, is a next-gen tissue factor-targeting exatecan ADC with a DAR of 8, aiming for Phase 1 data in mid-2026. Despite claims of improved safety via Fc-silencing and novel linker chemistry, prior ADCs (luveltamab tazevibulin) with similar strategies suffered high toxicities and discontinuation. Cash reserves and Vaxcyte equity holdings have dropped from ~$400M between 2023 to 2025 to $141.5M as of March 2026, raising sustainability concerns ahead of key clinical readouts. Read the full article on Seeking Alpha
Narrative Update Apr 25

STRO: ADC Progress And Equity Offering Will Shape Balanced Future Outlook

Analysts have raised their price target for Sutro Biopharma by about $2, reflecting updated fair value estimates along with revised assumptions for the discount rate, revenue growth, profit margin and future P/E. What's in the News Sutro reported promising preclinical data for multiple next generation antibody drug conjugates (ADCs), including STRO-004, STRO-006 and STRO-227, at the American Association for Cancer Research Annual Meeting 2026.
Narrative Update Apr 10

STRO: Equity Offering And Lockup Structure Will Support Future Upside

Analysts now place Sutro Biopharma's price target at about $30.11, up from roughly $27.88. This reflects updated assumptions around fair value, discount rate, future revenue trends, profit margin, and a higher future P/E of about 199x.
Narrative Update Mar 27

STRO: Recent Equity Raises And Lockup Structure Will Support Future Upside

Analysts have revised their price target for Sutro Biopharma from $21.25 to $27.88, reflecting updated assumptions around discount rate, revenue growth, profit margin, and a higher future P/E in their models. What's in the News Sutro Biopharma filed a follow-on equity offering of up to US$100 million in common stock as an at-the-market program, providing flexibility to issue shares over time.
Narrative Update Mar 10

STRO: Equity Raise And Index Removal Will Set Up Future Upside Potential

Analysts have kept their $51.00 price target on Sutro Biopharma unchanged, as a slightly lower discount rate and a higher assumed future P/E multiple are seen as offsetting a softer revenue outlook and reduced profit margin expectations. What's in the News Sutro Biopharma completed a follow on equity offering of approximately US$110.0 million, issuing 7,868,383 common shares at US$13.98 per share with a US$0.8388 discount per share (Key Developments).
Narrative Update Feb 24

STRO: Reverse Split And Equity Raise Will Support Future Upside

Analysts have inched up their price target on Sutro Biopharma to $21.25 from $21, citing updated assumptions that include a slightly lower discount rate, modest changes to long term profit margin expectations, and a higher future P/E multiple. What's in the News Sutro Biopharma completed a follow on equity offering of common stock, raising about US$110.0m through the sale of 7,868,383 shares at US$13.98 per share, reflecting a US$0.8388 per share discount (Key Developments).
Narrative Update Feb 09

STRO: Reverse Split And ADC Pipeline Progress Will Support Future Upside Potential

Analysts have maintained their price target on Sutro Biopharma at US$51.00, making only minor adjustments to their models. Slightly softer assumptions for long-term revenue growth and profit margins are largely offset by a higher future P/E multiple.
Analysis Article Feb 04

Here's Why We're A Bit Worried About Sutro Biopharma's (NASDAQ:STRO) Cash Burn Situation

We can readily understand why investors are attracted to unprofitable companies. For example, biotech and mining...
Narrative Update Jan 26

STRO: Reverse Split And ADC Pipeline Progress Will Drive Future Upside

Analysts lifted their price target on Sutro Biopharma to US$51.00 per share, highlighting updated assumptions around fair value, discount rate, revenue growth expectations, profit margins, and a slightly lower future P/E as the key drivers of the change. What's in the News Sutro Biopharma regained compliance with Nasdaq’s continued listing standard for minimum share price under Rule 5450(a)(1) after its common stock maintained an average closing price of at least US$1.00 following a 1:10 reverse stock split effective December 3, 2025 (company announcement).
Narrative Update Jan 10

STRO: Reverse Split And ADC Pipeline Progress Will Support Future Upside

Analysts have trimmed their price target on Sutro Biopharma from US$22.29 to US$21.00, citing updated assumptions that include a slightly lower discount rate, a wider expected revenue decline of about 6.3 percentage points, a modestly higher profit margin, and a higher future P/E multiple. What's in the News Sutro Biopharma was removed from the Nasdaq Biotechnology Index, which can affect index fund ownership that tracks this benchmark (Index Constituent Drops).
Analysis Article Dec 31

Sutro Biopharma, Inc.'s (NASDAQ:STRO) Price Is Right But Growth Is Lacking After Shares Rocket 46%

Sutro Biopharma, Inc. ( NASDAQ:STRO ) shareholders would be excited to see that the share price has had a great month...
Narrative Update Dec 17

STRO: Reverse Split And ADC Pipeline Focus Will Drive Future Upside

Narrative Update on Sutro Biopharma Analysts have reduced their price target on Sutro Biopharma from approximately $28.00 to about $22.30 per share. This reflects a lower assumed future price to earnings multiple, while expectations for revenue growth and profit margins remain largely unchanged.
Narrative Update Dec 03

STRO: Reverse Split And ADC Focus Will Drive Long-Term Upside

Analysts have raised their price target on Sutro Biopharma from 2.69 dollars to 28.00 dollars, citing expectations for improved long term profit margins despite softer revenue growth assumptions and a modestly higher discount rate. What's in the News Sutro Biopharma approved a 1 for 10 reverse stock split or significant stock dividend effective December 3, 2025, aimed at improving its share price profile for investors (company announcement).
Narrative Update Sep 10

ADC Pipeline Focus Will Advance Preclinical Drug Development

The downward revision in Sutro Biopharma’s price target reflects worsening net profit margin and deeper negative revenue growth forecasts, with fair value decreasing from $3.11 to $2.69. What's in the News Sutro Biopharma entered a collaboration with the FDA to co-develop reference materials and improve regulatory standards for ADC drug development, leveraging Sutro's XpressCF technology and FDA's analytical capabilities.
Analysis Article Jul 01

Here's Why We're A Bit Worried About Sutro Biopharma's (NASDAQ:STRO) Cash Burn Situation

Even when a business is losing money, it's possible for shareholders to make money if they buy a good business at the...
Analysis Article Apr 18

Benign Growth For Sutro Biopharma, Inc. (NASDAQ:STRO) Underpins Stock's 36% Plummet

Unfortunately for some shareholders, the Sutro Biopharma, Inc. ( NASDAQ:STRO ) share price has dived 36% in the last...
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New Narrative Apr 03

ADC Pipeline Focus Will Advance Preclinical Drug Development

Strategic focus on preclinical programs and restructuring is set to drive future growth by enhancing drug development and revenue potential.
Analysis Article Mar 04

Sutro Biopharma, Inc. (NASDAQ:STRO) Not Doing Enough For Some Investors As Its Shares Slump 25%

To the annoyance of some shareholders, Sutro Biopharma, Inc. ( NASDAQ:STRO ) shares are down a considerable 25% in the...
Seeking Alpha Jan 02

Sutro Biopharma: I Don't Buy That Their Pipeline Is Worthless

Summary STRO's valuation remains compelling despite recent market hits, with optimism for a turnaround driven by late-stage clinical trials and strong pipeline potential. Luveltamab tazevibulin shows promising efficacy in ovarian cancer, with manageable toxicity, positioning it for potential Accelerated Approval by mid-2027. Financially, STRO has a two-year runway with current cash reserves, but further financing may be needed, risking shareholder dilution. Casting a wider net in pivotal trials carries risks but could expand patient eligibility, enhancing the overall investment thesis. Read the full article on Seeking Alpha
Analysis Article Nov 30

Why Investors Shouldn't Be Surprised By Sutro Biopharma, Inc.'s (NASDAQ:STRO) 26% Share Price Plunge

Unfortunately for some shareholders, the Sutro Biopharma, Inc. ( NASDAQ:STRO ) share price has dived 26% in the last...
Analysis Article Oct 11

Revenues Working Against Sutro Biopharma, Inc.'s (NASDAQ:STRO) Share Price Following 25% Dive

The Sutro Biopharma, Inc. ( NASDAQ:STRO ) share price has fared very poorly over the last month, falling by a...
Seeking Alpha Sep 23

Sutro Biopharma's Competitive ADCs Position It For Future Growth In Oncology

Summary STRO specializes in ADCs for oncology, leveraging XpressCF and XpressCF+ platforms for precise antibody-drug conjugates without living cells. STRO-002, a promising ADC for ovarian cancer, has shown favorable safety and efficacy in trials, with potential FDA approval by 2026-2027. Collaborations with Merck, Vaxcyte, and Astellas Pharma could generate up to $3 billion in milestone payments. In my view, STRO's valuation appears cheap relative to its potential. It has ample resources to fund operations and research, making it a "strong buy" despite inherent biotech risks. Read the full article on Seeking Alpha
Analysis Article Aug 24

There's No Escaping Sutro Biopharma, Inc.'s (NASDAQ:STRO) Muted Revenues Despite A 29% Share Price Rise

Sutro Biopharma, Inc. ( NASDAQ:STRO ) shares have had a really impressive month, gaining 29% after a shaky period...
Analysis Article Aug 22

Brokers Are Upgrading Their Views On Sutro Biopharma, Inc. (NASDAQ:STRO) With These New Forecasts

Celebrations may be in order for Sutro Biopharma, Inc. ( NASDAQ:STRO ) shareholders, with the analysts delivering a...
Analysis Article Aug 16

Analysts Are Upgrading Sutro Biopharma, Inc. (NASDAQ:STRO) After Its Latest Results

Sutro Biopharma, Inc. ( NASDAQ:STRO ) defied analyst predictions to release its quarterly results, which were ahead of...
Analysis Article Jun 26

The Market Doesn't Like What It Sees From Sutro Biopharma, Inc.'s (NASDAQ:STRO) Revenues Yet As Shares Tumble 28%

Unfortunately for some shareholders, the Sutro Biopharma, Inc. ( NASDAQ:STRO ) share price has dived 28% in the last...
Analysis Article May 31

We Think The Compensation For Sutro Biopharma, Inc.'s (NASDAQ:STRO) CEO Looks About Right

Key Insights Sutro Biopharma to hold its Annual General Meeting on 6th of June Salary of US$686.7k is part of CEO Bill...
Analysis Article Apr 02

Bearish: Analysts Just Cut Their Sutro Biopharma, Inc. (NASDAQ:STRO) Revenue and EPS estimates

Market forces rained on the parade of Sutro Biopharma, Inc. ( NASDAQ:STRO ) shareholders today, when the analysts...
Analysis Article Mar 28

The Market Doesn't Like What It Sees From Sutro Biopharma, Inc.'s (NASDAQ:STRO) Revenues Yet

With a price-to-sales (or "P/S") ratio of 2x Sutro Biopharma, Inc. ( NASDAQ:STRO ) may be sending very bullish signals...
Analysis Article Dec 19

Sutro Biopharma, Inc.'s (NASDAQ:STRO) Price Is Right But Growth Is Lacking After Shares Rocket 43%

Sutro Biopharma, Inc. ( NASDAQ:STRO ) shares have had a really impressive month, gaining 43% after a shaky period...
Analysis Article Aug 24

Is Sutro Biopharma (NASDAQ:STRO) Using Debt In A Risky Way?

David Iben put it well when he said, 'Volatility is not a risk we care about. What we care about is avoiding the...
Analysis Article Feb 10

Is Sutro Biopharma (NASDAQ:STRO) Using Too Much Debt?

David Iben put it well when he said, 'Volatility is not a risk we care about. What we care about is avoiding the...
Analysis Article Jan 12

An Intrinsic Calculation For Sutro Biopharma, Inc. (NASDAQ:STRO) Suggests It's 47% Undervalued

Key Insights Sutro Biopharma's estimated fair value is US$13.8 based on 2 Stage Free Cash Flow to Equity Current share...
Seeking Alpha Aug 16

Sutro Biopharma: Partnership Progress Warrants Exposure

Shares of Sutro Biopharma have lost one-third of their value over the past 3 years. Consolidation in the antibody drug conjugate space has made it an attractive area for drug development. Sutro has inked a number of partnerships recently and management commentary leads me to believe that more are coming. Internal pipeline leaves much to be desired, but STRO-002 could have a path forward to a broad population if neutropenia is adequately addressed. I consider STRO a Buy below the $6 level. Key risks include competition in ovarian cancer and with FRα target, as well as discontinuation of partnerships or certain assets. Shares of Sutro Biopharma (STRO) have lost 68% since my December 2020 article extolled the advantages of its cell free ADC platform. At the time, I considered the stock to be a Buy after promising initial data for STRO-002 in ovarian cancer that seemed indicative of broad applicability. Over a 3-year timeframe, shares have lost one-third of their value as lead drug candidates move forward in the clinic and big pharma collaborations made significant progress. After a reader mentioned this name, I decided to revisit given my interest in the ADC space, differentiated technology and advancements particularly with partnered efforts. Another point influential in my revisiting was the phase 3 success of ADC peer ImmunoGen (IMGN), whose drug mirvetuximab is limited to FRα-high expressors whereas in the past I noted that Sutro’s STRO-002 appears to have a more broadly-applicable profile (though with significant tolerability challenges). Lastly, the China licensing deal made this name even more interesting given terms (respectable $40 million upfront cash payment) and specific language (plans now in the works to try the STRO-001 in indications of TNBC and NSCLC). This was followed by Astellas iADC pact including $90M upfront payment. Chart FinViz Figure 1: STRO weekly chart (Source: Finviz) When looking at charts, clarity often comes from taking a look at distinct time frames in order to determine important technical levels and get a feel for what's going on. In the weekly chart above, we can see shares rise to a high of $28 in early 2021 on heels of early data for STRO-002 in heavily pretreated ovarian cancer patients. From there, shares have fallen to a low in the mid- single digits and appear to have bottomed. My initial take is that the current valuation offers investors an attractive point of entry, but as I have less confidence in the internal pipeline and more in partnered efforts, I think this is a multi-year story that will require significant patience and long-term mindset. Overview Reflecting on my December 2020 article, here are our previously stated keys to the bullish thesis: Initially, Sutro’s lead solid tumor program targeting folate-receptor alpha (FRα) did not interest me given that the target was plagued by a history of failures. I was also aware of ImmunoGen’s mirvetuximab flunking a prior pivotal study and giving it a second try via registrational study in just the FRα high population. However, Sutro’s clinical readout for STRO-002 attracted my interest given impressive response rate and durability in a very heavily pretreated population (lends credence to management commentary that the drug is best-in-class as they did not have to stratify or enrich for FRα high expressors). On the con side, however, therapeutic window could be narrower than it originally appeared given the neutropenia events requiring dose reduction. Per my notes on Evercore presentation and KOL call, I came away with the impression that CEO Bill Newell was a straight shooter who clearly outlined benefits of the company’s cell free protein synthesis technology versus more traditional CHO or E coli cells (poor mechanism for discovery and scaling to commercial production). Cell free approach allowed the company to make many versions of a molecule rapidly, finding the best site of attachment and then varying linker & warhead to achieve optimal drug profile). Importantly, this approach allows them to rapidly scale and move forward (speed in the clinic). The purported advantages of this approach were apparent in STRO-002 data, (much greater tumor killing effect as drug doesn’t get removed when it’s internalized, has relatively fast clearance rate and half life of 2.5 hours versus 35 to 40 hours for the competition). They are able to get the molecule into the tumor microenvironment, do its job and minimize bystander effect to achieve a much better toxicity profile. Per initial phase 1 data update in all comers, 87% of adverse events were grade 1 or 2 (very manageable). Women in the study had 5 prior lines of therapy and life expectancy of 6 to 9 months (population you would NOT expect to see much activity in). Mid 20s response rate was quite promising in that light, not to mention duration of women on the study (including those with stable disease receiving clinical benefit for 12 weeks or longer). We compared these results to ImmunoGen’s mirvetuximab, which saw far fewer responses in dose escalation study and considerably less durability. Given 002’s initial data, I expected even better response/durability in earlier lines of therapy. One partnership that caught my attention was EMD Serono's EGFR-MUC1 bispecific ADC, which would be the first time in history that a bispecific, dual targeted ADC entered the clinic. The objective was to get away from the well-known toxicity profile of EGFR and preclinical data in NSCLC & esophageal squamous cell carcinoma showed complete tumor kill. Merck (MRK) collaboration in the area of cytokine derivatives continued to steadily move forward, with the big pharma company exercising option to extend research term. Lastly, I reminded readers that the company owned 1.6 million shares of Vaxcyte (PCVX) along with a 4% royalty. Corporate Slides Figure 2: Pipeline (Source: corporate presentation) As can be seen above, pipeline has expanded considerably since last time we revisited. Additionally, enterprise value of around $500 million has fallen considerably over the past year (to less than $100 million) despite clinical progress achieved. Select Recent Developments In May of 2021 the company shared additional dose escalation data for STRO-002 in patients with advanced ovarian cancer. Again, keep in mind these were heavily pretreated (6 prior lines of therapy). Of 31 patients, there was 1 complete response and four confirmed partial responses (5 unconfirmed PRs as well). Median progression free survival was 7.2 months, and again 86% of treatment emergent adverse events were Grade 1 or 2. Most common Grade 3 and 4 AEs were neutropenia, arthralgia, fatigue, neuropathy and abdominal pain (all manageable with treatment, dose reductions or dose delays). Dose limiting toxicities were observed at higher dose levels (6 mg/kg and 6.4 mg/kg) in two patients. Corporate Slides Figure 3: STRO-002 treatment shows promising signs of durability in dose escalation trial (Source: corporate presentation) Corporate Slides Figure 4: Anti-tumor activity observed across various FolRa-expression levels, suggestive of STRO-002 addressing a broader opportunity than its competition in FRa (Source: corporate presentation) In August the company appointed Jane Chung as Chief Commercial Officer (served prior as President of AstraZeneca, Canada). Later on in September, leadership team was expanded as well, with Nicole Chieffo joining as VP of Clinical Operations (formerly Sr Director, Oncology Global Operations Head at Janssen) and Werner Rubas joining as VP of Preclinical Operations (served prior at Nektar Therapeutics). On September 30th, it could be considered a green flag that Merck decided to extend research term for the first cytokine derivative program under 2018 collaboration agreement with Sutro. The two companies are pursuing a second candidate as well (uses different approach for the same target). Flash forward to December, where it appears that nonclinical data shows STRO-001 might not be as dead in the water as I thought it was (showed potential for CD74 in adult and pediatric AML and ALL). Additionally, STRO-002 was shown to have therapeutic potential in a rare, pediatric AML subtype expressing RolRa (CBFA2T3-GLIS2 fusion AML), in which preclinical model showed complete leukemia clearance. Of more material impact, December’s China licensing deal for STRO-002 with Tasly Biopharmaceuticals had interesting terms, including an impressive $40 million upfront cash payment (up to $345 million in milestone payments along with tiered, double-digit royalties). As noted prior, I found it highly interesting that language in the press release highlights potential to expand into additional oncology indications of NSCLC and TNBC (both of which represent sizeable opportunities that other FRα-targeting peers have not made inroads on). On January 5th the company reported interim data on its dose expansion study of STRO-002. ORR was 33% in 33 RECIST evaluable patients across all FolRa expression levels and both dose levels. However, ORR was 47% in 17 patients who started at the 5.2mg/kg dose level (keeping in mind some could not tolerate it and were stepped down to 4.3mg/kg). Interestingly enough, ORR of 40% was observed for patients with TPS score greater than 25%, which represents about 70% of the advanced ovarian cancer patient population (quite broad). Corporate Slides Figure 5: Change in sum diameters for target lesions over time (Source: corporate presentation) While the company touted "no new safety signals", it's still worth mentioning that the AE of note was neutropenia leading to treatment delay or dose reduction. However, the majority of these cases were asymptomatic and resolved with 1 week dose delay or standard medical treatment including use of G-CSF. It is a cause for concern that there were multiple cases of febrile neutropenia (one Grade 5 at 5.2 mg/kg, one Grade 3 at 4.3 mg/kg). Corporate Slides Figure 6: Emerging safety profile for STRO-002 (Source: corporate presentation) Moving on to June 27th, Sutro announced global collaboration with Astellas Pharma focused on development of novel immunostimulatory ADCs. The simple goal here is to bring new therapies to patients who do not respond to existing immunotherapies. iADCs will combine an antibody with a small molecule compound that induces immunogenic cell death in addition to an immune activating molecule, which in turn has the potential to boost anti-cancer action. Development will be pursued for 3 distinct biological targets, with each partner bringing unique expertise to the table (Sutro's being advanced technologies for drug linkers to antibodies and linkable cytotoxins). Importantly, Sutro is receiving $90M upfront and remains eligible to receive up to $422.5M in milestones for EACH product candidate along with tiered royalties ranging from low double-digit to mid-teens on worldwide sales. Management wisely retained the option to share in costs and profits for developing candidates in the US (commonly known as "co-development" option). This should not be overlooked, as commonly I see these smaller partners retain such options for perhaps one candidate involved in a particular deal but rarely as in this case for all of them. Lastly, on July 26th the company announced first patient had been dosed in phase 1 study of investigational candidate (novel cytokine derivative therapeutic) resulting from the collaboration between Sutro and Merck. Sutro received a $10M milestone payment and more importantly this represents important thesis progression as this partnership originated in July 2018 and is seeing its first drug candidate move forward in the clinic. Other Information For the second quarter of 2022, the company reported cash and equivalents of $191.6M (does not include $90M upfront payment from Astellas) as compared to operating expenses of $47.5M. I assume annual cash burn of $200M, which puts the company at just 1.5 years operational runway with current resources. At JMP presentation in June, CEO makes the following points: 6 clinical programs in development today, two of which are proprietary. They expect to integrate CDMOs into manufacturing as the company makes its way into late-stage studies. History of ADC field has been one of peaks and valleys. In past 5 years they've gained more understanding on how to optimize ADCs and get the desired targeted tumor kill with manageable safety profile. Goal is to attain superior efficacy and safety to chemotherapy, which is typically the alternative standard of care. Some ADCs are based on older technology, but chemistry and linkers used in Gen1 molecules are not state-of-the-art (heterogeneous mixtures). Competitors, including in ovarian cancer, use an average drug-antibody ratio because some species in vial are competent to do what they are supposed to do and others are not competent (i.e. some molecules with DAR of 4, some with 2 and not potent enough to get cell kill). Sutro believes that average is perhaps good enough in some circumstances, but far from optimal. Company believes homogeneity will allow them to have broader therapeutic window than competition along with better cell kill (optimized to do the job they want it to do, designing a better molecule and proving it in the clinic). For STRO-002 dose expansion phase, they are exploring two doses (5.2mg/kg and 4.3mg/kg). They are within therapeutic window of molecule with potential differences between efficacy and safety. Final data will be reported before year end. They hope to establish in platinum-resistant ovarian cancer population with up to 3 prior lines of therapy, that they can get robust response rates with good durability and meaningful progression-free survival for patients who do not respond. TMPS score above 25% is the ideal cutoff they've identified where patients have greater likelihood of responding to therapy (40% ORR versus low double digit response rate below this score). This break point gives them about 70% of market opportunity, perhaps as much as 80%. One competitor (ImmunoGen) identified a narrow therapeutic window for their molecule (6 mg/kg dosing regimen, as 7 mg/kg was too toxic and below 6 lacked efficacy). They also determined that they needed to use IHC assay and stick with only high expressors (smaller market opportunity). ImmunoGen reckons that allows for around 30% of the total market. Corporate Slides Figure 7: ImmunoGen estimated market opportunity in FRa-high patients (Source: corporate presentation) For STRO-002, they've already had FDA meeting regarding inclusion/exclusion criteria, patient selection, dosing strategy, path forward & pivotal trial design, etc. Conclusion is that they have the opportunity to do a registration-directed study with potential accelerated approval pathway depending on the quality of the data. That study will likely start in early 2023. As for bevacizumab combo study ongoing, bevacizumab is used much earlier in therapy (not reserved for late line). Almost 2/3rds of ovarian cancer patients are treated with bevacizumab in initial lines of therapy. They don't believe 1+1=5, in other words toxicity effects are not additive between the two agents. They started combo study at lower dose to ensure tolerability was there, then escalate up. Data will likely come in 2023. Analyst makes an important question for STRO-001 (go/no-go decision), given that multiple myeloma and NHL treatment landscape is shifting and increasingly crowded. They've seen promising early data including 1 CR and 2 PRs in 7 DLBCL patients along with decent safety profile (no ocular toxicity in either agent). 001 looks quite safe, they are still seeking efficacy signals at higher doses and it's been hard to recruit more patients recently (now enrolling ex-US where patients have less access to other treatments and have had fewer cycles of therapy). BioNova deal for 001 covers rest of costs to get to recommended phase 2 dose (using other people's money instead of burning company resources up). As for other partnered efforts, Bristol's (BMY) BCMA ADC continues to be optimized but CEO otherwise is not informed on how or if they will proceed forward. EMD Serono has initiated development of their MUC1-EGFR ADC and data is expected next year. Partner Merck is on the cusp as well with cytokine ADC. They've received almost $500M from partnerships and each one is about to have a product in the clinic. At end of Q1 they have $192M in bank, run rate takes them into 2H 2023. Final STRO-002 data analysis from expansion study will be single most important value driver, per Newell. Moving onto the virtual deep dive into iADC efforts, here were the key takeaways for me: ROR1 ADC is pursuing a target widely expressed a broad range of tumor types. STRO-003 (ROR1) will be their 7th product candidate to enter the clinic. ROR1 is an attract target due to its role in cancer progression and its specificity of expression on tumors (restricted on normal tissue so low potential for on-target toxicity). ROR1 is broadly expressed across heme malignancies as well as solid tumors including NSCLC and breast cancer. Prostate cancer for example has 90% and above prevalence (15% high grade, the lower that number is the more potent and efficient the ADC has to be). Other targets are active in preclinical pipeline, including Liv-1, PTK7, CEACAM5, Tissue Factor, etc. These are antigens management is very interested in at the moment (looking at them as both monospecific or potentially bispecific to combine with one another). As for Q&A, management states they've had a lot of interest from potential partners for their technology (not just Astellas). They are "open for business" and look forward to continuing discussions (sounds like more deal flow in the works). In regard to competitive data for ROR1 on the horizon, the company is still waiting to see how VelosBio data turns out in coming year or two. Readers may recall that VelosBio was acquired by Merck for $2.75 billion price tag for its ROR1 ADC in late 2020. At the time, data was scant but promising nonetheless (7/15 mantle cell lymphoma patients with complete responses, 4 of 5 patients in DLBCL cohort with complete responses). Merck had plans to move into triple negative breast cancer and non-small cell lung cancer, at the time. Sutro believes their epitope overlaps if not being identical to the VelosBio antibody (sounds like lack of differentiation here). They will be following the VelosBio program closely and this appears to be a "fast follower" situation where there's room for more than one winner. Corporate Slides Figure 8: ROR1 broadly expressed across wide range of tumor types (Source: corporate presentation) As for accumulated deficit, $334M as of December 31 seems quite reasonable for a company founded back in 2003 (well managed balance sheet and partnerships chipping in to offset cash burn). As for prior financings, December 2020 offering took place at $21 per share (3x upside from current levels). As for competition particularly in the FRa space, I'd like to point to data from MORAb-202, which was the subject of $3.1 billion joint development deal between Eisai (ESALF) (ESALY) and Bristol Myers ($650M upfront, up to $2.45 billion in milestones). MORAb-202 produced an impressive 52% ORR in higher dose cohort of Japanese PROC (platinum resistant ovarian cancer) patients. Importantly, here efficacy was seen IRRESPECTIVE of FRa levels. Median PFS was an impressive 8.2 months (I believe the bar was set at around 4 to 5 months by ImmunoGen). On the con side, the most common TEAE was interstitial lung disease (ILD)/pneumonitis at both dose levels (Cohort 1: 37.5% [n=9; 8 with grade 1, 1 with grade 2]; Cohort 2: 66.7% [n=14; 6 with grade 1, 7 with grade 2, 1 with grade 3]), which is a rough adverse event for patients to have to deal with. Responses were also observed in breast, endometrial and non-small cell lung cancer (phase 1/2 studies are now pursuing these indications).

Earnings and Revenue Growth Forecasts

NasdaqGM:STRO - Analysts future estimates and past financials data (USD Millions)
DateRevenueEarningsFree Cash FlowCash from OpAvg. No. Analysts
12/31/202822-158-152-718
12/31/202724-140-123-5312
12/31/202632-144-128-12213
12/31/2025102-191-179-177N/A
9/30/2025106-217-225-223N/A
6/30/2025104-209-252-249N/A
3/31/202566-245-199-195N/A
12/31/202462-227-195-192N/A
9/30/2024161-124-109-106N/A
6/30/2024169-124-78-75N/A
3/31/2024154-115-119-115N/A
12/31/2023154-107-116-112N/A
9/30/202349-172-156-150N/A
6/30/202357-143-57-50N/A
3/31/202375-130-29-22N/A
12/31/202268-119-44N/A
9/30/202270-123-16N/A
6/30/202253-134-96-84N/A
3/31/202253-114-101-87N/A
12/31/202162-106-97-82N/A
9/30/202160-127-93-79N/A
6/30/202169-79-85-72N/A
3/31/202150-43-88-79N/A
12/31/202043-32-75-68N/A
9/30/20204613-70-62N/A
6/30/202040-17-66-61N/A
3/31/202041-61-68-64N/A
12/31/201943-56-69-65N/A
9/30/201951-42N/A-58N/A
6/30/201946-40N/A6N/A
3/31/201941-38N/A8N/A
12/31/201838-35N/A13N/A
9/30/201823-49N/A14N/A
6/30/201833-40N/A-36N/A
3/31/201842-30N/A-37N/A
12/31/201752-20N/A-37N/A
12/31/201660N/AN/A-13N/A

Analyst Future Growth Forecasts

Earnings vs Savings Rate: STRO is forecast to remain unprofitable over the next 3 years.

Earnings vs Market: STRO is forecast to remain unprofitable over the next 3 years.

High Growth Earnings: STRO is forecast to remain unprofitable over the next 3 years.

Revenue vs Market: STRO's revenue is expected to decline over the next 3 years (-22.2% per year).

High Growth Revenue: STRO's revenue is forecast to decline over the next 3 years (-22.2% per year).


Earnings per Share Growth Forecasts


Future Return on Equity

Future ROE: Insufficient data to determine if STRO's Return on Equity is forecast to be high in 3 years time


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Company Analysis and Financial Data Status

DataLast Updated (UTC time)
Company Analysis2026/05/07 14:44
End of Day Share Price 2026/05/07 00:00
Earnings2025/12/31
Annual Earnings2025/12/31

Data Sources

The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.

PackageDataTimeframeExample US Source *
Company Financials10 years
  • Income statement
  • Cash flow statement
  • Balance sheet
Analyst Consensus Estimates+3 years
  • Forecast financials
  • Analyst price targets
Market Prices30 years
  • Stock prices
  • Dividends, Splits and Actions
Ownership10 years
  • Top shareholders
  • Insider trading
Management10 years
  • Leadership team
  • Board of directors
Key Developments10 years
  • Company announcements

* Example for US securities, for non-US equivalent regulatory forms and sources are used.

Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more.

Analysis Model and Snowflake

Details of the analysis model used to generate this report is available on our Github page, we also have guides on how to use our reports and tutorials on Youtube.

Learn about the world class team who designed and built the Simply Wall St analysis model.

Industry and Sector Metrics

Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on Github.

Analyst Sources

Sutro Biopharma, Inc. is covered by 19 analysts. 13 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.

AnalystInstitution
Zhiqiang ShuBerenberg
Tazeen AhmadBofA Global Research
Thomas ShraderBTIG