A Fresh Look at Oncolytics Biotech (ONCY) Valuation Following Key Clinical Data on Pelareorep

Simply Wall St

If you have been following Oncolytics Biotech (NasdaqCM:ONCY), you likely noticed its stock has become a talking point after the company released fresh clinical data on pelareorep. The latest results show that this immunotherapy, when combined with standard care, delivered longer progression-free and overall survival for patients with KRAS mutant metastatic colorectal cancer. With studies like REO 022 and GOBLET surpassing efficacy goals and the company signaling plans to move ahead on regulatory fronts, investors are understandably taking another look at what ONCY could mean for their portfolios.

This news plugs into a year that already saw ONCY’s share price gain momentum, jumping over 50% in the past month and more than doubling in the last three months. Along the way, Oncolytics has presented at investment conferences and shared updated safety data for pelareorep, providing extra narrative for investors who want more than just a headline. These multiple data releases and strategic updates appear to be building a case for sustained attention, if not lasting investor optimism.

But after this run higher and with future studies on the way, is the market underestimating ONCY’s upside or already baking in all the expected growth?

Price-to-Book of 29.9x: Is it justified?

According to the data, Oncolytics Biotech is currently trading at a Price-to-Book Ratio of 29.9x, which is substantially higher than the US Biotechs industry average of 2.2x. This means the stock appears expensive on this metric compared to its sector peers.

The Price-to-Book Ratio measures a company's market value relative to its book value. It is often used for companies in biotech, where tangible assets on the balance sheet can tell part of the valuation story. For a biotech like ONCY, a high multiple may suggest investors have strong expectations for future breakthroughs or revenue that are not yet reflected in the company's assets.

This elevated ratio could indicate that the market is pricing in significant potential for future success. It also raises the question whether such optimism is justified given ONCY’s current fundamentals and lack of profitability. As a result, the valuation may reflect more hope than current financial reality.

Result: Fair Value of $138.26 (UNDERVALUED)

See our latest analysis for Oncolytics Biotech.

However, disappointing trial outcomes or delays in regulatory progress could quickly challenge the optimism currently reflected in Oncolytics Biotech’s valuation.

Find out about the key risks to this Oncolytics Biotech narrative.

Another View: Discounted Cash Flow Model

While the first approach suggests Oncolytics Biotech appears expensive, our DCF model tells a different story. It indicates the stock could be undervalued. How can these two models reach such different conclusions?

Look into how the SWS DCF model arrives at its fair value.
ONCY Discounted Cash Flow as at Sep 2025
Stay updated when valuation signals shift by adding Oncolytics Biotech to your watchlist or portfolio. Alternatively, explore our screener to discover other companies that fit your criteria.

Build Your Own Oncolytics Biotech Narrative

If you see things differently or want to run your own analysis, you can build a personalized view in just a few minutes using Do it your way.

A great starting point for your Oncolytics Biotech research is our analysis highlighting 2 key rewards and 5 important warning signs that could impact your investment decision.

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This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

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