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Neurogene Inc.NasdaqGM:NGNE Stock Report

Market Cap US$558.4m
Share Price
n/a
1Y75.9%
7D10.3%
1D4.3%
Portfolio Value
View

Neurogene Inc.

NasdaqGM:NGNE Stock Report

Market Cap: US$558.4m

Neurogene (NGNE) Stock Overview

A clinical stage biotechnology company, develops genetic medicines for rare neurological diseases. More details

NGNE fundamental analysis
Snowflake Score
Valuation4/6
Future Growth0/6
Past Performance0/6
Financial Health5/6
Dividends0/6

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Neurogene Inc. Competitors

Price History & Performance

Summary of share price highs, lows and changes for Neurogene
Historical stock prices
Current Share PriceUS$35.34
52 Week HighUS$37.27
52 Week LowUS$15.93
Beta1.96
1 Month Change33.41%
3 Month Change72.64%
1 Year Change75.91%
3 Year Changen/a
5 Year Changen/a
Change since IPO134.04%

Recent News & Updates

Seeking Alpha Jul 02

Neurogene: 'Hold' EMBOLDEN Study Underway And 2nd Half 2027 Topline Data

Summary Neurogene remains a 'Hold' as all value hinges on phase 3 EMBOLDEN trial success for NGN-401 in Rett Syndrome. NGNE secured FDA alignment for a single-arm, open-label phase 3 design, with topline data expected in 2H 2027 and a low efficacy threshold [33% response]. Phase 1/2 data showed 100% of patients improved on CGI-I and gained ≥1 milestone, closely matching the phase 3 primary endpoint; durability was observed up to 30 months. The company boasts a strong cash runway into 2028 after a $125M raise, but competitive and trial risks persist, especially with Taysha Gene Therapies (TSHA) reporting data first in the 1st half of 2027. Read the full article on Seeking Alpha

Recent updates

Seeking Alpha Jul 02

Neurogene: 'Hold' EMBOLDEN Study Underway And 2nd Half 2027 Topline Data

Summary Neurogene remains a 'Hold' as all value hinges on phase 3 EMBOLDEN trial success for NGN-401 in Rett Syndrome. NGNE secured FDA alignment for a single-arm, open-label phase 3 design, with topline data expected in 2H 2027 and a low efficacy threshold [33% response]. Phase 1/2 data showed 100% of patients improved on CGI-I and gained ≥1 milestone, closely matching the phase 3 primary endpoint; durability was observed up to 30 months. The company boasts a strong cash runway into 2028 after a $125M raise, but competitive and trial risks persist, especially with Taysha Gene Therapies (TSHA) reporting data first in the 1st half of 2027. Read the full article on Seeking Alpha
Analysis Article Apr 20

Companies Like Neurogene (NASDAQ:NGNE) Are In A Position To Invest In Growth

Even when a business is losing money, it's possible for shareholders to make money if they buy a good business at the...
Analysis Article Dec 31

Here's Why We're Not Too Worried About Neurogene's (NASDAQ:NGNE) Cash Burn Situation

We can readily understand why investors are attracted to unprofitable companies. For example, although...
Analysis Article Aug 13

We Think Neurogene (NASDAQ:NGNE) Can Afford To Drive Business Growth

Even when a business is losing money, it's possible for shareholders to make money if they buy a good business at the...
Seeking Alpha Mar 07

Neurogene: Potential To Target Root Cause Of Rett Syndrome With NGN-401

Summary Additional Neurogene Inc. interim update data from the phase 1/2 study, using AAV9 capsid gene therapy NGN-401 for treatment of patients with Rett syndrome, expected 2nd half of 2025. NGNE plans to provide an update on a potential registrational phase 3 study, using NGN-401 for the treatment of patients with Rett Syndrome, in the 1st half of 2025. The global Rett Syndrome market size is estimated to reach $1.6 billion by the end of 2037. Neurogene had $139 million as of September 30th of 2024 & did an oversubscribed $200 million private placement agreement; Cash on hand enough to fund operations into the 2nd half of 2027. Read the full article on Seeking Alpha
Seeking Alpha Nov 10

Neurogene: Interesting CNS Disease Company, Data Coming Soon

Summary Neurogene, formed from multiple mergers, has a $903M market cap with two phase 1/2 assets, NGN-401 for Rett Syndrome and NGN-101 for CLN5 Batten Disease. NGN-401, an AAV9 gene therapy for Rett Syndrome, shows early safety and efficacy but faces competition from Acadia's FDA-approved trofinetide. Financially, Neurogene has a cash runway until 2026 but may need fundraising post-positive phase 1/2 data; current valuation seems high. The investment thesis hinges on upcoming clinical data to differentiate Neurogene from competitors; cautious optimism until more data is available. Read the full article on Seeking Alpha
Seeking Alpha Mar 26

Neurogene Stock: Gene Therapy Specialist May Break Chain Of Failed Mergers

Summary Neurogene Inc., a clinical-stage company focused on genetic medicines for rare neurological diseases, has seen a significant increase in its share price since joining the Nasdaq in December 2023. The company is progressing two drug candidates, NGN-401 for Rett Syndrome and NGN-101 for CLN5 Batten Disease, with key milestones planned for 2024. Neurogene's success will depend on the outcome of its clinical programs and the potential of its proprietary "transgene regulation technology" platform. Read the full article on Seeking Alpha

Shareholder Returns

NGNEUS BiotechsUS Market
7D10.3%4.1%1.6%
1Y75.9%41.1%18.6%

Return vs Industry: NGNE exceeded the US Biotechs industry which returned 41.1% over the past year.

Return vs Market: NGNE exceeded the US Market which returned 18.6% over the past year.

Price Volatility

Is NGNE's price volatile compared to industry and market?
NGNE volatility
NGNE Average Weekly Movement9.7%
Biotechs Industry Average Movement10.3%
Market Average Movement7.3%
10% most volatile stocks in US Market16.7%
10% least volatile stocks in US Market3.2%

Stable Share Price: NGNE has not had significant price volatility in the past 3 months compared to the US market.

Volatility Over Time: NGNE's weekly volatility (10%) has been stable over the past year.

About the Company

FoundedEmployeesCEOWebsite
2018131Rachel McMinnwww.neurogene.com

Neurogene Inc., a clinical stage biotechnology company, develops genetic medicines for rare neurological diseases. The company's product candidates include NGN-401 that is packaged in an adeno-associated virus 9, which is in Phase 1/2 clinical trial for the treatment of Rett syndrome; and NGN-101, a conventional gene therapy candidate that is in Phase 1/2 clinical trial to treat CLN5 Batten disease. It has a license agreement with The University of Edinburgh, Virovek, Inc., Sigma-Aldrich Co. LLC., and Leland Stanford Junior University.

Neurogene Inc. Fundamentals Summary

How do Neurogene's earnings and revenue compare to its market cap?
NGNE fundamental statistics
Market capUS$558.44m
Earnings (TTM)-US$98.64m
Revenue (TTM)n/a
0.0x
P/S Ratio
-5.7x
P/E Ratio

Earnings & Revenue

Key profitability statistics from the latest earnings report (TTM)
NGNE income statement (TTM)
RevenueUS$0
Cost of RevenueUS$82.28m
Gross Profit-US$82.28m
Other ExpensesUS$16.36m
Earnings-US$98.64m

Last Reported Earnings

Mar 31, 2026

Next Earnings Date

n/a

Earnings per share (EPS)-6.24
Gross Margin0.00%
Net Profit Margin0.00%
Debt/Equity Ratio0%

How did NGNE perform over the long term?

See historical performance and comparison

Company Analysis and Financial Data Status

DataLast Updated (UTC time)
Company Analysis2026/07/05 03:57
End of Day Share Price 2026/07/02 00:00
Earnings2026/03/31
Annual Earnings2025/12/31

Data Sources

The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.

PackageDataTimeframeExample US Source *
Company Financials10 years
  • Income statement
  • Cash flow statement
  • Balance sheet
Analyst Consensus Estimates+3 years
  • Forecast financials
  • Analyst price targets
Market Prices30 years
  • Stock prices
  • Dividends, Splits and Actions
Ownership10 years
  • Top shareholders
  • Insider trading
Management10 years
  • Leadership team
  • Board of directors
Key Developments10 years
  • Company announcements

* Example for US securities, for non-US equivalent regulatory forms and sources are used.

Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more.

Analysis Model and Snowflake

Details of the analysis model used to generate this report is available on our Github page, we also have guides on how to use our reports and tutorials on Youtube.

Learn about the world class team who designed and built the Simply Wall St analysis model.

Industry and Sector Metrics

Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on Github.

Analyst Sources

Neurogene Inc. is covered by 10 analysts. 7 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.

AnalystInstitution
Whitney IjemCanaccord Genuity
Gum-Ming LoweCraig-Hallum Capital Group LLC
Debjit ChattopadhyayGuggenheim Securities, LLC