Fulcrum Therapeutics Management
Management criteria checks 2/4
Fulcrum Therapeutics' CEO is Alex Sapir, appointed in Jul 2023, has a tenure of 2.92 years. total yearly compensation is $3.25M, comprised of 20% salary and 80% bonuses, including company stock and options. directly owns 0.3% of the company’s shares, worth $693.17K. The average tenure of the management team and the board of directors is 3.3 years and 8 years respectively.
Key information
Alex Sapir
Chief executive officer
US$3.3m
Total compensation
| CEO salary percentage | 19.99% |
| CEO tenure | 2.9yrs |
| CEO ownership | 0.3% |
| Management average tenure | 3.3yrs |
| Board average tenure | 8yrs |
Recent management updates
Recent updates
Seeking Alpha • Jun 03
Fulcrum: 'Hold' On Pociredir Discontinuation And Strategic Alternatives Shift
Summary Fulcrum Therapeutics maintains a 'Hold' rating after discontinuing pociredir for Sickle Cell Disease due to malignancy risk concerns tied to PRC2 inhibition. FULC's promising phase 1b SCD data showed robust HbF induction and favorable safety, but FDA feedback and class-wide malignancy signals halted development. With $333.3 million in cash, the company can fund operations into 2029, aided by cost reductions and a potential $100 million ATM facility. The company is exploring strategic alternatives, including mergers or asset acquisitions, but the timeline and outcome remain uncertain, justifying the continued 'Hold' stance. Read the full article on Seeking AlphaAnalysis Article • Apr 01
Fulcrum Therapeutics (NASDAQ:FULC) Is In A Good Position To Deliver On Growth Plans
We can readily understand why investors are attracted to unprofitable companies. By way of example, Fulcrum...
New Narrative • Mar 20
Fetal Hemoglobin Induction Will Reshape Sickle Cell Care And Broaden Long Term Hematology Potential
Catalysts About Fulcrum Therapeutics Fulcrum Therapeutics is a clinical stage biopharmaceutical company focused on small molecule treatments for genetically defined diseases, with an emphasis on sickle cell disease and hematologic conditions. What are the underlying business or industry changes driving this perspective?
New Narrative • Mar 04
Oral Fetal Hemoglobin Induction Will Reshape Severe Sickle Cell Treatment Over The Long Term
Catalysts About Fulcrum Therapeutics Fulcrum Therapeutics is a clinical stage biopharmaceutical company focused on developing oral fetal hemoglobin inducers for sickle cell disease and other hemoglobinopathies. What are the underlying business or industry changes driving this perspective?Analysis Article • Sep 25
We're Not Very Worried About Fulcrum Therapeutics' (NASDAQ:FULC) Cash Burn Rate
There's no doubt that money can be made by owning shares of unprofitable businesses. For example, Fulcrum Therapeutics...Analysis Article • Apr 04
Fulcrum Therapeutics, Inc.'s (NASDAQ:FULC) Business And Shares Still Trailing The Industry
You may think that with a price-to-sales (or "P/S") ratio of 1.7x Fulcrum Therapeutics, Inc. ( NASDAQ:FULC ) is a stock...Analysis Article • Dec 23
There's Reason For Concern Over Fulcrum Therapeutics, Inc.'s (NASDAQ:FULC) Massive 34% Price Jump
Fulcrum Therapeutics, Inc. ( NASDAQ:FULC ) shareholders have had their patience rewarded with a 34% share price jump in...Analysis Article • Nov 08
We Think Fulcrum Therapeutics (NASDAQ:FULC) Can Easily Afford To Drive Business Growth
We can readily understand why investors are attracted to unprofitable companies. For example, biotech and mining...Analysis Article • Sep 13
Some Confidence Is Lacking In Fulcrum Therapeutics, Inc. (NASDAQ:FULC) As Shares Slide 62%
Fulcrum Therapeutics, Inc. ( NASDAQ:FULC ) shareholders that were waiting for something to happen have been dealt a...Seeking Alpha • Sep 12
Fulcrum Therapeutics: Tough Day As Losmapimod FSHD Phase 3 Misses Badly
Summary Fulcrum Therapeutics, Inc.'s stock plummeted over 60% after its lead candidate, losmapimod, failed to meet primary and secondary endpoints in a Phase 3 study for FSHD. Despite prior optimism and significant investments from Sanofi and positive analyst ratings, the REACH trial's results were disappointing, leading to the suspension of the losmapimod program. Fulcrum's management, facing leadership changes and a challenging market, will now focus on its other clinical-stage candidate, pociredir, for sickle cell disease. With a market cap of $550m and nearly $300m in cash, the future value of Fulcrum's pipeline remains uncertain amidst intense competition. Read the full article on Seeking AlphaAnalysis Article • Jul 12
Will Fulcrum Therapeutics (NASDAQ:FULC) Spend Its Cash Wisely?
Just because a business does not make any money, does not mean that the stock will go down. By way of example, Fulcrum...Analysis Article • Feb 11
Fulcrum Therapeutics (NASDAQ:FULC) Is In A Good Position To Deliver On Growth Plans
We can readily understand why investors are attracted to unprofitable companies. For example, although Amazon.com made...Analysis Article • Oct 28
We Think Fulcrum Therapeutics (NASDAQ:FULC) Needs To Drive Business Growth Carefully
There's no doubt that money can be made by owning shares of unprofitable businesses. For example, although Amazon.com...Analysis Article • Jul 11
We Think Fulcrum Therapeutics (NASDAQ:FULC) Needs To Drive Business Growth Carefully
There's no doubt that money can be made by owning shares of unprofitable businesses. For example, although Amazon.com...Analysis Article • Nov 17
What You Need To Know About The Fulcrum Therapeutics, Inc. (NASDAQ:FULC) Analyst Downgrade Today
The latest analyst coverage could presage a bad day for Fulcrum Therapeutics, Inc. ( NASDAQ:FULC ), with the analysts...Analysis Article • Oct 18
We're Keeping An Eye On Fulcrum Therapeutics' (NASDAQ:FULC) Cash Burn Rate
Even when a business is losing money, it's possible for shareholders to make money if they buy a good business at the...Analysis Article • Aug 13
Newsflash: Fulcrum Therapeutics, Inc. (NASDAQ:FULC) Analysts Have Been Trimming Their Revenue Forecasts
Today is shaping up negative for Fulcrum Therapeutics, Inc. ( NASDAQ:FULC ) shareholders, with the analysts delivering...Seeking Alpha • Aug 11
Fulcrum Therapeutics GAAP EPS of -$0.83 misses by $0.17, revenue of $1.9M misses by $1.06M
Fulcrum Therapeutics press release (NASDAQ:FULC): Q2 GAAP EPS of -$0.83 misses by $0.17. Revenue of $1.9M (-56.6% Y/Y) misses by $1.06M. As of June 30, 2022, cash, cash equivalents, and marketable securities were $169.0M, as compared to $218.2M as of December 31, 2021. Based on current operating plans, including successful implementation of the operational realignment, Fulcrum expects that its existing cash, cash equivalents, and marketable securities will be sufficient to enable it to fund its operating expenses and capital expenditure requirements into mid-2024.Seeking Alpha • Jul 11
Fulcrum Therapeutics says chief medical officer Christopher Morabito to leave
Fulcrum Therapeutics (NASDAQ:FULC) on Monday said its chief medical officer Christopher Morabito will be leaving the company effective July 13. FULC said its R&D president Judith Dunn will be the interim chief medical officer while the company searches for a new executive. FULC said Dunn had assumed direct oversight of all clinical activities and related functions. Prior to joining Fulcrum (FULC), Dunn had held multiple leadership positions including leading global clinical development for Roche (OTCQX:RHHBY) (OTCQX:RHHBF). FULC stock earlier closed -4.1% at $5.69.Seeking Alpha • Jul 05
Fulcrum begins dosing in late-stage study of losmapimod for rare muscle disorder
Fulcrum Therapeutics (NASDAQ:FULC) said the first patient was dosed in a phase 3 trial of losmapimod to treat Facioscapulohumeral Muscular Dystrophy (FSHD). FSHD is a rare progressive disorder characterized by muscle weakness and wasting and initially affects the face, shoulder blades and upper arms. The study, dubbed REACH, will enroll ~230 adults at over 30 sites in North America and Europe and evaluate losmapimod, given orally as a 15-mg tablet twice a day, against placebo. The company said that a phase 2 trial, called ReDUX4, showed that losmapimod was superior to placebo and slowed disease progression and helped maintain function in adults with FSHD.Seeking Alpha • Jun 27
Fulcrum Therapeutics: Value Loss On SCD Data Update Is Telling
Fulcrum lost hugely this month after announcing data from an early Sickle Cell Disease trial. The other program is also beset with issues. This does not look attractive to us right now.CEO Compensation Analysis
| Date | Total Compensation | Salary | Company Earnings |
|---|---|---|---|
| Mar 31 2026 | n/a | n/a | -US$76m |
| Dec 31 2025 | US$3m | US$650k | -US$75m |
| Sep 30 2025 | n/a | n/a | -US$71m |
| Jun 30 2025 | n/a | n/a | -US$73m |
| Mar 31 2025 | n/a | n/a | -US$510k |
| Dec 31 2024 | US$1m | US$650k | -US$10m |
| Sep 30 2024 | n/a | n/a | -US$18m |
| Jun 30 2024 | n/a | n/a | -US$20m |
| Mar 31 2024 | n/a | n/a | -US$99m |
| Dec 31 2023 | US$7m | US$369k | -US$97m |
Compensation vs Market: Alex's total compensation ($USD3.25M) is above average for companies of similar size in the US market ($USD1.64M).
Compensation vs Earnings: Alex's compensation has increased whilst the company is unprofitable.
CEO
Alex Sapir (59 yo)
2.9yrs
Tenure
US$3,251,490
Compensation
Mr. Alexander C. Sapir, also known as Alex, serves as Chief Executive Officer, President and Director at Fulcrum Therapeutics, Inc. since July 01, 2023. Mr. Sapir has been Director at PhaseBio Pharmaceutic...
Leadership Team
| Name | Position | Tenure | Compensation | Ownership |
|---|---|---|---|---|
| CEO, President & Director | 2.9yrs | US$3.25m | 0.30% $ 693.2k | |
| Chief Financial Officer | 2.8yrs | US$1.81m | 0% $ 0 | |
| Chief Legal Officer | 5.6yrs | US$1.48m | 0.015% $ 35.4k | |
| Founder | no data | no data | no data | |
| Founder | no data | no data | no data | |
| Founder | no data | no data | no data | |
| Founder | no data | no data | no data | |
| Founder | no data | no data | no data | |
| Chief Scientific Officer | 3.6yrs | no data | no data | |
| Chief People Officer | 5.6yrs | no data | no data | |
| Senior Vice President of Early Development | 3.3yrs | no data | no data | |
| Head of Program Strategy & Vice President | 1yr | no data | no data |
3.3yrs
Average Tenure
63yo
Average Age
Experienced Management: FULC's management team is considered experienced (3.3 years average tenure).
Board Members
| Name | Position | Tenure | Compensation | Ownership |
|---|---|---|---|---|
| CEO, President & Director | 2.9yrs | US$3.25m | 0.30% $ 693.2k | |
| Independent Director | 9.9yrs | US$274.91k | 0.14% $ 313.0k | |
| Independent Director | 1.6yrs | US$265.77k | 0% $ 0 | |
| Member of Scientific Advisory Board | no data | no data | no data | |
| Independent Director | 6.4yrs | US$279.41k | 0% $ 0 | |
| Member of Scientific Advisory Board | no data | no data | no data | |
| Director | 9.9yrs | US$269.41k | 0.68% $ 1.6m | |
| Independent Director | 9.5yrs | US$273.05k | 0.043% $ 99.8k | |
| Independent Chair of the Board | 8yrs | US$300.91k | 0% $ 0 | |
| Member of FSHD Clinical Advisory Board | no data | no data | no data | |
| Member of FSHD Clinical Advisory Board | no data | no data | no data | |
| Member of FSHD Clinical Advisory Board | no data | no data | no data |
8.0yrs
Average Tenure
68yo
Average Age
Experienced Board: FULC's board of directors are considered experienced (8 years average tenure).
Company Analysis and Financial Data Status
| Data | Last Updated (UTC time) |
|---|---|
| Company Analysis | 2026/06/16 01:21 |
| End of Day Share Price | 2026/06/15 00:00 |
| Earnings | 2026/03/31 |
| Annual Earnings | 2025/12/31 |
Data Sources
The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.
| Package | Data | Timeframe | Example US Source * |
|---|---|---|---|
| Company Financials | 10 years |
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| Analyst Consensus Estimates | +3 years |
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| Market Prices | 30 years |
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| Ownership | 10 years |
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| Management | 10 years |
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| Key Developments | 10 years |
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* Example for US securities, for non-US equivalent regulatory forms and sources are used.
Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more.
Analysis Model and Snowflake
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Industry and Sector Metrics
Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on Github.
Analyst Sources
Fulcrum Therapeutics, Inc. is covered by 16 analysts. 9 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.
| Analyst | Institution |
|---|---|
| Tazeen Ahmad | BofA Global Research |
| Dae Gon Ha | BTIG |
| Kristen Kluska | Cantor Fitzgerald & Co. |