Stock Analysis

CRISPR Therapeutics (CRSP): Evaluating Its Valuation as Shares Attract Fresh Attention

CRISPR Therapeutics (CRSP) just delivered another move that has investors paying attention. There is no blockbuster news behind this latest shift, but the uptick in daily and weekly returns could have those watching from the sidelines asking if the market is signaling something beneath the surface. With the biotech sector known for rapid swings in sentiment, any fresh momentum in a stock like CRSP is enough to make both bulls and bears wonder what is coming next. Stepping back, CRISPR Therapeutics has seen a mixed year overall. While the stock is up a steady 15% over the past year and nearly 36% over the past three months, it is still working its way back from longer-term declines. Returns are negative over the past three and five years. Recent weeks have seen a small pullback, but the bigger picture shows a company shaking off some of the hesitation that has weighed on it in years past. After this year’s climb, is CRISPR Therapeutics still flying under Wall Street’s radar, or has the market already priced in all the upside for this gene-editing pioneer?
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Price-to-Book of 3x: Is it justified?

CRISPR Therapeutics is currently trading at a price-to-book (P/B) ratio of 3, which is above the US Biotechs industry average of 2.2 but below the peer average of 5.4. This suggests the stock is valued higher than many industry peers on a book value basis, yet offers relative value compared to other top names in the field.

The price-to-book ratio compares a company's market value to its book value, indicating how much investors are willing to pay for each dollar of net asset value. For biotech firms like CRISPR Therapeutics, which typically invest heavily in research while remaining unprofitable, the P/B ratio can signal the market’s expectations for future breakthroughs and long-term growth potential.

While the company appears expensive next to the industry average, its valuation is more favorable when compared to similar innovative firms. This pricing may reflect the anticipation of strong revenue growth and pipeline progress, even as current earnings remain negative.

Result: Fair Value of $143.16 (UNDERVALUED)

See our latest analysis for CRISPR Therapeutics.

However, risks such as volatile revenue growth and persistent net losses could quickly shift perceptions. This may make future gains less certain for CRISPR Therapeutics.

Find out about the key risks to this CRISPR Therapeutics narrative.

Another View: SWS DCF Model

Looking from the perspective of our DCF model, the outlook shifts. This approach suggests the stock may actually be undervalued. This adds another layer to the debate. Which valuation do you trust more?

Look into how the SWS DCF model arrives at its fair value.
CRSP Discounted Cash Flow as at Sep 2025
CRSP Discounted Cash Flow as at Sep 2025
Stay updated when valuation signals shift by adding CRISPR Therapeutics to your watchlist or portfolio. Alternatively, explore our screener to discover other companies that fit your criteria.

Build Your Own CRISPR Therapeutics Narrative

If you see the numbers differently or want to follow your own path, you can start building your own view in just a few minutes. Do it your way

A great starting point for your CRISPR Therapeutics research is our analysis highlighting 2 key rewards and 1 important warning sign that could impact your investment decision.

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This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

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