Stock Analysis

AstraZeneca (LSE:AZN): Assessing Valuation After Recent Share Price Fluctuation

It’s not every day that AstraZeneca (LSE:AZN) catches the eye with a sudden swing in its share price. The recent move has investors double-checking what, if anything, has changed beneath the surface. Without a press-grabbing headline or blockbuster event to point to, this development naturally raises the question: is this just noise or could it be the market’s early signal of a shift in expectations for AstraZeneca’s future? Looking at the bigger picture, the past year has been something of a mixed bag for AstraZeneca. After delivering a steady climb over previous years, with a 20% gain across three, the stock has slipped about 2% in the last year while it is up roughly 7% year to date. Recent momentum has been positive over the last three months, even as the longer-term performance has lost some steam. That said, annual revenue and earnings both show meaningful growth, so fundamentals may not be the main question for investors right now. With a modest rally in recent months, the key question for investors is whether there is value now or if the stock is already reflecting everything that is coming down the pipeline.
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Most Popular Narrative: 15% Undervalued

According to the most widely followed narrative, AstraZeneca shares are currently undervalued by 15%, with analysts seeing strong upside driven by pipeline progress and expansion into new markets. The narrative's fair value estimate uses a discount rate of 6.8%.

"The company's robust and diversified late-stage pipeline, particularly in oncology, rare diseases, and cardiovascular/metabolic therapies, is set to deliver multiple blockbuster launches over the next several years. Management estimates these new medicines could generate $10+ billion in peak risk-adjusted revenue, directly supporting both long-term high-margin revenue growth and future earnings expansion."

Want to know why analysts think AstraZeneca is so undervalued? The story hinges on some bold revenue and profit forecasts built on a pipeline unlike any in recent memory. Is the projected growth really enough to justify today’s valuation? Surprising financial assumptions are driving this target; see the numbers powering this upbeat outlook.

Result: Fair Value of $134.64 (UNDERVALUED)

Have a read of the narrative in full and understand what's behind the forecasts.

However, execution missteps in new drug launches or tighter price controls in key markets could quickly undercut AstraZeneca’s expected growth story.

Find out about the key risks to this AstraZeneca narrative.

Another View: What Does the Market Multiple Say?

While the narrative and fair value calculation suggest upside, looking at market pricing from a different perspective offers an alternative view. Compared to the industry average, AstraZeneca appears expensive by this measure. Could it be that the market knows something the models miss?

See what the numbers say about this price — find out in our valuation breakdown.

LSE:AZN PE Ratio as at Sep 2025
LSE:AZN PE Ratio as at Sep 2025

Stay updated when valuation signals shift by adding AstraZeneca to your watchlist or portfolio. Alternatively, explore our screener to discover other companies that fit your criteria.

Build Your Own AstraZeneca Narrative

If this perspective does not quite align with your own, or you would rather dig into the details firsthand, you can shape your own take on AstraZeneca in under three minutes by using the following resource: Do it your way.

A great starting point for your AstraZeneca research is our analysis highlighting 3 key rewards and 3 important warning signs that could impact your investment decision.

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This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

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