공시 • Jul 31
Cytosorbents Leads A New Era in Sepsis Treatment
CytoSorbents Corporation announced new studies that demonstrate the vital and evolving role of CytoSorb® therapy in the treatment of sepsis and septic shock – among the deadliest challenges in critical care medicine. Recent data demonstrate early and intensive use of CytoSorb therapy improves clinical outcomes for patients suffering from these conditions. Today, the Company provides an overview of CytoSorb's unique approach and the evolving data supporting its use, in advance of its September 10, 2025 World Sepsis Day Global Webinar – being held in commemoration of Sepsis Awareness Month and World Sepsis Day in September. Dr. Phillip Chan, MD, PhD, Chief Executive Officer, will host a special presentation with physician-user guests to discuss CytoSorb therapy best practices and its impact in the fight against sepsis. Sepsis is a complex, life-threatening condition where the inflammatory response to a serious infection can spiral out of control, fueled by the excessive production of cytokines (cytokine storm), bacterial toxins, and other inflammatory agents. Left unchecked, this inflammation can lead to septic shock – an often fatal complication marked by circulatory collapse and a lethal drop in blood pressure, the failure of multiple vital organs, and fluid overload – essentially drowning the patient from within. Each year, sepsis and septic shock afflict an estimated 49 million people worldwide, killing 11 million, accounting for up to 20% of all global deaths. Despite decades of effort, standard treatments of septic shock such as antibiotics, fluids, vasopressors, and organ support are often not enough, with mortality rates of 30-50% that can escalate rapidly with multiple organ failure. Survivors often face long-term disability and shorter life spans. The complexity of sepsis has led to the failure of hundreds of therapy candidates and over 100 Phase II and III clinical trials over many decades – underscoring the urgent need for more effective solutions. CytoSorb® is a first-in-class, extracorporeal blood purification therapy approved in the European Union with nearly 300,000 human treatments across more than 70 countries globally. It uses advanced porous polymer beads to remove a wide array of toxic substances directly from the bloodstream, including, for example, inflammatory cytokines and mediators, bacterial toxins, and other damaging molecules that contribute to inflammation, shock, blood vessel damage, and organ injury. However, what sets CytoSorb apart from other approaches, that often simply focus on a single target or pathway, is a comprehensive, multi-faceted approach to the core problems of sepsis and septic shock. Based on a substantial body of published, peer-reviewed literature, CytoSorb can: Control inflammation by reducing cytokine storm and a wide array of other inflammatory mediators such as activated complement, Remove circulating bacterial toxins produced by the active infection that can cause widespread inflammation and tissue damage, Redirect activated immune cells to sites of infection and away from healthy tissues thereby reducing collateral damage, Reverse shock and restore natural blood pressure, reducing the need for vasopressors and restoring oxygenated blood flow to vital organs, Improve microcirculation among small blood vessels, improving oxygen delivery to tissues and organs like the kidney and reducing lactic acidosis – an independent risk factor of mortality, Protect blood vessels and promote reversal of leaky blood vessels (capillary leak) by binding and removing numerous toxic substances in the blood that damage or kill the endothelial cells lining the blood vessel wall, Remove excessive fluid and improve fluid balance once capillary leak is resolved, Improve lung function and reduce time on mechanical support such as mechanical ventilation and extracorporeal membrane oxygenation (ECMO), Prevent and treat sepsis-associated acute kidney injury, key to maintaining the ability to remove excessive fluid, maintain proper acid base balance, and eliminate toxic metabolic wastes, Remove liver toxins and support liver dysfunction that is common in sepsis. This broad-spectrum approach helps to support five essential treatment goals of CytoSorb in septic shock: Break the vicious cycle of uncontrolled inflammation, Reverse shock and restore oxygenated blood flow, Promote the repair of leaky blood vessels, Actively remove excessive fluid and reduce fluid overload in organs. Prevent or treat multiple organ failureLike antibiotics, CytoSorb works best when used early, intensively, and at the right dose – the foundation of the Company's "Right patient, Right Timing, Right Dosing" educational campaign. Positive Clinical Results Backing Early and Intensive CytoSorb Use: CytoSorbents' clinical impact is supported by hundreds of peer-reviewed publications in many different clinical applications such as sepsis, including data from the COVID-19 pandemic, where CytoSorb was granted U.S.FDA Emergency Use Authorization in critically ill COVID-19 patients with respiratory failure. In the 100-patient, multi-center registry of U.S. COVID-19 patients on CytoSorb and ECMO, published in the journal Critical Care (2023), where all had refractory respiratory failure and sepsis with 76% in septic shock, Hayanga and colleagues reported 74% 90-day survival, that rose to 82% in those treated early. This significantly outperformed published U.S. survival benchmarks of approximately 50% when CytoSorb was not used. A separate, retrospective study of 175 septic shock patients recently published by Berlot and team in the Journal of Intensive Care Medicine (2025) demonstrated that early and intensive CytoSorb use (=3 cartridges within 2–3 days) nearly doubled survival rates (70% observed vs. 37% predicted), with strong correlations between clinical benefit and treatment intensity. The study also corroborated the findings of another 75 septic shock patient retrospective study published by Schultz, et al. (2021) in the Journal of Critical Care that correlated survival with higher volumes of blood treated, highlighting that duration of treatment is critically important.