お知らせ • Sep 04
Quest Diagnostics Launches Advanced Pharmacogenomics Offering
Quest Diagnostics announced an advanced pharmacogenomic (PGx) laboratory test service designed to help providers understand the patient's individual genetic response to select drug therapies. This innovative offering aims to help providers determine appropriate medication on selection and dosing. It utilizes PGx information across a wide range of medical specialties including psychiatry, neurology, cardiology, oncology, rheumatology, pain management, and the transplant recipient space. Research has shown that PGx testing may have great potential to prevent therapeutic failure and Adverse Drug Interactions (ADIs), and can help avoid unnecessary drug costs, as well as the costs associated with the management of drug-related complications1. The Quest PGx offering includes 17 genes and 4 HLA alleles, encompassing genes with recognized evidence of gene-drug associations and defined medical utility. These genes possess clinically actionable pharmacogenetic associations informed by expert groups like Clinical Pharmacogenetics Implementation Consortium (CPIC), the Food and Drug Administration (FDA), and ClinPGx to offer a select spectrum of insights in a single test. The offering includes a Quest-delivered report with genotype (diplotye) and predicted phenotypic response, alongside vital medication guidance via a link to a personalized report powered by Coriell Life Sciences (now InformedDNA®?). Clinicians will also have direct access to GeneDose LIVE, CLS's clinical decision support tool that healthcare providers can use to conduct a comprehensive evaluation of the patient's therapeutic regimen, assessing each medication for genetic and non-genetic risks in the context of all other prescribed therapies. The full report is based on current, evidence-based gene-drug associations, providing dynamic and actionable recommendations. Patients can access testing by presenting a requisition (test order) from their doctor at one of Quest's 2,000 patient service centers across the United States. Quest is also offering convenient home collection services via its at-home phlebotomy collection, for when scheduling, distance, or other barriers make in-office testing difficult. About PGx Testing: Variations in drug-metabolizing enzymes, drug-target proteins, and drug transporters can influence a patient's drug response. These variations may cause a patient to metabolize a drug too quickly, too slowly, or not at all, potentially leading to treatment failure or Adverse Drug Interactions (ADIs), which according to research is the fourth leading cause of death in the United States.2 By leveraging genetic insights, PGx testing can help providers tailor therapeutic regimes to individual genetic profiles, supporting safer, more effective prescribing decisions. This powerful combination brings together InformedDNA's deep genetics expertise and innovative technology with Coriell Life Science's scientific innovation in pharmacogenomics. Together, the company's diagnostic insights reveal new avenues to identify and treat disease, inspire healthy behaviors and improve healthcare management. Quest Diagnostics annually serves one in three adult Americans and half the physicians and hospitals in the United States, and more than 55,000 employees understand that, in the right hands and with the right context, the company diagnostic insights can inspire actions that transform lives and create a healthier world. Preventable adverse drug reactions: A focus on drug reactions: A focus on Drug Interactions (CPIC), the food and Drug Administration (FDA"), and ClinPGx to offer an select spectrum of insights in a select spectrum of insights in an single test.