Karyopharm Therapeutics (KPTI) Resumen de Acciones
Karyopharm Therapeutics Inc, empresa farmacéutica en fase comercial, descubre, desarrolla y comercializa en Estados Unidos fármacos dirigidos contra la exportación nuclear para el tratamiento del cáncer y otras enfermedades. Saber más
| Puntuación del snowflake | |
|---|---|
| Valoración | 4/6 |
| Crecimiento futuro | 2/6 |
| Rendimiento pasado | 0/6 |
| Salud financiera | 2/6 |
| Dividendos | 0/6 |
Recompensas
Análisis de riesgos
KPTI Community Fair Values
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Analyst Price Targets
Competidores de Karyopharm Therapeutics Inc.
Historial de precios y rendimiento
| Precios históricos de las acciones | |
|---|---|
| Precio actual de la acción | US$7.41 |
| Máximo en las últimas 52 semanas | US$10.99 |
| Mínimo de 52 semanas | US$3.65 |
| Beta | 0.81 |
| Cambio en 1 mes | -27.42% |
| Variación en 3 meses | -13.84% |
| Cambio de 1 año | 69.57% |
| Variación en 3 años | -72.56% |
| Variación en 5 años | -94.13% |
| Variación desde la OPV | -96.92% |
Noticias y actualizaciones recientes
Actualización de narrativa • Jul 22
KPTI: Reset Expectations And Misunderstood Compensation Plan Will Support Bullish Repricing
Karyopharm Therapeutics' updated analyst price target of $16, reduced from $23, reflects a reset in fair value assumptions along with revised expectations for revenue growth, profit margins, and future P/E. Analysts point to recent stock weakness around the compensation plan as a potential misread rather than a change in the underlying story.Seeking Alpha • Jul 21
Karyopharm Therapeutics: Balance Sheet Poor But Catalysts Ahead
Summary Karyopharm Therapeutics markets Xpovio (selinexor) in multiple myeloma and is running trials in multiple myeloma, myelofibrosis, and endometrial cancer, with key clinical catalysts ahead. The SENTRY trial in myelofibrosis patients showed mixed results on the co-primary endpoints, but a preliminary survival benefit may strengthen with mature data. Prior SIENDO trial data in endometrial cancer revealed a potential benefit for selinexor in certain subgroups, supporting the upcoming XPORT-EC-042 readout. KPTI faces cash burn and debt concerns, but positive trial results and potential treatment guideline inclusion for selinexor in myelofibrosis could provide it with strategic options. Read the full article on Seeking Alpha
Actualización de narrativa • Jul 08
KPTI: Elevated Expectations For 2026 Revenue Will Likely Constrain Future Upside
Analysts have raised their fair value estimate for Karyopharm Therapeutics from $5.00 to $7.31, citing updated assumptions about discount rates, revenue growth, profit margins, and future P/E, which are reflected in recent price target increases from the Street. Analyst Commentary Recent Street research on Karyopharm Therapeutics highlights a mix of optimism around the company’s potential and caution around how that potential is reflected in the stock price.
Actualización de narrativa • Jun 24
KPTI: Phase 3 Myelofibrosis Data Will Shape 2026 Risk Reward Profile
Analysts have adjusted their outlook on Karyopharm Therapeutics with a revised consensus price target, reflecting shifts in recent $5 and $8 upward revisions and $7 and $4 downward revisions as they reassess the company's risk profile and long term earnings potential. Analyst Commentary Recent Street research on Karyopharm Therapeutics shows a split view, with some firms revising price targets upward and others marking them down.Actualización de narrativa • Jun 07
KPTI: Phase 3 Myelofibrosis Data Will Drive 2026 Frontline Opportunity
Analysts have revised their price target on Karyopharm Therapeutics, citing updated views on fair value, growth, and profitability assumptions. The new target is $13.50, compared with the prior $15.33.Recent updates
Actualización de narrativa • Jul 22
KPTI: Reset Expectations And Misunderstood Compensation Plan Will Support Bullish Repricing
Karyopharm Therapeutics' updated analyst price target of $16, reduced from $23, reflects a reset in fair value assumptions along with revised expectations for revenue growth, profit margins, and future P/E. Analysts point to recent stock weakness around the compensation plan as a potential misread rather than a change in the underlying story.Seeking Alpha • Jul 21
Karyopharm Therapeutics: Balance Sheet Poor But Catalysts Ahead
Summary Karyopharm Therapeutics markets Xpovio (selinexor) in multiple myeloma and is running trials in multiple myeloma, myelofibrosis, and endometrial cancer, with key clinical catalysts ahead. The SENTRY trial in myelofibrosis patients showed mixed results on the co-primary endpoints, but a preliminary survival benefit may strengthen with mature data. Prior SIENDO trial data in endometrial cancer revealed a potential benefit for selinexor in certain subgroups, supporting the upcoming XPORT-EC-042 readout. KPTI faces cash burn and debt concerns, but positive trial results and potential treatment guideline inclusion for selinexor in myelofibrosis could provide it with strategic options. Read the full article on Seeking AlphaActualización de narrativa • Jul 08
KPTI: Elevated Expectations For 2026 Revenue Will Likely Constrain Future Upside
Analysts have raised their fair value estimate for Karyopharm Therapeutics from $5.00 to $7.31, citing updated assumptions about discount rates, revenue growth, profit margins, and future P/E, which are reflected in recent price target increases from the Street. Analyst Commentary Recent Street research on Karyopharm Therapeutics highlights a mix of optimism around the company’s potential and caution around how that potential is reflected in the stock price.Actualización de narrativa • Jun 24
KPTI: Phase 3 Myelofibrosis Data Will Shape 2026 Risk Reward Profile
Analysts have adjusted their outlook on Karyopharm Therapeutics with a revised consensus price target, reflecting shifts in recent $5 and $8 upward revisions and $7 and $4 downward revisions as they reassess the company's risk profile and long term earnings potential. Analyst Commentary Recent Street research on Karyopharm Therapeutics shows a split view, with some firms revising price targets upward and others marking them down.Actualización de narrativa • Jun 07
KPTI: Phase 3 Myelofibrosis Data Will Drive 2026 Frontline Opportunity
Analysts have revised their price target on Karyopharm Therapeutics, citing updated views on fair value, growth, and profitability assumptions. The new target is $13.50, compared with the prior $15.33.Actualización de narrativa • May 03
KPTI: Selinexor Commercialization And Funding Pressures Will Likely Constrain Future Upside
Analyst price targets for Karyopharm Therapeutics have shifted, with recent cuts and a subsequent $8 increase tied to reassessments of revenue potential, profit margins and future P/E assumptions around selinexor and the broader pipeline. Analyst Commentary Recent Street research on Karyopharm Therapeutics shows a mixed picture, with one price target increase following several cuts over a relatively short window.Actualización de narrativa • Apr 19
KPTI: Funding Uncertainty And Execution Risks Will Likely Cap Future Returns
Analysts have trimmed their average price target on Karyopharm Therapeutics by several dollars, citing updated views on discount rates, revenue assumptions and long term profit margins following recent Street research. Analyst Commentary Recent Street research shows several bearish analysts cutting their Karyopharm price targets by mid single digit to high single digit dollar amounts, pointing to revised assumptions on discount rates, revenue potential and long term margins.Actualización de narrativa • Apr 04
KPTI: Funding Strains And Execution Risks Will Likely Restrain Future Upside
The Street’s blended fair value estimate for Karyopharm has been trimmed by $1.00 to $5.00, as analysts fold in lower projected revenue growth, a slightly softer profit margin outlook, a higher discount rate, and updated P/E assumptions following recent target cuts from multiple firms. Analyst Commentary Recent Street research has tilted more cautious on Karyopharm, with multiple bearish analysts cutting price targets and reassessing the risk profile around execution, profitability, and the timing and scale of future revenue contributions.Actualización de narrativa • Mar 21
KPTI: Phase 1 Myelofibrosis Data Will Support 2026 Frontline Opportunity
Analysts have adjusted their price target for Karyopharm Therapeutics to $28, citing confidence in selinexor's differentiated mechanism of action, compelling Phase 1 data in myelofibrosis, and a projected peak revenue opportunity of $800m to $850m in frontline myelofibrosis, with further potential from multiple myeloma programs. Analyst Commentary Bullish Takeaways Bullish analysts see selinexor's differentiated mechanism of action as a key driver for long term value, supporting the $28 price target as they factor in a distinct clinical profile within myelofibrosis.Actualización de narrativa • Mar 07
KPTI: Refreshed Revenue And Margin Outlook Will Support Bullish Repricing
Analysts have updated their price target on Karyopharm Therapeutics from $66.25 to $23.00, citing refreshed assumptions around revenue growth, profit margins, discount rate, and future P/E following recent bullish Street research. Analyst Commentary Bullish analysts are framing the reset in price target to $23.00 as part of a broader constructive view on Karyopharm Therapeutics, where refreshed modeling assumptions are more closely aligned with recent positive Street research.Actualización de narrativa • Feb 20
KPTI: Execution And Funding Risks Will Likely Cap Bullish Repricing
Analysts have raised their $6.00 price target for Karyopharm Therapeutics, citing slightly lower perceived risk, a modestly stronger revenue outlook, and a small increase in the expected future P/E as the key factors behind the update. Analyst Commentary Recent research commentary around Karyopharm Therapeutics has centered on how much risk investors should assign to the story, how sustainable the current revenue trajectory may be, and what a reasonable P/E might look like given execution needs ahead.Actualización de narrativa • Feb 06
KPTI: Lower Risk View Will Support 2026 Myelofibrosis Phase III Milestone
Analysts have modestly raised their price target on Karyopharm Therapeutics to US$15.33, citing a slightly lower required return and similar long term growth and margin assumptions that keep the fair value estimate steady. Analyst Commentary Recent Street research has focused on how the updated price target for Karyopharm Therapeutics lines up with its risk profile and execution needs, rather than materially changing long term growth or margin assumptions.Actualización de narrativa • Jan 23
KPTI: Extended Cash Runway Will Support 2026 Myelofibrosis Phase III Milestone
Narrative update on Karyopharm Therapeutics Analysts have nudged their fair value estimate for Karyopharm Therapeutics higher from US$14.67 to US$15.33, citing recent Street research that points to steady Xpovio sales, reduced financing overhangs, maintained MF timelines into March 2026, and updated price targets that reflect the latest financing transactions. Analyst Commentary Recent Street research highlights a mix of optimism around execution and caution around financing and valuation as analysts update their views on Karyopharm Therapeutics.Artículo de análisis • Jan 11
Karyopharm Therapeutics Inc.'s (NASDAQ:KPTI) Prospects Need A Boost To Lift Shares
You may think that with a price-to-sales (or "P/S") ratio of 1.1x Karyopharm Therapeutics Inc. ( NASDAQ:KPTI ) is...Actualización de narrativa • Jan 09
KPTI: Financing Overhangs Will Likely Outweigh MF Timeline Support
Analysts have trimmed their 12 month price target on Karyopharm Therapeutics to US$19 from US$30, citing recent financing transactions. They also point to solid Xpovio sales and maintained MF timelines into March 2026 as support for the stock’s overall risk and reward profile.Actualización de narrativa • Dec 25
KPTI Extended Cash Runway Will Likely Be Outweighed By Dilution Risk
Analysts have cut their price target on Karyopharm Therapeutics to about $6 from roughly $8 per share, citing the impact of recent financing transactions on valuation. At the same time, extended cash runway, solid Xpovio sales and visibility into key 2026 myelofibrosis data support a still constructive risk and reward profile.Actualización de narrativa • Dec 11
KPTI: Extended Cash Runway Will Support Pivotal 2026 Myelofibrosis Phase III Readout
Analysts have modestly reduced their price targets on Karyopharm Therapeutics, trimming expectations from a prior average in the low $20s to the high teens. Recent financing transactions extend the cash runway into 2026 and also dilute near term upside, despite a solid outlook for Xpovio sales and key myelofibrosis data in 2026.Actualización de narrativa • Nov 27
KPTI: Extended Cash Runway Will Support Key Myelofibrosis Phase III Data
Analysts have lowered their price targets on Karyopharm Therapeutics, with reductions such as $19 from $30 and $6 from $8. They cite the impact of recent financing transactions while maintaining positive views on the company's risk profile and its cash runway extension, which is expected to support upcoming trial milestones.Actualización de narrativa • Nov 11
KPTI: Upcoming Myelofibrosis Phase III Readout Will Drive Future Opportunity
Karyopharm Therapeutics’ analyst fair value price target has decreased by $1.00 to $14.67. Analysts cite recent financing transactions and updated growth forecasts as key factors behind the revision.Actualización de narrativa • Oct 28
Extended Cash Runway Will Support Pivotal Phase III Clinical Milestones
Karyopharm Therapeutics' analyst price target has been reduced sharply from approximately $23.07 to $15.67 per share. Analysts cite the company’s recent strategic financing measures and updated projections following extended cash runway and upcoming clinical milestones.Actualización de narrativa • Oct 13
Phase III Trials And Global Partnerships Will Advance Personalized Medicine
Karyopharm Therapeutics' analyst price target has been reduced from $8 to $6. This reflects analysts' views that, while strategic financing has extended the company's cash runway into Q2 2026, financial constraints and the timeline to key clinical trial readouts warrant a tempered outlook.Artículo de análisis • Sep 11
Karyopharm Therapeutics Inc. (NASDAQ:KPTI) Held Back By Insufficient Growth Even After Shares Climb 65%
Karyopharm Therapeutics Inc. ( NASDAQ:KPTI ) shares have had a really impressive month, gaining 65% after a shaky...Actualización de narrativa • Aug 15
Phase III Trials And Global Partnerships Will Advance Personalized Medicine
Karyopharm Therapeutics’ net profit margin has improved and its future P/E has declined—indicating stronger profitability and a more attractive valuation—while the consensus analyst price target remains unchanged at $25.92. What's in the News Provided 2025 earnings guidance, expecting total revenue between $140 million and $155 million, including U.S. XPOVIO net product and partner-derived revenue.Artículo de análisis • Aug 14
US$25.92: That's What Analysts Think Karyopharm Therapeutics Inc. (NASDAQ:KPTI) Is Worth After Its Latest Results
NasdaqGS:KPTI 1 Year Share Price vs Fair Value Explore Karyopharm Therapeutics's Fair Values from the Community and...Artículo de análisis • May 24
Investors Don't See Light At End Of Karyopharm Therapeutics Inc.'s (NASDAQ:KPTI) Tunnel And Push Stock Down 27%
Unfortunately for some shareholders, the Karyopharm Therapeutics Inc. ( NASDAQ:KPTI ) share price has dived 27% in the...Artículo de análisis • May 22
Here's Why Shareholders May Want To Be Cautious With Increasing Karyopharm Therapeutics Inc.'s (NASDAQ:KPTI) CEO Pay Packet
Key Insights Karyopharm Therapeutics' Annual General Meeting to take place on 28th of May CEO Richard Paulson's total...
Nueva narrativa • Apr 08
Phase III SENTRY And XPOVIO Approvals Will Secure Future Success
Positive trial outcomes in myelofibrosis and endometrial cancer could significantly boost revenue and redefine care standards.Artículo de análisis • Dec 24
Lacklustre Performance Is Driving Karyopharm Therapeutics Inc.'s (NASDAQ:KPTI) 27% Price Drop
Karyopharm Therapeutics Inc. ( NASDAQ:KPTI ) shareholders won't be pleased to see that the share price has had a very...Artículo de análisis • Oct 01
Why Investors Shouldn't Be Surprised By Karyopharm Therapeutics Inc.'s (NASDAQ:KPTI) Low P/S
You may think that with a price-to-sales (or "P/S") ratio of 0.7x Karyopharm Therapeutics Inc. ( NASDAQ:KPTI ) is...Rentabilidad de los accionistas
| KPTI | US Biotechs | Mercado US | |
|---|---|---|---|
| 7D | -0.8% | -1.3% | -1.0% |
| 1Y | 69.6% | 29.0% | 14.7% |
Rentabilidad vs. Industria: KPTI superó a la industria US Biotechs, que obtuvo un rendimiento del 29% el año pasado.
Rentabilidad vs. Mercado: KPTI superó al mercado US, que obtuvo un rendimiento del 14.7% el año pasado.
Volatilidad de los precios
| KPTI volatility | |
|---|---|
| KPTI Average Weekly Movement | 11.8% |
| Biotechs Industry Average Movement | 10.1% |
| Market Average Movement | 7.1% |
| 10% most volatile stocks in US Market | 16.0% |
| 10% least volatile stocks in US Market | 3.2% |
Precio estable de las acciones: El precio de las acciones de KPTI ha sido volátil durante los últimos 3 meses en comparación con el mercado US.
Volatilidad a lo largo del tiempo: La volatilidad semanal de KPTI(12%) se ha mantenido estable durante el último año, pero sigue siendo superior al 75% de las acciones de US.
Acerca de la empresa
| Fundada | Empleados | CEO | Página web |
|---|---|---|---|
| 2008 | 228 | Richard Paulson | www.karyopharm.com |
Karyopharm Therapeutics Inc, empresa farmacéutica en fase comercial, descubre, desarrolla y comercializa en Estados Unidos fármacos dirigidos contra la exportación nuclear para el tratamiento del cáncer y otras enfermedades. La empresa descubre, desarrolla y comercializa compuestos novedosos y pequeñas moléculas inhibidoras selectivas de la exportación nuclear (SINE) que inhiben la proteína de exportación nuclear exportina 1 (XPO1). Entre sus compuestos principales figuran XPOVIO en combinación con bortezomib y dexametasona para el tratamiento de pacientes adultos con mieloma múltiple; en combinación con dexametasona para el tratamiento de pacientes adultos con mieloma múltiple en recaída o refractario; y para el tratamiento de pacientes adultos con linfoma difuso de células B grandes (LDCBG) en recaída o refractario.
Resumen de fundamentos de Karyopharm Therapeutics Inc.
| Estadísticas fundamentales de KPTI | |
|---|---|
| Capitalización bursátil | US$167.93m |
| Beneficios(TTM) | -US$194.97m |
| Ingresos (TTM) | US$151.12m |
1.1x
Ratio precio-ventas (PS)-0.9x
Ratio precio-beneficio (PE)¿Está KPTI sobrevalorada?
Ver valor justo y análisis de valoraciónBeneficios e Ingresos
| Cuenta de resultados (TTM) de KPTI | |
|---|---|
| Ingresos | US$151.12m |
| Coste de los ingresos | US$130.79m |
| Beneficio bruto | US$20.33m |
| Otros gastos | US$215.30m |
| Beneficios | -US$194.97m |
Últimos beneficios comunicados
Mar 31, 2026
Próxima fecha de beneficios
n/a
| Beneficios por acción (BPA) | -8.60 |
| Margen bruto | 13.45% |
| Margen de beneficio neto | -129.02% |
| Ratio deuda/patrimonio | -111.7% |
¿Cómo se ha desempeñado KPTI a largo plazo?
Ver rendimiento histórico y comparativaAnálisis de la empresa y estado de los datos financieros
| Datos | Última actualización (huso horario UTC) |
|---|---|
| Análisis de la empresa | 2026/07/27 10:19 |
| Precio de las acciones al final del día | 2026/07/24 00:00 |
| Beneficios | 2026/03/31 |
| Ingresos anuales | 2025/12/31 |
Fuentes de datos
Los datos utilizados en nuestro análisis de empresas proceden de S&P Global Market Intelligence LLC. Los siguientes datos se utilizan en nuestro modelo de análisis para generar este informe. Los datos están normalizados, lo que puede introducir un retraso desde que la fuente está disponible.
| Paquete | Datos | Marco temporal | Ejemplo Fuente EE.UU. * |
|---|---|---|---|
| Finanzas de la empresa | 10 años |
| |
| Estimaciones del consenso de analistas | +3 años |
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|
| Precios de mercado | 30 años |
| |
| Propiedad | 10 años |
| |
| Gestión | 10 años |
| |
| Principales avances | 10 años |
|
* Ejemplo para valores de EE.UU., para no EE.UU. se utilizan formularios y fuentes normativas equivalentes.
A menos que se especifique lo contrario, todos los datos financieros se basan en un periodo anual, pero se actualizan trimestralmente. Esto se conoce como datos de los últimos doce meses (TTM) o de los últimos doce meses (LTM). Más información.
Modelo de análisis y copo de nieve
Los detalles del modelo de análisis utilizado para generar este informe están disponibles en nuestra página de Github, también tenemos guías sobre cómo utilizar nuestros informes y tutoriales en Youtube.
Conozca al equipo de talla mundial que diseñó y construyó el modelo de análisis Simply Wall St.
Métricas industriales y sectoriales
Simply Wall St calcula cada 6 horas nuestras métricas sectoriales y de sección. Los detalles de nuestro proceso están disponibles en Github.
Fuentes analistas
Karyopharm Therapeutics Inc. está cubierta por 20 analistas. 6 de esos analistas presentaron las estimaciones de ingresos o ganancias utilizadas como datos para nuestro informe. Las estimaciones de los analistas se actualizan a lo largo del día.
| Analista | Institución |
|---|---|
| Colleen Kusy | Baird |
| Ying Huang | BofA Global Research |
| Harshita Polishetty | B. Riley Securities, Inc. |