U.S. Biotech Breakthroughs

Sierra Oncology

Market Cap: US$1.3b

Sierra Oncology, Inc., a late-stage biopharmaceutical company, engages in researching, developing, and commercializing therapies for the treatment of patients with hematology and oncology needs.

Inovio Pharmaceuticals

Market Cap: US$111.2m

A biotechnology company, focuses on the discovery, development, and commercialization of DNA medicines to treat and protect people from diseases associated with human papillomavirus (HPV), cancer, and infectious diseases.

KalVista Pharmaceuticals

Market Cap: US$839.1m

A biopharmaceutical company, engages in the discovery, development, and commercialization of drug therapies inhibitors for diseases with unmet needs.

Celcuity

Market Cap: US$4.9b

A clinical-stage biotechnology company, focuses on the development of targeted therapies for the treatment of various solid tumors in the United States.

Legend Biotech

Market Cap: US$3.2b

Through its subsidiaries, operates as a biopharmaceutical company that discovers, develops, manufactures, and commercializes novel cell therapies for oncology and other indications in the United States, China, and Europe.

Geron

Market Cap: US$986.4m

A commercial-stage biopharmaceutical company, focuses on the development of therapeutics products for oncology.

GeoVax Labs

Market Cap: US$3.9m

A clinical-stage biotechnology company, develops human vaccines and immunotherapies against infectious diseases and solid tumor cancers using novel proprietary platforms in the United States.

Protagonist Therapeutics

Market Cap: US$6.3b

Operates as a discovery and development company in the United States.

Tonix Pharmaceuticals Holding

Market Cap: US$215.6m

A fully integrated biopharmaceutical company, develops and commercializes therapies for central nervous system (CNS) disorders, immunology and immuno-oncology, infectious diseases, and rare diseases in the United States.

Sangamo Therapeutics

Market Cap: US$124.5m

A clinical-stage genomic medicine company, focuses on translating science into medicines that transform the lives of patients and families afflicted with serious diseases in the United States.

Prothena

Market Cap: US$474.8m

A late-stage clinical biotechnology company, focuses on discovery and development of novel therapies to treat diseases caused by protein dysregulation.

Heron Therapeutics

Market Cap: US$150.8m

A commercial-stage biotechnology company, engages in developing and commercializing therapeutic that enhances medical care.

CareDx

Market Cap: US$899.4m

Provides solutions for improving outcomes for transplant patients and advancing organ health in the United States and internationally.

Caris Life Sciences

Market Cap: US$5.4b

An artificial intelligence TechBio company, provides molecular profiling services in the United States and internationally.

Immunocore Holdings

Market Cap: US$1.5b

Engages in the development and commercialization of immunomodulating medicines for patients with cancer, infectious diseases, and autoimmune disease in the United States, Europe, and internationally.

Candel Therapeutics

Market Cap: US$365.5m

A clinical stage biopharmaceutical company, develops immunotherapies for cancer patients.

Protalix BioTherapeutics

Market Cap: US$171.6m

A biopharmaceutical company, engages in the development, production, and commercialization of recombinant therapeutic proteins based on the ProCellEx plant cell-based protein expression system.

Zymeworks

Market Cap: US$1.8b

A biotechnology company, develops biotherapeutics for the treatment of cancer, inflammation, and autoimmune diseases.

Natera

Market Cap: US$28.4b

A diagnostics company, engages in the development and commercialization of molecular testing services worldwide.