Vertex Pharmaceuticals Incorporated

NasdaqGS:VRTX Stock Report

Market Cap: US$107.7b

Vertex Pharmaceuticals Future Growth

Future criteria checks 2/6

Vertex Pharmaceuticals is forecast to grow earnings and revenue by 13% and 9.8% per annum respectively. EPS is expected to grow by 12.7% per annum. Return on equity is forecast to be 21.4% in 3 years.

Key information

13.0%

Earnings growth rate

12.74%

EPS growth rate

Biotechs earnings growth24.1%
Revenue growth rate9.8%
Future return on equity21.39%
Analyst coverage

Good

Last updated05 May 2026

Recent future growth updates

Recent updates

Vertex Pharmaceuticals Q1 Earnings Review: Pharma May Need Bolder M&A Strategy

May 06

VRTX: CF Base And Nephrology Expansion Will Define Balanced Future Risk Profile

Analysts have inched their average price target for Vertex Pharmaceuticals higher by a few dollars, citing stronger confidence in povetacicept after positive Phase 3 RAINIER data in IgA nephropathy and a broader nephrology pipeline thesis, while keeping valuation assumptions such as P/E and discount rate broadly consistent. Analyst Commentary Recent Street research on Vertex Pharmaceuticals has centered on povetacicept and the nephrology pipeline, with several major firms adjusting their models after the Phase 3 RAINIER interim readout in IgA nephropathy and following Q4 results.

VRTX: CF Franchise And Kidney Pipeline Will Shape Balanced Risk Profile

Vertex Pharmaceuticals' fair value estimate has shifted from $403.80 to $412.49 as analysts refresh models following multiple price target increases tied to positive Phase 3 povetacicept data and a reassessment of the company's nephrology pipeline potential. Analyst Commentary Recent Street research on Vertex Pharmaceuticals has leaned constructive overall, with several firms lifting price targets following the Phase 3 RAINIER interim readout for povetacicept and updating models around the nephrology pipeline.

VRTX: Renal Franchise Progress And CF Leadership Will Drive Future Upside

Vertex Pharmaceuticals' analyst fair value estimate has shifted to $641 from $604. This reflects analysts' updated views on the company's diversified pipeline following positive Phase 3 povetacicept data in IgA nephropathy and a series of higher Street price targets.

VRTX: Renal Trial Success And Nephrology Pipeline Will Drive Next Phase

Vertex Pharmaceuticals' analyst fair value estimate has moved from $504.04 to $547.72. Analysts point to higher modeled revenue growth, slightly stronger profit margins, a richer future P/E assumption, and a wave of Street price target hikes tied to positive povetacicept Phase 3 RAINIER data and the growing nephrology pipeline.

VRTX: CF Dependence Will Heighten Risk Around Upcoming Renal Readouts

Analysts have nudged their target on Vertex Pharmaceuticals higher, with our fair value estimate moving from $401.30 to $403.80. This reflects updated Q4 results, slightly adjusted revenue growth and margin assumptions, and ongoing confidence in the broader pipeline, as seen in a series of recent price target increases across the Street.

Vertex Pharmaceuticals (VRTX): The Diversification Juggernaut – Beyond the CF Monopoly

Vertex Pharmaceuticals (VRTX) has entered a transformative era where its identity is shifting from a "Cystic Fibrosis (CF) company" to a multi-disease powerhouse. Following its Q4 fiscal 2025 earnings report on February 12, 2026 , the stock demonstrated resilience, trading at $495.43 as of February 27.

VRTX: CF Reliance Will Expose Renal Pipeline Execution Risks

Vertex Pharmaceuticals' updated analyst price target reflects an increase of $23.78 to $401.30, as analysts incorporate refreshed Q4 outcomes, pipeline commentary on programs like povetacicept and IgAN, and modest adjustments to assumptions for revenue growth, profit margin, and future P/E. Analyst Commentary Street research around Vertex Pharmaceuticals has been active following the latest Q4 update, with several firms revisiting their models, refreshing pipeline assumptions, and revising price targets.

VRTX: CF Dependence And Pipeline Execution Risks Will Test Bullish Repricing

Analysts have raised their fair value estimate for Vertex Pharmaceuticals by about US$33 to approximately US$378, citing a series of recent rating upgrades and higher price targets linked to its cystic fibrosis franchise and late-stage pipeline potential. Analyst Commentary Recent research on Vertex Pharmaceuticals has been dominated by upgrades and higher price targets, with several firms shifting to more positive ratings and highlighting the cystic fibrosis portfolio and late stage pipeline as key supports for the updated fair value assessments.

VRTX: CF Cash Flows And Renal Data Will Shape Balanced Next Phase

Analysts have nudged their fair value estimate for Vertex Pharmaceuticals higher to about $504, citing a slightly richer assumed future P/E multiple and modestly stronger revenue growth expectations, even as they factor in a lower profit margin and a slightly higher discount rate. Analyst Commentary Recent Street research on Vertex Pharmaceuticals has turned more constructive, with several firms shifting to more positive ratings and setting price targets above the current fair value estimate.

VRTX: CF Durability And Kidney Pipeline Data Will Define Next Phase

Analysts have lifted their Vertex Pharmaceuticals fair value estimate by about US$11 to US$496.16, reflecting updated assumptions on revenue growth, margins and future P/E, as recent research highlights confidence in the durability of its cystic fibrosis franchise and potential upside from its broader pipeline. Analyst Commentary Recent Street research around Vertex Pharmaceuticals points to a generally constructive view, with most commentary focusing on the durability of the cystic fibrosis franchise, the breadth of the pipeline and how these factors feed into valuation targets and rating changes.

VRTX: Cystic Fibrosis And Gene Editing Advances Will Drive Upside Potential

Narrative Update The analyst price target for Vertex Pharmaceuticals has been modestly reduced to about $604 from roughly $616 as analysts factor in a slightly higher discount rate and marginally slower revenue growth, partially offset by improved profitability and a lower assumed future P/E multiple. Analyst Commentary Bullish analysts remain broadly constructive on Vertex Pharmaceuticals, emphasizing durable execution in cystic fibrosis, a deep late stage pipeline, and multiple emerging revenue drivers that, in their view, support premium valuation multiples despite modest target tweaks.

VRTX: Kidney Pipeline And Gene Editing Will Shape Next Phase

The analyst price target for Vertex Pharmaceuticals has been nudged higher to about $485 from roughly $480 as analysts point to a healthier long term earnings profile supported by ongoing strength in the cystic fibrosis franchise, measured diversification investments, and an increasingly innovation focused large cap biopharma setup. Analyst Commentary Recent research updates on Vertex Pharmaceuticals highlight a broadly constructive stance on the name, with most price target changes and rating initiations reinforcing confidence in the company’s growth algorithm and innovation pipeline, even as some voices flag valuation and execution constraints as the franchise matures.

Vertex Pharmaceuticals' (NASDAQ:VRTX) Performance Is Even Better Than Its Earnings Suggest

Nov 11
Vertex Pharmaceuticals' (NASDAQ:VRTX) Performance Is Even Better Than Its Earnings Suggest

Vertex Pharmaceuticals Incorporated's (NASDAQ:VRTX) Popularity With Investors Is Under Threat From Overpricing

Sep 19
Vertex Pharmaceuticals Incorporated's (NASDAQ:VRTX) Popularity With Investors Is Under Threat From Overpricing

Gene Editing And New Therapies Will Transform Global Healthcare

Analysts maintain a cautious-but-constructive stance on Vertex Pharmaceuticals, citing strong CF performance and resilient topline results offset by pipeline setbacks and future revenue concentration risks, with the consensus price target unchanged at $481.04. Analyst Commentary Bullish analysts highlight Vertex’s continued strong execution track record, robust base cystic fibrosis (CF) business, solid Q2 results with topline beats, and a positive long-term growth outlook beyond near-term setbacks.

New ALYFTREK And JOURNAVX Will Expand Patient Access

Vertex is set to drive revenue growth by expanding its drug portfolio, notably with ALYFTREK and JOURNAVX, targeting new patient demographics.

Vertex Pharmaceuticals: A Look At Their Pain Therapy Program

Apr 06

Vertex Pharmaceuticals: Company Passes My Health Check With Flying Colors, Upholding Buy Rating

Mar 06

Vertex Pharma Stock Surges After FDA Approves Non-Opioid Pain Drug

Jan 31

Vertex Therapeutics: The Pain Comes With The Territory For Suzetrigine

Jan 14

Vertex Pharmaceuticals: Jim Cramer Fires A Warning Shot But I Remain Invested

Dec 31

Vertex Pharmaceuticals: Progress Check Suggests Stock Remains A Solid Buy

Dec 11

Vertex Pharma: Why I Am Buying This Dip

Nov 25

Vertex Pharmaceuticals: Strong Execution Continued In Q3 But The Valuation Reflects It

Nov 05

Vertex Pharmaceuticals: The Future Looks Bright, But It May Be A Choppy Ride

Oct 18

Vertex Joined The M&A Craze - Limited Upside Potential (Downgrade)

Oct 10

Investors Are Underestimating The Potential Of Vertex's Non-Addictive Pain Drug

Sep 15

Vertex Pharmaceuticals: Is The Recent Barclays Downgrade Justified? I'm Not Convinced

Sep 05

Vertex Stock: Came For CF Drugs, Staying For Gene Therapy

Aug 02

Earnings and Revenue Growth Forecasts

NasdaqGS:VRTX - Analysts future estimates and past financials data (USD Millions)
DateRevenueEarningsFree Cash FlowCash from OpAvg. No. Analysts
12/31/202815,8725,9815,728N/A23
12/31/202714,2875,0725,145N/A28
12/31/202613,0364,4444,863N/A29
3/31/202612,2184,338N/AN/AN/A
12/31/202512,0013,9533,1943,631N/A
9/30/202511,7233,6753,3373,718N/A
6/30/202511,4193,6383,5003,846N/A
3/31/202511,100-989-1,258-980N/A
12/31/202411,020-536-978-493N/A
9/30/202410,626-480-1,351-843N/A
6/30/202410,337-490-1,426-944N/A
3/31/202410,1854,0193,4793,944N/A
12/31/20239,8693,6203,2793,537N/A
9/30/20239,6543,4704,2054,381N/A
6/30/20239,5053,3653,8794,068N/A
3/31/20239,2083,2603,8904,074N/A
12/31/20228,9313,3223,9254,130N/A
9/30/20228,7013,2733,8144,047N/A
6/30/20228,3503,1953,7874,018N/A
3/31/20227,9482,4512,4512,679N/A
12/31/20217,5742,3422,4092,644N/A
9/30/20217,1302,1761,9192,140N/A
6/30/20216,6841,9921,7772,121N/A
3/31/20216,4152,7623,0483,359N/A
12/31/20206,2062,7122,9943,254N/A
9/30/20205,9912,6912,9793,208N/A
6/30/20205,4032,0812,5572,635N/A
3/31/20204,8191,5111,9832,060N/A
12/31/20194,1631,177N/A1,569N/A
9/30/20193,6202,144N/A1,438N/A
6/30/20193,4542,215N/A1,484N/A
3/31/20193,2652,155N/A1,342N/A
12/31/20183,0482,096N/A1,270N/A
9/30/20182,829647N/A1,183N/A
6/30/20182,623415N/A972N/A
3/31/20182,415226N/A832N/A
12/31/20172,489263N/A845N/A
9/30/20172,296196N/A762N/A
6/30/20172,131259N/A658N/A
3/31/20172,019177N/A517N/A
12/31/20161,702-112N/A236N/A
9/30/20161,661-219N/A121N/A
6/30/20161,557-275N/A-7N/A
3/31/20161,292-399N/A-158N/A
12/31/20151,032-556N/A-365N/A
9/30/2015759-659N/A-576N/A
6/30/2015628-734N/A-602N/A

Analyst Future Growth Forecasts

Earnings vs Savings Rate: VRTX's forecast earnings growth (13% per year) is above the savings rate (3.5%).

Earnings vs Market: VRTX's earnings (13% per year) are forecast to grow slower than the US market (16.1% per year).

High Growth Earnings: VRTX's earnings are forecast to grow, but not significantly.

Revenue vs Market: VRTX's revenue (9.8% per year) is forecast to grow slower than the US market (11.3% per year).

High Growth Revenue: VRTX's revenue (9.8% per year) is forecast to grow slower than 20% per year.

Earnings per Share Growth Forecasts

Future Return on Equity

Future ROE: VRTX's Return on Equity is forecast to be high in 3 years time (21.4%)

Discover growth companies

7D

1Y

7D

1Y

7D

1Y

Company Analysis and Financial Data Status

DataLast Updated (UTC time)
Company Analysis2026/05/06 21:38
End of Day Share Price 2026/05/06 00:00
Earnings2026/03/31
Annual Earnings2025/12/31

Data Sources

The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.

PackageDataTimeframeExample US Source *
Company Financials10 years
  • Income statement
  • Cash flow statement
  • Balance sheet
Analyst Consensus Estimates+3 years
  • Forecast financials
  • Analyst price targets
Market Prices30 years
  • Stock prices
  • Dividends, Splits and Actions
Ownership10 years
  • Top shareholders
  • Insider trading
Management10 years
  • Leadership team
  • Board of directors
Key Developments10 years
  • Company announcements

* Example for US securities, for non-US equivalent regulatory forms and sources are used.

Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more.

Analysis Model and Snowflake

Details of the analysis model used to generate this report is available on our Github page, we also have guides on how to use our reports and tutorials on Youtube.

Learn about the world class team who designed and built the Simply Wall St analysis model.

Industry and Sector Metrics

Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on Github.

Analyst Sources

Vertex Pharmaceuticals Incorporated is covered by 58 analysts. 29 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.

AnalystInstitution
Jasper HellwegArgus Research Company
Brian SkorneyBaird
Ying HuangBarclays