Spero Therapeutics Valuation

Is SPRO undervalued compared to its fair value, analyst forecasts and its price relative to the market?

Valuation Score

2/6

Valuation Score 2/6

Below Future Cash Flow Value
Significantly Below Future Cash Flow Value
Price-To-Sales vs Peers
Price-To-Sales vs Industry
Price-To-Sales vs Fair Ratio
Analyst Forecast

Share Price vs Future Cash Flow Value

What is the Fair Price of SPRO when looking at its future cash flows? For this estimate we use a Discounted Cash Flow model.

Ultimate guide to DCF valuation for stock investing

Learn how to determine fair value like the best investors in the world.

Below Future Cash Flow Value: Insufficient data to calculate SPRO's future cash flow value for valuation analysis.

Significantly Below Future Cash Flow Value: Insufficient data to calculate SPRO's future cash flow value for valuation analysis.

Key Valuation Metric

Which metric is best to use when looking at relative valuation for SPRO?

Key metric: As SPRO is unprofitable we use its Price-To-Sales Ratio for relative valuation analysis.

The above table shows the Price to Sales ratio for SPRO. This is calculated by dividing SPRO's market cap by their current revenue.
What is SPRO's PS Ratio?
PS Ratio	3.1x
Sales	US$40.55m
Market Cap	US$126.20m

SPRO key valuation metrics and ratios. From Price to Earnings, Price to Sales and Price to Book to Price to Earnings Growth Ratio, Enterprise Value and EBITDA.
Key Statistics
Enterprise Value/Revenue	2x
Enterprise Value/EBITDA	-1.8x
PEG Ratio	n/a

Price to Sales Ratio vs Peers

How does SPRO's PS Ratio compare to its peers?

The above table shows the PS ratio for SPRO vs its peers. Here we also display the market cap and forecasted growth for additional consideration.
Company	Forward PS	Estimated Growth	Market Cap
Peer Average	19.8x
WHWK Whitehawk Therapeutics	10.2x	-69.76%	US$141.4m
EQ Equillium	26.6x	-87.27%	US$112.7m
AGEN Agenus	1x	15.63%	US$104.4m
ALPS Alps Group	41.4x	n/a	US$151.4m
SPRO Spero Therapeutics	3.1x	n/a	US$126.2m

Price-To-Sales vs Peers: SPRO is good value based on its Price-To-Sales Ratio (3.1x) compared to the peer average (19.8x).

Historical Price to Sales Ratio

Historical Price to Sales Ratio compares a stock's price to its sales over time. Higher ratios indicate that investors are willing to pay more for the stock.

Fetching historical data

Price to Sales Ratio vs Industry

How does SPRO's PS Ratio compare vs other companies in the US Biotechs Industry?

129 Companies	Price / Sales	Estimated Growth	Market Cap
Industry Avg.	11.9x	19.4%
SPRO Spero Therapeutics	3.1x	n/a	US$126.20m
BIIB Biogen	2.9x	-0.44%	US$28.81b
INCY Incyte	3.9x	-1.40%	US$20.07b

129 Companies		Estimated Growth	Market Cap
Industry Avg.	11.9x	22.7%
SPRO Spero Therapeutics	3.1x	n/a	US$126.20m

No more companies

Price-To-Sales vs Industry: SPRO is good value based on its Price-To-Sales Ratio (3.1x) compared to the US Biotechs industry average (11.7x).

Price to Sales Ratio vs Fair Ratio

What is SPRO's PS Ratio compared to its Fair PS Ratio? This is the expected PS Ratio taking into account the company's forecast earnings growth, profit margins and other risk factors.

SPRO PS Ratio vs Fair Ratio.
Fair Ratio
Current PS Ratio	3.1x
Fair PS Ratio	n/a

Price-To-Sales vs Fair Ratio: Insufficient data to calculate SPRO's Price-To-Sales Fair Ratio for valuation analysis.

Analyst Price Targets

What is the analyst 12-month forecast and do we have any statistical confidence in the consensus price target?

AnalystPriceTarget

Community Contributor

US$4

Fair Value

44.3% undervalued

Number of Analysts

Analyst Forecast: Insufficient data to show price forecast.

Discover undervalued companies

Company Analysis and Financial Data Status

Data	Last Updated (UTC time)
Company Analysis	2026/02/24 14:24
End of Day Share Price	2026/02/24 00:00
Earnings	2025/09/30
Annual Earnings	2024/12/31

Data Sources

The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.

Package	Data	Timeframe	Example US Source ^*
Company Financials	10 years	Income statement Cash flow statement Balance sheet	SEC Form 10-K SEC Form 10-Q
Analyst Consensus Estimates	+3 years	Forecast financials Analyst price targets	Analyst Research Reports Blue Matrix
Market Prices	30 years	Stock prices Dividends, Splits and Actions	ICE Market Data SEC Form S-1
Ownership	10 years	Top shareholders Insider trading	SEC Form 4 SEC Form 13D
Management	10 years	Leadership team Board of directors	SEC Form 10-K SEC Form DEF 14A
Key Developments	10 years	Company announcements	SEC Form 8-K

^* Example for US securities, for non-US equivalent regulatory forms and sources are used.

Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more.

Analysis Model and Snowflake

Details of the analysis model used to generate this report is available on our Github page, we also have guides on how to use our reports and tutorials on Youtube.

Learn about the world class team who designed and built the Simply Wall St analysis model.

Industry and Sector Metrics

Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on Github.

Analyst Sources

Spero Therapeutics, Inc. is covered by 6 analysts. 0 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.

Analyst	Institution
Esther Lannie Hong	Berenberg
Jason Matthew Gerberry	BofA Global Research
Esther Lannie Hong	Brean Capital Historical (Janney Montgomery)