Spero Therapeutics, Inc.

NasdaqGS:SPRO Stock Report

Market Cap: US$172.5m

Spero Therapeutics Ownership

Who are the major shareholders and have insiders been buying or selling?

Recent Insider Transactions

NasdaqGS:SPRO Recent Insider Transactions by Companies or Individuals
DateValueNameEntityRoleSharesMax Price
04 May 26SellUS$63,352Esther RajaveluIndividual25,240US$2.51
06 Feb 26SellUS$44,019Timothy KeutzerIndividual18,652US$2.36
06 Feb 26SellUS$207,484Esther RajaveluIndividual87,917US$2.36
04 Feb 26SellUS$101,175Timothy KeutzerIndividual46,586US$2.24
02 Feb 26SellUS$40,572Esther RajaveluIndividual18,442US$2.20
07 Nov 25SellUS$95,440Esther RajaveluIndividual40,270US$2.37
28 Aug 25SellUS$3,339Timothy KeutzerIndividual1,695US$1.97
28 Aug 25SellUS$12,947Ankit MahadeviaIndividual6,572US$1.97

Insider Trading Volume

Insider Buying: SPRO insiders have only sold shares in the past 3 months.

Ownership Breakdown

What is the ownership structure of SPRO?
Owner TypeNumber of SharesOwnership Percentage
Individual Insiders2,188,5033.78%
VC/PE Firms9,190,60615.9%
Institutions11,460,02819.8%
General Public35,062,35660.6%

Dilution of Shares: Shareholders have not been meaningfully diluted in the past year.

Top Shareholders

Top 25 shareholders own 37.84% of the company
OwnershipNameSharesCurrent ValueChange %Portfolio %
15.9%
GSK Equity Investments, Limited
9,190,606US$27.4m0%2.67%
4.08%
Pfizer Venture Investments LLC
2,362,348US$7.0m0%2.74%
3.11%
Vanguard Capital Management, LLC
1,799,880US$5.4m0%no data
2.05%
Renaissance Technologies LLC
1,189,235US$3.5m-7.06%no data
1.7%
Esther Rajavelu
986,851US$2.9m485%no data
1.54%
GV Management Company, LLC
889,979US$2.7m0%0.3%
1.53%
Two Sigma Investments, LP
885,631US$2.6m138%no data
0.9%
Geode Capital Management, LLC
519,922US$1.5m-1.75%no data
0.75%
BlackRock, Inc.
433,202US$1.3m-0.1%no data
0.73%
Anson Group
421,956US$1.3m-32.5%0.11%
0.66%
Ankit Mahadevia
383,795US$1.1m0%no data
0.65%
Citadel Advisors LLC
376,458US$1.1m-5.38%no data
0.58%
Susquehanna International Group, LLP
333,115US$992.7k13.4%no data
0.5%
Timothy Keutzer
288,547US$859.9k90.7%no data
0.48%
GSA Capital Partners LLP
278,304US$829.3k55.5%0.05%
0.46%
Vanguard Fiduciary Trust Company
264,115US$787.1k0%no data
0.37%
State Street Global Advisors, Inc.
214,751US$640.0k2.19%no data
0.34%
Ionic Capital Management LLC
195,939US$583.9k0%0.44%
0.34%
Squarepoint OPS LLC
194,301US$579.0k62.7%no data
0.27%
Marshall Wace LLP
157,072US$468.1k0%no data
0.22%
Satyavrat Shukla
127,856US$381.0k0%no data
0.21%
Northern Trust Global Investments
120,984US$360.5k0%no data
0.2%
Bridgeway Capital Management, LLC
114,800US$342.1k0%no data
0.18%
Jane Street Group, LLC
106,345US$316.9k-32.8%no data
0.12%
Milind Deshpande
71,454US$212.9k0%no data

Company Analysis and Financial Data Status

DataLast Updated (UTC time)
Company Analysis2026/06/05 22:02
End of Day Share Price 2026/06/05 00:00
Earnings2026/03/31
Annual Earnings2025/12/31

Data Sources

The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.

PackageDataTimeframeExample US Source *
Company Financials10 years
  • Income statement
  • Cash flow statement
  • Balance sheet
Analyst Consensus Estimates+3 years
  • Forecast financials
  • Analyst price targets
Market Prices30 years
  • Stock prices
  • Dividends, Splits and Actions
Ownership10 years
  • Top shareholders
  • Insider trading
Management10 years
  • Leadership team
  • Board of directors
Key Developments10 years
  • Company announcements

* Example for US securities, for non-US equivalent regulatory forms and sources are used.

Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more.

Analysis Model and Snowflake

Details of the analysis model used to generate this report is available on our Github page, we also have guides on how to use our reports and tutorials on Youtube.

Learn about the world class team who designed and built the Simply Wall St analysis model.

Industry and Sector Metrics

Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on Github.

Analyst Sources

Spero Therapeutics, Inc. is covered by 6 analysts. 0 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.

AnalystInstitution
Esther Lannie HongBerenberg
Jason Matthew GerberryBofA Global Research
Esther Lannie HongBrean Capital Historical (Janney Montgomery)