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Sage Therapeutics NasdaqGM:SAGE Stock Report

Last Price


Market Cap







04 Oct, 2022


Company Financials +
SAGE fundamental analysis
Snowflake Score
Future Growth2/6
Past Performance0/6
Financial Health5/6

SAGE Stock Overview

Sage Therapeutics, Inc., a biopharmaceutical company, develops and commercializes medicines to treat central nervous system disorders.

Sage Therapeutics Competitors

Price History & Performance

Summary of all time highs, changes and price drops for Sage Therapeutics
Historical stock prices
Current Share PriceUS$41.23
52 Week HighUS$47.75
52 Week LowUS$27.36
1 Month Change6.68%
3 Month Change19.27%
1 Year Change-8.42%
3 Year Change-70.45%
5 Year Change-34.00%
Change since IPO37.43%

Recent News & Updates

Aug 02

Sage Therapeutics GAAP EPS of -$2.13 beats by $0.02, revenue of $1.5M misses by $0.27M

Sage Therapeutics press release (NASDAQ:SAGE): Q2 GAAP EPS of -$2.13 beats by $0.02. Revenue of $1.5M (-8.5% Y/Y) misses by $0.27M. Cash Position: Cash, cash equivalents and marketable securities as of June 30, 2022 were $1.5 billion compared to $1.6 billion at March 31, 2022 Rolling NDA submission for zuranolone in MDD and PPD remains on track, with completion expected in the second half of 2022 Announced positive topline data from the Phase 3 SKYLARK Study evaluating 50 mg zuranolone for PPD Enrolling multiple Phase 2 studies across neuropsychiatry and neurology franchises, additional trials expected to initiate throughout 2022 Cash and cash equivalents, anticipated funding from ongoing collaborations, and potential revenue, expected to support operations into 2025

Jun 15
We're Hopeful That Sage Therapeutics (NASDAQ:SAGE) Will Use Its Cash Wisely

We're Hopeful That Sage Therapeutics (NASDAQ:SAGE) Will Use Its Cash Wisely

Even when a business is losing money, it's possible for shareholders to make money if they buy a good business at the...

Shareholder Returns

SAGEUS BiotechsUS Market

Return vs Industry: SAGE exceeded the US Biotechs industry which returned -22.7% over the past year.

Return vs Market: SAGE exceeded the US Market which returned -20% over the past year.

Price Volatility

Is SAGE's price volatile compared to industry and market?
SAGE volatility
SAGE Average Weekly Movement6.2%
Biotechs Industry Average Movement11.1%
Market Average Movement6.8%
10% most volatile stocks in US Market15.5%
10% least volatile stocks in US Market2.8%

Stable Share Price: SAGE is not significantly more volatile than the rest of US stocks over the past 3 months, typically moving +/- 6% a week.

Volatility Over Time: SAGE's weekly volatility (6%) has been stable over the past year.

About the Company

2010471Barry Greene

Sage Therapeutics, Inc., a biopharmaceutical company, develops and commercializes medicines to treat central nervous system disorders. Its lead product candidate is ZULRESSO, an intravenous formulation of brexanolone for the treatment of postpartum depression (PPD) in adults. The company’s product pipeline also includes zuranolone, a neuroactive steroid, which is in Phase III clinical trials for treating PPD, major depressive disorders, treatment resistant disorders, generalized anxiety disorders, and bipolar depression; and SAGE-324, a compound that is in Phase II clinical trial to treat essential tremors, as well as has completed Phase I clinical trial for epilepsy and Parkinson’s diseases.

Sage Therapeutics Fundamentals Summary

How do Sage Therapeutics's earnings and revenue compare to its market cap?
SAGE fundamental statistics
Market CapUS$2.45b
Earnings (TTM)-US$503.20m
Revenue (TTM)US$6.16m


P/S Ratio


P/E Ratio

Earnings & Revenue

Key profitability statistics from the latest earnings report
SAGE income statement (TTM)
Cost of RevenueUS$314.96m
Gross Profit-US$308.79m
Other ExpensesUS$194.40m

Last Reported Earnings

Jun 30, 2022

Next Earnings Date


Earnings per share (EPS)-8.47
Gross Margin-5,009.65%
Net Profit Margin-8,163.50%
Debt/Equity Ratio0%

How did SAGE perform over the long term?

See historical performance and comparison
We’ve recently updated our valuation analysis.


Is SAGE undervalued compared to its fair value, analyst forecasts and its price relative to the market?

Valuation Score


Valuation Score 4/6

  • Price-To-Book vs Peers

  • Price-To-Book vs Industry

  • Price-To-Book vs Fair Ratio

  • Below Fair Value

  • Significantly Below Fair Value

  • Analyst Forecast

Key Valuation Metric

Which metric is best to use when looking at relative valuation for SAGE?

Other financial metrics that can be useful for relative valuation.

SAGE key valuation metrics and ratios. From Price to Earnings, Price to Sales and Price to Book to Price to Earnings Growth Ratio, Enterprise Value and EBITDA.
Key Statistics
Enterprise Value/Revenue154.4x
Enterprise Value/EBITDA-1.9x
PEG Ration/a

Price to Book Ratio vs Peers

How does SAGE's PB Ratio compare to its peers?

SAGE PB Ratio vs Peers
The above table shows the PB ratio for SAGE vs its peers. Here we also display the market cap and forecasted growth for additional consideration.
CompanyPBEstimated GrowthMarket Cap
Peer Average3.8x
TWST Twist Bioscience
XENE Xenon Pharmaceuticals
SWTX SpringWorks Therapeutics
RARE Ultragenyx Pharmaceutical
SAGE Sage Therapeutics

Price-To-Book vs Peers: SAGE is good value based on its Price-To-Book Ratio (1.6x) compared to the peer average (3.7x).

Price to Earnings Ratio vs Industry

How does SAGE's PE Ratio compare vs other companies in the US Biotechs Industry?

Price-To-Book vs Industry: SAGE is good value based on its Price-To-Book Ratio (1.6x) compared to the US Biotechs industry average (1.7x)

Price to Book Ratio vs Fair Ratio

What is SAGE's PB Ratio compared to its Fair PB Ratio? This is the expected PB Ratio taking into account the company's forecast earnings growth, profit margins and other risk factors.

SAGE PB Ratio vs Fair Ratio.
Fair Ratio
Current PB Ratio1.6x
Fair PB Ration/a

Price-To-Book vs Fair Ratio: Insufficient data to calculate SAGE's Price-To-Book Fair Ratio for valuation analysis.

Share Price vs Fair Value

What is the Fair Price of SAGE when looking at its future cash flows? For this estimate we use a Discounted Cash Flow model.

Below Fair Value: SAGE ($41.23) is trading below our estimate of fair value ($233.26)

Significantly Below Fair Value: SAGE is trading below fair value by more than 20%.

Analyst Price Targets

What is the analyst 12-month forecast and do we have any statistical confidence in the consensus price target?

Analyst Forecast: Target price is more than 20% higher than the current share price, but analysts are not within a statistically confident range of agreement.

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Future Growth

How is Sage Therapeutics forecast to perform in the next 1 to 3 years based on estimates from 22 analysts?

Future Growth Score


Future Growth Score 2/6

  • Earnings vs Savings Rate

  • Earnings vs Market

  • High Growth Earnings

  • Revenue vs Market

  • High Growth Revenue

  • Future ROE


Forecasted annual earnings growth

Earnings and Revenue Growth Forecasts

Analyst Future Growth Forecasts

Earnings vs Savings Rate: SAGE is forecast to remain unprofitable over the next 3 years.

Earnings vs Market: SAGE is forecast to remain unprofitable over the next 3 years.

High Growth Earnings: SAGE is forecast to remain unprofitable over the next 3 years.

Revenue vs Market: SAGE's revenue (66.7% per year) is forecast to grow faster than the US market (7.6% per year).

High Growth Revenue: SAGE's revenue (66.7% per year) is forecast to grow faster than 20% per year.

Earnings per Share Growth Forecasts

Future Return on Equity

Future ROE: SAGE is forecast to be unprofitable in 3 years.

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Past Performance

How has Sage Therapeutics performed over the past 5 years?

Past Performance Score


Past Performance Score 0/6

  • Quality Earnings

  • Growing Profit Margin

  • Earnings Trend

  • Accelerating Growth

  • Earnings vs Industry

  • High ROE


Historical annual earnings growth

Earnings and Revenue History

Quality Earnings: SAGE is currently unprofitable.

Growing Profit Margin: SAGE is currently unprofitable.

Past Earnings Growth Analysis

Earnings Trend: SAGE is unprofitable, but has reduced losses over the past 5 years at a rate of 14.9% per year.

Accelerating Growth: Unable to compare SAGE's earnings growth over the past year to its 5-year average as it is currently unprofitable

Earnings vs Industry: SAGE is unprofitable, making it difficult to compare its past year earnings growth to the Biotechs industry (29.2%).

Return on Equity

High ROE: SAGE has a negative Return on Equity (-33.45%), as it is currently unprofitable.

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Financial Health

How is Sage Therapeutics's financial position?

Financial Health Score


Financial Health Score 5/6

  • Short Term Liabilities

  • Long Term Liabilities

  • Debt Level

  • Reducing Debt

  • Stable Cash Runway

  • Forecast Cash Runway

Financial Position Analysis

Short Term Liabilities: SAGE's short term assets ($1.6B) exceed its short term liabilities ($89.2M).

Long Term Liabilities: SAGE's short term assets ($1.6B) exceed its long term liabilities ($7.9M).

Debt to Equity History and Analysis

Debt Level: SAGE is debt free.

Reducing Debt: SAGE has not had any debt for past 5 years.

Balance Sheet

Cash Runway Analysis

For companies that have on average been loss making in the past we assess whether they have at least 1 year of cash runway.

Stable Cash Runway: SAGE has sufficient cash runway for more than 3 years based on its current free cash flow.

Forecast Cash Runway: Insufficient data to determine if SAGE has enough cash runway if its free cash flow continues to grow or shrink based on historical rates.

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What is Sage Therapeutics's current dividend yield, its reliability and sustainability?

Dividend Score


Dividend Score 0/6

  • Notable Dividend

  • High Dividend

  • Stable Dividend

  • Growing Dividend

  • Earnings Coverage

  • Cash Flow Coverage

Dividend Yield vs Market

Sage Therapeutics Dividend Yield vs Market
How does Sage Therapeutics dividend yield compare to the market?
SegmentDividend Yield
Company (Sage Therapeutics)n/a
Market Bottom 25% (US)1.6%
Market Top 25% (US)4.6%
Industry Average (Biotechs)2.8%
Analyst forecast in 3 Years (Sage Therapeutics)0%

Notable Dividend: Unable to evaluate SAGE's dividend yield against the bottom 25% of dividend payers, as the company has not reported any recent payouts.

High Dividend: Unable to evaluate SAGE's dividend yield against the top 25% of dividend payers, as the company has not reported any recent payouts.

Stability and Growth of Payments

Stable Dividend: Insufficient data to determine if SAGE's dividends per share have been stable in the past.

Growing Dividend: Insufficient data to determine if SAGE's dividend payments have been increasing.

Earnings Payout to Shareholders

Earnings Coverage: Insufficient data to calculate payout ratio to determine if its dividend payments are covered by earnings.

Cash Payout to Shareholders

Cash Flow Coverage: Unable to calculate sustainability of dividends as SAGE has not reported any payouts.

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How experienced are the management team and are they aligned to shareholders interests?


Average management tenure


Barry Greene (59 yo)





Mr. Barry E. Greene serves as President and Chief Executive Officer at Sage Therapeutics, Inc. since December 15, 2020 and its Director since October 1, 2020. He is a Director at BCLS Acquisition Corp., si...

CEO Compensation Analysis

Barry Greene's Compensation vs Sage Therapeutics Earnings
How has Barry Greene's remuneration changed compared to Sage Therapeutics's earnings?
DateTotal Comp.SalaryCompany Earnings
Jun 30 2022n/an/a


Mar 31 2022n/an/a


Dec 31 2021US$59mUS$735k


Sep 30 2021n/an/a


Jun 30 2021n/an/a


Mar 31 2021n/an/a


Dec 31 2020US$836kUS$53k


Compensation vs Market: Barry's total compensation ($USD58.86M) is above average for companies of similar size in the US market ($USD6.84M).

Compensation vs Earnings: Barry's compensation has increased whilst the company is unprofitable.

Leadership Team

Experienced Management: SAGE's management team is considered experienced (3.7 years average tenure).

Board Members

Experienced Board: SAGE's board of directors are considered experienced (8.4 years average tenure).


Who are the major shareholders and have insiders been buying or selling?

Insider Trading Volume

Insider Buying: Insufficient data to determine if insiders have bought more shares than they have sold in the past 3 months.

Recent Insider Transactions

NasdaqGM:SAGE Recent Insider Transactions by Companies or Individuals
DateValueNameEntityRoleSharesMax Price
05 May 22BuyUS$251,563George GolumbeskiIndividual8,000US$31.45

Ownership Breakdown

What is the ownership structure of SAGE?
Owner TypeNumber of SharesOwnership Percentage
State or Government00%
Individual Insiders1,216,3602.0%
Public Companies6,241,47310.3%

Dilution of Shares: Shareholders have not been meaningfully diluted in the past year.

Top Shareholders

Top 25 shareholders own 81.73% of the company
OwnershipNameSharesCurrent ValueChange %Portfolio %
Biogen Inc.
6,241,473$257.3m0%no data
Wellington Management Group LLP
The Vanguard Group, Inc.
4,742,839$195.5m2.55%no data
BlackRock, Inc.
4,241,813$174.9m54.01%no data
Bellevue Asset Management AG
State Street Global Advisors, Inc.
T. Rowe Price Group, Inc.
Marshall Wace LLP
J.P. Morgan Asset Management, Inc.
Point72 Asset Management, L.P.
Tavistock Life Sciences
Geode Capital Management, LLC
Palo Alto Investors LP
First Trust Advisors LP
Columbia Management Investment Advisers, LLC
Janus Henderson Group plc
D. E. Shaw & Co., L.P.
Goldman Sachs Asset Management, L.P.
Dimensional Fund Advisors LP
Manulife Asset Management
Northern Trust Global Investments
603,959$24.9m130.14%no data
Deutsche Asset & Wealth Management
Morgan Stanley, Investment Banking and Brokerage Investments
537,149$22.1m-1.26%no data
Steven Paul
514,572$21.2m0%no data

Company Information

Sage Therapeutics, Inc.'s employee growth, exchange listings and data sources

Key Information

  • Name: Sage Therapeutics, Inc.
  • Ticker: SAGE
  • Exchange: NasdaqGM
  • Founded: 2010
  • Industry: Biotechnology
  • Sector: Pharmaceuticals & Biotech
  • Implied Market Cap: US$2.450b
  • Shares outstanding: 59.42m
  • Website:

Number of Employees


  • Sage Therapeutics, Inc.
  • 215 First Street
  • Cambridge
  • Massachusetts
  • 2142
  • United States


TickerExchangePrimary SecuritySecurity TypeCountryCurrencyListed on
SAGENasdaqGM (Nasdaq Global Market)YesCommon StockUSUSDJul 2014
SG7BST (Boerse-Stuttgart)YesCommon StockDEEURJul 2014
SG7DB (Deutsche Boerse AG)YesCommon StockDEEURJul 2014

Company Analysis and Financial Data Status

All financial data provided by Standard & Poor's Capital IQ.
DataLast Updated (UTC time)
Company Analysis2022/10/04 00:00
End of Day Share Price2022/10/04 00:00
Annual Earnings2021/12/31

Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more here.