Announcement • Jan 08

Enanta Pharmaceuticals, Inc. Provides Update on Its Research and Development Programs

Enanta Pharmaceuticals, Inc. announced updates on its research and development programs and highlighted upcoming key milestones for 2026. Pipeline Updates Virology Enanta’s virology pipeline includes the leading portfolio in development for RSV treatment, consisting of zelicapavir and EDP-323, both of which received Fast Track designation from the FDA. Enanta most recently evaluated zelicapavir, an oral, once-daily RSV N-protein inhibitor, in RSVHR, a Phase 2b study in a high-risk adult outpatient population, including the elderly and/or those with asthma, chronic obstructive pulmonary disease, or congestive heart failure. In September 2025, the Company announced positive data from the study. A clinically meaningful improvement in time to complete resolution of all 13 RSV symptoms was observed for zelicapavir compared to placebo, with a benefit of 6.7 days for patients with congestive heart failure, chronic obstructive pulmonary disease or age 75 or older, termed the HR3 population. Zelicapavir also showed an improvement in time to complete resolution on the 29-parameter total RiiQ™ symptom scale of 7.2 days for the HR3 population compared to placebo. The study met key secondary endpoints, including a reduction in hospitalization and antiviral effects. Zelicapavir has been dosed in more than 700 people to date and continues to be well-tolerated with a favorable safety profile. Enanta is continuing Phase 3 enabling activities, including aligning with the FDA on an adult Phase 3 trial design and overall registration path. In parallel, the Company is exploring potential business development opportunities related to its RSV program. Enanta’s second RSV candidate, EDP-323, is an oral, once-daily RSV L-protein inhibitor, which can be used alone or in combination with other agents, such as zelicapavir, to potentially broaden the treatment window or addressable patient populations. In October, the Company presented data on a post-exposure prophylaxis analysis performed in subjects who were not infected by Day 5 after RSV exposure in the EDP-323 human challenge study. The data showed the potential for EDP-323 to be effective in preventing RSV infection when initiated up to five days after RSV exposure, building on the previously reported EDP-323 challenge study treatment data. Immunology Enanta’s immunology pipeline is focused on designing and developing highly potent and selective oral inhibitors for the treatment of inflammatory diseases, by targeting key drivers of the type 2 immune response. Enanta today announced its third immunology program targeting MRGPRX2, a non-canonical G-Protein-Coupled-Receptor (GPCR) expressed predominantly on mast cells. Inhibiting MRGPRX2 may have potential to address multiple chronic inflammatory diseases including urticaria, asthma, prurigo nodularis and others. Currently, Enanta is advancing novel, potent and selective oral inhibitors of MRGPRX2. The Company’s prototype MRGPRX2 inhibitors exhibit potent inhibition invitro and in vivo. Specifically, they demonstrate MRGPRX2 inhibition with nanomolar potency (EC50 of 1-2nM) in cellular assays and prevent skin mast cell activation in humanized MRGPRX2 mouse models. Further, the Company’s MRGPRX2 prototype inhibitors show potent activity across multiple MRGPRX2 agonists. These prototypes are highly selective for MRGPRX2 versus other GPCRs. Finally, these prototypes show favorable in vitro and in vivo ADME properties supporting once daily dosing. Enanta continues to evaluate multiple compounds in preclinical studies and expects to select a development candidate in the second half of 2026. Enanta recently selected EDP-978, a novel, potent and selective oral KIT inhibitor, as its clinical candidate for the treatment of chronic spontaneous urticaria and potentially other mast cell driven diseases. EDP-978 demonstrates nanomolar potency in both binding and cellular assays, sub-nanomolar activity in vivo, and high selectivity for KIT versus other kinases. EDP-978 also exhibits favorable in vitro and in vivo ADME properties preclinically. The Company is on track to submit an IND in the first quarter, with topline Phase 1 data expected in the fourth quarter of 2026. In November, Enanta nominated EPS-3903, a novel, potent and selective oral STAT6 inhibitor, as its lead development candidate for the treatment of atopic dermatitis and other diseases currently treated by dupilumab. Preclinical data show EPS-3903 exhibits nanomolar activity in binding and cellular assays and high selectivity for STAT6. Importantly, EPS-3903 shows rapid, continuous and complete (>90%) inhibition of phosphorylated STAT6 (pSTAT6) after oral dosing in mice. Further, EPS-3903 demonstrates efficacy comparable to dupilumab in multiple disease models. Specifically, in a house dust mite asthma model, treatment with EPS-3903 results in complete (>90%) inhibition of lung pSTAT6 and decreased inflammation comparable to dupilumab, including clinically relevant biomarkers of eosinophils and TARC in the lung and serum IgE. Additionally, in an MC903 atopic dermatitis mouse model, EPS-3903 demonstrates efficacy comparable to dupilumab, with complete (>90%) inhibition of pSTAT6 in the skin and spleen, as well as a robust decrease in serum IgE. EPS-3903 has favorable in vitro and in vivo ADME properties with once-daily dosing potential. The Company is currently performing scale-up and IND enabling activities and targeting an IND filing in the second half of 2026. Corporate In August 2025, Enanta filed a patent infringement action in the Unified Patent Court (UPC) of the European Union against Pfizer Inc. and certain of its subsidiaries. The suit seeks a determination of liability for infringement of European Patent No. EP 4 051 265 (the “’265 Patent”) in connection with Pfizer’s manufacture, use, and sale of Paxlovid™ (nirmatrelvir tablets; ritonavir tablets) in the 18 EU member states participating in the UPC. Under UPC procedures, a hearing on the infringement action is expected to occur within the UPC’s published 12-month target, with a decision rendered within weeks thereafter. Enanta expects to provide an update on the UPC litigation in the second half of 2026. The Company expects the following milestones across its pipeline in 2026: Virology Respiratory Syncytial Virus Align with FDA on adult Phase 3 design and registration path in Second Quarter 2026 Prepare for a Phase 3 study of zelicapavir in high-risk adults in 2H 2026 Explore business development opportunities for RSV assets Immunology KIT Program File IND for EDP-978 in First Quarter 2026 Report Phase 1 data for EDP-978 in Fourth Quarter 2026 STAT6 Program File an IND for EPS-3903 in 2H 2026 MRGPRX2 Program Nominate development candidate in 2H 2026.

Announcement • Oct 21

Enanta Pharmaceuticals, Inc. Presents New Data for Zelicapavir, its N-Protein Inhibitor and EDP-323, L-Protein Inhibitor

Enanta Pharmaceuticals, Inc. announced that new data for zelicapavir, its oral, once-daily, N-protein inhibitor, and EDP-323, its oral, once- daily, N-protein inhibitor, both in development for the treatment of respiratory syncytial virus (RSV), will be presented at IDWeek™? 2025 being held October 19 - 22, 2025, virtually and in Atlanta, Georgia. A post hoc analysis of a Phase 2 study of zelicapavir in children 28 days to 36 months reported in December 2024, demonstrated that treatment with zelicapavir resulted in a shorter time to complete resolution of RSV-related symptoms, as measured by ReSViNET, a parent/guardian clinical scoring system. The randomized, double-blind, placebo-controlled trial was conducted in children 28 days to 36 months of age evaluating the safety, pharmacokinetics, and antiviral activity of zelicapavir given once daily for 5 days. Caregivers reported the severity of RSV-related symptoms daily from baseline through Day 14. In the study, 96 patients were randomized and dosed (n=69 zelicapavir, n=27 placebo). Although resolution of symptom severity to mild showed no difference, a post hoc analysis of time to complete resolution of symptoms (defined as absent and discharged from hospital), showed an estimated Kaplan-Meier median of 6.99 days for zelicapavir versus 8.60 days for placebo. Similarly, an analysis of sustained resolution (defined as absent and remaining absent at all subsequent time points and discharged from hospital) resulted in 6.99 days for zelicapavir versus 10.68 days for placebo. All zelicapavir recipients achieved model-predicted target drug exposures. Adverse events (AEs) were similar between treatment groups, with none leading to treatment discontinuation or study withdrawal. These data demonstrate that treatment with zelicapavir is associated with a shorter time to complete resolution of RSV symptoms in children, thereby supporting further evaluation of zelicapavir in pediatric clinical trials. A randomized, double-blind, placebo-controlled human viral challenge Phase 2a study evaluated the efficacy, antiviral activity, safety and pharmacokinetics of EDP-323. Healthy volunteers were inoculated with RSV-A on Day 0. After confirmed RSV infection or 5 days later, randomized participants received EDP-323 600mg (n=47), 200mg (with 600mg loading dose, n=47), or placebo (n=47) once daily for 5 days and were followed through 28 days. Clinical symptoms were assessed once-daily using the Respiratory Infection Intensity and Impact Questionnaire (RiiQ™) and viral loads were assessed by quantitative real-time PCR on nasal washes. Participants showed rapid (within the first 24 hours) and statistically significant improvements in RiiQ™ RSV symptoms and viral load after EDP-323 dosing. Compared to placebo, there were 73% (p=0.0012), 61% (p=0.0010), and 67% (p<0.0001) RiiQ™ total symptom score AUC reductions in the 200mg, 600mg, and EDP-323 pooled recipients, respectively. Lower respiratory tract disease scores AUC were reduced by 95% (p=0.0002), 73% (p=0.0088), and 85% (p=0.0002) respectively, in the 200mg, 600mg, and pooled EDP-323 recipients versus placebo. There were 87% and 85% viral load AUC reductions in 200mg and 600mg recipients, respectively versus placebo (all p<0.0001). EDP-323 dosing groups showed similar efficacies. Frequencies of treatment-emergent adverse events (TEAEs) were similar across EDP-323 and placebo groups. No serious TEAEs, severe AEs, or AEs leading to treatment discontinuation or study withdrawal occurred. These findings support the further development of EDP-323 as a once-daily, oral RSV treatment. A randomized, double-blind, placebo-controlled, human viral challenge Phase 2a study evaluated the efficacy, antiviral activity, safety and pharmacokinetics of EDP-323. Healthy volunteers were inoculated with RSV-A on Day 0. RSV real-time PCR was performed, and nasal washes were collected twice daily on Days 2-12. Study participants were randomized 1:1:1 and received either 600mg of EDP-323 orally for 5 days (high-dose group), 600mg loading dose for 1 day followed by 200mg once daily for 4 days (low-dose group), or placebo. A post exposure prophylaxis (PEP) analysis was performed in subjects who were not infected by Day 5 after RSV exposure. In this population, 68 RSV-exposed, susceptible subjects were randomized to receive EDP-323 (low dose n=24, high dose n=21) or placebo (n=23). Of these subjects, 26% (6/23) of those who received placebo became infected versus 0% (0/45) of EDP-323 recipients (p<0.001). Evaluated separately, the two EDP-323 dosing groups’ PEP effects were statistically significant (low dose p=0.009, high dose p=0.022) versus placebo. There were no serious TEAEs, severe AEs, or AEs leading to treatment discontinuation or study withdrawal occurred. The frequency of TEAEs were similar across EDP-323 and placebo groups. These data suggest that EDP-323 is highly effective in preventing RSV infection when initiated up to 5 days after RSV exposure and further support evaluating the drug for prophylaxis.

Biotechs Industry Growth	17.04%
Revenue growth rate	-9.07%
Return on equity	-53.17%
Net Margin	-89.56%
Next Earnings Update	10 Aug 2026

Date	Revenue	Earnings	G+A Expenses	R&D Expenses
31 Mar 26	69	-62	38	91
31 Dec 25	67	-72	40	100
30 Sep 25	65	-82	44	107
30 Jun 25	65	-92	48	114
31 Mar 25	64	-96	51	115
31 Dec 24	67	-105	54	123
30 Sep 24	68	-116	58	131
30 Jun 24	72	-115	58	137
31 Mar 24	73	-132	57	151
31 Dec 23	74	-138	57	159
30 Sep 23	79	-134	53	164
30 Jun 23	81	-132	52	162
31 Mar 23	81	-125	52	158
31 Dec 22	82	-121	49	157
30 Sep 22	86	-122	45	165
30 Jun 22	89	-120	41	179
31 Mar 22	92	-112	37	187
31 Dec 21	93	-101	35	186
30 Sep 21	97	-79	33	174
30 Jun 21	97	-84	31	162
31 Mar 21	94	-74	29	150
31 Dec 20	102	-58	28	141
30 Sep 20	122	-36	27	137
30 Jun 20	150	2	27	139
31 Mar 20	176	24	26	139
31 Dec 19	188	34	26	140
30 Sep 19	205	46	26	142
30 Jun 19	221	65	26	130
31 Mar 19	234	78	26	124
31 Dec 18	238	86	25	112
30 Sep 18	207	72	23	95
30 Jun 18	215	81	23	84
31 Mar 18	166	52	22	71
31 Dec 17	131	34	22	63
30 Sep 17	103	18	21	57
30 Jun 17	40	-21	20	52
31 Mar 17	46	-13	19	48
31 Dec 16	50	-10	18	44
30 Sep 16	88	22	17	40
30 Jun 16	90	29	16	36
31 Mar 16	87	33	16	31
31 Dec 15	132	63	15	28
30 Sep 15	161	79	14	23
30 Jun 15	149	68	13	21

Data	Last Updated (UTC time)
Company Analysis	2026/05/29 14:49
End of Day Share Price	2026/05/29 00:00
Earnings	2026/03/31
Annual Earnings	2025/09/30

Package	Data	Timeframe	Example US Source ^*
Company Financials	10 years	Income statement Cash flow statement Balance sheet	SEC Form 10-K SEC Form 10-Q
Analyst Consensus Estimates	+3 years	Forecast financials Analyst price targets	Analyst Research Reports Blue Matrix
Market Prices	30 years	Stock prices Dividends, Splits and Actions	ICE Market Data SEC Form S-1
Ownership	10 years	Top shareholders Insider trading	SEC Form 4 SEC Form 13D
Management	10 years	Leadership team Board of directors	SEC Form 10-K SEC Form DEF 14A
Key Developments	10 years	Company announcements	SEC Form 8-K

Analyst	Institution
Brian Skorney	Baird
Geoffrey Meacham	Barclays
Patrick Trucchio	Berenberg

Enanta Pharmaceuticals Past Earnings Performance

Past criteria checks 0/6

Key information

Recent past performance updates

Enanta Pharmaceuticals, Inc. to Report Q3, 2026 Results on Aug 10, 2026

Second quarter 2026 earnings: EPS exceeds analyst expectations

First quarter 2026 earnings: EPS and revenues exceed analyst expectations

Enanta Pharmaceuticals, Inc. to Report Q2, 2026 Results on May 11, 2026

Full year 2025 earnings: EPS and revenues miss analyst expectations

Enanta Pharmaceuticals, Inc. to Report Q1, 2026 Results on Feb 09, 2026

Recent updates

Consensus estimates of losses per share improve by 19%

Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA) Just Released Its Second-Quarter Earnings: Here's What Analysts Think

Enanta Pharmaceuticals, Inc. to Report Q3, 2026 Results on Aug 10, 2026

Second quarter 2026 earnings: EPS exceeds analyst expectations

Enanta Pharmaceuticals Inc Announces First Participant Dosed in Phase 1 Clinical Trial of Edp-978

Price target decreased by 8.6% to US$18.50

Price target increased by 7.2% to US$20.50

Analysts Are Updating Their Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA) Estimates After Its First-Quarter Results

First quarter 2026 earnings: EPS and revenues exceed analyst expectations

Enanta Pharmaceuticals, Inc. to Report Q2, 2026 Results on May 11, 2026

Enanta Pharmaceuticals, Inc., Annual General Meeting, Mar 11, 2026

Enanta Pharmaceuticals, Inc. Provides Update on Its Research and Development Programs

Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA) Stock Catapults 27% Though Its Price And Business Still Lag The Industry

Consensus EPS estimates fall by 33%

President recently sold US$67k worth of stock

President notifies of intention to sell stock

Health Check: How Prudently Does Enanta Pharmaceuticals (NASDAQ:ENTA) Use Debt?

Consensus EPS estimates upgraded to US$2.30 loss

Full year 2025 earnings: EPS and revenues miss analyst expectations

Enanta Pharmaceuticals, Inc. to Report Q1, 2026 Results on Feb 09, 2026

Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA) Not Doing Enough For Some Investors As Its Shares Slump 30%

Enanta Pharmaceuticals, Inc. Presents New Data for Zelicapavir, its N-Protein Inhibitor and EDP-323, L-Protein Inhibitor

New major risk - Shareholder dilution

Price target increased by 9.8% to US$19.14

Enanta Pharmaceuticals, Inc. has completed a Follow-on Equity Offering in the amount of $65 million.

Enanta Pharmaceuticals Reports Positive Topline Results from Its Phase 2B Study of Zelicapavir for the Treatment of Respiratory Syncytial Virus in High-Risk Adults

New major risk - Share price stability

Enanta: Despite Primary Endpoint Miss Zelicapavir Could Benefit From Trial Design Change

Enanta Pharmaceuticals, Inc. Announces Demise of Paul J. Mellett Jr, Chief Financial and Administrative Officer

Enanta Pharmaceuticals, Inc.'s (NASDAQ:ENTA) Price Is Right But Growth Is Lacking After Shares Rocket 27%

Enanta Pharmaceuticals, Inc. Announces Executive Changes on August 26, 2025

Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA) Third-Quarter Results: Here's What Analysts Are Forecasting For Next Year

Third quarter 2025 earnings: EPS and revenues exceed analyst expectations

Enanta Pharmaceuticals, Inc. to Report Q4, 2025 Results on Nov 17, 2025

New major risk - Revenue and earnings growth

Enanta Pharmaceuticals, Inc. Announces U.S. Food and Drug Administration Approves Label Expansion for MAVYRET (Glecaprevir/Pibrentasvir), Oral Pangenotypic Direct Acting Antiviral (DAA) Therapy

Consensus EPS estimates upgraded to US$3.73 loss, revenue downgraded

Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA) Second-Quarter Results Just Came Out: Here's What Analysts Are Forecasting For This Year

Price target increased by 12% to US$17.00

Second quarter 2025 earnings: EPS exceeds analyst expectations while revenues lag behind

Enanta Pharmaceuticals, Inc. to Report Q3, 2025 Results on Aug 11, 2025

New minor risk - Market cap size

Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA) Not Doing Enough For Some Investors As Its Shares Slump 27%

President recently bought US$256k worth of stock

Enanta Pharmaceuticals, Inc.'s (NASDAQ:ENTA) Shares Bounce 55% But Its Business Still Trails The Industry

New minor risk - Share price stability

Price target decreased by 8.6% to US$15.43

First quarter 2025 earnings: EPS exceeds analyst expectations while revenues lag behind

Enanta Pharmaceuticals, Inc. to Report Q2, 2025 Results on May 12, 2025

Enanta Pharmaceuticals, Inc., Annual General Meeting, Mar 13, 2025

New major risk - Revenue and earnings growth

Price target decreased by 13% to US$15.75

Enanta Pharmaceuticals Announces Positive Topline Results from First-In-Pediatrics Phase 2 Study Evaluating Zelicapavir for the Treatment of Respiratory Syncytial Virus

Analysts Have Been Trimming Their Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA) Price Target After Its Latest Report

Price target decreased by 7.6% to US$18.13

Benign Growth For Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA) Underpins Stock's 27% Plummet

Full year 2024 earnings: EPS and revenues miss analyst expectations

Health Check: How Prudently Does Enanta Pharmaceuticals (NASDAQ:ENTA) Use Debt?

New major risk - Revenue and earnings growth

Here's What Analysts Are Forecasting For Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA) After Its Third-Quarter Results

New major risk - Revenue and earnings growth

Third quarter 2024 earnings: EPS and revenues exceed analyst expectations

Enanta Pharmaceuticals, Inc. to Report Q4, 2024 Results on Nov 25, 2024

Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA) Held Back By Insufficient Growth Even After Shares Climb 26%

Senior VP & Chief Medical Officer notifies of intention to sell stock

Is Enanta Pharmaceuticals (NASDAQ:ENTA) Using Debt In A Risky Way?

Insider notifies of intention to sell stock

Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA) Just Released Its Second-Quarter Earnings: Here's What Analysts Think

Enanta Pharmaceuticals, Inc. to Report Q3, 2024 Results on Aug 05, 2024