Stock Analysis

A Closer Look at Amgen (AMGN) Valuation After Its 12-Month 28% Share Price Gain

Amgen (AMGN) has quietly delivered a strong year, with the stock up roughly 28% over the past 12 months and about 20% in the past 3 months, outpacing many large-cap healthcare peers.

See our latest analysis for Amgen.

That steady climb in Amgen’s 1 month share price return, up 14.65 percent, and 90 day share price return of 19.93 percent, alongside a 1 year total shareholder return of 28.03 percent, suggests positive momentum is building as investors warm to its growth and earnings outlook.

If Amgen’s run has you thinking more broadly about opportunities in healthcare, it could be a good moment to explore other healthcare stocks that the market may be overlooking.

With the shares near record highs and trading above some analyst targets but still showing a hefty intrinsic discount, the key question now is whether Amgen is genuinely undervalued or whether the market has already priced in its next leg of growth.

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Most Popular Narrative Narrative: 5.4% Overvalued

Compared with the most followed fair value estimate of about $322.88, Amgen’s last close at $340.16 implies investors are already paying a premium for its future growth path.

Advancements in personalized and targeted therapies, reflected in the robust late-stage pipeline (e.g., MariTide for obesity/type 2 diabetes, Repatha and olpasiran for cardiovascular, multiple bispecific T cell engagers for oncology), position Amgen to launch high margin, first in class products that drive both top line growth and margin expansion in the coming years.

Read the complete narrative.

Curious which future revenue mix, margin uplift, and earnings power justify paying above today’s price? The narrative hinges on a bold, tightly modeled profit roadmap.

Result: Fair Value of $322.88 (OVERVALUED)

Have a read of the narrative in full and understand what's behind the forecasts.

However, mounting drug pricing pressure and accelerating biosimilar competition could quickly erode margins and challenge the optimistic profit roadmap that underpins this valuation.

Find out about the key risks to this Amgen narrative.

Another View: Multiples Point to More Room

While the popular narrative calls Amgen around 5 percent overvalued, its 26.1 times earnings looks cheaper than the peer average of 59.7 times and below a 29.6 times fair ratio, even if it is richer than the 19.3 times industry level. Is that a justified premium or creeping risk?

See what the numbers say about this price — find out in our valuation breakdown.

NasdaqGS:AMGN PE Ratio as at Dec 2025
NasdaqGS:AMGN PE Ratio as at Dec 2025

Simply Wall St performs a discounted cash flow (DCF) on every stock in the world every day (check out Amgen for example). We show the entire calculation in full. You can track the result in your watchlist or portfolio and be alerted when this changes, or use our stock screener to discover 907 undervalued stocks based on their cash flows. If you save a screener we even alert you when new companies match - so you never miss a potential opportunity.

Build Your Own Amgen Narrative

If you see the story differently, or want to dig into the numbers yourself, you can build a personalized perspective in just minutes: Do it your way.

A great starting point for your Amgen research is our analysis highlighting 4 key rewards and 2 important warning signs that could impact your investment decision.

Ready for more investment ideas?

Put your research momentum to work now, or risk missing the next opportunity, by scanning targeted stock ideas tailored to different strategies and risk levels.

This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

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Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com

About NasdaqGS:AMGN

Amgen

Amgen Inc. discovers, develops, manufactures, and delivers human therapeutics worldwide.

Established dividend payer and good value.

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