Stock Analysis

BillionToOne (BLLN): Revisiting Valuation After a Volatile Week for the Share Price

BillionToOne (BLLN) has been quietly catching investor attention after a choppy week, with the stock edging up about 1% today but still down roughly 20% over the past week.

See our latest analysis for BillionToOne.

That sharp 7 day share price return of negative 20.1 percent comes after a more modest year to date share price return of negative 4.5 percent at a last close of 104.02 dollars. This suggests momentum has recently faded as investors reassess execution risk and valuation.

If BillionToOne's swings have you rethinking concentration risk, this could be a good moment to explore healthcare stocks as a way to uncover other healthcare names with different risk reward profiles.

With BillionToOne still lossmaking but growing revenue fast, and trading at roughly a third below the average analyst price target, investors now face a pivotal question: is this a mispriced growth story, or has the market already factored in its future potential?

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Price-to-Sales of 22.6x: Is it justified?

BillionToOne currently trades on a rich price-to-sales ratio of 22.6 times, which looks stretched given the latest close of 104.02 dollars and its lack of profitability.

The price-to-sales multiple compares the company’s market value to its revenue, making it a common yardstick for high growth, loss making healthcare and diagnostics businesses where earnings are not yet a reliable guide.

In this case, the 22.6 times sales tag implies investors are already baking in very strong future revenue growth and a successful path to profitability, even though the company is still loss making and reports a negative return on equity of 18.07 percent.

Set against the broader US Healthcare industry’s average price-to-sales of just 1.3 times and a peer average of 4.5 times, BillionToOne’s valuation stands out as dramatically higher. This suggests the market is placing a hefty premium on its precision diagnostics platform and long term growth story rather than current fundamentals.

See what the numbers say about this price — find out in our valuation breakdown.

Result: Price-to-Sales of 22.6x (OVERVALUED)

However, future gains still hinge on sustaining rapid revenue growth and proving the diagnostics platform can scale profitably in an increasingly competitive, innovation-driven market.

Find out about the key risks to this BillionToOne narrative.

Another View: DCF Points to Slight Undervaluation

While the price to sales ratio seems expensive, our DCF model paints a calmer picture, suggesting BillionToOne is trading about 2.3 percent below its estimated fair value of 106.45 dollars. If the cash flows align with expectations, today’s volatility may be offering a narrow entry window.

Look into how the SWS DCF model arrives at its fair value.

BLLN Discounted Cash Flow as at Dec 2025
BLLN Discounted Cash Flow as at Dec 2025

Simply Wall St performs a discounted cash flow (DCF) on every stock in the world every day (check out BillionToOne for example). We show the entire calculation in full. You can track the result in your watchlist or portfolio and be alerted when this changes, or use our stock screener to discover 908 undervalued stocks based on their cash flows. If you save a screener we even alert you when new companies match - so you never miss a potential opportunity.

Build Your Own BillionToOne Narrative

If you see the story differently or want to dig into the numbers yourself, you can build a personalised view in just a few minutes: Do it your way.

A great starting point for your BillionToOne research is our analysis highlighting 4 key rewards and 1 important warning sign that could impact your investment decision.

Ready for more investment ideas?

Now is the moment to broaden your opportunity set, and the Simply Wall St screener can surface compelling ideas you might regret overlooking later.

This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

Valuation is complex, but we're here to simplify it.

Discover if BillionToOne might be undervalued or overvalued with our detailed analysis, featuring fair value estimates, potential risks, dividends, insider trades, and its financial condition.

Access Free Analysis

Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com

About NasdaqGS:BLLN

BillionToOne

A precision diagnostics company, quantifies biology to create molecular diagnostics.

High growth potential with adequate balance sheet.

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