Stock Analysis

Ono Pharmaceutical (TSE:4528): Valuation in Focus Following Harness Therapeutics Collaboration on Rare Disease Therapies

Ono Pharmaceutical (TSE:4528) caught investor attention after its venture arm announced a new collaboration with Harness Therapeutics. The partnership aims to develop therapies for a rare genetic disorder and includes upfront funding as well as an exclusivity option.

See our latest analysis for Ono Pharmaceutical.

The partnership with Harness Therapeutics spotlights Ono Pharmaceutical’s determination to expand its pipeline in rare genetic disorders, but the market response has yet to reflect new momentum. Over the past year, total shareholder return is essentially flat at -0.09%, while share price performance shows only modest fluctuations. These are clear signs that investors remain cautious as they wait for tangible results from these innovative initiatives.

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With shares holding steady and analysts setting price targets only slightly below current levels, the question now is whether Ono Pharmaceutical is actually undervalued or if the market has accurately priced in all the potential upside from its latest moves.

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Price-to-Earnings of 19.1x: Is it justified?

Ono Pharmaceutical’s shares currently trade at a price-to-earnings (P/E) ratio of 19.1x, which is almost identical to its estimated fair P/E of 19.2x. The comparison suggests today’s price is in line with fair value models, reflecting neither marked optimism nor deep pessimism from the market.

The price-to-earnings ratio is a key benchmark for this sector, signaling how much investors are willing to pay for current earnings. For pharmaceutical companies with established cash flows and consistent profitability, this multiple is an important gauge of sentiment about future growth.

In a broader context, Ono Pharmaceutical’s P/E is considerably lower than the industry peer average of 28.6x but is slightly higher than the JP Pharmaceuticals sector average of 16x. This indicates the market is assigning a value that acknowledges steady profits but stops short of any growth premium. With the fair P/E ratio almost a perfect match, the market may be signaling it views analyst or model-based fundamentals as largely priced in, with little divergence expected in the near term.

Explore the SWS fair ratio for Ono Pharmaceutical

Result: Price-to-Earnings of 19.1x (ABOUT RIGHT)

However, ongoing revenue declines or weaker net income growth could quickly challenge the current valuation narrative. This may prompt the market to reassess its outlook.

Find out about the key risks to this Ono Pharmaceutical narrative.

Another View: Discounted Cash Flow Signals Undervaluation

Looking from a different angle, our DCF model values Ono Pharmaceutical at ¥3,432.42 per share. This suggests the stock is trading 49% below that estimate. This method sees significantly more upside. Could the market be missing something, or is the DCF model being too optimistic?

Look into how the SWS DCF model arrives at its fair value.

4528 Discounted Cash Flow as at Oct 2025
4528 Discounted Cash Flow as at Oct 2025

Simply Wall St performs a discounted cash flow (DCF) on every stock in the world every day (check out Ono Pharmaceutical for example). We show the entire calculation in full. You can track the result in your watchlist or portfolio and be alerted when this changes, or use our stock screener to discover undervalued stocks based on their cash flows. If you save a screener we even alert you when new companies match - so you never miss a potential opportunity.

Build Your Own Ono Pharmaceutical Narrative

If you have your own perspective or want to dig deeper into the numbers, you can build a personalized view in just a few minutes, Do it your way

A great starting point for your Ono Pharmaceutical research is our analysis highlighting 2 key rewards and 2 important warning signs that could impact your investment decision.

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This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

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