Alnylam Pharmaceuticals, Inc.

LSE:0HD2 Stock Report

Market Cap: US$31.7b

Alnylam Pharmaceuticals Valuation

Is 0HD2 undervalued compared to its fair value, analyst forecasts and its price relative to the market?

Valuation Score

2/6

Valuation Score 2/6

  • Below Fair Value

  • Significantly Below Fair Value

  • Price-To-Sales vs Peers

  • Price-To-Sales vs Industry

  • Price-To-Sales vs Fair Ratio

  • Analyst Forecast

Share Price vs Fair Value

What is the Fair Price of 0HD2 when looking at its future cash flows? For this estimate we use a Discounted Cash Flow model.

Below Fair Value: 0HD2 ($244.6) is trading below our estimate of fair value ($545)

Significantly Below Fair Value: 0HD2 is trading below fair value by more than 20%.

Key Valuation Metric

Which metric is best to use when looking at relative valuation for 0HD2?

Key metric: As 0HD2 is unprofitable we use its Price-To-Sales Ratio for relative valuation analysis.

The above table shows the Price to Sales ratio for 0HD2. This is calculated by dividing 0HD2's market cap by their current revenue.
What is 0HD2's PS Ratio?
PS Ratio15.1x
SalesUS$2.09b
Market CapUS$31.66b

Price to Sales Ratio vs Peers

How does 0HD2's PS Ratio compare to its peers?

The above table shows the PS ratio for 0HD2 vs its peers. Here we also display the market cap and forecasted growth for additional consideration.
CompanyForward PSEstimated GrowthMarket Cap
Peer Average6.6x
GNS Genus
1.5x3.7%UK£994.5m
OXB Oxford Biomedica
4.6x21.2%UK£451.8m
AVCT Avacta Group
7.7x0.4%UK£173.8m
BVXP Bioventix
12.8xn/aUK£173.6m
0HD2 Alnylam Pharmaceuticals
15.1x22.3%US$31.7b

Price-To-Sales vs Peers: 0HD2 is expensive based on its Price-To-Sales Ratio (15.1x) compared to the peer average (6.6x).

Price to Sales Ratio vs Industry

How does 0HD2's PS Ratio compare vs other companies in the GB Biotechs Industry?

5 CompaniesPrice / SalesEstimated GrowthMarket Cap
GNS Genus
1.5x3.7%US$1.25b
TRX Tissue Regenix Group
1.7x15.1%US$53.30m
VRCI Verici Dx
1.8x78.8%US$8.01m
DEST Destiny Pharma
3.5x-171.4%US$5.85m
0HD2 15.1xIndustry Avg. 8.1xNo. of Companies7PS01632486480+
5 CompaniesEstimated GrowthMarket Cap
No more companies

Price-To-Sales vs Industry: 0HD2 is expensive based on its Price-To-Sales Ratio (15.1x) compared to the European Biotechs industry average (8.1x).

Price to Sales Ratio vs Fair Ratio

What is 0HD2's PS Ratio compared to its Fair PS Ratio? This is the expected PS Ratio taking into account the company's forecast earnings growth, profit margins and other risk factors.

0HD2 PS Ratio vs Fair Ratio.
Fair Ratio
Current PS Ratio15.1x
Fair PS Ratio13.4x

Price-To-Sales vs Fair Ratio: 0HD2 is expensive based on its Price-To-Sales Ratio (15.1x) compared to the estimated Fair Price-To-Sales Ratio (13.4x).

Analyst Price Targets

What is the analyst 12-month forecast and do we have any statistical confidence in the consensus price target?

The above table shows the analyst 0HD2 forecast and predictions for the stock price in 12 month’s time.
DateShare PriceAverage 1Y Price TargetDispersionHighLow1Y Actual priceAnalysts
CurrentUS$244.60
US$299.11
+22.3%
17.1%US$400.00US$178.00n/a30
Dec ’25US$253.86
US$298.77
+17.7%
17.2%US$400.00US$178.00n/a30
Nov ’25US$269.22
US$301.32
+11.9%
16.7%US$400.00US$180.00n/a29
Oct ’25US$276.02
US$285.91
+3.6%
19.6%US$400.00US$160.50n/a28
Sep ’25US$262.52
US$282.72
+7.7%
19.5%US$400.00US$160.50n/a27
Aug ’25US$263.11
US$269.76
+2.5%
19.5%US$400.00US$160.50n/a27
Jul ’25US$243.94
US$248.46
+1.9%
21.9%US$400.00US$150.00n/a27
Jun ’25US$149.41
US$220.38
+47.5%
23.1%US$400.00US$138.00n/a26
May ’25US$146.24
US$219.85
+50.3%
23.1%US$395.00US$136.00n/a27
Apr ’25US$149.88
US$220.62
+47.2%
23.3%US$395.00US$136.00n/a26
Mar ’25US$153.56
US$219.65
+43.0%
22.9%US$395.00US$136.00n/a26
Feb ’25US$174.88
US$226.12
+29.3%
20.7%US$395.00US$144.00n/a26
Jan ’25US$193.09
US$224.46
+16.2%
21.6%US$395.00US$135.00n/a26
Dec ’24US$168.86
US$224.08
+32.7%
21.6%US$395.00US$135.00US$253.8626
Nov ’24US$153.35
US$225.41
+47.0%
21.8%US$395.00US$125.00US$269.2226
Oct ’24US$176.87
US$243.63
+37.7%
18.9%US$405.00US$134.00US$276.0226
Sep ’24US$202.57
US$244.07
+20.5%
18.9%US$405.00US$141.00US$262.5225
Aug ’24US$189.53
US$245.82
+29.7%
18.7%US$405.00US$140.00US$263.1125
Jul ’24US$195.56
US$247.71
+26.7%
19.4%US$415.00US$136.00US$243.9425
Jun ’24US$189.16
US$245.72
+29.9%
19.6%US$415.00US$136.00US$149.4126
May ’24US$200.59
US$247.18
+23.2%
20.7%US$415.00US$136.00US$146.2425
Apr ’24US$198.15
US$246.99
+24.6%
20.8%US$415.00US$136.00US$149.8825
Mar ’24US$196.13
US$246.87
+25.9%
20.8%US$415.00US$136.00US$153.5625
Feb ’24US$222.53
US$247.31
+11.1%
20.4%US$415.00US$143.00US$174.8824
Jan ’24US$230.54
US$240.43
+4.3%
21.0%US$415.00US$145.00US$193.0924
Dec ’23US$221.44
US$236.31
+6.7%
21.0%US$415.00US$145.00US$168.8624

Analyst Forecast: Target price is more than 20% higher than the current share price, but analysts are not within a statistically confident range of agreement.

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Company Analysis and Financial Data Status

DataLast Updated (UTC time)
Company Analysis2024/12/22 19:55
End of Day Share Price 2024/12/20 00:00
Earnings2024/09/30
Annual Earnings2023/12/31

Data Sources

The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.

PackageDataTimeframeExample US Source *
Company Financials10 years
  • Income statement
  • Cash flow statement
  • Balance sheet
Analyst Consensus Estimates+3 years
  • Forecast financials
  • Analyst price targets
Market Prices30 years
  • Stock prices
  • Dividends, Splits and Actions
Ownership10 years
  • Top shareholders
  • Insider trading
Management10 years
  • Leadership team
  • Board of directors
Key Developments10 years
  • Company announcements

* example for US securities, for non-US equivalent regulatory forms and sources are used.

Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more here.

Analysis Model and Snowflake

Details of the analysis model used to generate this report is available on our Github page, we also have guides on how to use our reports and tutorials on Youtube.

Learn about the world class team who designed and built the Simply Wall St analysis model.

Industry and Sector Metrics

Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on .

Analyst Sources

Alnylam Pharmaceuticals, Inc. is covered by 66 analysts. 30 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.

AnalystInstitution
Ishan MajumdarBaptista Research
Huidong WangBarclays
Emily BodnarBerenberg