Announcement • Apr 11
Avaí Bio, Inc. Presents Latest Data on ?-Klotho Anti-Aging Therapy and Advances Cell-Based Therapies For most of modern biology, aging has been treated as a backdrop — the inevitable canvas on which individual diseases are painted. That is beginning to change. A new generation of biotechnology companies is targeting the cellular and molecular drivers of aging itself, and the capital flowing into the space reflects the shift. The longevity biotech market was valued at $9.86 billion in 2025 and is projected to expand to nearly $29.7 billion by 2034, a 12.84% compound annual growth rate [3]. Cellular therapies, gene editing platforms, and metabolic interventions once confined to academic papers are now moving into late-stage human trials.
One of the most intriguing approaches sits at the intersection of cell therapy and the biology of aging itself. Avaí Bio, Inc. (OTCQB: AVAI), an emerging biotechnology company developing transformative cell-based therapies for diabetes, age-related disorders, and anti-aging, announced on April 7, 2026, that it will present the latest data from its a-Klotho anti-aging therapy at the Second Annual Klotho Conference through its joint venture with Austrianova. Representing Avaí Bio, Austrianova, and their joint venture Klothonova, Rahul Pawa, Chief Production Officer at Austrianova, will deliver the presentation during the September conference. The presentation will focus on the production of the longevity protein a-Klotho from genetically modified and encapsulated cells — an approach designed to sustainably restore circulating a-Klotho levels and support potential therapeutic applications in aging and related conditions. For Avaí Bio, Klothonova is the lead anti-aging program, but it is not the only one. The company's second program, Insulinova, targets diabetes — overlapping directly with one of the fastest-growing therapeutic segments in anti-aging medicine, where metabolic health is increasingly viewed as inseparable from biological aging. Both programs rely on the same underlying approach: using encapsulated, genetically modified cell lines to produce therapeutic proteins inside the body, on demand, for extended periods. Announcement • Apr 10
Avaí Bio, Inc. and Austrianova Present Latest Data on Klotho Anti-Aging Therapy Avaí Bio, Inc. announced that in collaboration with its joint venture partner, Austrianova, it will present the latest data from its a-Klotho anti-aging therapy. The presentation will take place at the Second Annual Klotho Conference, which focuses on the future of Klotho-based therapies. Representing Avaí Bio, Austrianova, and their joint venture, Klothonova, Rahul Pawa, Chief Production Officer at Austrianova, will deliver the presentation during the September conference. The presentation will focus on the production of the longevity protein a-Klotho from encapsulated cells, an approach designed to sustainably restore circulating a-Klotho levels and support potential therapeutic applications in aging and related conditions. The conference brings together a distinguished group of thought leaders, researchers, drug developers, clinicians, executives, analysts, and investors at the forefront of Klotho science and innovation. Featured speakers include key researchers and medical experts, including Dr. Makoto Kuro-o, the physician-scientist widely recognized for discovering the Klotho gene. Announcement • Aug 12
Avant Technologies and Ainnova Tech Announce Enhanced Patient Recruitment Strategy Ahead of FDA Clinical Trial Avant Technologies Inc. and its Joint Venture partner, Ainnova Tech Inc. announced that Ainnova is refining its patient recruitment strategy for the Company's planned clinical trial for its Vision AI platform in the early detection of diabetic retinopathy. Ainnova will work directly with Fortrea, a globally recognized Contract Research Organization (CRO) renowned for its expertise in ophthalmology studies and medical device trials, following the guidance the Company received from its recent meeting with the U.S. Food and Drug Administration (FDA). The planned clinical study, which will be performed in 8-10 clinical sites around the U.S., will prioritize the recruitment of approximately 1,000 multiethnic patients, with a focus on individuals living with diabetes. By targeting community clinics and primary care facilities rather than specialized ophthalmology centers, Ainnova aims to capture real-world data that reflects the diverse population affected by diabetic retinopathy. This strategic approach ensures the study aligns with the practical realities of diabetes care, providing robust and relevant data to support the Company's FDA 510(k) submission. Ainnova's collaboration with Fortrea underscores its commitment to conducting a rigorous and inclusive clinical study. By leveraging Fortrea's deep expertise in ophthalmology and medical device trials, Ainnova is well-positioned to deliver high-quality data to support the regulatory approval process to market Vision AI, a platform poised to transform early disease detection for diabetic patients worldwide, in the United States. AAC has the worldwide licensing rights for Ainnova's technology portfolio. The licensing rights include the U.S., where the FDA regulates drug and medical device development, so the success of Ainnova's clinical trial is paramount to marketing the technology portfolio in the United States. Entering the U.S. market will unlock significant commercial potential, and this early engagement with the FDA ensures AAC can do so with speed,ibility, and a validated product. 
