Announcement • Oct 13
Bruker Cellular Analysis, Inc. Files Form 15 Bruker Cellular Analysis, Inc. has announced that it has filed a Form 15 with the Securities and Exchange Commission to voluntarily deregister its Common stock under the Securities Exchange Act of 1934, as amended. The par value of the company's Common stock was $0.001 per share. Announcement • Sep 28
Phenomex Announces Opto Memory B Discovery Human Workflow on the Beacon®? Optofluidic Platform PhenomeX Inc. announced the Opto Memory B Discovery Human workflow, further expanding diversity of antibodies customers can discover on the Beacon optofluidic platform. The new workflow and reagents, to be commercially available by the end of the year, enable rapid, automated generation of antigen-specific, functional monoclonal antibodies from human memory B cells, building on prior workflows and reagents that used rabbit memory B cells and mouse plasma cells. Directly accessing the human pertoire with new workflow and reagents allows researchers to find more physiologically relevant and efficacious antibodies faster in a rapidly evolving biomedical field aimed at addressing infectious, autoimmune, and oncologic diseases. Using the Opto Memory B Discovery human workflow, PhenomeX estimates customers can: prepare memory B cells from a wide variety of traditional enrichment strategies for screening in Screen up to 60,000 single B cells per workflow in five days, depending on chip selection and number of chips used per workflow; Identify hundreds to thousands of antigen-specific hits per workflow; and Recover high-quality antibody sequences for the majority of discovered hits. The workflow broadens PhenomeX's market opportunity beyond rodent models, enabling direct discovery of high-value human antibodies that are well-suited for therapeutics, diagnostics, and research reagents without the explicit need for experimentation in animal models. Announcement • Sep 22
PhenomeX Inc. Announces the Release of SpotLight™ Human Lambda Reagent for the Beacon® Platform to Accelerate Cell Line Development Workflows PhenomeX Inc. announced that GSK will present data on the SpotLight™ Human Lambda reagent for the Beacon® platform at the 16th annual Conference on Protein Expression in Animal Cells, which is being held in Sitges, Spain from September 24-28, 2023. The goal of the PEACe Conference is to continue the tradition of bringing together scientists from academia and industry to share knowledge in the field of recombinant protein expression. Molly Robinson, a senior scientist with GSK, will present data demonstrating how the SpotLight Human Fc, SpotLight Human Kappa and SpotLight Human Lambda reagents can be used in cell line development productivity assays on the Beacon platform. In this study, as an early access PhenomeX customer, GSK screened clones secreting IgG Lambda light chain monoclonal antibodies and clones secreting bispecific lambda-kappa antibodies. Additionally, the GSK team was able to characterize a variety of molecular formats using the library of SpotLight reagents, and they are excited to continue using these reagents to investigate complex molecular candidates. PhenomeX's fluorescent SpotLight reagents, which are non-destructive and certified as animal- component free, allow early productivity and product quality screens to be run in parallel across thousands of clonal populations. SpotLight™ Human Fc reagent binds to the Fc region of human antibodies SpotLight™ Human Kappa reagent binds to the kappa light chain of human antibodies Soon-to-be released SpotLight™ Human Lambda reagent binds to the lambda light chain of human antibodies As demonstrated by GSK, these reagents can be used individually for screening of monospecific antibodies or in combination to screen bispecific lambda-kappa antibodies. 
