Announcement • Apr 30
PRF Technologies Ltd. Announces FDA Clearance Of IND Application For OcuRing-K Phase II Clinical Trial PRF Technologies Ltd. announced that the U.S. Food and Drug Administration has cleared the Company’s Investigational New Drug application for OcuRing-K, enabling the initiation of a Phase II clinical trial in patients undergoing cataract surgery. The IND clearance marks an important regulatory milestone for PRF and advances the Company’s strategy to develop OcuRing-K as a drop-less, sustained-release therapy designed to address pain and inflammation following cataract surgery. OcuRing-K is a patent-protected, bio-erodible intraocular ring designed to deliver ketorolac through a single intraoperative application. The platform is intended to provide sustained, localized drug release at the surgical site, potentially eliminating the need for complex post-surgical eye-drop regimens that can burden patients and contribute to inconsistent compliance. Following IND clearance and completion of trial-startup activities, PRF plans to initiate a multi-center Phase II clinical trial in the United States, with patient enrollment expected to begin in the second half of 2026. The study is expected to evaluate endpoints related to pain reduction, inflammation control, and overall safety. Cataract surgery is one of the most commonly performed surgical procedures worldwide, yet post-operative recovery often still depends on weeks of topical steroid and NSAID eye drops. PRF believes OcuRing-K’s sustained-release, intraoperative approach may offer a differentiated alternative by improving drug-delivery consistency, reducing dosing burden, and supporting better patient adherence. PRF has previously highlighted that the broader LayerBio ocular platform may also support additional ophthalmic applications over time, including other NSAID, steroid, antibiotic, and anti-VEGF opportunities. Through its majority ownership of LayerBio Inc., PRF believes it is building a differentiated ophthalmic platform with the potential to expand across multiple product candidates and indications, while creating an additional long-term value driver within its broader healthcare portfolio. Board Change • Mar 12
Less than half of directors are independent Following the recent departure of a director, there are only 2 independent directors on the board. The company's board is composed of: 2 independent directors. 3 non-independent directors. Independent External Director Gus Lawlor was the last independent director to join the board, commencing their role in 2020. The company's minority of independent directors is a risk according to the Simply Wall St Risk Model. Announcement • Jan 21
PRF Technologies Ltd. Files Its First Patent Application for Solar Plant Micro-Climate Forecast Modeling Designed to Improve Energy Production Forecast Accuracy PRF Technologies Ltd. announced that it has filed a patent application covering proprietary methods for solar plant-level micro-climate modeling designed to significantly improve the accuracy of solar energy production forecasts in competitive electric utility markets. The patent follows acceptance into the NVIDIA Connect Program and aims to protect core intellectual property underlying DeepSolar Predict, PRF Technologies' solar forecasting software platform. The technology is designed to address a critical limitation in conventional solar forecasting: the reliance on regional or broad-area weather models that fail to capture the highly localized conditions that directly impact power output at individual solar plants. By modeling micro-climate behavior unique to each solar installation, the patented approach aims to enable more precise short-term and intraday production forecasts that reflect real operating conditions rather than broad regional averages. The system continuously adapts to localized environmental dynamics, allowing forecasts to evolve in real time as conditions change. Improved forecast accuracy has direct commercial implications for solar asset owners, operators, and energy market participants. More reliable production estimates can potentially support stronger positioning in day-ahead and intraday electricity markets, reduce financial penalties from forecast errors, enhance revenue capture during favorable pricing conditions, and improve operational decision-making across plant control and energy management systems. PRF Technologies believes that, upon commercialization, DeepSolar Predict can help utility-scale solar operators and energy traders optimize dispatch decisions, improve risk management, and enhance the overall financial performance of solar plants, particularly in markets where pricing volatility and imbalance penalties materially affect returns. The patent filing further strengthens PRF Technologies' growing portfolio of energy-focused intellectual property and supports the Company's strategy to expand its presence in the rapidly growing global market for data-driven renewable energy optimization solutions. 
