Announcement • Jul 10
IN8bio Publishes Peer-Reviewed Clinical Data Demonstrating DeltEx DRI Doubles Progression-Free Survival In Newly Diagnosed Glioblastoma IN8bio published peer-reviewed clinical data from its Phase 1 trial of INB-200 in The Journal of Clinical Oncology. The publication, titled: “Intracranial injection of ex vivo expanded and activated gamma-delta T cells engineered with a MGMT-expressing lentivector in patients with primary glioblastoma,” reports results from the first-in-human study of an autologous, genetically modified ?d T cell therapy. The expanded, activated ?d T cells are engineered to be resistant to chemotherapy (DeltEx DRI) and delivered intracranially in combination with standard of care temozolomide chemotherapy. The Phase 1 trial is a frequency-escalation study of DeltEx DRI in GBM patients in combination with the standard of care Stupp regimen (surgical resection followed by chemoradiation and maintenance chemotherapy). A total of 13 patients were enrolled and treated across three cohorts with subjects in their respective cohorts receiving 1, 3, or up to 6 doses of DeltEx DRI in 28-day cycles during maintenance chemotherapy. Evaluations included the safety and feasibility of repeated intracranial administration during maintenance chemotherapy. In the Phase 1 study, DeltEx DRI in combination with standard of care demonstrated a well-tolerated safety profile with no dose-limiting toxicities, no cytokine release syndrome, and no immune effector cell-associated neurotoxicity observed. Across all 13 treated patients, median progression-free survival was 9.9 months, and a 43.5% improvement over the 6.9 months typically reported with standard of care alone. The results were most striking in repeat-dose patients (those receiving 3 to 6 doses) where median progression-free survival reached 16.1 months, more than double the standard of care benchmark. Overall survival was equally notable: median overall survival in repeat-dose patients was 19.5 months, compared to a historical standard of care median overall survival of approximately 14.6 months in this patient population. The DeltEx DRI technology directly addresses this challenge: ?d T cells are engineered to resist being killed by the chemotherapy that is administered concurrently, then delivered intracranially to the tumor site, where they can attack residual cancer cells and potentially achieve deeper, more durable tumor responses. These JCO-published results offer meaningful evidence that this strategy can extend disease control in these patients with significant unmet need and support its continued advancement as a potential new treatment paradigm for solid tumors. IN8bio expects to provide additional updates to the DeltEx DRI program in newly diagnosed GBM later this year. INB-200 and INB-400 are an autologous, genetically modified gamma-delta T cell therapy engineered with an MGMT-expressing lentivector designed to resist alkylating chemotherapy. The therapy is administered intracranially and is intended to work in combination with temozolomide to target residual tumor cells, enhance immune activation, and prolong disease control in patients with glioblastoma. Announcement • Jun 01
IN8bio, Inc. has filed a Follow-on Equity Offering in the amount of $2.8 million. IN8bio, Inc. has filed a Follow-on Equity Offering in the amount of $2.8 million.
Security Name: Common Stock
Security Type: Common Stock
Transaction Features: At the Market Offering Announcement • May 15
In8bio Inc Presents New Translational Data Demonstrating Deltex Dri Reshapes the Immune Landscape in Glioblastoma IN8bio, Inc. highlighted compelling new clinical translational data from two scientific forums. Presented at the International Society for Cell & Gene Therapy 2026 Annual Meeting and the American Society of Gene & Cell Therapy 2026 Annual Meeting, the data advance the mechanistic and clinical understanding of its DeltEx Drug Resistant Immunotherapy platform in solid tumors such as glioblastoma. Together, the presentations provide mechanistic insight into how repeated dosing of genetically modified ?d T cells (DeltEx DRI), exerts therapeutic pressure on the tumor microenvironment to counteract chemotherapy-induced immune suppression, drive anti-tumor activity, and potentially improve survival outcomes in patients with newly diagnosed GBM. The new analysis builds on previously reported clinical findings from IN8bio’s ongoing Phase 1 and 2 trials evaluating DeltEx DRI in newly diagnosed GBM patients. In patients receiving multiple doses, the company previously reported median progression-free survival (mPFS) of 13.0 months, compared to 6.6 months for standard-of-care (SOC) patients, representing a 97% improvement, with median overall survival (mOS) of greater than 17.2+ months compared to 13.2 months for SOC controls. The new mechanistic data now provides a potential biological rational for these outcomes. New analyses presented at ASGCT 2026, revealed a key immunological advantage of multidose DeltEx DRI therapy. Patients receiving repeated dosing demonstrated sustained stability of CD3+, CD4+, CD8+ and ?d T cell populations during TMZ maintenance therapy, in contrast to single dose patients who exhibited the well-characterized, progressive T cell decline associated with SOC TMZ chemotherapy. Chemotherapy-induced lymphopenia is a known driver of treatment delays and poor prognosis in GBM, making this immune-preservation effect clinically significant. Quantitative analyses further demonstrated that higher cumulative ?d T cell exposure correlated with improved overall survival, and that greater CD4+ T cell reconstitution during treatment was independently associated with favorable patient outcomes. These findings are consistent with prior population-level observations linking high endogenous ?d T cell levels to improved survival across multiple cancer type. Critically, IN8bio’s new data show this survival-associated immune state can be actively induced and sustained through therapeutic intervention. A composite immune score integrating cytokine balance and immune dynamics demonstrated clear separation between higher- and lower-survival patient groups, establishing a potential framework for biomarker-driven patient stratification. In collaboration with Elucidate Bio, spatially resolved transcriptomic and single-cell analysis of paired GBM tumor samples collected at diagnosis and recurrence were presented at ISCT 2026. The findings reveal a striking degree of intratumoral immune remodeling attributable to DeltEx DRI treatment, including an 18x increase in intratumoral CD8+ T cell density and a 90% reduction in granulocyte density, representing a fundamental shift in the tumor immune environment. Complementary analyses demonstrated reduced expression of T cell exhaustion markers alongside enhanced cytotoxic immune activity, indicative of a functionally robust, tumor-directed immune response. At the single-cell molecular level, the data further defined the coordinated immune evasion pathways deployed by recurrent GBM tumors. Collectively, the translational insights from both presentations support the potential for DeltEx DRI to address GBM through a multi-pronged mechanism: preserving systemic immune competence and reactivating intra-tumoral cytotoxic responses while providing the mechanistic foundation for rational biomarker discovery. 
