Announcement • Jun 04
GH Research PLC Publishes Full Results from Phase 2A Trial in Postpartum Depression and Announces Acceptance of Two Oral Presentations At CINP 2026 GH Research PLC announced the publication of the full results from its Phase 2a trial in postpartum depression (PPD) and the acceptance of two oral presentations at the 37th World Congress of Neuropsychopharmacology (CINP 2026). The peer-reviewed article, titled “Inhaled Mebufotenin (GH001) for Adult Patients with Postpartum Depression: A Phase 2a Open-Label Clinical Trial,” has been published in The Journal of Clinical Psychiatry (DOI: 10.4088/JCP.25m16284). The article reports the full results from the Phase 2a, single-arm, open-label trial, which enrolled 10 adult women with PPD. Primary endpoint met: Mean Montgomery–Åsberg Depression Rating Scale (MADRS) reduction of -35.4 points from baseline to Day 8. 100% of patients (10/10) achieved remission (MADRS total score =10) within two hours of dosing, sustained through Day 8. Improved maternal functioning: Mean 34.1-point (56%) increase on the Barkin Index of Maternal Functioning at Day 8. Well-tolerated: No serious adverse events; all treatment-emergent adverse events mild or moderate; no treatment-emergent suicidal ideation or behavior. An analysis of breast milk supports a treatment strategy with only a brief interruption of breastfeeding around GH001 dosing. The Company also announced that two featured communications have been accepted for oral presentation at CINP 2026, to be held June 26–29, 2026 in Glasgow, United Kingdom. Both present data from the Phase 2b GH001-TRD-201 trial of GH001 in treatment-resistant depression (TRD). GHRS
Live News • May 24
GH Research Advances TRD Program With Positive Phase 2b Data and US$400 Million Shelf Approval GH Research reported positive Phase 2b results for its inhaled mebufotenin candidate GH001 in treatment-resistant depression, with Day 8 remission rates between 53.9% and 63.6% and benefits observed through a 6-month open-label extension.
The company has completed enrollment in two Phase 1 studies of its proprietary aerosol delivery device and selected doses for a planned global Phase 3 program, targeting trial initiation in late 2026 following FDA alignment.
GH Research’s Form F-3 shelf registration for up to US$400m of various securities became effective on May 19, 2026, providing flexibility to fund clinical development, pre-commercial work, and general corporate needs, alongside a reported cash position of US$267.3m as of March 31, 2026.
The combination of Phase 2b data publication in JAMA Psychiatry, progression toward a global Phase 3 program, and an effective US$400m shelf registration indicates a company preparing for more capital-intensive late-stage trials and potential pre-commercial activities.
For you as an investor, the key considerations are clinical and regulatory execution in TRD and the likelihood of future equity or other security offerings under the shelf that could affect your stake. Board Change • May 20
Insufficient new directors No new directors have joined the board in the last 3 years. The company's board is composed of: No new directors. 3 experienced directors. 1 highly experienced director. Independent Non-Executive Director Dermot Hanley was the last director to join the board, commencing their role in 2021. The company’s insufficient board refreshment is considered a risk according to the Simply Wall St Risk Model. 
