New Risk • Apr 29
New major risk - Share price stability The company's share price has been highly volatile over the past 3 months. It is more volatile than 90% of British stocks, typically moving 12% a week. This is considered a major risk. Share price volatility increases the risk of potential losses in the short-term as the stock tends to have larger drops in price more frequently than other stocks. It may also indicate the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. Currently, the following risks have been identified for the company: Major Risks Share price has been highly volatile over the past 3 months (12% average weekly change). High level of non-cash earnings (43% accrual ratio). Minor Risk Market cap is less than US$100m (UK£58.0m market cap, or US$78.3m). Announcement • Apr 28
Aoti, Inc. Demonstrates Superior Durable Healing of Chronic Wounds with Two2 Therapy AOTI, INC. announces findings from a large newly published multicentre retrospective cohort study in the Journal of Vascular Surgery-Vascular Insights evaluating the effectiveness of Topical Wound Oxygen (TWO2 therapy) in the treatment of chronic lower extremity wounds. The study demonstrated a high rate of complete durable healing utilising AOTI's intermittent TWO2 therapy as an adjunct to standard of care in hard-to-heal wounds that had failed to heal with other advanced wound care for an average of 7 months. It encompassed 3,126 patients with broad wound types, including diabetic foot ulcers (DFUs), venous leg ulcers (VLUs), arterial ulcers and atypical wounds, building on previously published randomised clinical trial data and real-world evidence as to the therapy's efficacy in healing DFUs. Treatment of chronic lower extremity wounds in a complex, comorbid patient population with TWO2 therapy resulted in superior and more durable complete wound healing outcomes, compared with those reported in population-based real-world studies. The primary outcome of complete wound healing was achieved in 64.8% (n = 2,027) of patients, in a mean time of 4.2 months, despite a mean pre-treatment wound age of 7 months. The need for retreatment due to wound recurrence was only 2.7% (n=54), over a mean follow up time of 13.9 months. TWO2 therapy significantly reduced the rates of hospitalisations and amputations for this high-risk patient population when compared with historical norms reporting only 3.7% (n=115) and 6.1% (n=191) respectively. Announcement • Apr 22
AOTI, Inc., Annual General Meeting, May 21, 2026 AOTI, Inc., Annual General Meeting, May 21, 2026. Location: the offices of burges salmon llp, 6 great new street, ec4a 3bf, london United Kingdom