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Key Takeaways
- Expansion into new treatment areas and product portfolio diversification signal potential for increased revenue and market presence.
- Strategic investments in R&D and sales/marketing infrastructure aim to propel market penetration and ensure sustained long-term growth.
- Leadership transitions, increasing SG&A expenses, and reliance on key products like INGREZZA may pose risks to future revenue growth and profitability.
Catalysts
About Neurocrine Biosciences- Neurocrine Biosciences, Inc. discovers, develops, and markets pharmaceuticals for neurological, neuroendocrine, and neuropsychiatric disorders in the United States and internationally.
- The ongoing growth of INGREZZA, with 30% year-over-year growth, indicates increasing market penetration in tardive dyskinesia (TD) and Huntington's disease chorea which suggests potential for continued revenue growth.
- The introduction and potential approval of crinecerfont, alongside its orphan drug and breakthrough therapy designations, signals a new revenue stream and diversification of the product portfolio, impacting revenue positively.
- Expansion of the sales force and direct-to-consumer advertising for INGREZZA are expected to further propel its market penetration and education among healthcare providers (HCPs) and patients, potentially increasing revenue.
- The robust pipeline, including a potent, highly selective AMPA modulator for major depressive disorder moving towards end of Phase II discussions with FDA suggests future growth through pipeline development, impacting future earnings.
- The company's financial flexibility and continued investment in R&D indicate a strategic focus on sustaining long-term growth through advancing clinical programs and launching new products, potentially impacting net margins and earnings.
Assumptions
How have these above catalysts been quantified?- Analysts are assuming Neurocrine Biosciences's revenue will grow by 16.9% annually over the next 3 years.
- Analysts assume that profit margins will shrink from 16.0% today to 0.3% in 3 years time.
- Analysts expect earnings to reach $1.1 billion (and earnings per share of $10.12) by about August 2027, up from $339.2 million today. However, there is a considerable amount of disagreement amongst the analysts with the most bullish expecting $1.3 billion in earnings, and the most bearish expecting $509 million.
- In order for the above numbers to justify the analysts price target, the company would need to trade at a PE ratio of 21.3x on those 2027 earnings, down from 44.5x today. This future PE is lower than the current PE for the US Biotechs industry at 22.9x.
- Analysts expect the number of shares outstanding to grow by 3.4% per year for the next 3 years.
- To value all of this in today's dollars, we will use a discount rate of 6.29%, as per the Simply Wall St company report.
Risks
What could happen that would invalidate this narrative?- Concerns regarding the ongoing clinical trials and the developmental pipeline could pose a risk if the anticipated positive outcomes for luvadaxistat or NBI-'568, the M4 agonist, do not materialize or face delays, potentially affecting revenue growth and future earnings projections.
- A CEO transition is underway, with Kyle Gano slated to take over from Kevin Gorman. Leadership changes can introduce uncertainty and affect strategic direction, potentially impacting company performance and investor confidence.
- Increased investments in sales forces and marketing, particularly for INGREZZA and crinecerfont, indicate higher SG&A expenses. While these are intended to spur growth, there is a risk that these investments may not yield the expected return, potentially affecting net margins.
- The reliance on INGREZZA's continued revenue growth as a major revenue source carries the risk of market saturation or competitive pressures that could impact future revenue and earnings.
- The company's forward-looking statements on expanding its clinical trial portfolio and launching new products, such as crinecerfont, involve significant R&D investment. Should these initiatives fail to achieve approval or market acceptance, it could substantially impact anticipated revenue growth and profitability.
Valuation
How have all the factors above been brought together to estimate a fair value?- The analysts have a consensus price target of $172.36 for Neurocrine Biosciences based on their expectations of its future earnings growth, profit margins and other risk factors. However, there is a degree of disagreement amongst analysts, with the most bullish reporting a price target of $219.0, and the most bearish reporting a price target of just $131.0.
- In order for you to agree with the analyst's consensus, you'd need to believe that by 2027, revenues will be $3.4 billion, earnings will come to $1.1 billion, and it would be trading on a PE ratio of 21.3x, assuming you use a discount rate of 6.3%.
- Given the current share price of $149.59, the analyst's price target of $172.36 is 13.2% higher.
- We always encourage you to reach your own conclusions though. So sense check these analyst numbers against your own assumptions and expectations based on your understanding of the business and what you believe is probable.
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Disclaimer
Warren A.I. is a tool utilizing a Large Language Model (LLM) that ingests data on consensus price targets, forecasted revenue and earnings figures, as well as the transcripts of earnings calls to produce qualitative analysis. The narratives produced by Warren A.I. are general in nature and are based solely on analyst data and publicly-available material published by the respective companies. These scenarios are not indicative of the company's future performance and are exploratory in nature. Simply Wall St has no position in the company(s) mentioned. The price targets and estimates used are consensus data, and do not constitute a recommendation to buy or sell any stock, and they do not take account of your objectives, or your financial situation. Note that Warren A.I.'s analysis may not factor in the latest price-sensitive company announcements or qualitative material.