공시 • Mar 30
Pacira BioSciences Presents Real-World Data on EXPAREL Showing Reduced Cost of Care
Pacira BioSciences, Inc. announced findings from two real-world studies evaluating the economic benefits of EXPAREL (bupivacaine liposome injectable suspension) in orthopaedic procedures, including total knee arthroplasty (TKA) and spinal fusion. In both studies, EXPAREL was associated with lower total cost of care compared with ropivacaine in one study and standard of care options (non-LB) in the other, with reductions observed in both outpatient and inpatient surgical settings. The data will be presented at the Orthopaedic Research Society (ORS) 2026 Annual Meeting taking place March 27–31 in Charlotte, North Carolina. Briefly, the analyses include two propensity score-matched cohort studies evaluating outcomes on surgery day and throughout 30 days of follow-up in commercial and Medicare Advantage populations. Across both studies, EXPAREL was associated with lower total costs and reductions in select healthcare resource utilization measures. In the spinal fusion study, these reductions were driven primarily by a shorter length of hospital stay. Pacira Presentations at ORS 2026: 1) “Costs and Health Care Resource Utilization of Liposomal Bupivacaine and Ropivacaine in the Total Knee Arthroplasty in the Hospital Outpatient Department: a Propensity Score-Matched Cohort Study” Presenter: Jennifer Lin, Senior Director, Epidemiology in Health Outcomes Economics Research & RWE Department, Pacira BioSciences Poster Number: 1224 Date & Time: Monday, March 30, 4:45–5:30 p.m. ET This study evaluated real-world outcomes of liposomal bupivacaine (LB) compared with ropivacaine in patients undergoing TKA in the HOPD setting, with a focus on healthcare resource utilization and total cost of care on surgery day and during the subsequent 30 days of follow-up. In a propensity score-matched analysis of commercial and Medicare Advantage populations (in the commercial cohort, there were 9,463 patients each in the LB and ropivacaine group; for the MA cohort, there were 2,924 patients in each group), LB was associated with significantly lower total costs versus ropivacaine (commercial: -$409 [$37,466 vs $37,875]; Medicare Advantage: -$1,359 [$19,814 vs $21,173]; P 2) Lower Costs and Health Care Resource Utilization of Patients Undergoing Spinal Fusion Treated With Liposomal Bupivacaine in the Inpatient Commercial Setting: a Propensity Score-Matched Cohort Presenter: Jennifer Lin, Senior Director, Epidemiology in Health Outcomes Economics Research & RWE Department, Pacira BioSciences Poster Number: 1798 Date & Time: Monday, March 30, 4:45–5:30 p.m. ET This study evaluated real-world economic and healthcare resource utilization outcomes of LB compared with non-LB analgesia in commercially insured patients undergoing spinal fusion surgery in the inpatient setting on surgery day and over subsequent 30-day episode of care. In a propensity score-matched cohort (n=478 LB; n=1,434 non-LB), LB use was associated with significantly lower mean total costs (-$5,993.17 [$75,703.78 vs $81,696.95]; P EXPAREL is indicated to produce postsurgical local analgesia via infiltration in patients aged 6 years and older, and postsurgical regional analgesia via an interscalene brachial plexus block in adults, a sciatic nerve block in the popliteal fossa in adults, and an adductor canal block in adults. The safety and effectiveness of EXPAREL have not been established to produce postsurgical regional analgesia via other nerve blocks besides an interscalene brachial plexus nerve block, a sciatic nerve block in the popliteal fossa, or an adductor canal block. The product combines bupivacaine with multivesicular liposomes, a proven product delivery technology that delivers medication over a desired time period. EXPAREL represents the first and only multivesicular liposome local anesthetic that can be utilized in the peri- or postsurgical setting. By utilizing the multivesicular liposome platform, a single dose of EXPAREL delivers bupivacaine over time, providing significant reductions in cumulative pain scores with up to a 78% decrease in opioid consumption; the clinical benefit of the opioid reduction was not demonstrated. EXPAREL should not be used in obstetrical paracervical block anesthesia. In studies in adults where EXPAREL was injected into a wound, the most common side effects were nausea, constipation, and vomiting. In studies in adults where EXPAREL was injected near a nerve, the most common side effects were nausea, fever, headache, and constipation. In the study where EXPAREL was given to children, the most common side effects were nausea, vomiting, constipation, low blood pressure, low number of red blood cells, muscle twitching, blurred vision, itching, and rapid heartbeat. EXPAREL can cause a temporary loss of feeling and/or loss of muscle movement. How much and how long the loss of feeling and/or muscle movement depends on where and how much of EXPAREL was injected and may last for up to 5 days. EXPAREL is not recommended to be used in patients younger than 6 years old for injection into the wound, for patients younger than 18 years old for injection near a nerve, and/or in pregnant women. Tell your health care provider if you or your child has liver disease, since this may affect how the active ingredient (bupivacaine) in EXPAREL is eliminated from the body. EXPAREL should not be injected into the spine, joints, or veins. The active ingredient in EXPAREL can affect the nervous system and the cardiovascular system; may cause an allergic reaction; may cause damage if injected into the joints; and can cause a rare blood disorder.