Raphael Pharmaceutical（RAPH）株式概要Raphael Pharmaceutical Inc.は医薬品の研究開発会社で、カンナビノイドに基づく生命を改善する薬物療法の発見と臨床開発に注力している。 詳細RAPH ファンダメンタル分析スノーフレーク・スコア評価0/6将来の成長0/6過去の実績0/6財務の健全性0/6配当金0/6報酬過去5年間の収益は年間5%増加しました。 リスク分析収益が 100 万ドル未満 ( $0 )マイナスの株主資本 キャッシュランウェイが1年未満である 株式の流動性は非常に低い +1 さらなるリスクすべてのリスクチェックを見るRAPH Community Fair Values Create NarrativeSee what others think this stock is worth. Follow their fair value or set your own to get alerts.Your Fair ValueUS$Current PriceUS$1.40該当なし内在価値ディスカウントEst. Revenue$PastFuture-3m12016201920222025202620282031Revenue US$1.0Earnings US$0.2AdvancedSet Fair ValueView all narrativesRaphael Pharmaceutical Inc. 競合他社NextCureSymbol: NasdaqGS:NXTCMarket cap: US$25.3mABVC BioPharmaSymbol: NasdaqCM:ABVCMarket cap: US$32.6mCervoMedSymbol: NasdaqCM:CRVOMarket cap: US$28.2mLisata TherapeuticsSymbol: NasdaqCM:LSTAMarket cap: US$28.9m価格と性能株価の高値、安値、推移の概要Raphael Pharmaceutical過去の株価現在の株価US$1.4052週高値US$1.4052週安値US$0.04ベータ21ヶ月の変化2,592.31%3ヶ月変化n/a1年変化315.43%3年間の変化-30.00%5年間の変化n/aIPOからの変化-36.36%最新ニュースお知らせ • Nov 19Raphael Pharmaceutical Inc. Announces Filing of Provisional Patent Application for the Treatment of Neutrophil-Dominant Autoimmune Diseases, Including Rheumatoid ArthritisR Raphael Pharmaceutical Inc. announced the filing of a provisional patent application with the United States Patent and Trademark Office. The application covers the use of the Company's highly purified cannabinoid-based technology platform in the treatment of neutrophil-dominant autoimmune diseases, including its lead product candidate for rheumatoid arthritis (RA), as well as psoriatic arthritis, inflammatory bowel disease, systemic lupus erythematosus with neutrophil involvement, and gout. Raphael previously announced positive proof-of-concept clinical study results for its cannabinoid-based formula for the management of RA. The study was successfully completed in the United States under Institutional Review Board ("IRB") approval and in compliance with U.S. Food and Drug Administration ("FDA") regulations. No adverse effects were reported throughout the trial. The provisional patent application, titled, "R Raphael Pharmaceutical Inc. /Rambam MedTech Formula for Treating Neutrophil-Dominant Autoimmune Diseases (including RA)" (No. 63/911,729), was filed jointly with the Medical Cannabis Research and Innovation Center (MCRIC) at Rambam Health Care Campus - one of the world's leading university hospitals. Raphael and Rambam have collaborated under a sponsored research agreement signed in 2019, granting Raphael exclusive access to Rambam's world-class cannabinoid research and development program, led by Dr. Igal Louria-Hayon, who serves as both Chief Technology Officer (CTO) of Raphael and Head of the Medical Cannabis Research and innovation Center at Rambam Health Care campus. Dr. Louria-Hayon is a global expert in cannabinoid research and cell-to-cell communication. Key Findings from the Proof-of-Concept Clinical Study: Raphael Pharmaceutical utilizes a highly purified cannabinoid formulation derived from the hemp plant, entirely free of psychoactive cannabis components, with exceptional anti-inflammatory potential. The formulation is administered orally and demonstrated no side effects. It is designed to interact with the human endocannabinoid system by activating cannabinoid receptors expressed on immune cells. In 2025, the Company announced positive Proof-of-Concept clinical results for the use of its cannabinoid-based formula in the treatment of RA. The eight-week IRB-approved study conducted in the United States showed significant improvements in pain, sleep quality, and overall well-being, which became evident as early as week four and persisted through the end of the trial. This included a reduction in DAS28 scores from high disease activity to moderate disease severity.お知らせ • Jan 07Raphael Pharmaceutical Inc. Announces Positive Proof-Of-Concept Clinical Study Results for the Company's Cannabinoid-Based Formula for the Treatment of Rheumatoid ArthritisR Raphael Pharmaceutical Inc. announced positive proof-of-concept clinical study results for the Company's cannabinoid-based formula for the management of rheumatoid arthritis ("RA"). Citruslabs, a leading contract research organization, successfully completed this proof-of- concept clinical study in the United States under Institutional Review Board ("IRB") approval and in compliance with U.S. Food and Drug Administration ("FDA") regulations. Key Findings of the Proof-of-Concept Clinical Study: The single-group clinical trial evaluated the effects of Raphael Pharmaceutical's highly purified cannabinoid-based formula on RA and involved 12 adult participants, each of whom used 0.5 mL of the formula daily over an eight-week period. The study results demonstrate promising efficacy, with significant improvements observed in critical health outcomes, including pain levels, sleep quality, and overall well-being. These benefits became evident as early as Week 4 and were sustained through the end of the trial. The study's key findings: Reduction in Disease Activity Score ("DAS28"): DAS28, a comprehensive metric assessing RA disease activity, declined by 19.2%, reflecting a shift in participants from high to moderate disease activity. DAS28 is a widely used measure of RA disease activity that combines the number of tender and swollen joints, levels of inflammation, and the patient's self-assessed health. A lower DAS28 score indicates reduced disease activity, and achieving low scores is a key goal in RA management. Of note, among the data: Participants in remission increased from 0% at baseline to 16.67% by Week 8. The Company intends to protect its intellectual property and highly purified cannabinoid formulation with a registered patent.お知らせ • Jan 01Raphael Pharmaceutical Inc. Receives Clinical Study Results After Successful Completion of a Proof-Of-Concept Clinical StudyOn December 23, 2024, Raphael Pharmaceutical Inc. (“Raphael” or the “Company”) received clinical study results after a successful completion of a proof-of-concept clinical study (the “Study”), evaluating the efficacy of the Company’s Cannabinoid based formula (“Raphael’s Formula”) in patients with active Rheumatoid Arthritis (“RA”). The single-group Study was managed by MindMate Inc./dba Citruslabs (“Citruslabs”) and conducted in Santa Monica, California, United States, under Institutional Review Board (“IRB”) approval, in compliance with the United States Food and Drug Administration (the “FDA”) regulations and in accordance with applicable industry standards and regulations. The Study evaluated the impact of Raphael’s Formula on RA related health outcomes in 12 adult participants, each of whom used 0.5 mL Raphael’s Formula product daily at home over an 8-week period, completed questionnaires and attended their local Quest Diagnostics Center for blood biomarker testing at designated intervals. According to the Study results, the questionnaires results demonstrated significant improvement in certain health parameters, including pain levels, sleep quality and overall well-being, with certain parameters remaining significantly improved through the end of the Study. The key findings from the Study results included a reduction in the Disease Activity Score (a comprehensive metric assessing RA disease activity) (“DAS28”) by 19.2%, reflecting a total decrease from high to moderate disease activity. A low DAS28 score indicates reduced disease activity and is a key goal in RA management. Additionally, the percentage of participants classified according to disease activity was evaluated and the findings included an increase in the percentage of participants classified as in remission from 0% at baseline to 16.67% at week 8, an increase in the percentage of participants classified as having low disease activity from 8.33% to 16.67% and a decreased in the percentage of participants classified as having high disease activity from 66.67% at baseline to 41.67% at week 8. The Study results also showed an improvement in health-related parameters, as evaluated through the questionnaires. For example, pain levels dropped from 75% participants reporting a negative result to 50% in week 8 and morning stiffness showed a notable reduction from 75% participants reporting such symptom at baseline to 41.67% at week 8. Additionally, participant perceptions were highly positive, with approximately 83.3% of participants willing to continue using the product and approximately 91.7% of participants indicating they would recommend Raphael’s Formula to others with RA.お知らせ • May 27Raphael Pharmaceutical Inc. Contemplates Bankruptcy Raphael Pharmaceutical Inc. is contemplating filing for bankruptcy, as of May 25, 2023. According to company press release, the company said that additional funding will be required to complete the Company’s research and development and clinical trials, to attain regulatory approvals, to begin the commercialization efforts of the Company’s product and to achieve a level of sales adequate to support the Company’s cost structure. If such sufficient financing is not received timely, the Company will not have sufficient cash flows and liquidity to finance its business operations as currently contemplated and would then need to pursue a plan to license its assets, seek to be acquired by another entity, cease operations or seek bankruptcy protection.最新情報をもっと見るRecent updatesお知らせ • Nov 19Raphael Pharmaceutical Inc. Announces Filing of Provisional Patent Application for the Treatment of Neutrophil-Dominant Autoimmune Diseases, Including Rheumatoid ArthritisR Raphael Pharmaceutical Inc. announced the filing of a provisional patent application with the United States Patent and Trademark Office. The application covers the use of the Company's highly purified cannabinoid-based technology platform in the treatment of neutrophil-dominant autoimmune diseases, including its lead product candidate for rheumatoid arthritis (RA), as well as psoriatic arthritis, inflammatory bowel disease, systemic lupus erythematosus with neutrophil involvement, and gout. Raphael previously announced positive proof-of-concept clinical study results for its cannabinoid-based formula for the management of RA. The study was successfully completed in the United States under Institutional Review Board ("IRB") approval and in compliance with U.S. Food and Drug Administration ("FDA") regulations. No adverse effects were reported throughout the trial. The provisional patent application, titled, "R Raphael Pharmaceutical Inc. /Rambam MedTech Formula for Treating Neutrophil-Dominant Autoimmune Diseases (including RA)" (No. 63/911,729), was filed jointly with the Medical Cannabis Research and Innovation Center (MCRIC) at Rambam Health Care Campus - one of the world's leading university hospitals. Raphael and Rambam have collaborated under a sponsored research agreement signed in 2019, granting Raphael exclusive access to Rambam's world-class cannabinoid research and development program, led by Dr. Igal Louria-Hayon, who serves as both Chief Technology Officer (CTO) of Raphael and Head of the Medical Cannabis Research and innovation Center at Rambam Health Care campus. Dr. Louria-Hayon is a global expert in cannabinoid research and cell-to-cell communication. Key Findings from the Proof-of-Concept Clinical Study: Raphael Pharmaceutical utilizes a highly purified cannabinoid formulation derived from the hemp plant, entirely free of psychoactive cannabis components, with exceptional anti-inflammatory potential. The formulation is administered orally and demonstrated no side effects. It is designed to interact with the human endocannabinoid system by activating cannabinoid receptors expressed on immune cells. In 2025, the Company announced positive Proof-of-Concept clinical results for the use of its cannabinoid-based formula in the treatment of RA. The eight-week IRB-approved study conducted in the United States showed significant improvements in pain, sleep quality, and overall well-being, which became evident as early as week four and persisted through the end of the trial. This included a reduction in DAS28 scores from high disease activity to moderate disease severity.お知らせ • Jan 07Raphael Pharmaceutical Inc. Announces Positive Proof-Of-Concept Clinical Study Results for the Company's Cannabinoid-Based Formula for the Treatment of Rheumatoid ArthritisR Raphael Pharmaceutical Inc. announced positive proof-of-concept clinical study results for the Company's cannabinoid-based formula for the management of rheumatoid arthritis ("RA"). Citruslabs, a leading contract research organization, successfully completed this proof-of- concept clinical study in the United States under Institutional Review Board ("IRB") approval and in compliance with U.S. Food and Drug Administration ("FDA") regulations. Key Findings of the Proof-of-Concept Clinical Study: The single-group clinical trial evaluated the effects of Raphael Pharmaceutical's highly purified cannabinoid-based formula on RA and involved 12 adult participants, each of whom used 0.5 mL of the formula daily over an eight-week period. The study results demonstrate promising efficacy, with significant improvements observed in critical health outcomes, including pain levels, sleep quality, and overall well-being. These benefits became evident as early as Week 4 and were sustained through the end of the trial. The study's key findings: Reduction in Disease Activity Score ("DAS28"): DAS28, a comprehensive metric assessing RA disease activity, declined by 19.2%, reflecting a shift in participants from high to moderate disease activity. DAS28 is a widely used measure of RA disease activity that combines the number of tender and swollen joints, levels of inflammation, and the patient's self-assessed health. A lower DAS28 score indicates reduced disease activity, and achieving low scores is a key goal in RA management. Of note, among the data: Participants in remission increased from 0% at baseline to 16.67% by Week 8. The Company intends to protect its intellectual property and highly purified cannabinoid formulation with a registered patent.お知らせ • Jan 01Raphael Pharmaceutical Inc. Receives Clinical Study Results After Successful Completion of a Proof-Of-Concept Clinical StudyOn December 23, 2024, Raphael Pharmaceutical Inc. (“Raphael” or the “Company”) received clinical study results after a successful completion of a proof-of-concept clinical study (the “Study”), evaluating the efficacy of the Company’s Cannabinoid based formula (“Raphael’s Formula”) in patients with active Rheumatoid Arthritis (“RA”). The single-group Study was managed by MindMate Inc./dba Citruslabs (“Citruslabs”) and conducted in Santa Monica, California, United States, under Institutional Review Board (“IRB”) approval, in compliance with the United States Food and Drug Administration (the “FDA”) regulations and in accordance with applicable industry standards and regulations. The Study evaluated the impact of Raphael’s Formula on RA related health outcomes in 12 adult participants, each of whom used 0.5 mL Raphael’s Formula product daily at home over an 8-week period, completed questionnaires and attended their local Quest Diagnostics Center for blood biomarker testing at designated intervals. According to the Study results, the questionnaires results demonstrated significant improvement in certain health parameters, including pain levels, sleep quality and overall well-being, with certain parameters remaining significantly improved through the end of the Study. The key findings from the Study results included a reduction in the Disease Activity Score (a comprehensive metric assessing RA disease activity) (“DAS28”) by 19.2%, reflecting a total decrease from high to moderate disease activity. A low DAS28 score indicates reduced disease activity and is a key goal in RA management. Additionally, the percentage of participants classified according to disease activity was evaluated and the findings included an increase in the percentage of participants classified as in remission from 0% at baseline to 16.67% at week 8, an increase in the percentage of participants classified as having low disease activity from 8.33% to 16.67% and a decreased in the percentage of participants classified as having high disease activity from 66.67% at baseline to 41.67% at week 8. The Study results also showed an improvement in health-related parameters, as evaluated through the questionnaires. For example, pain levels dropped from 75% participants reporting a negative result to 50% in week 8 and morning stiffness showed a notable reduction from 75% participants reporting such symptom at baseline to 41.67% at week 8. Additionally, participant perceptions were highly positive, with approximately 83.3% of participants willing to continue using the product and approximately 91.7% of participants indicating they would recommend Raphael’s Formula to others with RA.お知らせ • May 27Raphael Pharmaceutical Inc. Contemplates Bankruptcy Raphael Pharmaceutical Inc. is contemplating filing for bankruptcy, as of May 25, 2023. According to company press release, the company said that additional funding will be required to complete the Company’s research and development and clinical trials, to attain regulatory approvals, to begin the commercialization efforts of the Company’s product and to achieve a level of sales adequate to support the Company’s cost structure. If such sufficient financing is not received timely, the Company will not have sufficient cash flows and liquidity to finance its business operations as currently contemplated and would then need to pursue a plan to license its assets, seek to be acquired by another entity, cease operations or seek bankruptcy protection.株主還元RAPHUS BiotechsUS 市場7D0%1.0%1.3%1Y315.4%34.2%27.7%株主還元を見る業界別リターン: RAPH過去 1 年間で34.2 % の収益を上げたUS Biotechs業界を上回りました。リターン対市場: RAPH過去 1 年間で27.7 % の収益を上げたUS市場を上回りました。価格変動Is RAPH's price volatile compared to industry and market?RAPH volatilityRAPH Average Weekly Movementn/aBiotechs Industry Average Movement10.9%Market Average Movement7.2%10% most volatile stocks in US Market16.6%10% least volatile stocks in US Market3.0%安定した株価: RAPHの株価は、 US市場と比較して過去 3 か月間で変動しています。時間の経過による変動: 過去 1 年間のRAPHのボラティリティの変化を判断するには データが不十分です。会社概要設立従業員CEO（最高経営責任者ウェブサイトn/an/aShlomo Pilowww.raphaelpharmaceutical.com医薬品の研究開発会社であるRaphael Pharmaceutical Inc.は、カンナビノイドに基づく生命を改善する薬物療法の発見と臨床開発に注力している。同社は、関節リウマチ治療のための主要製品候補を開発している。また、カンナビノイドをベースとしたがん治療薬や自己免疫疾患治療薬の開発も目指している。本社はイスラエルのテルアビブ・ジャファ。もっと見るRaphael Pharmaceutical Inc. 基礎のまとめRaphael Pharmaceutical の収益と売上を時価総額と比較するとどうか。RAPH 基礎統計学時価総額US$28.25m収益（TTM）-US$1.08m売上高(TTM)n/a0.0xP/Sレシオ-26.2xPER（株価収益率RAPH は割高か？公正価値と評価分析を参照収益と収入最新の決算報告書（TTM）に基づく主な収益性統計RAPH 損益計算書（TTM）収益US$0売上原価US$0売上総利益US$0その他の費用US$1.08m収益-US$1.08m直近の収益報告Mar 31, 2026次回決算日該当なし一株当たり利益（EPS）-0.053グロス・マージン0.00%純利益率0.00%有利子負債／自己資本比率-2.2%RAPH の長期的なパフォーマンスは？過去の実績と比較を見るView Valuation企業分析と財務データの現状データ最終更新日（UTC時間）企業分析2026/05/28 14:46終値2026/04/29 00:00収益2026/03/31年間収益2025/12/31データソース企業分析に使用したデータはS&P Global Market Intelligence LLC のものです。本レポートを作成するための分析モデルでは、以下のデータを使用しています。データは正規化されているため、ソースが利用可能になるまでに時間がかかる場合があります。パッケージデータタイムフレーム米国ソース例会社財務10年損益計算書キャッシュ・フロー計算書貸借対照表SECフォーム10-KSECフォーム10-Qアナリストのコンセンサス予想+プラス3年予想財務アナリストの目標株価アナリストリサーチレポートBlue Matrix市場価格30年株価配当、分割、措置ICEマーケットデータSECフォームS-1所有権10年トップ株主インサイダー取引SECフォーム4SECフォーム13Dマネジメント10年リーダーシップ・チーム取締役会SECフォーム10-KSECフォームDEF 14A主な進展10年会社からのお知らせSECフォーム8-K* 米国証券を対象とした例であり、非米国証券については、同等の規制書式および情報源を使用。特に断りのない限り、すべての財務データは1年ごとの期間に基づいていますが、四半期ごとに更新されます。これは、TTM（Trailing Twelve Month）またはLTM（Last Twelve Month）データとして知られています。詳細はこちら。分析モデルとスノーフレーク本レポートを生成するために使用した分析モデルの詳細は当社のGithubページでご覧いただけます。また、レポートの使用方法に関するガイドやYoutubeのチュートリアルも掲載しています。シンプリー・ウォールストリート分析モデルを設計・構築した世界トップクラスのチームについてご紹介します。業界およびセクターの指標私たちの業界とセクションの指標は、Simply Wall Stによって6時間ごとに計算されます。アナリスト筋Raphael Pharmaceutical Inc. 0 これらのアナリストのうち、弊社レポートのインプットとして使用した売上高または利益の予想を提出したのは、 。アナリストの投稿は一日中更新されます。0
お知らせ • Nov 19Raphael Pharmaceutical Inc. Announces Filing of Provisional Patent Application for the Treatment of Neutrophil-Dominant Autoimmune Diseases, Including Rheumatoid ArthritisR Raphael Pharmaceutical Inc. announced the filing of a provisional patent application with the United States Patent and Trademark Office. The application covers the use of the Company's highly purified cannabinoid-based technology platform in the treatment of neutrophil-dominant autoimmune diseases, including its lead product candidate for rheumatoid arthritis (RA), as well as psoriatic arthritis, inflammatory bowel disease, systemic lupus erythematosus with neutrophil involvement, and gout. Raphael previously announced positive proof-of-concept clinical study results for its cannabinoid-based formula for the management of RA. The study was successfully completed in the United States under Institutional Review Board ("IRB") approval and in compliance with U.S. Food and Drug Administration ("FDA") regulations. No adverse effects were reported throughout the trial. The provisional patent application, titled, "R Raphael Pharmaceutical Inc. /Rambam MedTech Formula for Treating Neutrophil-Dominant Autoimmune Diseases (including RA)" (No. 63/911,729), was filed jointly with the Medical Cannabis Research and Innovation Center (MCRIC) at Rambam Health Care Campus - one of the world's leading university hospitals. Raphael and Rambam have collaborated under a sponsored research agreement signed in 2019, granting Raphael exclusive access to Rambam's world-class cannabinoid research and development program, led by Dr. Igal Louria-Hayon, who serves as both Chief Technology Officer (CTO) of Raphael and Head of the Medical Cannabis Research and innovation Center at Rambam Health Care campus. Dr. Louria-Hayon is a global expert in cannabinoid research and cell-to-cell communication. Key Findings from the Proof-of-Concept Clinical Study: Raphael Pharmaceutical utilizes a highly purified cannabinoid formulation derived from the hemp plant, entirely free of psychoactive cannabis components, with exceptional anti-inflammatory potential. The formulation is administered orally and demonstrated no side effects. It is designed to interact with the human endocannabinoid system by activating cannabinoid receptors expressed on immune cells. In 2025, the Company announced positive Proof-of-Concept clinical results for the use of its cannabinoid-based formula in the treatment of RA. The eight-week IRB-approved study conducted in the United States showed significant improvements in pain, sleep quality, and overall well-being, which became evident as early as week four and persisted through the end of the trial. This included a reduction in DAS28 scores from high disease activity to moderate disease severity.
お知らせ • Jan 07Raphael Pharmaceutical Inc. Announces Positive Proof-Of-Concept Clinical Study Results for the Company's Cannabinoid-Based Formula for the Treatment of Rheumatoid ArthritisR Raphael Pharmaceutical Inc. announced positive proof-of-concept clinical study results for the Company's cannabinoid-based formula for the management of rheumatoid arthritis ("RA"). Citruslabs, a leading contract research organization, successfully completed this proof-of- concept clinical study in the United States under Institutional Review Board ("IRB") approval and in compliance with U.S. Food and Drug Administration ("FDA") regulations. Key Findings of the Proof-of-Concept Clinical Study: The single-group clinical trial evaluated the effects of Raphael Pharmaceutical's highly purified cannabinoid-based formula on RA and involved 12 adult participants, each of whom used 0.5 mL of the formula daily over an eight-week period. The study results demonstrate promising efficacy, with significant improvements observed in critical health outcomes, including pain levels, sleep quality, and overall well-being. These benefits became evident as early as Week 4 and were sustained through the end of the trial. The study's key findings: Reduction in Disease Activity Score ("DAS28"): DAS28, a comprehensive metric assessing RA disease activity, declined by 19.2%, reflecting a shift in participants from high to moderate disease activity. DAS28 is a widely used measure of RA disease activity that combines the number of tender and swollen joints, levels of inflammation, and the patient's self-assessed health. A lower DAS28 score indicates reduced disease activity, and achieving low scores is a key goal in RA management. Of note, among the data: Participants in remission increased from 0% at baseline to 16.67% by Week 8. The Company intends to protect its intellectual property and highly purified cannabinoid formulation with a registered patent.
お知らせ • Jan 01Raphael Pharmaceutical Inc. Receives Clinical Study Results After Successful Completion of a Proof-Of-Concept Clinical StudyOn December 23, 2024, Raphael Pharmaceutical Inc. (“Raphael” or the “Company”) received clinical study results after a successful completion of a proof-of-concept clinical study (the “Study”), evaluating the efficacy of the Company’s Cannabinoid based formula (“Raphael’s Formula”) in patients with active Rheumatoid Arthritis (“RA”). The single-group Study was managed by MindMate Inc./dba Citruslabs (“Citruslabs”) and conducted in Santa Monica, California, United States, under Institutional Review Board (“IRB”) approval, in compliance with the United States Food and Drug Administration (the “FDA”) regulations and in accordance with applicable industry standards and regulations. The Study evaluated the impact of Raphael’s Formula on RA related health outcomes in 12 adult participants, each of whom used 0.5 mL Raphael’s Formula product daily at home over an 8-week period, completed questionnaires and attended their local Quest Diagnostics Center for blood biomarker testing at designated intervals. According to the Study results, the questionnaires results demonstrated significant improvement in certain health parameters, including pain levels, sleep quality and overall well-being, with certain parameters remaining significantly improved through the end of the Study. The key findings from the Study results included a reduction in the Disease Activity Score (a comprehensive metric assessing RA disease activity) (“DAS28”) by 19.2%, reflecting a total decrease from high to moderate disease activity. A low DAS28 score indicates reduced disease activity and is a key goal in RA management. Additionally, the percentage of participants classified according to disease activity was evaluated and the findings included an increase in the percentage of participants classified as in remission from 0% at baseline to 16.67% at week 8, an increase in the percentage of participants classified as having low disease activity from 8.33% to 16.67% and a decreased in the percentage of participants classified as having high disease activity from 66.67% at baseline to 41.67% at week 8. The Study results also showed an improvement in health-related parameters, as evaluated through the questionnaires. For example, pain levels dropped from 75% participants reporting a negative result to 50% in week 8 and morning stiffness showed a notable reduction from 75% participants reporting such symptom at baseline to 41.67% at week 8. Additionally, participant perceptions were highly positive, with approximately 83.3% of participants willing to continue using the product and approximately 91.7% of participants indicating they would recommend Raphael’s Formula to others with RA.
お知らせ • May 27Raphael Pharmaceutical Inc. Contemplates Bankruptcy Raphael Pharmaceutical Inc. is contemplating filing for bankruptcy, as of May 25, 2023. According to company press release, the company said that additional funding will be required to complete the Company’s research and development and clinical trials, to attain regulatory approvals, to begin the commercialization efforts of the Company’s product and to achieve a level of sales adequate to support the Company’s cost structure. If such sufficient financing is not received timely, the Company will not have sufficient cash flows and liquidity to finance its business operations as currently contemplated and would then need to pursue a plan to license its assets, seek to be acquired by another entity, cease operations or seek bankruptcy protection.
お知らせ • Nov 19Raphael Pharmaceutical Inc. Announces Filing of Provisional Patent Application for the Treatment of Neutrophil-Dominant Autoimmune Diseases, Including Rheumatoid ArthritisR Raphael Pharmaceutical Inc. announced the filing of a provisional patent application with the United States Patent and Trademark Office. The application covers the use of the Company's highly purified cannabinoid-based technology platform in the treatment of neutrophil-dominant autoimmune diseases, including its lead product candidate for rheumatoid arthritis (RA), as well as psoriatic arthritis, inflammatory bowel disease, systemic lupus erythematosus with neutrophil involvement, and gout. Raphael previously announced positive proof-of-concept clinical study results for its cannabinoid-based formula for the management of RA. The study was successfully completed in the United States under Institutional Review Board ("IRB") approval and in compliance with U.S. Food and Drug Administration ("FDA") regulations. No adverse effects were reported throughout the trial. The provisional patent application, titled, "R Raphael Pharmaceutical Inc. /Rambam MedTech Formula for Treating Neutrophil-Dominant Autoimmune Diseases (including RA)" (No. 63/911,729), was filed jointly with the Medical Cannabis Research and Innovation Center (MCRIC) at Rambam Health Care Campus - one of the world's leading university hospitals. Raphael and Rambam have collaborated under a sponsored research agreement signed in 2019, granting Raphael exclusive access to Rambam's world-class cannabinoid research and development program, led by Dr. Igal Louria-Hayon, who serves as both Chief Technology Officer (CTO) of Raphael and Head of the Medical Cannabis Research and innovation Center at Rambam Health Care campus. Dr. Louria-Hayon is a global expert in cannabinoid research and cell-to-cell communication. Key Findings from the Proof-of-Concept Clinical Study: Raphael Pharmaceutical utilizes a highly purified cannabinoid formulation derived from the hemp plant, entirely free of psychoactive cannabis components, with exceptional anti-inflammatory potential. The formulation is administered orally and demonstrated no side effects. It is designed to interact with the human endocannabinoid system by activating cannabinoid receptors expressed on immune cells. In 2025, the Company announced positive Proof-of-Concept clinical results for the use of its cannabinoid-based formula in the treatment of RA. The eight-week IRB-approved study conducted in the United States showed significant improvements in pain, sleep quality, and overall well-being, which became evident as early as week four and persisted through the end of the trial. This included a reduction in DAS28 scores from high disease activity to moderate disease severity.
お知らせ • Jan 07Raphael Pharmaceutical Inc. Announces Positive Proof-Of-Concept Clinical Study Results for the Company's Cannabinoid-Based Formula for the Treatment of Rheumatoid ArthritisR Raphael Pharmaceutical Inc. announced positive proof-of-concept clinical study results for the Company's cannabinoid-based formula for the management of rheumatoid arthritis ("RA"). Citruslabs, a leading contract research organization, successfully completed this proof-of- concept clinical study in the United States under Institutional Review Board ("IRB") approval and in compliance with U.S. Food and Drug Administration ("FDA") regulations. Key Findings of the Proof-of-Concept Clinical Study: The single-group clinical trial evaluated the effects of Raphael Pharmaceutical's highly purified cannabinoid-based formula on RA and involved 12 adult participants, each of whom used 0.5 mL of the formula daily over an eight-week period. The study results demonstrate promising efficacy, with significant improvements observed in critical health outcomes, including pain levels, sleep quality, and overall well-being. These benefits became evident as early as Week 4 and were sustained through the end of the trial. The study's key findings: Reduction in Disease Activity Score ("DAS28"): DAS28, a comprehensive metric assessing RA disease activity, declined by 19.2%, reflecting a shift in participants from high to moderate disease activity. DAS28 is a widely used measure of RA disease activity that combines the number of tender and swollen joints, levels of inflammation, and the patient's self-assessed health. A lower DAS28 score indicates reduced disease activity, and achieving low scores is a key goal in RA management. Of note, among the data: Participants in remission increased from 0% at baseline to 16.67% by Week 8. The Company intends to protect its intellectual property and highly purified cannabinoid formulation with a registered patent.
お知らせ • Jan 01Raphael Pharmaceutical Inc. Receives Clinical Study Results After Successful Completion of a Proof-Of-Concept Clinical StudyOn December 23, 2024, Raphael Pharmaceutical Inc. (“Raphael” or the “Company”) received clinical study results after a successful completion of a proof-of-concept clinical study (the “Study”), evaluating the efficacy of the Company’s Cannabinoid based formula (“Raphael’s Formula”) in patients with active Rheumatoid Arthritis (“RA”). The single-group Study was managed by MindMate Inc./dba Citruslabs (“Citruslabs”) and conducted in Santa Monica, California, United States, under Institutional Review Board (“IRB”) approval, in compliance with the United States Food and Drug Administration (the “FDA”) regulations and in accordance with applicable industry standards and regulations. The Study evaluated the impact of Raphael’s Formula on RA related health outcomes in 12 adult participants, each of whom used 0.5 mL Raphael’s Formula product daily at home over an 8-week period, completed questionnaires and attended their local Quest Diagnostics Center for blood biomarker testing at designated intervals. According to the Study results, the questionnaires results demonstrated significant improvement in certain health parameters, including pain levels, sleep quality and overall well-being, with certain parameters remaining significantly improved through the end of the Study. The key findings from the Study results included a reduction in the Disease Activity Score (a comprehensive metric assessing RA disease activity) (“DAS28”) by 19.2%, reflecting a total decrease from high to moderate disease activity. A low DAS28 score indicates reduced disease activity and is a key goal in RA management. Additionally, the percentage of participants classified according to disease activity was evaluated and the findings included an increase in the percentage of participants classified as in remission from 0% at baseline to 16.67% at week 8, an increase in the percentage of participants classified as having low disease activity from 8.33% to 16.67% and a decreased in the percentage of participants classified as having high disease activity from 66.67% at baseline to 41.67% at week 8. The Study results also showed an improvement in health-related parameters, as evaluated through the questionnaires. For example, pain levels dropped from 75% participants reporting a negative result to 50% in week 8 and morning stiffness showed a notable reduction from 75% participants reporting such symptom at baseline to 41.67% at week 8. Additionally, participant perceptions were highly positive, with approximately 83.3% of participants willing to continue using the product and approximately 91.7% of participants indicating they would recommend Raphael’s Formula to others with RA.
お知らせ • May 27Raphael Pharmaceutical Inc. Contemplates Bankruptcy Raphael Pharmaceutical Inc. is contemplating filing for bankruptcy, as of May 25, 2023. According to company press release, the company said that additional funding will be required to complete the Company’s research and development and clinical trials, to attain regulatory approvals, to begin the commercialization efforts of the Company’s product and to achieve a level of sales adequate to support the Company’s cost structure. If such sufficient financing is not received timely, the Company will not have sufficient cash flows and liquidity to finance its business operations as currently contemplated and would then need to pursue a plan to license its assets, seek to be acquired by another entity, cease operations or seek bankruptcy protection.
