Chiome Bioscience（4583）株式概要カイオム・バイオサイエンス株式会社は、日本、シンガポールおよび海外で抗体医薬の研究開発を行っている。 詳細4583 ファンダメンタル分析スノーフレーク・スコア評価0/6将来の成長0/6過去の実績0/6財務の健全性5/6配当金0/6報酬過去5年間の収益は年間6%増加しました。 リスク分析意味のある時価総額がありません ( ¥6B )意味のある収益がありません ( ¥593M )すべてのリスクチェックを見る4583 Community Fair Values Create NarrativeSee what others think this stock is worth. Follow their fair value or set your own to get alerts.Your Fair ValueJP¥Current PriceJP¥89.00181.1% 割高 内在価値ディスカウントGrowth estimate overAnnual revenue growth rate5 Yearstime period%/yrDecreaseIncreasePastFuture-2b781m2016201920222025202620282031Revenue JP¥682.9mEarnings JP¥87.4mAdvancedSet Fair ValueView all narrativesChiome Bioscience Inc. 競合他社WDB cocoSymbol: TSE:7079Market cap: JP¥6.2bPrecision System ScienceSymbol: TSE:7707Market cap: JP¥6.8bCellSourceSymbol: TSE:4880Market cap: JP¥7.0bCyfuse Biomedical K.KSymbol: TSE:4892Market cap: JP¥6.1b価格と性能株価の高値、安値、推移の概要Chiome Bioscience過去の株価現在の株価JP¥89.0052週高値JP¥168.0052週安値JP¥87.00ベータ0.381ヶ月の変化-12.75%3ヶ月変化-22.61%1年変化-37.32%3年間の変化-57.62%5年間の変化-63.82%IPOからの変化-69.70%最新ニュースお知らせ • Apr 24Chiome Bioscience Inc. to Report Q1, 2026 Results on May 14, 2026Chiome Bioscience Inc. announced that they will report Q1, 2026 results on May 14, 2026New Risk • Feb 19New minor risk - Share price stabilityThe company's share price has been volatile over the past 3 months. It is more volatile than 75% of Japanese stocks, typically moving 5.5% a week. This is considered a minor risk. Share price volatility indicates the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. It also increases the risk of potential losses in the short term as the stock tends to have larger drops in price more frequently than other stocks. Currently, the following risks have been identified for the company: Minor Risks Share price has been volatile over the past 3 months (5.5% average weekly change). Revenue is less than US$5m (JP¥593m revenue, or US$3.8m). Market cap is less than US$100m (JP¥8.49b market cap, or US$54.9m).Reported Earnings • Feb 14Full year 2025 earnings released: JP¥14.47 loss per share (vs JP¥17.54 loss in FY 2024)Full year 2025 results: JP¥14.47 loss per share (improved from JP¥17.54 loss in FY 2024). Revenue: JP¥593.3m (down 24% from FY 2024). Net loss: JP¥982.8m (loss narrowed 3.7% from FY 2024). Over the last 3 years on average, earnings per share has increased by 20% per year but the company’s share price has fallen by 16% per year, which means it is significantly lagging earnings.お知らせ • Feb 10Chiome Bioscience Inc., Annual General Meeting, Mar 27, 2026Chiome Bioscience Inc., Annual General Meeting, Mar 27, 2026.お知らせ • Dec 27Chiome Bioscience Inc. to Report Fiscal Year 2025 Results on Feb 10, 2026Chiome Bioscience Inc. announced that they will report fiscal year 2025 results on Feb 10, 2026New Risk • Nov 17New major risk - Financial positionThe company has less than a year of cash runway based on its current free cash flow trend. Free cash flow: -JP¥996m This is considered a major risk. With less than a year's worth of cash, the company will need to raise capital or take on debt unless its cash flows improve. This would dilute existing shareholders or increase balance sheet risk. Currently, the following risks have been identified for the company: Major Risk Less than 1 year of cash runway based on free cash flow trend (-JP¥996m free cash flow). Minor Risks Revenue is less than US$5m (JP¥728m revenue, or US$4.7m). Market cap is less than US$100m (JP¥8.37b market cap, or US$54.1m).最新情報をもっと見るRecent updatesお知らせ • Apr 24Chiome Bioscience Inc. to Report Q1, 2026 Results on May 14, 2026Chiome Bioscience Inc. announced that they will report Q1, 2026 results on May 14, 2026New Risk • Feb 19New minor risk - Share price stabilityThe company's share price has been volatile over the past 3 months. It is more volatile than 75% of Japanese stocks, typically moving 5.5% a week. This is considered a minor risk. Share price volatility indicates the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. It also increases the risk of potential losses in the short term as the stock tends to have larger drops in price more frequently than other stocks. Currently, the following risks have been identified for the company: Minor Risks Share price has been volatile over the past 3 months (5.5% average weekly change). Revenue is less than US$5m (JP¥593m revenue, or US$3.8m). Market cap is less than US$100m (JP¥8.49b market cap, or US$54.9m).Reported Earnings • Feb 14Full year 2025 earnings released: JP¥14.47 loss per share (vs JP¥17.54 loss in FY 2024)Full year 2025 results: JP¥14.47 loss per share (improved from JP¥17.54 loss in FY 2024). Revenue: JP¥593.3m (down 24% from FY 2024). Net loss: JP¥982.8m (loss narrowed 3.7% from FY 2024). Over the last 3 years on average, earnings per share has increased by 20% per year but the company’s share price has fallen by 16% per year, which means it is significantly lagging earnings.お知らせ • Feb 10Chiome Bioscience Inc., Annual General Meeting, Mar 27, 2026Chiome Bioscience Inc., Annual General Meeting, Mar 27, 2026.お知らせ • Dec 27Chiome Bioscience Inc. to Report Fiscal Year 2025 Results on Feb 10, 2026Chiome Bioscience Inc. announced that they will report fiscal year 2025 results on Feb 10, 2026New Risk • Nov 17New major risk - Financial positionThe company has less than a year of cash runway based on its current free cash flow trend. Free cash flow: -JP¥996m This is considered a major risk. With less than a year's worth of cash, the company will need to raise capital or take on debt unless its cash flows improve. This would dilute existing shareholders or increase balance sheet risk. Currently, the following risks have been identified for the company: Major Risk Less than 1 year of cash runway based on free cash flow trend (-JP¥996m free cash flow). Minor Risks Revenue is less than US$5m (JP¥728m revenue, or US$4.7m). Market cap is less than US$100m (JP¥8.37b market cap, or US$54.1m).Reported Earnings • Nov 17Third quarter 2025 earnings released: JP¥3.82 loss per share (vs JP¥9.79 loss in 3Q 2024)Third quarter 2025 results: JP¥3.82 loss per share (improved from JP¥9.79 loss in 3Q 2024). Revenue: JP¥118.0m (down 26% from 3Q 2024). Net loss: JP¥260.0m (loss narrowed 26% from 3Q 2024). Over the last 3 years on average, earnings per share has increased by 24% per year but the company’s share price has fallen by 6% per year, which means it is significantly lagging earnings.New Risk • Oct 30New minor risk - Revenue sizeThe company makes less than US$5m in revenue. Total revenue: JP¥769m (US$5.0m) This is considered a minor risk. Companies with a small amount of revenue are most likely businesses that have not yet released a product to market or are simply a very small company without a wide reach. Either way, risk is elevated with these companies because there is a chance the product may not come to fruition or the company's addressable market or demand may not be as large as expected. In addition, if the company's size is the main factor, it is less likely to have many investors and analysts following it and scrutinizing its performance and outlook. Currently, the following risks have been identified for the company: Minor Risks Revenue is less than US$5m (JP¥769m revenue, or US$5.0m). Market cap is less than US$100m (JP¥8.57b market cap, or US$55.6m).分析記事 • Oct 10Is Chiome Bioscience (TSE:4583) Weighed On By Its Debt Load?Howard Marks put it nicely when he said that, rather than worrying about share price volatility, 'The possibility of...Reported Earnings • Aug 14Second quarter 2025 earnings released: JP¥4.04 loss per share (vs JP¥4.63 loss in 2Q 2024)Second quarter 2025 results: JP¥4.04 loss per share. Revenue: JP¥113.1m (down 16% from 2Q 2024). Net loss: JP¥274.2m (loss widened 5.5% from 2Q 2024).お知らせ • Aug 13Chiome Bioscience Inc. to Report Q3, 2025 Results on Nov 11, 2025Chiome Bioscience Inc. announced that they will report Q3, 2025 results on Nov 11, 2025お知らせ • May 31Chiome Bioscience Inc. to Report Q2, 2025 Results on Aug 12, 2025Chiome Bioscience Inc. announced that they will report Q2, 2025 results on Aug 12, 2025お知らせ • Mar 13Chiome Bioscience Inc. to Report Q1, 2025 Results on May 12, 2025Chiome Bioscience Inc. announced that they will report Q1, 2025 results on May 12, 2025Reported Earnings • Feb 18Full year 2024 earnings released: JP¥17.54 loss per share (vs JP¥24.62 loss in FY 2023)Full year 2024 results: JP¥17.54 loss per share (improved from JP¥24.62 loss in FY 2023). Revenue: JP¥780.8m (up 14% from FY 2023). Net loss: JP¥1.02b (loss narrowed 16% from FY 2023). Over the last 3 years on average, earnings per share has increased by 26% per year but the company’s share price has only increased by 5% per year, which means it is significantly lagging earnings growth.お知らせ • Feb 13Chiome Bioscience Inc., Annual General Meeting, Mar 28, 2025Chiome Bioscience Inc., Annual General Meeting, Mar 28, 2025.お知らせ • Dec 20Chiome Bioscience Inc. Announces Publication on CBA-1205 Non-Clinical DataChiome Bioscience Inc. announced that the research results were published in an international academic journal International Journal of Molecular Sciences. The paper discusses the findings on the non-clinical data for CBA-1205, a therapeutic antibody for cancer treatment currently in clinical trials at the company. In this study, CBA-1205, which selectively binds to delta-like 1 homolog (DLK1), destroyed cells expressed DLK1 through Antibody-Dependent Cellular Cytotoxicity (ADCC) activity. CBA-1205 also inhibited tumor growth on mouse-model transplanted with human liver cancer cells expressing DLK1. Furthermore, by combining with Lenvatinib, an standard of care of hepatocellular carcinoma, CBA-1205 inhibited tumor growth more effectively than single-dose administration in the same animal model. This combining effect of Lenvatinib and CBA-1205 lasted long during the observation period after the administration. In the toxicology study using cynomolgus monkeys, it showed no serious toxicological changes caused by the administration of CBA-1205. As a result of these findings, the paper discusses the potential of CBA-1205 as one of the treatment options for patients with hepatocellular carcinoma.分析記事 • Nov 21Is Chiome Bioscience (TSE:4583) Weighed On By Its Debt Load?Legendary fund manager Li Lu (who Charlie Munger backed) once said, 'The biggest investment risk is not the volatility...お知らせ • Nov 12Chiome Bioscience Inc. to Report Fiscal Year 2024 Results on Feb 13, 2025Chiome Bioscience Inc. announced that they will report fiscal year 2024 results on Feb 13, 2025Reported Earnings • Aug 17Second quarter 2024 earnings released: JP¥4.63 loss per share (vs JP¥9.00 loss in 2Q 2023)Second quarter 2024 results: JP¥4.63 loss per share (improved from JP¥9.00 loss in 2Q 2023). Revenue: JP¥134.1m (down 29% from 2Q 2023). Net loss: JP¥259.9m (loss narrowed 40% from 2Q 2023). Over the last 3 years on average, earnings per share has increased by 14% per year but the company’s share price has fallen by 24% per year, which means it is significantly lagging earnings.お知らせ • Aug 14Chiome Bioscience Inc. to Report Q3, 2024 Results on Nov 12, 2024Chiome Bioscience Inc. announced that they will report Q3, 2024 results on Nov 12, 2024分析記事 • Jun 28Is Chiome Bioscience (TSE:4583) Using Too Much Debt?Warren Buffett famously said, 'Volatility is far from synonymous with risk.' It's only natural to consider a company's...お知らせ • Jun 13Chiome Bioscience Inc. to Report Q2, 2024 Results on Aug 13, 2024Chiome Bioscience Inc. announced that they will report Q2, 2024 results on Aug 13, 2024お知らせ • Mar 01Chiome Bioscience Inc. to Report Q1, 2024 Results on May 14, 2024Chiome Bioscience Inc. announced that they will report Q1, 2024 results on May 14, 2024Reported Earnings • Feb 14Full year 2023 earnings released: JP¥24.13 loss per share (vs JP¥28.26 loss in FY 2022)Full year 2023 results: JP¥24.13 loss per share (improved from JP¥28.26 loss in FY 2022). Revenue: JP¥682.5m (up 8.2% from FY 2022). Net loss: JP¥1.22b (loss narrowed 1.8% from FY 2022). Over the last 3 years on average, earnings per share has increased by 9% per year but the company’s share price has fallen by 14% per year, which means it is significantly lagging earnings.お知らせ • Feb 13Chiome Bioscience Inc., Annual General Meeting, Mar 26, 2024Chiome Bioscience Inc., Annual General Meeting, Mar 26, 2024.お知らせ • Dec 05Chiome Bioscience Inc. to Report Fiscal Year 2023 Results on Feb 13, 2024Chiome Bioscience Inc. announced that they will report fiscal year 2023 results at 3:00 PM, Tokyo Standard Time on Feb 13, 2024New Risk • Nov 22New minor risk - Share price stabilityThe company's share price has been volatile over the past 3 months. It is more volatile than 75% of Japanese stocks, typically moving 5.5% a week. This is considered a minor risk. Share price volatility indicates the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. It also increases the risk of potential losses in the short term as the stock tends to have larger drops in price more frequently than other stocks. Currently, the following risks have been identified for the company: Minor Risks Share price has been volatile over the past 3 months (5.5% average weekly change). Shareholders have been diluted in the past year (9.4% increase in shares outstanding). Revenue is less than US$5m (JP¥721m revenue, or US$4.9m). Market cap is less than US$100m (JP¥6.83b market cap, or US$46.2m).Reported Earnings • Nov 15Third quarter 2023 earnings released: JP¥5.25 loss per share (vs JP¥5.79 loss in 3Q 2022)Third quarter 2023 results: JP¥5.25 loss per share (improved from JP¥5.79 loss in 3Q 2022). Revenue: JP¥165.1m (up 6.2% from 3Q 2022). Net loss: JP¥254.8m (flat on 3Q 2022). Over the last 3 years on average, earnings per share has increased by 9% per year but the company’s share price has fallen by 15% per year, which means it is significantly lagging earnings.お知らせ • Aug 27Chiome Bioscience Inc. to Report Q3, 2023 Results on Nov 14, 2023Chiome Bioscience Inc. announced that they will report Q3, 2023 results on Nov 14, 2023お知らせ • Jul 06Chiome Bioscience Inc. announced that it expects to receive ¥13.49304 million in fundingChiome Bioscience Inc. announced that it has entered into an purchase agreement to issue 64,560 units of 19th stock acquisition rights and 32,280 units of 20th stock acquisition rights at a price of ¥171 yen per 19th stock acquisition right, ¥76 per 20th stock acquisition right for gross proceeds of ¥1,931,609,040 through third-party allotment on July 4, 2023. The stock acquisition rights are exercisable 19th Stock Acquisition Rights ¥175, 20th stock acquisition rights ¥247. There is no maximum strike price. The minimum exercise price is ¥129. The transaction will include participation from Growth Capital and Barclays Bank. The transaction has been approved in the board of directors' meeting of the company. The exercisable period of the stock acquisition rights will start from July 21, 2023 to July 22, 2025. The stock acquisition rights have a hold period and cannot be transferred without the company's approval.お知らせ • Jun 02Chiome Bioscience Inc. to Report Q2, 2023 Results on Aug 09, 2023Chiome Bioscience Inc. announced that they will report Q2, 2023 results on Aug 09, 2023Reported Earnings • Feb 17Full year 2022 earnings released: JP¥28.26 loss per share (vs JP¥36.74 loss in FY 2021)Full year 2022 results: JP¥28.26 loss per share (improved from JP¥36.74 loss in FY 2021). Revenue: JP¥630.8m (down 12% from FY 2021). Net loss: JP¥1.24b (loss narrowed 16% from FY 2021). Over the last 3 years on average, earnings per share has increased by 6% per year but the company’s share price has fallen by 5% per year, which means it is significantly lagging earnings.お知らせ • Feb 14Chiome Bioscience Inc., Annual General Meeting, Mar 28, 2023Chiome Bioscience Inc., Annual General Meeting, Mar 28, 2023.お知らせ • Dec 28Chiome Bioscience Inc. to Report Fiscal Year 2022 Results on Feb 14, 2023Chiome Bioscience Inc. announced that they will report fiscal year 2022 results on Feb 14, 2023Reported Earnings • Nov 16Third quarter 2022 earnings released: JP¥5.96 loss per share (vs JP¥10.77 loss in 3Q 2021)Third quarter 2022 results: JP¥5.96 loss per share (improved from JP¥10.77 loss in 3Q 2021). Revenue: JP¥155.5m (flat on 3Q 2021). Net loss: JP¥256.6m (loss narrowed 41% from 3Q 2021). Over the last 3 years on average, earnings per share has increased by 10% per year but the company’s share price has fallen by 7% per year, which means it is significantly lagging earnings.Board Change • Nov 16No independent directorsFollowing the recent departure of a director, there are no independent directors on the board. The company's board is composed of: No independent directors. 4 non-independent directors. Audit & Supervisory Board Member Matsuo Kikuchi was the last director to join the board, commencing their role in 2022. The company's lack of independent directors is a risk according to the Simply Wall St Risk Model.お知らせ • Sep 28Chiome Bioscience Inc. to Report Q3, 2022 Results on Nov 14, 2022Chiome Bioscience Inc. announced that they will report Q3, 2022 results on Nov 14, 2022Reported Earnings • Aug 16First half 2022 earnings released: JP¥18.17 loss per share (vs JP¥10.16 loss in 1H 2021)First half 2022 results: JP¥18.17 loss per share (down from JP¥10.16 loss in 1H 2021). Revenue: JP¥278.2m (down 28% from 1H 2021). Net loss: JP¥771.0m (loss widened 89% from 1H 2021). Over the last 3 years on average, earnings per share has increased by 13% per year but the company’s share price has fallen by 4% per year, which means it is significantly lagging earnings.お知らせ • Jul 05Chiome Bioscience Inc. Announces First Patient in of Cancer Therapeutic Antibody CBA-1535 in A Phase 1 Clinical TrialChiome Bioscience Inc. announced that the first patient has been dosed CBA-1535 in a Phase I clinical trial. The first part of the trial will evaluate the safety, tolerability, pharmacokinetics, and identification of biomarker for the solid tumor patients. In the expansion part, exploratory efficacy will be evaluated in combination with cancer immunotherapy agent Pembrolizumab. This first-in-human study is conducted at National Cancer Center Hospital and Shizuoka Cancer Center. Will continue to update the future process in a timely manner.お知らせ • Jun 13Chiome Bioscience Inc. Announces Conclusion of Contract with Additional Institutes and First Dosing of CBA-1205 in the Second Part of Phase 1 StudyChiome Bioscience Inc. announced that new contract with additional institutes had been finalized and the first patient has been dosed CBA-1205, the first-in-class antibody, in the second part (expansion part) of Phase I study. In the first part of Phase I study, CBA-1205 exhibited good safety and tolerability. In the second part, two doses will be given to the patients with hepatocellular carcinoma to evaluate safety and to determine the optimum dose for further development. Also, the exploratory efficacy and pharmacokinetics will be investigated. The study will be conducted at National Cancer Center Hospital, National Cancer Center Hospital East. Additional institutes will be at Kanagawa Cancer Center and Niigata University Medical and Dental Hospital.お知らせ • Jun 02Chiome Bioscience Inc. to Report Q2, 2022 Results on Aug 10, 2022Chiome Bioscience Inc. announced that they will report Q2, 2022 results on Aug 10, 2022Board Change • Apr 27No independent directorsFollowing the recent departure of a director, there are no independent directors on the board. The company's board is composed of: No independent directors. 4 non-independent directors. Audit & Supervisory Board Member Matsuo Kikuchi was the last director to join the board, commencing their role in 2022. The company's lack of independent directors is a risk according to the Simply Wall St Risk Model.お知らせ • Apr 08Chiome Bioscience Inc. to Report Q1, 2022 Results on May 13, 2022Chiome Bioscience Inc. announced that they will report Q1, 2022 results on May 13, 2022お知らせ • Feb 17Chiome Bioscience Inc. Submits an Initial Application for Phase I Study on CBA-1535Chiome Bioscience Inc. announced that it has submitted an initial application for a Phase I study on CBA-1535 to the Pharmaceuticals and Medical Devices Agency (PMDA) on February 16, 2022. CBA-1535 is a trispecific antibody binding to 5T4 which highly expresses on solid tumor cells and CD3 on the surface of immune T cells. It forms a synapse between both cells and activates patients' intrinsic T cells that leads to killing the cancer cells. (This mechanism is called"T cell engager".) CBA-1535 is produced by the trispecific antibody generation technology called as Tribody. This is the first-in human study of multi-specific antibody in Tribody and consists of 2 parts. The first part is a dose escalation to assess the safety and initial pharmacokinetics as a single agent. The second part is an expansion part where safety and preliminary efficacy are evaluated in combination with cancer immunotherapy agent. In addition to the safety and efficacy, obtaining proof of concept as a T cell engager is a major objective. Once it is proved Tribody technology could be applicable to multiple types of tumor antigen. After submission of the application all the common regulatory procedure will be proceeded.Reported Earnings • Feb 16Full year 2021 earnings: Revenues and EPS in line with analyst expectationsFull year 2021 results: JP¥36.74 loss per share (down from JP¥36.06 loss in FY 2020). Revenue: JP¥712.9m (up 48% from FY 2020). Net loss: JP¥1.48b (loss widened 14% from FY 2020). Revenue was in line with analyst estimates. Over the last 3 years on average, earnings per share has increased by 28% per year but the company’s share price has fallen by 9% per year, which means it is significantly lagging earnings.お知らせ • Feb 15Chiome Bioscience Inc., Annual General Meeting, Mar 25, 2022Chiome Bioscience Inc., Annual General Meeting, Mar 25, 2022.お知らせ • Dec 24Chiome Bioscience Inc. Announces Move to the Second Half Part of Phase 1 Clinical Trial of First-In-Class CBA-1205Chiome Bioscience Inc. announced that it have successfully completed patient enrollment in the first part of phase I study of CBA-1205. CBA-1205 is the first in-class antibody which Chiome has been developing for cancer treatment. As a result of the safety evaluation, which is the primary objective of this part, Principal investigators and Chiome agreed with moving to the second part of phase I study to evaluate the safety and initial efficacy in patients with hepatocellular carcinoma. In the first part of the phase I study, which started in July 2020, the safety, tolerability, and pharmacokinetics of CBA-1205 were evaluated in patients with various solid tumors. This part is called "dose escalation part" where the patients are assigned to one of the several dose groups that are administered each dose in the order of the lowest to the dose to determine the dose that can be given safely without causing unacceptable side effects for the second part of the study. As the safety of this antibody has been proven to be high in the course of the first part, the original protocol was amended to add the higher dose groups to be administered. In December, enrollment in the first part of the phase I study of CBA-1205 has completed at The National Cancer Center Hospital and East Hospital. Principal investigators and Chiome concluded that this antibody was safe and well tolerated and that it was possible to conduct the second part of the study. In the second part, only patients with hepatocellular carcinoma will be enrolled and given CBA-1205 to evaluate safety and initial efficacy. CBA-1205 is an afucosylated humanized antibody targeting cell surface antigen "DLK-1 (Delta-like 1homolog)" which expresses on hepatocellular carcinoma and other solid cancers. CBA-1205 exhibits potent and specific anti-tumor activity in various DLK-1 expressing cancer models. DLK-1 is known to control the proliferation and differentiation of stem cells, progenitor cells, and other immature cells. CBA-1205 is expected to offer a new therapeutic option for the treatment of DLK-1 expressing cancer such as hepatocellular carcinoma.お知らせ • Dec 16Chiome Bioscience Inc. announced that it has received ¥16.8 million in funding from SMBC Nikko Securities Inc., Investment ArmOn December 15, 2021, Chiome Bioscience Inc. closed the transaction.お知らせ • Nov 30Chiome Bioscience Inc. announced that it expects to receive ¥16.8 million in funding from SMBC Nikko Securities Inc., Investment ArmChiome Bioscience Inc. announced that it has entered into an purchase agreement to issue 80,000 units of 18th stock acquisition rights at a price of ¥210 per stock for gross proceeds of ¥1,728,800,000 through third-party allotment on November 29, 2021. The stock acquisition rights are exercisable to purchase 8,000,000 shares which is equal to 100 shares per stock acquisition right at an initial exercise price of ¥215 per share. There is no maximum strike price. The minimum exercise price is ¥129. The transaction will include participation from SMBC Nikko Securities Inc., Investment Arm. The transaction has been approved in the board of directors' meeting of the company. The transaction is expected to close on December 15, 2021. The exercisable period of the stock acquisition rights will start from December 16, 2021 to December 19, 2023. The stock acquisition rights have a hold period and cannot be transferred without the company's approval.Reported Earnings • Aug 18Second quarter 2021 earnings released: JP¥6.16 loss per share (vs JP¥9.25 loss in 2Q 2020)The company reported a solid second quarter result with reduced losses, improved revenues and improved control over expenses. Second quarter 2021 results: Revenue: JP¥138.9m (up 68% from 2Q 2020). Net loss: JP¥248.0m (loss narrowed 20% from 2Q 2020).Reported Earnings • May 16First quarter 2021 earnings released: JP¥4.07 loss per share (vs JP¥12.78 loss in 1Q 2020)The company reported a solid first quarter result with reduced losses, improved revenues and improved control over expenses. First quarter 2021 results: Revenue: JP¥246.1m (up 171% from 1Q 2020). Net loss: JP¥160.7m (loss narrowed 62% from 1Q 2020).お知らせ • Feb 09Chiome Bioscience Inc., Annual General Meeting, Mar 26, 2021Chiome Bioscience Inc., Annual General Meeting, Mar 26, 2021.お知らせ • Jan 31Chiome Bioscience Inc. to Report Fiscal Year 2020 Results on Feb 09, 2021Chiome Bioscience Inc. announced that they will report fiscal year 2020 results on Feb 09, 2021お知らせ • Jan 15Shanghai Henlius Biotech, Inc. Enters into Exclusive License Agreement with Chiome Bioscience Inc. for Development and Commercialization of the Anti-Tpor-2 Antibodies, Liv-2008/2008BChiome Bioscience Inc. announced that Shanghai Henlius Biotech, Inc. has entered into Exclusive License Agreement with Chiome for development and commercialization of the anti-TPOR-2 antibodies, LIV-2008/2008b, generated by Chiome. Under the Exclusive License Agreement, Chiome will grant an exclusive license, with sublicensing rights, to Henlius concerning development, manufacturing and marketing in China (including Hong Kong Special Administrative Region and Macau Special Administrative Region and Taiwan region) for LIV-2008/2008b. In addition, Chiome grants to Henlius option rights concerning development, manufacturing and marketing of LIV-2008/2008b in the rest of the world other than the initial terretory, China (including Hong Kong Special Administrative Region and Macau Special Administrative Region and Taiwan region). Chiome will receive USD 1 million as an upfront payment upon signing the Exclusive License Agreement. In case Henlius exercises the option rights as described above, the total value of the agreement which Henlius shall pay to Chiome will be USD 122.5 million . In addition, after the launch of LIV-2008/2008b or related products (Product), Chiome is eligible to receive royalties according to Henlius's amount of sales of the Product. Upon execution of this Agreement, the upfront payment shall be booked as sales of Drug Discovery and Development Business for the first quarter of the fiscal year ending December 31, 2021 and the impact on the business performance for this fiscal year is currently being considered.Is New 90 Day High Low • Jan 15New 90-day high: JP¥241The company is up 6.0% from its price of JP¥228 on 16 October 2020. The Japanese market is up 15% over the last 90 days, indicating the company underperformed over that time. However, it outperformed the Life Sciences industry, which is down 10.0% over the same period.Is New 90 Day High Low • Dec 08New 90-day low: JP¥203The company is down 26% from its price of JP¥274 on 09 September 2020. The Japanese market is up 8.0% over the last 90 days, indicating the company underperformed over that time. It also underperformed the Life Sciences industry, which is down 14% over the same period.お知らせ • Nov 11Chiome Bioscience Inc. Announces Amendment to the License Agreement with ADC TherapeuticsChiome Bioscience Inc. announced that it has agreed with ADC Therapeutics SA to make an amendment to the License Agreement of September 27, 2017 under which Chiome granted ADCT the worldwide, exclusive, sub-licensable right to anti-DLK-1 antibody including LIV-1205 for the development, manufacture and commercialization in Antibody-Drug Conjugates (ADC) fields. With this amendment, both parties agreed that ADCT's exclusivity would be related to Pyrrolobenzodiazepine (PBD)-based ADC development only an area where ADCT has the exclusive proprietary rights to develop a PBD-based ADC targeting DLK-1, and in particular development of ADCT-701. This amendment allows Chiome to develop ADCs not incorporating a PBD-based ADC and gives Chiome greater flexibility in advancing strategic drug development of an anti-DLK-1 antibody, and to pursue the business potential of CBA-1205, including licensing opportunites, which is currently undergoing Phase 1 clinical trial. The amendment also restructured financial terms between the parties. There is no impact on the financial performance in the fiscal period ending December 31, 2020.お知らせ • Aug 30Chiome Bioscience Inc. to Report Q3, 2020 Results on Nov 10, 2020Chiome Bioscience Inc. announced that they will report Q3, 2020 results on Nov 10, 2020お知らせ • Jun 28Chiome Bioscience Inc. to Report Q2, 2020 Results on Aug 11, 2020Chiome Bioscience Inc. announced that they will report Q2, 2020 results on Aug 11, 2020株主還元4583JP Life SciencesJP 市場7D-4.3%-1.8%-3.1%1Y-37.3%-7.7%38.2%株主還元を見る業界別リターン: 4583過去 1 年間で-7.7 % の収益を上げたJP Life Sciences業界を下回りました。リターン対市場: 4583は、過去 1 年間で38.2 % のリターンを上げたJP市場を下回りました。価格変動Is 4583's price volatile compared to industry and market?4583 volatility4583 Average Weekly Movement4.6%Life Sciences Industry Average Movement6.2%Market Average Movement5.0%10% most volatile stocks in JP Market9.6%10% least volatile stocks in JP Market2.5%安定した株価: 4583 、 JP市場と比較して、過去 3 か月間で大きな価格変動はありませんでした。時間の経過による変動: 4583の 週次ボラティリティ ( 5% ) は過去 1 年間安定しています。会社概要設立従業員CEO（最高経営責任者ウェブサイト2005n/aMasamichi Koikewww.chiome.co.jpカイオム・バイオサイエンスは、日本、シンガポールおよび海外で抗体医薬の研究開発を行っている。創薬事業と創薬支援事業の2つのセグメントで事業を展開。創薬研究向けにニワトリ免疫細胞を用いたモノクローナル抗体作製技術「ADLibシステム」を提供。また、固形がんを適応症とするヒト化抗dlk1抗体ADCT-701、肝がん、肺がん、神経芽腫を適応症とするヒト化アフコシル化抗dlk1抗体CBA-1205、悪性中皮腫、小細胞肺がん、非小細胞肺がん、トリプルネガティブ乳がんを適応症とするヒト化抗5T4xCD3抗体CBA-1535など、臨床第I相試験中の薬剤の開発も行っている。さらに、肺がん、大腸がん、膵がん、乳がん、卵巣がんを適応症とするヒト化抗CDCP1抗体PCDC、悪性中皮腫、小細胞肺がん、非小細胞肺がん、トリプルネガティブ乳がんを適応症とするヒト化5T4/CD3/PD-L1抗体PTRYなど、前臨床試験中の薬剤の開発にも取り組んでいる；腎疾患およびその他の疾患の治療のためのヒト化抗センフォリン3a抗体BMAA、乳がん、肺がん、大腸がんの治療のためのヒト化抗TROP-2抗体LIV-2008/2008b、二次性進行性多発性硬化症の治療のためのヒト化抗CX3CR1抗体PFKR、胃がん、乳がん、卵巣腫瘍の治療のためのヒト化抗CXCL1/2/3/5抗体PXLR。さらに、タンパク質の発現・精製サービス、安定発現細胞株の作製、抗体の作製も行っている。同社は2005年に設立され、渋谷に本社を置いている。もっと見るChiome Bioscience Inc. 基礎のまとめChiome Bioscience の収益と売上を時価総額と比較するとどうか。4583 基礎統計学時価総額JP¥6.46b収益（TTM）-JP¥982.78m売上高(TTM)JP¥593.29m10.9xP/Sレシオ-6.6xPER（株価収益率4583 は割高か？公正価値と評価分析を参照収益と収入最新の決算報告書（TTM）に基づく主な収益性統計4583 損益計算書（TTM）収益JP¥593.29m売上原価JP¥237.71m売上総利益JP¥355.58mその他の費用JP¥1.34b収益-JP¥982.78m直近の収益報告Dec 31, 2025次回決算日該当なし一株当たり利益（EPS）-13.53グロス・マージン59.93%純利益率-165.65%有利子負債／自己資本比率7.7%4583 の長期的なパフォーマンスは？過去の実績と比較を見るView Valuation企業分析と財務データの現状データ最終更新日（UTC時間）企業分析2026/05/21 20:07終値2026/05/21 00:00収益2025/12/31年間収益2025/12/31データソース企業分析に使用したデータはS&P Global Market Intelligence LLC のものです。本レポートを作成するための分析モデルでは、以下のデータを使用しています。データは正規化されているため、ソースが利用可能になるまでに時間がかかる場合があります。パッケージデータタイムフレーム米国ソース例会社財務10年損益計算書キャッシュ・フロー計算書貸借対照表SECフォーム10-KSECフォーム10-Qアナリストのコンセンサス予想+プラス3年予想財務アナリストの目標株価アナリストリサーチレポートBlue Matrix市場価格30年株価配当、分割、措置ICEマーケットデータSECフォームS-1所有権10年トップ株主インサイダー取引SECフォーム4SECフォーム13Dマネジメント10年リーダーシップ・チーム取締役会SECフォーム10-KSECフォームDEF 14A主な進展10年会社からのお知らせSECフォーム8-K* 米国証券を対象とした例であり、非米国証券については、同等の規制書式および情報源を使用。特に断りのない限り、すべての財務データは1年ごとの期間に基づいていますが、四半期ごとに更新されます。これは、TTM（Trailing Twelve Month）またはLTM（Last Twelve Month）データとして知られています。詳細はこちら。分析モデルとスノーフレーク本レポートを生成するために使用した分析モデルの詳細は当社のGithubページでご覧いただけます。また、レポートの使用方法に関するガイドやYoutubeのチュートリアルも掲載しています。シンプリー・ウォールストリート分析モデルを設計・構築した世界トップクラスのチームについてご紹介します。業界およびセクターの指標私たちの業界とセクションの指標は、Simply Wall Stによって6時間ごとに計算されます。アナリスト筋Chiome Bioscience Inc. 0 これらのアナリストのうち、弊社レポートのインプットとして使用した売上高または利益の予想を提出したのは、 。アナリストの投稿は一日中更新されます。2 アナリスト機関Akitada IwasaDaiwa Securities Co. Ltd.Kiyokazu YamazakiIchiyoshi Research Institute Inc.
お知らせ • Apr 24Chiome Bioscience Inc. to Report Q1, 2026 Results on May 14, 2026Chiome Bioscience Inc. announced that they will report Q1, 2026 results on May 14, 2026
New Risk • Feb 19New minor risk - Share price stabilityThe company's share price has been volatile over the past 3 months. It is more volatile than 75% of Japanese stocks, typically moving 5.5% a week. This is considered a minor risk. Share price volatility indicates the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. It also increases the risk of potential losses in the short term as the stock tends to have larger drops in price more frequently than other stocks. Currently, the following risks have been identified for the company: Minor Risks Share price has been volatile over the past 3 months (5.5% average weekly change). Revenue is less than US$5m (JP¥593m revenue, or US$3.8m). Market cap is less than US$100m (JP¥8.49b market cap, or US$54.9m).
Reported Earnings • Feb 14Full year 2025 earnings released: JP¥14.47 loss per share (vs JP¥17.54 loss in FY 2024)Full year 2025 results: JP¥14.47 loss per share (improved from JP¥17.54 loss in FY 2024). Revenue: JP¥593.3m (down 24% from FY 2024). Net loss: JP¥982.8m (loss narrowed 3.7% from FY 2024). Over the last 3 years on average, earnings per share has increased by 20% per year but the company’s share price has fallen by 16% per year, which means it is significantly lagging earnings.
お知らせ • Feb 10Chiome Bioscience Inc., Annual General Meeting, Mar 27, 2026Chiome Bioscience Inc., Annual General Meeting, Mar 27, 2026.
お知らせ • Dec 27Chiome Bioscience Inc. to Report Fiscal Year 2025 Results on Feb 10, 2026Chiome Bioscience Inc. announced that they will report fiscal year 2025 results on Feb 10, 2026
New Risk • Nov 17New major risk - Financial positionThe company has less than a year of cash runway based on its current free cash flow trend. Free cash flow: -JP¥996m This is considered a major risk. With less than a year's worth of cash, the company will need to raise capital or take on debt unless its cash flows improve. This would dilute existing shareholders or increase balance sheet risk. Currently, the following risks have been identified for the company: Major Risk Less than 1 year of cash runway based on free cash flow trend (-JP¥996m free cash flow). Minor Risks Revenue is less than US$5m (JP¥728m revenue, or US$4.7m). Market cap is less than US$100m (JP¥8.37b market cap, or US$54.1m).
お知らせ • Apr 24Chiome Bioscience Inc. to Report Q1, 2026 Results on May 14, 2026Chiome Bioscience Inc. announced that they will report Q1, 2026 results on May 14, 2026
New Risk • Feb 19New minor risk - Share price stabilityThe company's share price has been volatile over the past 3 months. It is more volatile than 75% of Japanese stocks, typically moving 5.5% a week. This is considered a minor risk. Share price volatility indicates the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. It also increases the risk of potential losses in the short term as the stock tends to have larger drops in price more frequently than other stocks. Currently, the following risks have been identified for the company: Minor Risks Share price has been volatile over the past 3 months (5.5% average weekly change). Revenue is less than US$5m (JP¥593m revenue, or US$3.8m). Market cap is less than US$100m (JP¥8.49b market cap, or US$54.9m).
Reported Earnings • Feb 14Full year 2025 earnings released: JP¥14.47 loss per share (vs JP¥17.54 loss in FY 2024)Full year 2025 results: JP¥14.47 loss per share (improved from JP¥17.54 loss in FY 2024). Revenue: JP¥593.3m (down 24% from FY 2024). Net loss: JP¥982.8m (loss narrowed 3.7% from FY 2024). Over the last 3 years on average, earnings per share has increased by 20% per year but the company’s share price has fallen by 16% per year, which means it is significantly lagging earnings.
お知らせ • Feb 10Chiome Bioscience Inc., Annual General Meeting, Mar 27, 2026Chiome Bioscience Inc., Annual General Meeting, Mar 27, 2026.
お知らせ • Dec 27Chiome Bioscience Inc. to Report Fiscal Year 2025 Results on Feb 10, 2026Chiome Bioscience Inc. announced that they will report fiscal year 2025 results on Feb 10, 2026
New Risk • Nov 17New major risk - Financial positionThe company has less than a year of cash runway based on its current free cash flow trend. Free cash flow: -JP¥996m This is considered a major risk. With less than a year's worth of cash, the company will need to raise capital or take on debt unless its cash flows improve. This would dilute existing shareholders or increase balance sheet risk. Currently, the following risks have been identified for the company: Major Risk Less than 1 year of cash runway based on free cash flow trend (-JP¥996m free cash flow). Minor Risks Revenue is less than US$5m (JP¥728m revenue, or US$4.7m). Market cap is less than US$100m (JP¥8.37b market cap, or US$54.1m).
Reported Earnings • Nov 17Third quarter 2025 earnings released: JP¥3.82 loss per share (vs JP¥9.79 loss in 3Q 2024)Third quarter 2025 results: JP¥3.82 loss per share (improved from JP¥9.79 loss in 3Q 2024). Revenue: JP¥118.0m (down 26% from 3Q 2024). Net loss: JP¥260.0m (loss narrowed 26% from 3Q 2024). Over the last 3 years on average, earnings per share has increased by 24% per year but the company’s share price has fallen by 6% per year, which means it is significantly lagging earnings.
New Risk • Oct 30New minor risk - Revenue sizeThe company makes less than US$5m in revenue. Total revenue: JP¥769m (US$5.0m) This is considered a minor risk. Companies with a small amount of revenue are most likely businesses that have not yet released a product to market or are simply a very small company without a wide reach. Either way, risk is elevated with these companies because there is a chance the product may not come to fruition or the company's addressable market or demand may not be as large as expected. In addition, if the company's size is the main factor, it is less likely to have many investors and analysts following it and scrutinizing its performance and outlook. Currently, the following risks have been identified for the company: Minor Risks Revenue is less than US$5m (JP¥769m revenue, or US$5.0m). Market cap is less than US$100m (JP¥8.57b market cap, or US$55.6m).
分析記事 • Oct 10Is Chiome Bioscience (TSE:4583) Weighed On By Its Debt Load?Howard Marks put it nicely when he said that, rather than worrying about share price volatility, 'The possibility of...
Reported Earnings • Aug 14Second quarter 2025 earnings released: JP¥4.04 loss per share (vs JP¥4.63 loss in 2Q 2024)Second quarter 2025 results: JP¥4.04 loss per share. Revenue: JP¥113.1m (down 16% from 2Q 2024). Net loss: JP¥274.2m (loss widened 5.5% from 2Q 2024).
お知らせ • Aug 13Chiome Bioscience Inc. to Report Q3, 2025 Results on Nov 11, 2025Chiome Bioscience Inc. announced that they will report Q3, 2025 results on Nov 11, 2025
お知らせ • May 31Chiome Bioscience Inc. to Report Q2, 2025 Results on Aug 12, 2025Chiome Bioscience Inc. announced that they will report Q2, 2025 results on Aug 12, 2025
お知らせ • Mar 13Chiome Bioscience Inc. to Report Q1, 2025 Results on May 12, 2025Chiome Bioscience Inc. announced that they will report Q1, 2025 results on May 12, 2025
Reported Earnings • Feb 18Full year 2024 earnings released: JP¥17.54 loss per share (vs JP¥24.62 loss in FY 2023)Full year 2024 results: JP¥17.54 loss per share (improved from JP¥24.62 loss in FY 2023). Revenue: JP¥780.8m (up 14% from FY 2023). Net loss: JP¥1.02b (loss narrowed 16% from FY 2023). Over the last 3 years on average, earnings per share has increased by 26% per year but the company’s share price has only increased by 5% per year, which means it is significantly lagging earnings growth.
お知らせ • Feb 13Chiome Bioscience Inc., Annual General Meeting, Mar 28, 2025Chiome Bioscience Inc., Annual General Meeting, Mar 28, 2025.
お知らせ • Dec 20Chiome Bioscience Inc. Announces Publication on CBA-1205 Non-Clinical DataChiome Bioscience Inc. announced that the research results were published in an international academic journal International Journal of Molecular Sciences. The paper discusses the findings on the non-clinical data for CBA-1205, a therapeutic antibody for cancer treatment currently in clinical trials at the company. In this study, CBA-1205, which selectively binds to delta-like 1 homolog (DLK1), destroyed cells expressed DLK1 through Antibody-Dependent Cellular Cytotoxicity (ADCC) activity. CBA-1205 also inhibited tumor growth on mouse-model transplanted with human liver cancer cells expressing DLK1. Furthermore, by combining with Lenvatinib, an standard of care of hepatocellular carcinoma, CBA-1205 inhibited tumor growth more effectively than single-dose administration in the same animal model. This combining effect of Lenvatinib and CBA-1205 lasted long during the observation period after the administration. In the toxicology study using cynomolgus monkeys, it showed no serious toxicological changes caused by the administration of CBA-1205. As a result of these findings, the paper discusses the potential of CBA-1205 as one of the treatment options for patients with hepatocellular carcinoma.
分析記事 • Nov 21Is Chiome Bioscience (TSE:4583) Weighed On By Its Debt Load?Legendary fund manager Li Lu (who Charlie Munger backed) once said, 'The biggest investment risk is not the volatility...
お知らせ • Nov 12Chiome Bioscience Inc. to Report Fiscal Year 2024 Results on Feb 13, 2025Chiome Bioscience Inc. announced that they will report fiscal year 2024 results on Feb 13, 2025
Reported Earnings • Aug 17Second quarter 2024 earnings released: JP¥4.63 loss per share (vs JP¥9.00 loss in 2Q 2023)Second quarter 2024 results: JP¥4.63 loss per share (improved from JP¥9.00 loss in 2Q 2023). Revenue: JP¥134.1m (down 29% from 2Q 2023). Net loss: JP¥259.9m (loss narrowed 40% from 2Q 2023). Over the last 3 years on average, earnings per share has increased by 14% per year but the company’s share price has fallen by 24% per year, which means it is significantly lagging earnings.
お知らせ • Aug 14Chiome Bioscience Inc. to Report Q3, 2024 Results on Nov 12, 2024Chiome Bioscience Inc. announced that they will report Q3, 2024 results on Nov 12, 2024
分析記事 • Jun 28Is Chiome Bioscience (TSE:4583) Using Too Much Debt?Warren Buffett famously said, 'Volatility is far from synonymous with risk.' It's only natural to consider a company's...
お知らせ • Jun 13Chiome Bioscience Inc. to Report Q2, 2024 Results on Aug 13, 2024Chiome Bioscience Inc. announced that they will report Q2, 2024 results on Aug 13, 2024
お知らせ • Mar 01Chiome Bioscience Inc. to Report Q1, 2024 Results on May 14, 2024Chiome Bioscience Inc. announced that they will report Q1, 2024 results on May 14, 2024
Reported Earnings • Feb 14Full year 2023 earnings released: JP¥24.13 loss per share (vs JP¥28.26 loss in FY 2022)Full year 2023 results: JP¥24.13 loss per share (improved from JP¥28.26 loss in FY 2022). Revenue: JP¥682.5m (up 8.2% from FY 2022). Net loss: JP¥1.22b (loss narrowed 1.8% from FY 2022). Over the last 3 years on average, earnings per share has increased by 9% per year but the company’s share price has fallen by 14% per year, which means it is significantly lagging earnings.
お知らせ • Feb 13Chiome Bioscience Inc., Annual General Meeting, Mar 26, 2024Chiome Bioscience Inc., Annual General Meeting, Mar 26, 2024.
お知らせ • Dec 05Chiome Bioscience Inc. to Report Fiscal Year 2023 Results on Feb 13, 2024Chiome Bioscience Inc. announced that they will report fiscal year 2023 results at 3:00 PM, Tokyo Standard Time on Feb 13, 2024
New Risk • Nov 22New minor risk - Share price stabilityThe company's share price has been volatile over the past 3 months. It is more volatile than 75% of Japanese stocks, typically moving 5.5% a week. This is considered a minor risk. Share price volatility indicates the stock is highly sensitive to market conditions or economic conditions rather than being sensitive to its own business performance, which may also be inconsistent. It also increases the risk of potential losses in the short term as the stock tends to have larger drops in price more frequently than other stocks. Currently, the following risks have been identified for the company: Minor Risks Share price has been volatile over the past 3 months (5.5% average weekly change). Shareholders have been diluted in the past year (9.4% increase in shares outstanding). Revenue is less than US$5m (JP¥721m revenue, or US$4.9m). Market cap is less than US$100m (JP¥6.83b market cap, or US$46.2m).
Reported Earnings • Nov 15Third quarter 2023 earnings released: JP¥5.25 loss per share (vs JP¥5.79 loss in 3Q 2022)Third quarter 2023 results: JP¥5.25 loss per share (improved from JP¥5.79 loss in 3Q 2022). Revenue: JP¥165.1m (up 6.2% from 3Q 2022). Net loss: JP¥254.8m (flat on 3Q 2022). Over the last 3 years on average, earnings per share has increased by 9% per year but the company’s share price has fallen by 15% per year, which means it is significantly lagging earnings.
お知らせ • Aug 27Chiome Bioscience Inc. to Report Q3, 2023 Results on Nov 14, 2023Chiome Bioscience Inc. announced that they will report Q3, 2023 results on Nov 14, 2023
お知らせ • Jul 06Chiome Bioscience Inc. announced that it expects to receive ¥13.49304 million in fundingChiome Bioscience Inc. announced that it has entered into an purchase agreement to issue 64,560 units of 19th stock acquisition rights and 32,280 units of 20th stock acquisition rights at a price of ¥171 yen per 19th stock acquisition right, ¥76 per 20th stock acquisition right for gross proceeds of ¥1,931,609,040 through third-party allotment on July 4, 2023. The stock acquisition rights are exercisable 19th Stock Acquisition Rights ¥175, 20th stock acquisition rights ¥247. There is no maximum strike price. The minimum exercise price is ¥129. The transaction will include participation from Growth Capital and Barclays Bank. The transaction has been approved in the board of directors' meeting of the company. The exercisable period of the stock acquisition rights will start from July 21, 2023 to July 22, 2025. The stock acquisition rights have a hold period and cannot be transferred without the company's approval.
お知らせ • Jun 02Chiome Bioscience Inc. to Report Q2, 2023 Results on Aug 09, 2023Chiome Bioscience Inc. announced that they will report Q2, 2023 results on Aug 09, 2023
Reported Earnings • Feb 17Full year 2022 earnings released: JP¥28.26 loss per share (vs JP¥36.74 loss in FY 2021)Full year 2022 results: JP¥28.26 loss per share (improved from JP¥36.74 loss in FY 2021). Revenue: JP¥630.8m (down 12% from FY 2021). Net loss: JP¥1.24b (loss narrowed 16% from FY 2021). Over the last 3 years on average, earnings per share has increased by 6% per year but the company’s share price has fallen by 5% per year, which means it is significantly lagging earnings.
お知らせ • Feb 14Chiome Bioscience Inc., Annual General Meeting, Mar 28, 2023Chiome Bioscience Inc., Annual General Meeting, Mar 28, 2023.
お知らせ • Dec 28Chiome Bioscience Inc. to Report Fiscal Year 2022 Results on Feb 14, 2023Chiome Bioscience Inc. announced that they will report fiscal year 2022 results on Feb 14, 2023
Reported Earnings • Nov 16Third quarter 2022 earnings released: JP¥5.96 loss per share (vs JP¥10.77 loss in 3Q 2021)Third quarter 2022 results: JP¥5.96 loss per share (improved from JP¥10.77 loss in 3Q 2021). Revenue: JP¥155.5m (flat on 3Q 2021). Net loss: JP¥256.6m (loss narrowed 41% from 3Q 2021). Over the last 3 years on average, earnings per share has increased by 10% per year but the company’s share price has fallen by 7% per year, which means it is significantly lagging earnings.
Board Change • Nov 16No independent directorsFollowing the recent departure of a director, there are no independent directors on the board. The company's board is composed of: No independent directors. 4 non-independent directors. Audit & Supervisory Board Member Matsuo Kikuchi was the last director to join the board, commencing their role in 2022. The company's lack of independent directors is a risk according to the Simply Wall St Risk Model.
お知らせ • Sep 28Chiome Bioscience Inc. to Report Q3, 2022 Results on Nov 14, 2022Chiome Bioscience Inc. announced that they will report Q3, 2022 results on Nov 14, 2022
Reported Earnings • Aug 16First half 2022 earnings released: JP¥18.17 loss per share (vs JP¥10.16 loss in 1H 2021)First half 2022 results: JP¥18.17 loss per share (down from JP¥10.16 loss in 1H 2021). Revenue: JP¥278.2m (down 28% from 1H 2021). Net loss: JP¥771.0m (loss widened 89% from 1H 2021). Over the last 3 years on average, earnings per share has increased by 13% per year but the company’s share price has fallen by 4% per year, which means it is significantly lagging earnings.
お知らせ • Jul 05Chiome Bioscience Inc. Announces First Patient in of Cancer Therapeutic Antibody CBA-1535 in A Phase 1 Clinical TrialChiome Bioscience Inc. announced that the first patient has been dosed CBA-1535 in a Phase I clinical trial. The first part of the trial will evaluate the safety, tolerability, pharmacokinetics, and identification of biomarker for the solid tumor patients. In the expansion part, exploratory efficacy will be evaluated in combination with cancer immunotherapy agent Pembrolizumab. This first-in-human study is conducted at National Cancer Center Hospital and Shizuoka Cancer Center. Will continue to update the future process in a timely manner.
お知らせ • Jun 13Chiome Bioscience Inc. Announces Conclusion of Contract with Additional Institutes and First Dosing of CBA-1205 in the Second Part of Phase 1 StudyChiome Bioscience Inc. announced that new contract with additional institutes had been finalized and the first patient has been dosed CBA-1205, the first-in-class antibody, in the second part (expansion part) of Phase I study. In the first part of Phase I study, CBA-1205 exhibited good safety and tolerability. In the second part, two doses will be given to the patients with hepatocellular carcinoma to evaluate safety and to determine the optimum dose for further development. Also, the exploratory efficacy and pharmacokinetics will be investigated. The study will be conducted at National Cancer Center Hospital, National Cancer Center Hospital East. Additional institutes will be at Kanagawa Cancer Center and Niigata University Medical and Dental Hospital.
お知らせ • Jun 02Chiome Bioscience Inc. to Report Q2, 2022 Results on Aug 10, 2022Chiome Bioscience Inc. announced that they will report Q2, 2022 results on Aug 10, 2022
Board Change • Apr 27No independent directorsFollowing the recent departure of a director, there are no independent directors on the board. The company's board is composed of: No independent directors. 4 non-independent directors. Audit & Supervisory Board Member Matsuo Kikuchi was the last director to join the board, commencing their role in 2022. The company's lack of independent directors is a risk according to the Simply Wall St Risk Model.
お知らせ • Apr 08Chiome Bioscience Inc. to Report Q1, 2022 Results on May 13, 2022Chiome Bioscience Inc. announced that they will report Q1, 2022 results on May 13, 2022
お知らせ • Feb 17Chiome Bioscience Inc. Submits an Initial Application for Phase I Study on CBA-1535Chiome Bioscience Inc. announced that it has submitted an initial application for a Phase I study on CBA-1535 to the Pharmaceuticals and Medical Devices Agency (PMDA) on February 16, 2022. CBA-1535 is a trispecific antibody binding to 5T4 which highly expresses on solid tumor cells and CD3 on the surface of immune T cells. It forms a synapse between both cells and activates patients' intrinsic T cells that leads to killing the cancer cells. (This mechanism is called"T cell engager".) CBA-1535 is produced by the trispecific antibody generation technology called as Tribody. This is the first-in human study of multi-specific antibody in Tribody and consists of 2 parts. The first part is a dose escalation to assess the safety and initial pharmacokinetics as a single agent. The second part is an expansion part where safety and preliminary efficacy are evaluated in combination with cancer immunotherapy agent. In addition to the safety and efficacy, obtaining proof of concept as a T cell engager is a major objective. Once it is proved Tribody technology could be applicable to multiple types of tumor antigen. After submission of the application all the common regulatory procedure will be proceeded.
Reported Earnings • Feb 16Full year 2021 earnings: Revenues and EPS in line with analyst expectationsFull year 2021 results: JP¥36.74 loss per share (down from JP¥36.06 loss in FY 2020). Revenue: JP¥712.9m (up 48% from FY 2020). Net loss: JP¥1.48b (loss widened 14% from FY 2020). Revenue was in line with analyst estimates. Over the last 3 years on average, earnings per share has increased by 28% per year but the company’s share price has fallen by 9% per year, which means it is significantly lagging earnings.
お知らせ • Feb 15Chiome Bioscience Inc., Annual General Meeting, Mar 25, 2022Chiome Bioscience Inc., Annual General Meeting, Mar 25, 2022.
お知らせ • Dec 24Chiome Bioscience Inc. Announces Move to the Second Half Part of Phase 1 Clinical Trial of First-In-Class CBA-1205Chiome Bioscience Inc. announced that it have successfully completed patient enrollment in the first part of phase I study of CBA-1205. CBA-1205 is the first in-class antibody which Chiome has been developing for cancer treatment. As a result of the safety evaluation, which is the primary objective of this part, Principal investigators and Chiome agreed with moving to the second part of phase I study to evaluate the safety and initial efficacy in patients with hepatocellular carcinoma. In the first part of the phase I study, which started in July 2020, the safety, tolerability, and pharmacokinetics of CBA-1205 were evaluated in patients with various solid tumors. This part is called "dose escalation part" where the patients are assigned to one of the several dose groups that are administered each dose in the order of the lowest to the dose to determine the dose that can be given safely without causing unacceptable side effects for the second part of the study. As the safety of this antibody has been proven to be high in the course of the first part, the original protocol was amended to add the higher dose groups to be administered. In December, enrollment in the first part of the phase I study of CBA-1205 has completed at The National Cancer Center Hospital and East Hospital. Principal investigators and Chiome concluded that this antibody was safe and well tolerated and that it was possible to conduct the second part of the study. In the second part, only patients with hepatocellular carcinoma will be enrolled and given CBA-1205 to evaluate safety and initial efficacy. CBA-1205 is an afucosylated humanized antibody targeting cell surface antigen "DLK-1 (Delta-like 1homolog)" which expresses on hepatocellular carcinoma and other solid cancers. CBA-1205 exhibits potent and specific anti-tumor activity in various DLK-1 expressing cancer models. DLK-1 is known to control the proliferation and differentiation of stem cells, progenitor cells, and other immature cells. CBA-1205 is expected to offer a new therapeutic option for the treatment of DLK-1 expressing cancer such as hepatocellular carcinoma.
お知らせ • Dec 16Chiome Bioscience Inc. announced that it has received ¥16.8 million in funding from SMBC Nikko Securities Inc., Investment ArmOn December 15, 2021, Chiome Bioscience Inc. closed the transaction.
お知らせ • Nov 30Chiome Bioscience Inc. announced that it expects to receive ¥16.8 million in funding from SMBC Nikko Securities Inc., Investment ArmChiome Bioscience Inc. announced that it has entered into an purchase agreement to issue 80,000 units of 18th stock acquisition rights at a price of ¥210 per stock for gross proceeds of ¥1,728,800,000 through third-party allotment on November 29, 2021. The stock acquisition rights are exercisable to purchase 8,000,000 shares which is equal to 100 shares per stock acquisition right at an initial exercise price of ¥215 per share. There is no maximum strike price. The minimum exercise price is ¥129. The transaction will include participation from SMBC Nikko Securities Inc., Investment Arm. The transaction has been approved in the board of directors' meeting of the company. The transaction is expected to close on December 15, 2021. The exercisable period of the stock acquisition rights will start from December 16, 2021 to December 19, 2023. The stock acquisition rights have a hold period and cannot be transferred without the company's approval.
Reported Earnings • Aug 18Second quarter 2021 earnings released: JP¥6.16 loss per share (vs JP¥9.25 loss in 2Q 2020)The company reported a solid second quarter result with reduced losses, improved revenues and improved control over expenses. Second quarter 2021 results: Revenue: JP¥138.9m (up 68% from 2Q 2020). Net loss: JP¥248.0m (loss narrowed 20% from 2Q 2020).
Reported Earnings • May 16First quarter 2021 earnings released: JP¥4.07 loss per share (vs JP¥12.78 loss in 1Q 2020)The company reported a solid first quarter result with reduced losses, improved revenues and improved control over expenses. First quarter 2021 results: Revenue: JP¥246.1m (up 171% from 1Q 2020). Net loss: JP¥160.7m (loss narrowed 62% from 1Q 2020).
お知らせ • Feb 09Chiome Bioscience Inc., Annual General Meeting, Mar 26, 2021Chiome Bioscience Inc., Annual General Meeting, Mar 26, 2021.
お知らせ • Jan 31Chiome Bioscience Inc. to Report Fiscal Year 2020 Results on Feb 09, 2021Chiome Bioscience Inc. announced that they will report fiscal year 2020 results on Feb 09, 2021
お知らせ • Jan 15Shanghai Henlius Biotech, Inc. Enters into Exclusive License Agreement with Chiome Bioscience Inc. for Development and Commercialization of the Anti-Tpor-2 Antibodies, Liv-2008/2008BChiome Bioscience Inc. announced that Shanghai Henlius Biotech, Inc. has entered into Exclusive License Agreement with Chiome for development and commercialization of the anti-TPOR-2 antibodies, LIV-2008/2008b, generated by Chiome. Under the Exclusive License Agreement, Chiome will grant an exclusive license, with sublicensing rights, to Henlius concerning development, manufacturing and marketing in China (including Hong Kong Special Administrative Region and Macau Special Administrative Region and Taiwan region) for LIV-2008/2008b. In addition, Chiome grants to Henlius option rights concerning development, manufacturing and marketing of LIV-2008/2008b in the rest of the world other than the initial terretory, China (including Hong Kong Special Administrative Region and Macau Special Administrative Region and Taiwan region). Chiome will receive USD 1 million as an upfront payment upon signing the Exclusive License Agreement. In case Henlius exercises the option rights as described above, the total value of the agreement which Henlius shall pay to Chiome will be USD 122.5 million . In addition, after the launch of LIV-2008/2008b or related products (Product), Chiome is eligible to receive royalties according to Henlius's amount of sales of the Product. Upon execution of this Agreement, the upfront payment shall be booked as sales of Drug Discovery and Development Business for the first quarter of the fiscal year ending December 31, 2021 and the impact on the business performance for this fiscal year is currently being considered.
Is New 90 Day High Low • Jan 15New 90-day high: JP¥241The company is up 6.0% from its price of JP¥228 on 16 October 2020. The Japanese market is up 15% over the last 90 days, indicating the company underperformed over that time. However, it outperformed the Life Sciences industry, which is down 10.0% over the same period.
Is New 90 Day High Low • Dec 08New 90-day low: JP¥203The company is down 26% from its price of JP¥274 on 09 September 2020. The Japanese market is up 8.0% over the last 90 days, indicating the company underperformed over that time. It also underperformed the Life Sciences industry, which is down 14% over the same period.
お知らせ • Nov 11Chiome Bioscience Inc. Announces Amendment to the License Agreement with ADC TherapeuticsChiome Bioscience Inc. announced that it has agreed with ADC Therapeutics SA to make an amendment to the License Agreement of September 27, 2017 under which Chiome granted ADCT the worldwide, exclusive, sub-licensable right to anti-DLK-1 antibody including LIV-1205 for the development, manufacture and commercialization in Antibody-Drug Conjugates (ADC) fields. With this amendment, both parties agreed that ADCT's exclusivity would be related to Pyrrolobenzodiazepine (PBD)-based ADC development only an area where ADCT has the exclusive proprietary rights to develop a PBD-based ADC targeting DLK-1, and in particular development of ADCT-701. This amendment allows Chiome to develop ADCs not incorporating a PBD-based ADC and gives Chiome greater flexibility in advancing strategic drug development of an anti-DLK-1 antibody, and to pursue the business potential of CBA-1205, including licensing opportunites, which is currently undergoing Phase 1 clinical trial. The amendment also restructured financial terms between the parties. There is no impact on the financial performance in the fiscal period ending December 31, 2020.
お知らせ • Aug 30Chiome Bioscience Inc. to Report Q3, 2020 Results on Nov 10, 2020Chiome Bioscience Inc. announced that they will report Q3, 2020 results on Nov 10, 2020
お知らせ • Jun 28Chiome Bioscience Inc. to Report Q2, 2020 Results on Aug 11, 2020Chiome Bioscience Inc. announced that they will report Q2, 2020 results on Aug 11, 2020
