Declining Sequencing Costs Will Unlock Precision Oncology Growth

Key Takeaways

• Personalis' platform and innovation position it for dominant market share, accelerating revenue growth, and sustained clinical adoption as reimbursement and new markets unlock scale.
  
• Expanding into high-margin informatics with AI-driven analytics enables ongoing margin improvement and recurring revenue, reducing reliance on biopharma cycles.
  
• Ongoing revenue pressures, reliance on few major clients, mounting losses, regulatory risks, and fierce competition threaten Personalis' profitability and market position going forward.

Catalysts

Develops, markets, and sells advanced cancer genomic tests and services in the United States and internationally.

• Analyst consensus expects Personalis to capture a significant share of the growing $20 billion MRD market, primarily through NeXT Personal, but this likely understates the potential as the current 59% sequential test growth-with retention and depth expanding per physician-indicates Personalis could become the dominant player as test volume, and therefore revenue growth, dramatically accelerates following reimbursement.
  
• Analyst consensus views achieving Medicare coverage for two indications and Tempus distribution as a key catalyst for higher margins and revenue, but the real upside lies in a faster-than-expected ramp to scale once reimbursement is secured, enabling gross margin expansion beyond the projected 50% as fixed costs are leveraged and incremental test volumes become highly profitable, driving upside to earnings and net margin.
  
• The convergence of declining sequencing costs and Personalis' continued innovation in exome and transcriptome technologies will enable premium pricing for new clinical applications-simultaneously expanding addressable market and delivering structural gross margin improvement as advanced tests gain adoption.
  
• With surging global demand for cancer diagnostics and increasing physician adoption-including the opening of new colorectal and neoadjuvant breast cancer markets-Personalis is positioned for multi-year clinical volume growth and meaningful market share gains, resulting in compounding clinical revenue and a recurring revenue base less exposed to biopharma R&D cycles.
  
• Personalis' proprietary NeXT platform and AI-powered data analytics position the company to tap into a growing high-margin informatics/software opportunity alongside test sales; as value-based healthcare expands and payors reward actionable insights, this creates a potential pathway for sustained margin expansion and enhanced long-term earnings growth.

Personalis Future Earnings and Revenue Growth

Assumptions

• This narrative explores a more optimistic perspective on Personalis compared to the consensus, based on a Fair Value that aligns with the bullish cohort of analysts.
• The bullish analysts are assuming Personalis's revenue will grow by 25.8% annually over the next 3 years.
• Even the bullish analysts are not forecasting that Personalis will become profitable in next 3 years. To represent the Analyst Price Target as a Future PE Valuation we will estimate Personalis's profit margin will increase from -113.7% to the average US Life Sciences industry of 14.2% in 3 years.
• If Personalis's profit margin were to converge on the industry average, you could expect earnings to reach $22.7 million (and earnings per share of $0.21) by about August 2028, up from $-91.3 million today. The analysts are largely in agreement about this estimate.
• In order for the above numbers to justify the price target of the more bullish analyst cohort, the company would need to trade at a PE ratio of 52.9x on those 2028 earnings, up from -4.4x today. This future PE is greater than the current PE for the US Life Sciences industry at 28.5x.
• Analysts expect the number of shares outstanding to grow by 7.0% per year for the next 3 years.
• To value all of this in today's terms, we will use a discount rate of 7.32%, as per the Simply Wall St company report.

Personalis Future Earnings Per Share Growth

Risks

• Personalis is experiencing significant delays and revenue shortfalls in its biopharma and translational research segments due to broader industry-wide cutbacks and project deferrals, which, if persistent, may negatively impact their overall revenue trajectory in the medium and long term.
  
• Persistent operating losses, with a second quarter net loss of twenty million dollars and full-year expected losses of eighty-five million dollars, combined with continued negative gross margins ahead of reimbursement, threaten long-term earnings and could result in further shareholder dilution if not reversed.
  
• Personalis remains heavily dependent on a small number of large customers for substantial portions of revenue, including contracts that are winding down (such as with Natera) or subject to budgetary uncertainty from biopharma partners, increasing the risk of abrupt revenue declines if these relationships are lost or scaled back.
  
• Intense competition in the MRD and broader oncology diagnostics market, including new entrants winning coverage (Saga Diagnostics, for example) and larger, better-capitalized rivals, could pressure Personalis' pricing and market share, negatively affecting future revenues and profit margins.
  
• Heightened regulatory uncertainty and the growing risk of delays in Medicare reimbursement decisions or changes to data privacy requirements present risks to timely revenue recognition, gross margin expansion, and the ability to scale clinical adoption, all of which could limit Personalis' path to profitability and long-term earnings growth.

Valuation

• The assumed bullish price target for Personalis is $9.0, which is the highest price target estimate amongst analysts. This valuation is based on what can be assumed as the expectations of Personalis's future earnings growth, profit margins and other risk factors from analysts on the bullish end of the spectrum.
  
• However, there is a degree of disagreement amongst analysts, with the most bullish reporting a price target of $9.0, and the most bearish reporting a price target of just $5.0.
  
• In order for you to agree with the bullish analysts, you'd need to believe that by 2028, revenues will be $159.7 million, earnings will come to $22.7 million, and it would be trading on a PE ratio of 52.9x, assuming you use a discount rate of 7.3%.
  
• Given the current share price of $4.51, the bullish analyst price target of $9.0 is 49.9% higher.
  
• We always encourage you to reach your own conclusions though. So sense check these analyst numbers against your own assumptions and expectations based on your understanding of the business and what you believe is probable.