Policy Changes And Partnerships Will Expand Ambulatory Market Reach

Key Takeaways

• Increased adoption of non-opioid solutions and expanded outpatient procedure coverage are expected to drive sustained revenue growth for the company.
  
• Strategic partnerships, manufacturing efficiencies, and clinical pipeline progress support margin improvement and innovation-driven expansion into new markets.
  
• Heavy reliance on EXPAREL, slow market adoption, pricing pressures, R&D uncertainties, and partnership execution risks could constrain long-term revenue growth and profitability.

Catalysts

Engages in the development, manufacture, marketing, distribution, and sale of non-opioid pain management and regenerative health solutions to healthcare practitioners in the United States.

• Recent CMS policy changes phasing out the inpatient-only list and expanding coverage for procedures in ambulatory surgery centers are expected to increase the use of Pacira's EXPAREL in outpatient surgical settings-an area poised for growth as surgery volumes in these settings outpace inpatient procedures-supporting top-line revenue growth in coming years.
  
• Accelerated adoption of non-opioid pain management solutions due to mounting public and regulatory pressure to reduce opioid use is driving increasing formulary wins, broader commercial payer coverage (targeting 100 million covered lives by year-end), and institutional demand for EXPAREL, which is likely to sustain and expand revenue growth.
  
• The new strategic partnership with Johnson & Johnson MedTech for ZILRETTA is expected to double sales coverage and significantly expand reach across new physician specialties and healthcare systems, providing a forward catalyst for revenue growth in 2026 and beyond.
  
• Ongoing investments in manufacturing efficiency-including the commissioning of large-scale, lower-cost production suites and optimization of workforce-are driving higher gross margins (guidance raised to 78%-80%), which, combined with reduced operating expenses, should translate to improved net margins and long-term earnings growth.
  
• Progress in the clinical pipeline (e.g., PCRX-201 advancing through phase II, iovera° registrational studies, and real-world data from the iGOR registry) positions Pacira to capitalize on innovation-driven expansion into new indications and patient populations, which could diversify future revenue streams and reduce risk dependence on a single product.

Pacira BioSciences Future Earnings and Revenue Growth

Assumptions

• Analysts are assuming Pacira BioSciences's revenue will grow by 9.2% annually over the next 3 years.
• Analysts assume that profit margins will increase from -18.1% today to 12.1% in 3 years time.
• Analysts expect earnings to reach $111.4 million (and earnings per share of $2.34) by about August 2028, up from $-127.5 million today.
• In order for the above numbers to justify the analysts price target, the company would need to trade at a PE ratio of 14.1x on those 2028 earnings, up from -8.1x today. This future PE is lower than the current PE for the US Pharmaceuticals industry at 18.1x.
• Analysts expect the number of shares outstanding to decline by 2.59% per year for the next 3 years.
• To value all of this in today's terms, we will use a discount rate of 6.78%, as per the Simply Wall St company report.

Pacira BioSciences Future Earnings Per Share Growth

Risks

• While Pacira highlights strong recent performance and expanding coverage for EXPAREL, broader market adoption of its products can take 6–12 months per provider, with institutional inertia, slow formulary wins, and the need for robust commercial payer support possibly delaying or limiting the pace of revenue growth and margin expansion in the long term.
  
• The company remains highly dependent on its flagship product EXPAREL, which accounts for the majority of revenues-leaving revenues, margins, and earnings vulnerable to any loss of market exclusivity, adverse regulatory rulings, patent litigation, or faster-than-expected competitive encroachment, especially as additional patent expirations approach in the 2030s-2040s.
  
• Commercial success hinges on premium pricing, but the increasing use of bundled payments, payer discount negotiations, and group purchasing organizations (GPOs) may apply downward pressure on pricing and gross-to-net, while the emergence of generic/biosimilar competitors and pressure to reduce healthcare costs could erode pricing power and compress gross and operating margins over time.
  
• Long-term R&D and pipeline risk remains: Pacira's significant spending on development of PCRX-201 and other pipeline assets (with R&D up notably year-over-year) could weigh on operating margins and net income if clinical trials experience delays, fail to meet endpoints, or if Phase II/III results do not translate into regulatory approval or robust market uptake.
  
• There is a notable strategic emphasis on expansion through partnerships (such as the J&J MedTech collaboration on ZILRETTA and future ex-U.S. deals), but if such partnerships fail to deliver anticipated synergies or broaden market access as planned, or if international launches are delayed, long-term revenue and earnings growth could underperform management's targets and investor expectations.

Valuation

• The analysts have a consensus price target of $30.8 for Pacira BioSciences based on their expectations of its future earnings growth, profit margins and other risk factors. However, there is a degree of disagreement amongst analysts, with the most bullish reporting a price target of $44.0, and the most bearish reporting a price target of just $24.0.
  
• In order for you to agree with the analyst's consensus, you'd need to believe that by 2028, revenues will be $918.5 million, earnings will come to $111.4 million, and it would be trading on a PE ratio of 14.1x, assuming you use a discount rate of 6.8%.
  
• Given the current share price of $22.4, the analyst price target of $30.8 is 27.3% higher.
  
• We always encourage you to reach your own conclusions though. So sense check these analyst numbers against your own assumptions and expectations based on your understanding of the business and what you believe is probable.