Duyuru • Jul 09
Addex Therapeutics Publishes Preclinical Research Demonstrating Therapeutic Potential Of ADX71743 In Regulating Sleep And Wakefulness Addex Therapeutics announced publication of new preclinical research demonstrating that ADX71743, a selective negative allosteric modulator (NAM) of metabotropic glutamate receptor 7 (mGlu7), significantly modulates sleep-wake regulation and stress-related neurochemistry in animal models. The data, published in the International Journal of Neuropsychopharmacology, expands the growing body of evidence supporting mGlu7 as an important mechanism regulating key brain functions and a promising therapeutic target across a range of central nervous system disorders, including mood disorders, anxiety disorders, post-traumatic stress disorder (PTSD), and other conditions associated with dysregulated stress responses. In the study, ADX71743 increased wakefulness while reducing both REM and non-REM sleep in rats. The compound also altered stress-induced changes in key neurotransmitters, including glutamate, GABA and monoamines, across multiple brain regions in awake animals, producing neurochemical effects consistent with modulation of stress-responsive neural circuits. Together, these findings further validate the pharmacological profile of selective mGlu7 inhibition in vivo and provide additional support for the therapeutic potential of this novel mechanism. Previous studies have demonstrated that selective mGlu7 inhibition can modulate anxiety-related behaviours, disrupt maladaptive fear memory reconsolidation and influence glutamatergic signalling in both rodent and human brain tissue. ADX71743 is a potent, selective, brain-penetrant negative allosteric modulator of metabotropic glutamate receptor 7 (mGlu7). The compound has served as the prototype molecule underpinning numerous publications investigating the therapeutic potential of mGlu7 modulation across anxiety, stress-related disorders, sleep regulation, fear memory and visceral pain. ADX71743 was discovered by Addex and now forms part of the mGlu7 program being advanced by Neurosterix, the neuroscience company launched by Addex and Perceptive Advisors in 2024. Duyuru • Jun 09
Addex Therapeutics Ltd, Annual General Meeting, Jun 29, 2026 Addex Therapeutics Ltd, Annual General Meeting, Jun 29, 2026, at 11:00 W. Europe Standard Time. Location: at the campus biotech, chemin des mines 9,1202., geneva Switzerland Duyuru • May 02
Addex Therapeutics Ltd announced delayed 20-F filing On 04/30/2026, Addex Therapeutics Ltd announced that they will be unable to file their next 20-F by the deadline required by the SEC. Duyuru • May 01
Addex Therapeutics Demonstrates Solid Anti-Tussive Activity of GABAB PAM Candidate in Bleomycin IPF-Related Chronic Cough Model Addex Therapeutics announced encouraging preclinical data demonstrating antitussive activity of its GABAB positive allosteric modulator (PAM) candidate in a bleomycin (BLM)-induced idiopathic pulmonary fibrosis (IPF) exacerbated chronic cough model. In studies evaluating chronic once-daily (QD) administration of a lead GABAB PAM candidate in BLM-exposed animals, robust and sustained antitussive efficacy was observed, with significant reductions in cough frequency and increased cough latency over the treatment period. Improved lung pathology outcomes, including lower Ashcroft scores and reduced percentage of affected lung tissue suggesting an impact on fibrosis, were demonstrated compared to untreated BLM-exposed animals at both Day 7 and Day 28. The safety profile remained favorable, with no meaningful changes in respiratory rate, or body temperature. The compound was well tolerated throughout the study, supporting its potential for chronic administration. The main inhibitory neurotransmitter GABA activates ionotropic (GABAA) and metabotropic (GABAB) types of receptors. GABAB receptors are widely expressed throughout the central and peripheral cough neural circuit as well as in the lungs and airways. Activating GABAB receptors to treat chronic cough has been clinically validated with baclofen, a selective GABAB agonist, that binds the receptor within the GABA binding, orthosteric site. Baclofen is used off-label to treat chronic cough patients, but its wider use is limited due to serious side effects including sedation, short half-life and gradual loss of efficacy during chronic treatment. Targeting an allosteric site of the receptor encompasses many advantages, including higher selectivity, better tolerability and lack of tolerance compared to an orthosteric compound. Duyuru • Apr 22
Addex Therapeutics Ltd Demonstrates Robust Anti-Tussive Activity of Gabab Pam Candidate in Non-Human Primate Chronic Cough Model Addex Therapeutics Ltd. announced robust anti-tussive activity of its novel gamma-aminobutyric acid sub-type B receptor (GABAB) positive allosteric modulator (PAM) in a non-human primate (NHP) chronic cough model. In the NHP model of chronic cough, the GABAB PAM drug candidate significantly reduced citric acid-induced cough frequency. In the same model, the antitussive efficacy of the GABAB PAM drug candidate was similar to that observed with baclofen. As previously reported, in the citric acid induced guinea pig model of chronic cough, the GABAB PAM drug candidate significantly reduced cough frequency, increased cough latency and showed no signs of tolerance after sub-chronic treatment. In the same model, the antitussive efficacy of the GABAB PAM drug candidate appears to be superior to that observed with nalbuphine, baclofen, codeine or a P2X3 inhibitor. In addition, the GABAB PAM candidate demonstrated better tolerability and a wider therapeutic margin than that observed with nalbuphine, baclofen, or codeine, while being similar to that of a P2X3 inhibitor, based on the compound’s activity on respiratory rate. Duyuru • Mar 09
Addex Therapeutics Ltd to Report Fiscal Year 2025 Final Results on Apr 27, 2026 Addex Therapeutics Ltd announced that they will report fiscal year 2025 final results at 9:00 AM, Central European Standard Time on Apr 27, 2026 Duyuru • Jan 07
Addex Spin-Out Neurosterix Starts A Phase 1 Clinical Study with M4 Pam - Ntx-253 for Schizophrenia Addex Therapeutics Ltd. announced that its spin-out company, Neurosterix, has started a Phase 1 clinical study of NTX-253. NTX-253 is a potent, selective, orally available positive allosteric modulator (PAM) of the muscarinic M4 receptor being developed for the treatment of schizophrenia. The Phase 1 study is designed to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of NTX-253 in healthy volunteers. The progression of NTX-253 into clinical studies represents an important milestone for both Neurosterix and Addex. The M4 muscarinic receptor is a validated target for treating schizophrenia and related disorders through indirect modulation of dopamine signaling. NTX-253 is an potent, selective, orally available PAM of M4 that fine-tunes muscarinic signaling with the potential to reduce psychosis symptoms while avoiding the movement disorders and metabolic complications associated with traditional dopamine antagonists. Preclinical studies demonstrate robust antipsychotic-like activity and a favorable safety profile, supporting advancement into first-in-human clinical studies. Currently available antipsychotics typically target dopamine receptors, providing some success in ameliorating the positive symptoms of the disorder. However, targeting dopamine also can induce metabolic, cognitive, and motor side effects, limiting their therapeutic utility. Research suggest that M4 PAMs could indirectly modulate dopamine levels and induce antipsychotic activity without peripheral muscarinic side- effects seen with direct agonists. Highly selective M4 PAMs have been found to have robust antipsychotic-like effects in multiple rodent models and reverse multiple in vivo effects of psychomotorstimulants that induce increases in extracellular dopamine. Duyuru • Jun 18
Addex Therapeutics Ltd to Report Q1, 2025 Results on Jun 19, 2025 Addex Therapeutics Ltd announced that they will report Q1, 2025 results on Jun 19, 2025 Duyuru • Jun 06
Addex Therapeutics Announces Robust Anti-Tussive Activity in Multiple Chronic Cough Preclinical Models Addex Therapeutics announced robust anti-tussive activity of its novel gamma-aminobutyric acid sub-type B receptor (GABAB) positive allosteric modulator (PAM) in multiple preclinical models of chronic cough compared to reference drugs. Some of these preclinical data with Addex GABAB PAM drug candidate will be presented on June 7, 2025 at the 10thAmerican Cough Conference, in Dulles, Virginia by Dr. Mikhail Kalinichev, Head of Translational Science at Addex. In models of chronic cough, the GABAB PAM drug candidate significantly reduced citric acid-induced cough frequency, increased cough latency and showed no signs of tolerance after sub-chronic treatment. In the same model, the antitussive efficacy of the Addex GABAB PAM Drug candidate appears to be superior to that observed with nalbuphine, baclofen, codeine or a P2X3 inhibitor. In addition, the tolerability of the GABAB PAM candidate demonstrated better tolerability and a wider therapeutic margin than that observed with nalbuPHine, baclofen), or codeine, while being similar to that of a P2X3 inhibitor, based on the compound's activity on respiratory rate. About GABAB activation and cough: The main inhibitory neurotransmitter GABA activates ionotropic (GABAA) and metabotropic (GABAB) types of receptors. GABAB receptors are widely expressed on airways and in the central and peripheral components of the cough neural circuit. Activating GABAB receptors to treat chronic cough has been clinically validated with baclofen, a selective GABAB agonist, that binds the receptor within the GABA binding, orthosteric site. Baclofen is used off-label to treat chronic cough patients, but its wider use is limited due to serious side effects, short half-life and gradual loss of efficacy during chronic treatment. Targeting an allosteric site of the receptor encompasses many advantages, including higher selectivity, better tolerability and lack of tolerance compared to an orthosteric compound. Duyuru • Jun 04
Addex Therapeutics Ltd, Annual General Meeting, Jun 24, 2025 Addex Therapeutics Ltd, Annual General Meeting, Jun 24, 2025, at 11:00 W. Europe Standard Time. Location: campus biotech, chemin des mines 9, 1202, geneva Switzerland Duyuru • May 01
Addex Therapeutics Ltd announced delayed 20-F filing On 04/30/2025, Addex Therapeutics Ltd announced that they will be unable to file their next 20-F by the deadline required by the SEC. Duyuru • Apr 24
Addex Therapeutics Ltd to Report Fiscal Year 2024 Results on Apr 25, 2025 Addex Therapeutics Ltd announced that they will report fiscal year 2024 results at 12:00 PM, Central European Standard Time on Apr 25, 2025 Duyuru • Apr 17
Addex Regains Rights to Phase 2 Mglu2 Pam Asset ADX71149 Addex Therapeutics announced that following the previously announced termination of development of ADX71149 (JNJ-40411813) in epilepsy, its partner Janssen Pharmaceuticals Inc. (now known as J&J Innovative Medicine) has return all development and commercialization rights to ADX71149 (JNJ-40411813) and the partnership between the two companies has been terminated. Duyuru • Sep 10
Addex Therapeutics Ltd to Report First Half, 2024 Results on Sep 16, 2024 Addex Therapeutics Ltd announced that they will report first half, 2024 results on Sep 16, 2024 Duyuru • Aug 27
Addex Therapeutics Ltd and Indivior PLC Selects Clinical Candidates from Gabab Positive Allosteric Modulator Research Collaboration Addex Therapeutics Ltd. and Indivior PLC announced the selection of clinical candidates from their GABAB positive allosteric modulator (PAM) research collaboration. Indivior has selected a compound for future development in substance use disorder and will now undertake all future development of their selected compound. Under the terms of the agreement, Addex is eligible for payment of up to USD 330 million on successful achievement of prespecified regulatory, clinical and commercial milestones as well as tiered royalties on the level of net sales from high single digits up to low double-digit. Under the terms of the Agreement, Addex has also exercised its right to select a compound to advance its own independent GABAB PAM program for the treatment of chronic cough. The selection of GABAB PAM clinical candidates is the culmination of more than five years of research at Addex in close collaboration with the team at Indivior. During this time, the company were able to pinpoint specific candidates from thousands of compounds using the power of industrial-scale allosteric modulator discovery platform. The selection of GAM clinical candidates is the culmination the culmination of more than five year of research at Addex in near collaboration with the team at IndIVior. During this time, company were able to pinpoint specific candidate from thousands of compounds using the Power of industrial-scale allosterIC modulator discovery platform. The company look forward to the next steps in the development of the substance use disorder program under the control of Indivior. On the Addex side, the company are now focused on advancing its selected clinical candidate for chronic cough into IND enabling studies. Activation of gamma-aminobutyric acid subtype BGABAB) receptor, a Family C class of GPCR, is clinically and commercially validated. The generic GABAB receptor agonist, baclofen, marketed for spasticity, has been shown to be efficacious in several other disease areas, including alcohol use disorder, CMT1A, overactive bladder, chronic cough and pain. However, its wider use is limited due to a variety of side effects, rapid clearance and the development of tolerance. novel, potent, selective and orally available PAMs that potentiate GABA responses, rather than acting as orthosteric agonists at the GABAB receptor, like baclofen, are expected to deliver efficacy and have fewer adverse effects. Furthermore, PAMs only act when the natural ligand (GABA) activates the natural ligand (GAB) receptor. Duyuru • Jul 15
Addex Therapeutics Ltd Presents Positive Results from GABAB PAM Cough Program at the Thirteenth London International Cough Symposium Addex Therapeutics Ltd. announced that positive results from the Company's novel gamma-aminobutyric acid sub-type B receptor (GABAB) positive allosteric modulator (PAM) chronic cough program will be presented during the Thirteenth London International Cough Symposium (13 LICS) on July 19 and an abstract is available to conference participants on-line from July 15, 2024. In models of chronic cough in guinea pigs, the candidate GABAB PAM, significantly and dose-dependently reduced citric acid-induced cough frequency (minimal efficacious dose 1 mg/kg), increased cough latency and showed no signs of tolerance after sub-chronic treatment. In comparison with the GABAB agonist baclofen, the selective GABAB PAM showed a wider safety margin, separating its minimal efficacious dose from the dose linked to side-effects. Baclofen exhibits antitussive properties, but its broad clinical use is hampered by its short half-life and central nervous system side effects including sedation. Duyuru • Jun 08
Addex Therapeutics Ltd, Annual General Meeting, Jun 28, 2024 Addex Therapeutics Ltd, Annual General Meeting, Jun 28, 2024, at 11:00 W. Europe Standard Time. Location: geneva Switzerland Duyuru • Apr 11
Addex Therapeutics Ltd to Report Fiscal Year 2023 Results on Apr 18, 2024 Addex Therapeutics Ltd announced that they will report fiscal year 2023 results at 12:00 PM, Central European Standard Time on Apr 18, 2024 Duyuru • Apr 05
Addex Therapeutics Announces the Launch of Neurosterix, Company Focused on Developing Allosteric Modulators for the Treatment of Underserved Neurological Disorders Addex Therapeutics announced the launch of Neurosterix, a company focused on developing allosteric modulators for the treatment of underserved neurological disorders. With initial funding of $63 million from Perceptive Xontogeny Venture Fund II, with participation from Perceptive Life Sciences Fund and Acorn Bioventures, Neurosterix will acquire a portfolio of preclinical assets and the allosteric modulator drug discovery technology platform from Addex and accelerate their development. Addex's pipeline now consists of: ADX71149 - a metabotropic glutamate receptor subtype 2 positive allosteric modulator (mGlu2 PAM) currently in a Phase 2 clinical study for the treatment of epilepsy in collaboration with Janssen Pharmaceuticals Inc.; A GABAB PAM program licensed to Indivior currently in clinical candidate selection with a focus on substance use disorder; Dipraglurant a Phase 2 ready mGlu5 NAM under evaluation for future development in dyskinesia associated with Parkinson's disease and post-stroke/traumatic brain injury (TBI) recovery; and GABAB PAMs in clinical candidate selection for chronic cough. The launch of Neurosterix in partnership with Perceptive is an important validation of the Addex allosteric modulator drug discovery technology platform and provides the resources to accelerate development of important preclinical assets, including the M4 PAM and mGlu7 negative allosteric modulator (NAM) programs, into the clinic This transaction significantly reduces Addex operating costs and provides CHF5 million of cash thereby extending cash runway beyond 2026. This allows to reach important milestones from partnered programs, including the Phase 2 epilepsy data from Janssen partnership in the second quarter of 2024 as well as retaining an important upside in the future of Neurosterix through 20% equity interest. Allosteric modulators bind to their target receptor outside of the active site, where the natural ligand and traditional drugs operate. This non-competitive mode of action brings greater selectivity and more precision over the control of biological pathways, potentially delivering improved efficacy and safety. Addex pioneered the development of high-throughput industrial-scale discovery tools for allosteric modulator drug discovery, which have delivered a broad pipeline of oral small molecule drug candidates with the potential to transform the treatment of multiple neurological disorders. Addex's pipeline now consists of: ADX71149 - a metabotropic glutamate receptor subtype 2 positive allosteric modulator (mGlu2 PAM) currently in a Phase 2 clinical study for the treatment of epilepsy in collaboration with Janssen Pharmaceuticals Inc.; A GABAB PAM program licensed to Indivior currently in clinical candidate selection with a focus on substance use disorder; Dipraglurant a Phase 2 ready mGlu5 NAM under evaluation for future development in dyskinesia associated with Parkinson's disease and post-stroke/traumatic brain injury (TBI) recovery; and GABAB PAMs in clinical candidate selection for chronic cough. Duyuru • Jan 31
Addex Therapeutics Ltd has filed a Follow-on Equity Offering in the amount of $2.15 million. Addex Therapeutics Ltd has filed a Follow-on Equity Offering in the amount of $2.15 million.
Security Name: American Depositary Shares
Security Type: Depositary Receipt (Common Stock)
Transaction Features: At the Market Offering 
