Announcement • Jan 02

Galera Therapeutics Announces Board Changes

On December 30, 2024, Galera Therapeutics, Inc. acquired Nova Pharmaceuticals, Inc., in accordance with the terms of the Agreement and Plan of Merger, dated December 30, 2024 (the Merger Agreement), by and among Galera, Grape Merger Sub I, Inc., a Delaware corporation and a wholly owned subsidiary of Galera (First Merger Sub), Grape Merger Sub II, LLC, a Delaware limited liability company and wholly owned subsidiary of Galera (Second Merger Sub), and Nova. Galera Therapeutics, Inc. announced board of directors includes three current Galera board members, Mr. Larry Alleva and Mr. Kevin Lokay and Dr. Sorensen, and two additional board members selected by Nova, Mr. Michael Friedman and Dr. Nancy T. Chang. Mr. Friedman has an MBA from the University of Chicago and brings over 20 years’ experience in investment banking, in finance and in the life science industry to the Board of Galera. Dr. Chang is a PhD biochemist who has spent her career in leadership roles in academia, in large and small pharma companies and in the venture capital world and she has extensive experience in biopharma boards. Nancy Chang and Michael Friedman were appointed as members of the Board as Class I directors. None of the Director Appointees have been appointed to any committee of the Board. Dr. Nancy Chang, Ph.D. (Age 75) has been appointed to serve on the Board as a Class I director effective as of December 30, 2024. She completed her undergraduate studies at Taiwan National Tsing Hua University and attended the Ph. D. program at the Division of Medical Sciences at Harvard Medical School. Dr. Chang joined the founding team at Centocor, where she served as director of research and worked on the development of monoclonal antibody as therapeutics and to the HIV field including the development of the first HIV diagnosis assay. In 1986, Dr. Chang joined Baylor College of Medicine, where she served as Associate Professor of Virology until 1991. During this tenure, Dr. Chang co-founded Tanox, a company that focused on the treatment of immunological diseases including allergy, asthma, and inflammation by using antibodies as a therapeutic agent. From 1995 to 2000, Dr. Chang also served on the Texas Higher Education Coordinate Board under Governor George W. Bush. After 2007, Dr. Chang led OrbiMed's Asia fund as the chairman, founder and senior managing director. She served on the board of directors for various institutes including the Federal Reserve Bank in Houston, BioHouston, Biotechnology Innovation Organization (Bio), Charles River Laboratories, and several biotech companies. Currently, Dr. Chang serves as an advisor to ViRx at Stanford and to Baylor College of Medicine and as president of the Tang Family Foundation. Michael Friedman (Age 47) has been appointed to serve on the Board as a Class I director effective as of December 30, 2024. Mr. Friedman is a principal and executive in residence at Emerald Bioventures, LLC (Emerald"), a life science incubator and venture capital firm. At Emerald, Mr. Friedman handles company formation, corporate finance and operations within the portfolio. Mr. Friedman has over 20 years of investment banking experience, specializing in healthcare mergers and acquisitions, leveraged finance and capital markets at firms such as Bank of America Corporation, Merrill Lynch, Jefferies and Ladenburg. Mr. Friedman has worked on venture rounds, private investment in public equity transactions, licensing transactions, sell-side and buy-side mergers and acquisitions, initial public offerings, debt financings, asset sales and divestitures. Mr. Friedman has a Master of Business Administration from the University of Chicago and a Bachelor of Business Administration from the University of Wisconsin. Mr. Friedman previously served on the board of Akari Therapeutics Plc (formerly known as Peak Bio). In accordance with the Merger Agreement, on December 30, 2024, Michael Powell, Ph.D. (Class I director), Linda West (Class I director) and Emmett Cunningham, M.D., Ph.D. (Class III director) resigned from the Board (collectively, the Resignations"), effective immediately after the time of the filing of the First Merger Certificate of Merger with the Secretary of State of the State of Delaware (the First Effective Time"). None of the Resignations were the result, in whole or in part, of any disagreement with Galera or its management relating to Galera's operations, policies or practices.

Announcement • Feb 16

Galera Therapeutics, Inc. Announces FDA Acceptance and Priority Review of Avasopasem NDA for Radiotherapy-Induced Severe Oral Mucositis

Galera Therapeutics, Inc. announced that the U.S. Food and Drug Administration (FDA) has accepted for filing and granted priority review to the New Drug Application (NDA) for avasopasem manganese for radiotherapy (RT)-induced severe oral mucositis (SOM) in patients with head and neck cancer (HNC) undergoing standard-of-care treatment. There are currently no FDA-approved drugs to reduce SOM for these patients. With the 6-month priority review designation, the Prescription Drug User Fee Act (PDUFA) target date assigned by the FDA for this NDA is August 9, 2023. The FDA indicated in its acceptance of filing letter that it is not planning to hold an advisory committee meeting on the application. The FDA previously granted Breakthrough Therapy and Fast Track designations to avasopasem for the reduction of SOM induced by RT. The NDA is supported by two randomized, double-blind, placebo-controlled trials (Phase 3 ROMAN and Phase 2b GT-201), which enrolled a total of 678 patients. Both trials demonstrated clinically meaningful reductions across key measures of patients’ SOM burden, including decreasing the incidence and number of days of SOM, decreasing the severity (incidence of Grade 4 oral mucositis, the inability to eat or drink), and delaying the time to SOM onset. In addition, follow-up data that was collected on renal function through 12 months post administration of RT and avasopasem point to another clinically meaningful benefit for these patients, most of whom receive cisplatin chemotherapy as part of their care. In the ROMAN trial, results on a pre-defined exploratory endpoint showed that avasopasem reduced cisplatin-induced chronic kidney disease by half at one year. In both trials, the reported side effects were consistent with those caused by RT and cisplatin, other than some increases in rates of hypotension and mild nausea with avasopasem. There were nominal decreases in the rates of some side effects associated with RT or with cisplatin among avasopasem patients in the combined trials, such as oropharyngeal pain, radiation skin injury, tinnitus, and acute kidney injury. After long-term follow-up in both trials, patients treated with avasopasem in combination with the standard-of-care regimen (RT plus cisplatin) demonstrated comparable tumor outcomes and overall survival to patients in the placebo arm, showing that avasopasem protected HNC patients from SOM without affecting the treatment benefit of standard-of-care chemoradiotherapy. The Phase 3 ROMAN trial (GTI-4419-301) was a randomized, double-blind, placebo-controlled trial in 455 patients designed to evaluate the ability of avasopasem to reduce radiation-induced SOM in patients with locally advanced HNC, receiving seven weeks of standard-of-care radiotherapy plus cisplatin. Patients were randomized to one of the two treatment groups (3:2) to receive 90 mg of avasopasem or placebo by infusion on the days they receive their radiation treatment. Results from the 455-patient ROMAN trial demonstrated a clinically meaningful reduction in patients’ SOM burden across multiple endpoints, with statistically significant reductions on the primary endpoint of incidence of SOM and the secondary endpoint of number of days of SOM, more than halving the median number of days a patient suffered SOM. Meaningful reduction in the number of patients who developed the most severe form of SOM (Grade 4, the inability to eat or drink) was also observed. Exploratory analyses, such as time to SOM onset and SOM incidence at various landmarks of cumulative radiotherapy delivered, also demonstrated the clinical benefit of avasopasem in reducing the burden of SOM, along with a meaningful reduction in long-term loss of kidney function associated with concurrent cisplatin. Avasopasem was generally well tolerated compared to placebo. Overall, the adverse event (AE) incidences were consistent with the interpretation that avasopasem was not associated with a clinically meaningful increase in the AE profile expected for the target patient population receiving standard-of-care radiotherapy. After one-year follow-up in the ROMAN trial, patients treated with avasopasem in combination with the standard-of-care regimen (RT plus cisplatin) demonstrated comparable tumor outcomes and overall survival to patients in the placebo arm, showing that avasopasem protected HNC patients from SOM without affecting the treatment benefit of standard-of-care chemoradiotherapy. The GT-201 trial (GTI-4419-201) was a randomized, double-blind, placebo-controlled trial in 223 patients designed to evaluate the ability of avasopasem to reduce radiation-induced SOM in patients with locally advanced HNC, receiving seven weeks of standard-of-care radiotherapy plus cisplatin. Patients were randomized to one of the three treatment groups (1:1:1) to receive either 30 mg or 90 mg of avasopasem or placebo by infusion on the days they receive their radiation treatment. Results from the 223-patient Phase 2b trial demonstrated a meaningful reduction in patients’ SOM burden across multiple endpoints, with a statistically significant reduction on the primary endpoint of number of days of SOM in the 90 mg avasopasem arm compared to placebo. Avasopasem also resulted in clinically meaningful reductions in the incidence, severity (Grade 4 incidence), and onset of SOM compared to placebo. Avasopasem was generally well tolerated compared to placebo. The FDA granted Breakthrough Therapy designation to avasopasem for the reduction of SOM induced by radiotherapy, based on the positive results of the GT-201 trial. Avasopasem was generally well tolerated compared to placebo. Overall, the adverse event (AE) incidences were consistent with the interpretation that avasopasem was not associated with a clinically meaningful increase in the AE profile expected for the target patient population receiving standard-of-care radiotherapy. After two-year follow-up in the GT-201 trial, patients treated with avasopasem in combination with the standard-of-care regimen (RT plus cisplatin) demonstrated comparable tumor outcomes and overall survival to patients in the placebo arm, showing that avasopasem protected HNC patients from SOM without affecting the treatment benefit of standard-of-care chemoradiotherapy. The FDA granted Breakthrough Therapy designation to avasopasem for the reduction of SOM induced by radiotherapy, based on the positive results of the GT-201 trial.

Total Shareholder Yield	0%
Future Dividend Yield	n/a
Dividend Growth	n/a
Next dividend pay date	n/a
Ex dividend date	n/a
Dividend per share	n/a
Payout ratio	n/a

Segment	Dividend Yield
Company (GRTX.D)	n/a
Market Bottom 25% (US)	1.4%
Market Top 25% (US)	4.2%
Industry Average (Biotechs)	2.3%
Analyst forecast (GRTX.D) (up to 3 years)	n/a

Data	Last Updated (UTC time)
Company Analysis	2026/07/14 00:40
End of Day Share Price	2026/07/14 00:00
Earnings	2026/03/31
Annual Earnings	2025/12/31

Package	Data	Timeframe	Example US Source ^*
Company Financials	10 years	Income statement Cash flow statement Balance sheet	SEC Form 10-K SEC Form 10-Q
Analyst Consensus Estimates	+3 years	Forecast financials Analyst price targets	Analyst Research Reports Blue Matrix
Market Prices	30 years	Stock prices Dividends, Splits and Actions	ICE Market Data SEC Form S-1
Ownership	10 years	Top shareholders Insider trading	SEC Form 4 SEC Form 13D
Management	10 years	Leadership team Board of directors	SEC Form 10-K SEC Form DEF 14A
Key Developments	10 years	Company announcements	SEC Form 8-K

Analyst	Institution
Tazeen Ahmad	BofA Global Research
null null	BTIG
Yigal Nochomovitz	Citigroup Inc

Galera Therapeutics Dividends and Buybacks

Dividend criteria checks 0/6

Key information

Recent dividend and buyback updates

Recent updates

Obsidian Therapeutics, Inc. agreed to acquire Galera Therapeutics, Inc. (OTCPK:GRTX) in a reverse merger transaction.

Galera Therapeutics, Inc., Annual General Meeting, May 08, 2026

Galera Therapeutics Announces Board Changes

Galera Therapeutics, Inc., Annual General Meeting, Feb 24, 2025

Galera Therapeutics, Inc. announced delayed 10-Q filing

The Nasdaq Stock Market LLC to Delist Common Stock of Galera Therapeutics

Galera Therapeutics, Inc. Eliminates Robert A. Beardsley as Chief Operating Officer

Galera Therapeutics, Inc.(OTCPK:GRTX) dropped from S&P TMI Index

Nasdaq Hearings Panel Determines to Delist Galera Therapeutics' Shares from Nasdaq Due to the Failure to Meet Nasdaq’s Continued Listing Standards

New major risk - Financial position

Galera Therapeutics Receives Non-Compliance Letters from the Listing Qualifications Staff of Nasdaq

New major risk - Market cap size

New major risk - Revenue and earnings growth

Price target increased by 25% to US$0.50

Insufficient new directors

Galera Therapeutics Receives Notice from Nasdaq Regarding Listing Rule 5450(B)(2)(C)

Galera Therapeutics Receives Two Non-Compliance Notices from Nasdaq

New minor risk - Share price stability

Galera Therapeutics, Inc. Approves Reduction in the Company's Current Workforce by 22 Employees, or Approximately 70% of the Company's Headcount

Consensus revenue estimates increase by 17%

New minor risk - Market cap size

Galera Therapeutics, Inc. Presents Additional Chronic Kidney Disease Data from ROMAN Trial at 2023 ASCO Annual Meeting

Insufficient new directors

Consensus revenue estimates increase by 100%

Price target decreased by 11% to US$10.00

CEO, President & Director recently bought US$168k worth of stock

Price target increased by 11% to US$12.50

Galera Therapeutics, Inc. Announces FDA Acceptance and Priority Review of Avasopasem NDA for Radiotherapy-Induced Severe Oral Mucositis

Galera Therapeutics (NASDAQ:GRTX) Will Have To Spend Its Cash Wisely

Galera Submits New Drug Application for Avasopasem for Severe Oral Mucositis

Galera Therapeutics Receives Non-Compliance Notice from Nasdaq

Price target decreased to US$11.25

Price target increased to US$15.00

Price target increased to US$15.00

Galera Therapeutics, Inc. Announces Presentation of Phase 3 ROMAN Long-term Follow-up Data at 2022 American Society for Radiation Oncology (ASTRO) Annual Meeting

Galera Therapeutics (NASDAQ:GRTX) Will Have To Spend Its Cash Wisely

Galera Therapeutics, Inc Appoints Eugene P. Kennedy as Chief Medical Officer

Galera Therapeutics appoints chief medical officer

Price target increased to US$15.00

Galera Therapeutics, Inc. Announces Results from Phase 1 Stage of Greco-1 Trial of Rucosopasem with SBRT for Nsclc

Galera down ~8% after phase 1 data for non-small cell lung cancer combination treatment

Companies Like Galera Therapeutics (NASDAQ:GRTX) Could Be Quite Risky

Galera Therapeutics Receives Non-Compliance Letter from Nasdaq

Galera Therapeutics, Inc. Announces Oral Presentation At 2022 American Society of Clinical Oncology Annual Meeting Detailing Results from Phase 3 ROMAN Trial of Avasopasem

Galera Announces Plan to Submit Avasopasem NDA by Year End

Galera Therapeutics, Inc. Announces Topline Results from Phase 2A Aesop Trial of Avasopasem for Chemoradiotherapy-Induced Esophagitis

Galera to Present at 2022 American Society of Clinical Oncology Annual Meeting

Price target increased to US$12.25

Is Galera Therapeutics Stock A Buy, Sell, Or Hold? Several Catalysts To Watch In 2022

Here's Why We're A Bit Worried About Galera Therapeutics' (NASDAQ:GRTX) Cash Burn Situation

Galera Therapeutics: Trial Reversal Did Not Take The Stock Higher

Independent Director recently bought US$55k worth of stock

Galera Therapeutics, Inc. Announces Primary Endpoint Met Statistical Significance in Corrected Topline Efficacy Data of Phase 3 ROMAN Trial of Avasopasem

Companies Like Galera Therapeutics (NASDAQ:GRTX) Could Be Quite Risky

Price target decreased to US$11.50

Chief Medical Officer exercised options and sold US$288k worth of stock

Will Galera Therapeutics (NASDAQ:GRTX) Spend Its Cash Wisely?

Galera Therapeutics, Inc.(NasdaqGM:GRTX) dropped from Russell 3000E Index

Independent Director recently bought US$91k worth of stock

Galera Therapeutics, Inc. Ceases Enrolling Subjects in its Phase 2 Pilot Trial of Avasopasem in Hospitalized Patients

Independent Director recently bought US$173k worth of stock

Consensus forecasts updated

Galera Therapeutics, Inc. Announces First Patient Dosed with GC4711 in Phase 2b GRECO-2 Trial in Patients with Pancreatic Cancer

Price target increased to US$20.75

CEO, President & Director exercised options to buy US$1.8m worth of stock.

Here's Why We're Watching Galera Therapeutics' (NASDAQ:GRTX) Cash Burn Situation

New 90-day high: US$12.39

Chief Accounting Officer exercised options and sold US$179k worth of stock

New 90-day high: US$12.81

New 90-day high: US$9.81

Galera Therapeutics, Inc.(NasdaqGM:GRTX) dropped from Russell 3000 Value Index

Galera Therapeutics, Inc.(NasdaqGM:GRTX) dropped from Russell Microcap Value Index

Stability and Growth of Payments

Dividend Yield vs Market

Earnings Payout to Shareholders