Nuvation Bio (NUVB) Is Up 49.5% After Strong Phase 2 Glioma Data Shows Promising Progression-Free Survival

• Nuvation Bio recently published positive results from a Phase 2 study of safusidenib in Japanese patients with chemotherapy- and radiotherapy-naïve grade 2 IDH1-mutant gliomas, showing the study met its primary endpoint with encouraging efficacy and manageable safety data.
• An important detail is that after over two years of median follow-up, almost 88% of patients remained progression free, highlighting the potential for sustained benefit.
• We'll explore how the compelling progression-free survival data shapes Nuvation Bio’s investment narrative as it advances to Phase 3 trials.

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What Is Nuvation Bio's Investment Narrative?

To stand behind Nuvation Bio as a shareholder, you need to believe in its potential to deliver breakthrough therapies for cancer, especially now that safusidenib has shown such strong Phase 2 results in glioma. With a 44.4% objective response rate and nearly 88% of patients progression free at two years, this news directly impacts short-term catalysts by strengthening confidence in Phase 3 prospects and supporting the company’s narrative around long-term efficacy. Combined with the recent uptick in revenue and new regulatory wins for taletrectinib, there’s fresh momentum, reflected in very large recent share price gains. However, crucial risks remain: Nuvation is still unprofitable and not expected to break even soon. Persistent board turnover and clinical data integrity issues (like the GCP noncompliance) now share the spotlight with future regulatory decisions. On the other hand, data integrity remains a critical concern for investors to watch.

Nuvation Bio's shares have been on the rise but are still potentially undervalued. Find out how large the opportunity might be.

Exploring Other Perspectives

Five fair value estimates from the Simply Wall St Community range from US$0.76 to US$23.93 per share, reflecting significant disagreement on Nuvation Bio’s underlying value. Given the company’s climb in revenue alongside persistent losses, differing opinions on long-term profitability remain front and center. Explore more perspectives and decide where you stand.

Explore 5 other fair value estimates on Nuvation Bio - why the stock might be worth less than half the current price!

Build Your Own Nuvation Bio Narrative

Disagree with this assessment? Create your own narrative in under 3 minutes - extraordinary investment returns rarely come from following the herd.

• A great starting point for your Nuvation Bio research is our analysis highlighting 3 key rewards and 2 important warning signs that could impact your investment decision.
• Our free Nuvation Bio research report provides a comprehensive fundamental analysis summarized in a single visual - the Snowflake - making it easy to evaluate Nuvation Bio's overall financial health at a glance.

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This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

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