Spyre Therapeutics, Inc.

NasdaqGS:SYRE Stock Report

Market Cap: US$1.4b

Spyre Therapeutics Valuation

Is SYRE undervalued compared to its fair value, analyst forecasts and its price relative to the market?

Valuation Score

0/6

Valuation Score 0/6

  • Below Fair Value

  • Significantly Below Fair Value

  • Price-To-Book vs Peers

  • Price-To-Book vs Industry

  • Price-To-Book vs Fair Ratio

  • Analyst Forecast

Share Price vs Fair Value

What is the Fair Price of SYRE when looking at its future cash flows? For this estimate we use a Discounted Cash Flow model.

Below Fair Value: Insufficient data to calculate SYRE's fair value for valuation analysis.

Significantly Below Fair Value: Insufficient data to calculate SYRE's fair value for valuation analysis.

Key Valuation Metric

Which metric is best to use when looking at relative valuation for SYRE?

Key metric: As SYRE is unprofitable and pre-revenue we use its Price-To-Book Ratio for relative valuation analysis.

The above table shows the Price to Book ratio for SYRE. This is calculated by dividing SYRE's market cap by their current book value.
What is SYRE's PB Ratio?
PB Ratio7.7x
BookUS$171.57m
Market CapUS$1.39b

Price to Book Ratio vs Peers

How does SYRE's PB Ratio compare to its peers?

The above table shows the PB ratio for SYRE vs its peers. Here we also display the market cap and forecasted growth for additional consideration.
CompanyForward PBEstimated GrowthMarket Cap
Peer Average6.4x
SNDX Syndax Pharmaceuticals
2.9x25.5%US$1.1b
XENE Xenon Pharmaceuticals
3.7x12.6%US$3.0b
LENZ LENZ Therapeutics
3.8x41.0%US$861.3m
QURE uniQure
15x25.6%US$853.0m
SYRE Spyre Therapeutics
7.7x-10.1%US$1.4b

Price-To-Book vs Peers: SYRE is expensive based on its Price-To-Book Ratio (7.7x) compared to the peer average (6.4x).

Price to Book Ratio vs Industry

How does SYRE's PB Ratio compare vs other companies in the US Biotechs Industry?

63 CompaniesPrice / BookEstimated GrowthMarket Cap
GRAL GRAIL
0.2x35.7%US$658.58m
AMRN Amarin
0.3x-7.9%US$184.28m
LYEL Lyell Immunopharma
0.3x-14.9%US$181.49m
NKTX Nkarta
0.4x-11.5%US$170.07m
SYRE 7.7xIndustry Avg. 1.8xNo. of Companies79PB01.63.24.86.48+
63 CompaniesEstimated GrowthMarket Cap
No more companies

Price-To-Book vs Industry: SYRE is expensive based on its Price-To-Book Ratio (7.7x) compared to the US Biotechs industry average (1.7x).

Price to Book Ratio vs Fair Ratio

What is SYRE's PB Ratio compared to its Fair PB Ratio? This is the expected PB Ratio taking into account the company's forecast earnings growth, profit margins and other risk factors.

SYRE PB Ratio vs Fair Ratio.
Fair Ratio
Current PB Ratio7.7x
Fair PB Ration/a

Price-To-Book vs Fair Ratio: Insufficient data to calculate SYRE's Price-To-Book Fair Ratio for valuation analysis.

Analyst Price Targets

What is the analyst 12-month forecast and do we have any statistical confidence in the consensus price target?

The above table shows the analyst SYRE forecast and predictions for the stock price in 12 month’s time.
DateShare PriceAverage 1Y Price TargetDispersionHighLow1Y Actual priceAnalysts
CurrentUS$22.54
US$58.63
+160.1%
19.7%US$71.00US$40.00n/a8
Dec ’25US$28.43
US$58.63
+106.2%
19.7%US$71.00US$40.00n/a8
Nov ’25US$33.98
US$47.63
+40.2%
18.0%US$65.00US$37.00n/a8
Oct ’25US$27.46
US$47.00
+71.2%
10.7%US$54.00US$40.00n/a7
Sep ’25US$28.75
US$47.33
+64.6%
11.4%US$54.00US$40.00n/a6
Aug ’25US$26.92
US$45.00
+67.2%
16.8%US$54.00US$31.00n/a7
Jul ’25US$24.55
US$45.00
+83.3%
16.8%US$54.00US$31.00n/a7
Jun ’25US$34.95
US$45.00
+28.8%
16.8%US$54.00US$31.00n/a7
May ’25US$33.87
US$43.14
+27.4%
21.4%US$54.00US$31.00n/a7
Apr ’25US$37.00
US$40.00
+8.1%
22.1%US$54.00US$31.00n/a6
Mar ’25US$29.90
US$37.00
+23.7%
17.0%US$50.00US$31.00n/a6
Feb ’25US$25.86
US$30.33
+17.3%
32.1%US$44.00US$12.00n/a6
Jan ’25US$21.52
US$28.17
+30.9%
34.4%US$44.00US$12.00n/a6
Dec ’24US$19.58
US$17.50
-10.6%
31.4%US$23.00US$12.00US$28.432
Nov ’24US$11.43
US$17.75
+55.3%
29.6%US$23.00US$12.50US$33.982
Oct ’24US$12.25
US$17.75
+44.9%
29.6%US$23.00US$12.50US$27.462
Sep ’24US$14.50
US$17.50
+20.7%
28.6%US$22.50US$12.50US$28.752
Aug ’24US$13.79
US$35.42
+156.9%
80.6%US$75.00US$8.75US$26.923
Jul ’24US$11.26
US$77.92
+591.8%
74.1%US$150.00US$8.75US$24.553
Jun ’24US$3.26
US$77.92
+2,290.1%
74.1%US$150.00US$8.75US$34.953
May ’24US$4.20
US$77.92
+1,755.2%
74.1%US$150.00US$8.75US$33.873
Apr ’24US$7.25
US$65.00
+796.6%
71.3%US$150.00US$25.00US$37.005
Mar ’24US$9.88
US$67.50
+583.4%
65.8%US$150.00US$25.00US$29.905
Feb ’24US$12.02
US$67.50
+461.7%
65.8%US$150.00US$25.00US$25.865
Jan ’24US$11.25
US$67.50
+500.1%
65.8%US$150.00US$25.00US$21.525
Dec ’23US$10.58
US$67.50
+538.0%
65.8%US$150.00US$25.00US$19.585

Analyst Forecast: Target price is more than 20% higher than the current share price, but analysts are not within a statistically confident range of agreement.

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Company Analysis and Financial Data Status

DataLast Updated (UTC time)
Company Analysis2024/12/30 10:22
End of Day Share Price 2024/12/30 00:00
Earnings2024/09/30
Annual Earnings2023/12/31

Data Sources

The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.

PackageDataTimeframeExample US Source *
Company Financials10 years
  • Income statement
  • Cash flow statement
  • Balance sheet
Analyst Consensus Estimates+3 years
  • Forecast financials
  • Analyst price targets
Market Prices30 years
  • Stock prices
  • Dividends, Splits and Actions
Ownership10 years
  • Top shareholders
  • Insider trading
Management10 years
  • Leadership team
  • Board of directors
Key Developments10 years
  • Company announcements

* example for US securities, for non-US equivalent regulatory forms and sources are used.

Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more here.

Analysis Model and Snowflake

Details of the analysis model used to generate this report is available on our Github page, we also have guides on how to use our reports and tutorials on Youtube.

Learn about the world class team who designed and built the Simply Wall St analysis model.

Industry and Sector Metrics

Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on .

Analyst Sources

Spyre Therapeutics, Inc. is covered by 15 analysts. 9 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.

AnalystInstitution
Colleen KusyBaird
Mayur SomaiyaBMO Capital Markets Equity Research
Julian HarrisonBTIG