Spyre Therapeutics Ownership

Who are the major shareholders and have insiders been buying or selling?

Recent Insider Transactions

Insider Buying: Insufficient data to determine if insiders have bought more shares than they have sold in the past 3 months.

Dilution of Shares: Shareholders have been substantially diluted in the past year, with total shares outstanding growing by 1154.8%.

Top 25 shareholders own 86.48% of the company

Ownership	Name	Shares	Current Value	Change %	Portfolio %
14.8%	FMR LLC	7,507,983	US$199.5m	14%	0.01%
7.91%	Fairmount Funds Management LLC	4,018,101	US$106.8m	962%	9.47%
6.42%	RTW Investments, LP	3,258,360	US$86.6m	45.9%	1.26%
5.97%	Perceptive Advisors LLC	3,031,018	US$80.5m	18.6%	1.86%
5.29%	VR Adviser, LLC	2,685,448	US$71.4m	23.7%	3.22%
4.95%	Braidwell LP	2,514,538	US$66.8m	388%	3.09%
4.73%	BlackRock, Inc.	2,403,441	US$63.9m	332%	no data
3.91%	Commodore Capital LP	1,988,084	US$52.8m	5.52%	3.47%
3.76%	The Vanguard Group, Inc.	1,911,566	US$50.8m	284%	no data
3.62%	Avoro Capital Advisors LLC	1,839,138	US$48.9m	0%	0.6%
3.46%	Deep Track Capital, LP	1,756,667	US$46.7m	44.8%	1.23%
2.78%	State Street Global Advisors, Inc.	1,409,659	US$37.5m	949%	no data
2.27%	Adage Capital Management, L.P.	1,152,411	US$30.6m	4.27%	0.06%
1.73%	Goldman Sachs Group, Investment Banking and Securities Investments	880,804	US$23.4m	267%	0.01%
1.57%	Wellington Management Group LLP	795,946	US$21.1m	-2.08%	no data
1.51%	Geode Capital Management, LLC	765,834	US$20.3m	132%	no data
1.47%	Cameron Turtle	746,907	US$19.8m	0%	no data
1.46%	Franklin Resources, Inc.	741,904	US$19.7m	0%	0.01%
1.39%	Citadel Advisors LLC	707,586	US$18.8m	0%	0.02%
1.37%	Tavistock Life Sciences	696,480	US$18.5m	179%	0.89%
1.35%	Driehaus Capital Management LLC	687,080	US$18.3m	0%	0.12%
1.33%	Janus Henderson Group plc	673,867	US$17.9m	4,720%	0.01%
1.31%	Farallon Capital Management, L.L.C.	666,000	US$17.7m	42.9%	0.11%
1.13%	Logos Global Management, L.P.	575,000	US$15.3m	130%	1.69%
1.01%	Affinity Asset Advisors, LLC	513,420	US$13.6m	25.2%	2.28%