Septerna Ownership

Who are the major shareholders and have insiders been buying or selling?

Recent Insider Transactions

NasdaqGM:SEPN Recent Insider Transactions by Companies or Individuals
Date	Value	Name	Entity	Shares	Max Price
10 Nov 25	SellUS$63,223	Daniel Long	Individual	3,501	US$18.06
07 Mar 25	BuyUS$92,270	Alan Ezekowitz	Individual	13,319	US$6.93
06 Mar 25	BuyUS$515,934	Alan Ezekowitz	Individual	86,681	US$6.35
27 Feb 25	BuyUS$56,867	Gilbert Labrucherie	Individual	10,000	US$5.85
27 Feb 25	BuyUS$96,961	Jeffrey Finer	Individual	17,000	US$5.80
24 Feb 25	BuyUS$113,147	Third Rock Ventures, LLC	Company	18,861	US$6.00
21 Feb 25	BuyUS$172,297	Gilbert Labrucherie	Individual	30,000	US$5.88
21 Feb 25	BuyUS$6,167,378	Third Rock Ventures, LLC	Company	1,040,342	US$5.94

Insider Trading Volume

Insider Buying: SEPN insiders have only sold shares in the past 3 months.

Ownership Breakdown

What is the ownership structure of SEPN?
Owner Type	Number of Shares	Ownership Percentage
Individual Insiders	1,437,049	3.07%
Hedge Funds	4,015,790	8.57%
VC/PE Firms	20,572,236	43.9%
Institutions	20,855,225	44.5%

Dilution of Shares: Shareholders have not been meaningfully diluted in the past year.

Top Shareholders

Top 25 shareholders own 98.72% of the company

Ownership	Name	Shares	Current Value	Change %	Portfolio %
23.3%	Third Rock Ventures, LLC	10,427,250	US$298.4m	0%	35.95%
15.6%	RA Capital Management, L.P.	6,995,858	US$200.2m	0%	1.92%
11%	Driehaus Capital Management LLC	4,919,896	US$140.8m	5.12%	0.69%
8.97%	BVF Partners L.P.	4,015,790	US$114.9m	-8.65%	3.09%
7.03%	Samsara BioCapital LLC	3,149,128	US$90.1m	0%	8.47%
4.92%	Artal Group S.A.	2,202,514	US$63.0m	0%	1.26%
3.39%	The Vanguard Group, Inc.	1,518,757	US$43.5m	7.38%	no data
3.26%	BlackRock, Inc.	1,459,795	US$41.8m	4.96%	no data
3.17%	The Goldman Sachs Group, Inc.	1,417,214	US$40.6m	0.06%	0.01%
2.99%	Avoro Capital Advisors LLC	1,337,500	US$38.3m	8.08%	0.4%
2.63%	ADAR1 Capital Management, LLC	1,176,491	US$33.7m	38.9%	3.02%
1.85%	Jeffrey Finer	826,907	US$23.7m	0%	no data
1.36%	VR Management, LLC	610,808	US$17.5m	13%	0.58%
1.24%	Casdin Capital, LLC	553,268	US$15.8m	0%	1.03%
1.22%	Geode Capital Management, LLC	545,701	US$15.6m	11.8%	no data
1.21%	Perceptive Advisors LLC	541,450	US$15.5m	0%	0.33%
0.94%	State Street Global Advisors, Inc.	418,960	US$12.0m	13.2%	no data
0.86%	Millennium Management LLC	384,200	US$11.0m	640%	0.01%
0.66%	Catalio Capital Management, LP	294,360	US$8.4m	0%	0.96%
0.63%	Checkpoint Capital, LLC	283,158	US$8.1m	-51.7%	2.34%
0.63%	Woodline Partners LP	282,585	US$8.1m	0%	0.04%
0.54%	Orion Portfolio Solutions, LLC	239,767	US$6.9m	0.94%	0.05%
0.5%	Universal Investment GmbH	222,702	US$6.4m	0%	0.01%
0.42%	Sio Capital Management, LLC	189,199	US$5.4m	-67.6%	1.13%
0.42%	Charles Schwab Investment Management, Inc.	186,904	US$5.3m	20.8%	no data

Company Analysis and Financial Data Status

Data	Last Updated (UTC time)
Company Analysis	2025/12/29 11:28
End of Day Share Price	2025/12/26 00:00
Earnings	2025/09/30
Annual Earnings	2024/12/31

Data Sources

The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.

Package	Data	Timeframe	Example US Source ^*
Company Financials	10 years	Income statement Cash flow statement Balance sheet	SEC Form 10-K SEC Form 10-Q
Analyst Consensus Estimates	+3 years	Forecast financials Analyst price targets	Analyst Research Reports Blue Matrix
Market Prices	30 years	Stock prices Dividends, Splits and Actions	ICE Market Data SEC Form S-1
Ownership	10 years	Top shareholders Insider trading	SEC Form 4 SEC Form 13D
Management	10 years	Leadership team Board of directors	SEC Form 10-K SEC Form DEF 14A
Key Developments	10 years	Company announcements	SEC Form 8-K

^* Example for US securities, for non-US equivalent regulatory forms and sources are used.

Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more.

Analysis Model and Snowflake

Details of the analysis model used to generate this report is available on our Github page, we also have guides on how to use our reports and tutorials on Youtube.

Learn about the world class team who designed and built the Simply Wall St analysis model.

Industry and Sector Metrics

Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on Github.

Analyst Sources

Septerna, Inc. is covered by 8 analysts. 8 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.

Analyst	Institution
Joshua Schimmer	Cantor Fitzgerald & Co.
Raghuram Selvaraju	H.C. Wainwright & Co.
Catherine Novack	JonesTrading Institutional Services, LLC