Prothena Ownership

Who are the major shareholders and have insiders been buying or selling?

Recent Insider Transactions

Insider Buying: Insufficient data to determine if insiders have bought more shares than they have sold in the past 3 months.

Dilution of Shares: Shareholders have not been meaningfully diluted in the past year.

Top 25 shareholders own 97.06% of the company

Ownership	Name	Shares	Current Value	Change %	Portfolio %
21.5%	EcoR1 Capital, LLC	11,584,280	US$174.7m	0%	5.7%
15%	FMR LLC	8,066,976	US$121.7m	0.02%	0.01%
10.8%	Wellington Management Group LLP	5,798,741	US$87.4m	38.8%	0.01%
7.5%	William Scully	4,036,140	US$60.9m	13.2%	no data
7.49%	BlackRock, Inc.	4,028,387	US$60.7m	4.44%	no data
7.1%	T. Rowe Price Group, Inc.	3,822,434	US$57.6m	-9.79%	no data
3.23%	Palo Alto Investors LP	1,737,964	US$26.2m	4.3%	3.54%
3.11%	State Street Global Advisors, Inc.	1,674,909	US$25.3m	-13.3%	no data
3.07%	Armistice Capital LLC	1,650,000	US$24.9m	5.77%	0.61%
2.34%	The Vanguard Group, Inc.	1,259,101	US$19.0m	7.46%	no data
2.04%	Artal Group S.A.	1,099,840	US$16.6m	9.83%	0.41%
1.79%	Geode Capital Management, LLC	963,479	US$14.5m	-3.1%	no data
1.59%	Dimensional Fund Advisors LP	854,050	US$12.9m	-0.87%	no data
1.28%	Tavistock Life Sciences	690,000	US$10.4m	0%	0.64%
1.16%	Rock Springs Capital Management LP	625,048	US$9.4m	0%	0.3%
1.11%	Morgan Stanley, Investment Banking and Brokerage Investments	597,726	US$9.0m	-9.42%	no data
1.1%	UBS Asset Management AG	589,254	US$8.9m	571%	no data
0.9%	Prosight Management, LP	483,467	US$7.3m	68.5%	1.88%
0.85%	Todd Fennell	458,981	US$6.9m	77.4%	no data
0.81%	Finepoint Capital LP	433,471	US$6.5m	0%	0.68%
0.75%	Federated Hermes, Inc.	404,903	US$6.1m	823%	0.01%
0.69%	Northern Trust Global Investments	372,655	US$5.6m	2.35%	no data
0.65%	Candriam, Société En Commandite Par Actions	348,187	US$5.3m	0%	0.01%
0.6%	Charles Schwab Investment Management, Inc.	324,962	US$4.9m	-0.67%	no data
0.6%	Mariner, LLC	323,213	US$4.9m	63.2%	0.01%