Prelude Therapeutics Ownership

Who are the major shareholders and have insiders been buying or selling?

Recent Insider Transactions

NasdaqGS:PRLD Recent Insider Transactions by Companies or Individuals
Date	Value	Name	Entity	Role	Shares	Max Price
21 Apr 26	BuyUS$12,499,999	OrbiMed Advisors LLC	Company		2,815,315	US$4.44

Insider Trading Volume

Insider Buying: Insufficient data to determine if insiders have bought more shares than they have sold in the past 3 months.

Ownership Breakdown

What is the ownership structure of PRLD?
Owner Type	Number of Shares	Ownership Percentage
Public Companies	4,372,124	4.35%
Individual Insiders	4,507,501	4.48%
Institutions	8,041,614	8%
Hedge Funds	17,293,897	17.2%
VC/PE Firms	25,880,639	25.7%
General Public	40,456,675	40.2%

Dilution of Shares: Shareholders have been substantially diluted in the past year, with total shares outstanding growing by 30.1%.

Top Shareholders

Top 25 shareholders own 58.69% of the company

Ownership	Name	Shares	Current Value	Change %	Portfolio %
19.3%	OrbiMed Advisors LLC	19,404,757	US$91.2m	17%	1.33%
17.2%	Baker Bros. Advisors LP	17,293,897	US$81.3m	0%	0.43%
6.44%	RA Capital Management, L.P.	6,475,882	US$30.4m	0%	0.43%
4.35%	Incyte Corporation	4,372,124	US$20.5m	0%	no data
3.1%	Krishna Vaddi	3,117,278	US$14.7m	0%	no data
1.41%	The Vanguard Group, Inc.	1,413,986	US$6.6m	42.4%	no data
0.78%	Kynam Capital Management, LP	788,867	US$3.7m	0%	0.23%
0.78%	Two Sigma Investments, LP	788,695	US$3.7m	418%	0.01%
0.75%	T. Rowe Price Group, Inc.	755,956	US$3.6m	-13.7%	no data
0.55%	Blue Sky Trust	551,776	US$2.6m	0%	no data
0.53%	Acadian Asset Management LLC	535,703	US$2.5m	-0.9%	no data
0.5%	Paul Friedman	500,098	US$2.4m	0%	no data
0.48%	Andrew Combs	480,123	US$2.3m	0%	no data
0.33%	Morgan Stanley	334,916	US$1.6m	17.8%	no data
0.27%	Marshall Wace LLP	273,883	US$1.3m	0%	no data
0.27%	Geode Capital Management, LLC	272,886	US$1.3m	25.4%	no data
0.27%	Renaissance Technologies LLC	271,300	US$1.3m	-50.1%	no data
0.26%	BlackRock, Inc.	266,280	US$1.3m	0.49%	no data
0.24%	Two Sigma Advisers, LP	237,300	US$1.1m	6.56%	no data
0.18%	Peggy Scherle	185,685	US$872.7k	0%	no data
0.16%	TD Asset Management, Inc.	160,652	US$755.1k	0%	no data
0.15%	Millennium Management LLC	150,997	US$709.7k	-86.8%	no data
0.14%	Susquehanna International Group, LLP	135,909	US$638.8k	0%	no data
0.13%	State Street Global Advisors, Inc.	127,292	US$598.3k	30.4%	no data
0.12%	Sphera Funds Management Ltd	122,752	US$576.9k	0%	0.08%

Company Analysis and Financial Data Status

Data	Last Updated (UTC time)
Company Analysis	2026/05/04 22:04
End of Day Share Price	2026/05/04 00:00
Earnings	2025/12/31
Annual Earnings	2025/12/31

Data Sources

The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.

Package	Data	Timeframe	Example US Source ^*
Company Financials	10 years	Income statement Cash flow statement Balance sheet	SEC Form 10-K SEC Form 10-Q
Analyst Consensus Estimates	+3 years	Forecast financials Analyst price targets	Analyst Research Reports Blue Matrix
Market Prices	30 years	Stock prices Dividends, Splits and Actions	ICE Market Data SEC Form S-1
Ownership	10 years	Top shareholders Insider trading	SEC Form 4 SEC Form 13D
Management	10 years	Leadership team Board of directors	SEC Form 10-K SEC Form DEF 14A
Key Developments	10 years	Company announcements	SEC Form 8-K

^* Example for US securities, for non-US equivalent regulatory forms and sources are used.

Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more.

Analysis Model and Snowflake

Details of the analysis model used to generate this report is available on our Github page, we also have guides on how to use our reports and tutorials on Youtube.

Learn about the world class team who designed and built the Simply Wall St analysis model.

Industry and Sector Metrics

Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on Github.

Analyst Sources

Prelude Therapeutics Incorporated is covered by 5 analysts. 3 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.

Analyst	Institution
Tazeen Ahmad	BofA Global Research
Reni Benjamin	Citizens JMP Securities, LLC
Graig Suvannavejh	Goldman Sachs