Kymera Therapeutics (KYMR): Valuation Insights Following Promising KT-579 Preclinical Data in Lupus and Rheumatoid Arthritis

Simply Wall St

Kymera Therapeutics (KYMR) unveiled new preclinical results for its oral IRF5 degrader, KT-579, at a major rheumatology meeting. The data suggest KT-579 can target critical pathways in lupus and rheumatoid arthritis models.

See our latest analysis for Kymera Therapeutics.

The latest preclinical breakthrough from Kymera Therapeutics follows a string of high-profile presentations, building a sense of momentum in both its clinical story and market performance. After a steady run, the stock’s 41.64% share price return over the past 90 days and a 33.08% total shareholder return in the last year suggest that investors are warming to its growth prospects, with the share price climbing to $61.84.

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With excitement building on strong clinical data and rising shares, the key question now is whether Kymera’s current valuation leaves room for upside or if investors have already priced in the company’s growth trajectory.

Most Popular Narrative: 10% Undervalued

With Kymera Therapeutics closing at $61.84 and the most widely followed narrative assigning a fair value near $69, there is a notable gap between where the market is and what consensus expects. This sets up a compelling debate over what could drive the stock higher from here.

The ongoing progress of KT-621, especially as it advances through critical clinical milestones, is expected to remain a core value driver for the company in the near and long term. Transition to Phase 2 studies and imminent Phase 1b data readouts are viewed as key catalysts that could further de-risk the program and unlock shareholder value.

Read the complete narrative.

Want to know how ambitious revenue and earnings growth projections are shaping this valuation? The secret mix behind this number is hidden in surprising profitability forecasts and aggressive growth assumptions. There is more to this narrative than meets the eye. Discover the details by reading further.

Result: Fair Value of $69.05 (UNDERVALUED)

Have a read of the narrative in full and understand what's behind the forecasts.

However, lingering questions around KT-621's clinical data and execution risks in transitioning between trial phases could challenge the company’s current positive outlook.

Find out about the key risks to this Kymera Therapeutics narrative.

Another View: Looking at Market Price Ratios

While the narrative-based valuation signals Kymera Therapeutics is undervalued, the current price-to-book ratio tells a different story. At 4.6x, it stands well above the US Biotechs industry average of 2.5x and is slightly below its peer group’s 5.1x. This suggests investors might already be factoring in much of Kymera’s upside, which could mean less room for further gains unless performance beats expectations. Is the market setting the bar too high, or are these levels justified?

See what the numbers say about this price — find out in our valuation breakdown.

NasdaqGM:KYMR PB Ratio as at Nov 2025

Build Your Own Kymera Therapeutics Narrative

Keep in mind, if you see things differently or want to dive into the numbers yourself, you can craft your own view in under three minutes: Do it your way.

A great starting point for your Kymera Therapeutics research is our analysis highlighting 2 important warning signs that could impact your investment decision.

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This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

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